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Shan-Shan Wang,Hai-Xiang Sun 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.3
Purpose: Blastocyst transfer has been recommended to raise the implantation rate without affecting the pregnancy rate. The objective of this meta-analysis is to systematicallyevaluate whether the live birth rate and other pregnancy outcomes can be improved by blastocyst transfer compared with cleavage-stage embryos transfer. Materials and Methods: EMBASE and MEDLINE databases were searched for papers published between March 2004 and March 2013. An extensive range of the electronic databases yielded initially 317 studies from which seven trials met the inclusion criteria for further analysis. Our outcome measures were the live birth rate, clinical pregnancy rate, implantation rate, ongoing pregnancy rate, multiplepregnancy rate, first trimester miscarriage rate and ectopic pregnancy rate. Fixed effects models were chosen to calculate the odds ratio (OR). Results: Seven trials (n=1446 cases) were finally analyzed. Compared with cleavage-stage embryostransfer, the blastocyst transfer was statistically significantly associated with an increase in clinical pregnancy rate [OR 1.43; 95% confidence interval (CI), 1.15-1.78], implantation rate (OR 1.38; 95% CI, 1.09-1.74) and ongoing pregnancy rate (OR 2.15; 95% CI, 1.57-2.94), and also a reduction in the probability of first trimestermiscarriage rate (OR 0.51; 95% CI, 0.30-0.87). The improvement in the live birth rate was also observed (OR 1.77; 95% CI, 1.32-2.37). Moreover, there was no evidence of difference in multiple pregnancy and ectopic pregnancy rates. Conclusion: The available evidences suggest that live birth and other pregnancy outcomes after fresh in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) are significantly improved following blastocyst transfer as compared to cleavage-stage embryo transfer.
Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China
Xiang-Quan Xie,Kui-Cheng Zheng,Bing-Shan Wu,Tie-Hui Chen,Shan-Rong Lai,Zai-Sheng Lin,Kazuo Aoki 대한예방의학회 2014 Journal of Preventive Medicine and Public Health Vol.47 No.5
Objectives: In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increasedrisk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogenI:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthydietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developinggastric cancer than those in Nanjing do.
맹상삼(Xiang-Shan Meng),이광호(Kwang-Ho Lee) 한국엔터테인먼트산업학회 2020 한국엔터테인먼트산업학회논문지 Vol.14 No.6
본 논문은 대중문화 콘텐츠 변화에 의한 신조어를 비교 연구한 것이다. 한국과 중국은 교류가 긴밀해지면서 언어까지 영향을 주고받는다. 이에 따라 신조한 국어와 동일한 언어 특성을 가진 신조중국어가 발견된다. 또한 신조어는 언어의 새로운 발전 결과물이라고 여긴다. 이러한 신조어는 한국과 중국의 젊은층에서 널리 사용하고 있는 상황이다. 따라서 언어가 소통을 전제로 한다는 측면에서 학문적인 연구를 통하여 한중 신조어를 명확히 인식하는 것이 바람직하다. 2018년 신조중국어의 특성을 중심으로 먼저 2017년 이전의 신조중국어와 합성, 약어, 대치 등의 형태적인 요소와 비유, 은어 등 의미적인 측면에 의해 비교하여 분석하였다. 이를 통해 2018년 신조중국어의 특성을 추출하였다. 다음에 이러한 신조어의 구성방법에 의해 2018년의 신조한국어와의 공통점과 차이점도 확인하였다. 그리고 한국어와 중국어 신조어를 분석한 결과, 기존의 언어 재활용 현상이 두드러짐도 확인하였다. 이러한 한중 신조어가 표준어로 정착하는 과정을 보기 위해 신조어의 구성방법을 정확하게 탐색해보고자 하는 것이 중요하다. The purpose of this study is to analyze new words in Korean and Chinese based on changes in popular culture. As China and Korea embrace increasingly close communication in recent years, their languages have influenced each other. A lot of new Korean and Chinese words have been discovered to have the same linguistic characteristics. New words are considered as new developments of a language. They are welcomed and widely used by young people in Korea and China. Therefore, in terms of the communicative function of languages, it is worthwhile to understand new words in Korean and Chinese from the perspective of academic research. This study takes Chinese words created in 2018 as the research object. Firstly, a morphological and semantic comparison of Chinese words created in 2018 and those created in 2017 is carried out to extract the characteristic indicators of Chinese words created in 2018, with emphasis on compound words, abbreviations, substitutions, patters and rhetorical expressions. Secondly, the similarities and differences of these Chinese words with Korean words created in 2018 in terms of morphology are analyzed. Finally, after conducting sample classification and comparison, the characteristics of new Chinese and Korean words and the interaction mechanism under mutual influence are concluded. According to the study, the majority of the new words are created on the basis of existing words. Thus, it is important to explore the morphology of new words as a standard language.
사회문화적 양상에 따른 한중 [+사람] 신어의 비교 연구 - 2010년대의‘ㅇㅇ족(族)’계열 신어의 구조적과 의미 양상을 중심으로 -
맹상삼(Xiang-Shan Meng) 한국엔터테인먼트산업학회 2021 한국엔터테인먼트산업학회논문지 Vol.15 No.7
본 연구는 한·중 [+사람] 신어를 조어하는 데에 공통으로 사용된‘ㅇㅇ족(族)’계열 신어를 대상으로하여 2010부터 2019년까지 10년간의 출현 양상을 살펴보고,‘ㅇㅇ족(族)’계열 신어의 구조적과 의미 양상인 공통점 및 차이점을 밝히는 것에 목적을 둔다. 출현 양상에 있어서‘ㅇㅇ족’의 한국 신어는 10년간에 꾸준히 생성되었고,‘ㅇㅇ族’의 중국 신어는 2017년에 형성되지 않았다가 2018년과 2019년에 적은 양으로 다시 나타났다. ‘ㅇㅇ족(族)’계열 신어는 구조적 특징에 차이점이 보인다. 가장 활발히 형성된 합성의 경우 한국‘ㅇㅇ족’신어의 선행요소는 다양한 어원의 요소와 결합유형을 보여 주었다. 그러나‘ㅇㅇ族’으로 생성된 중국 신어는 고유어 합성만이 활발하여 제한된 조어양상을 보여 주었다. 파생도 이러한 차이점을 나타냈다. 한·중‘ㅇㅇ족(族)’계열 신어의 의미 자질로 분류하고 특성을 살펴봄으로써 그들은 보여주는 특성이 다르지만, 모두 다양한 영역의 문화와 현상, 그리고 새로운 표현 의미들을 선행요소로 수용한 것으로 나왔다. 이러한 다양함이 신어 생성에서 작용하여 영향을 끼친 것으로 보인다. The purpose of this study is to examine the appearance patterns of the ‘ㅇㅇjok(family)’ line, which is commonly used to abbreviate Korean and Chinese Neologisms, from 2010 to 2019, and to identify the structural and Meaningful similarities and differences of the ‘ㅇㅇjok(family)’ line Neologisms. In terms of appearance, the Korean Neologisms of the ‘ㅇㅇjok’ was constantly created for 10 years, and the Chinese Neologisms of the ‘ㅇㅇfamily’ was not formed in 2017 but reappeared in small quantities in 2018 and 2019. Korean and Chinese Neologisms of the ‘ㅇㅇjok(family)’ show differences in their structural characteristics. In the case of the most actively formed compound, the preceding elements of the Korean ‘ㅇㅇjok’ Neologisms showed various etymological elements and types. However, the Chinese Neologisms produced by ‘ㅇㅇfamily’ showed a limited linguistic aspect due to the active compound of native languages. Derivative also showed these differences. By Classifying ‘ㅇㅇjok(family)’ line in Korean and Chinese Neologisms as meaningful qualities, they have different characteristics, but both of them were found to have accepted colorful culture and phenomenon in various areas, and new expression meanings as their precedence element. These diverse cultures appear to have influenced the creation of the new language.
Meta-analysis of Gene Expression Data Identifies Causal Genes for Prostate Cancer
Wang, Xiang-Yang,Hao, Jian-Wei,Zhou, Rui-Jin,Zhang, Xiang-Sheng,Yan, Tian-Zhong,Ding, De-Gang,Shan, Lei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Prostate cancer is a leading cause of death in male populations across the globe. With the advent of gene expression arrays, many microarray studies have been conducted in prostate cancer, but the results have varied across different studies. To better understand the genetic and biologic mechanisms of prostate cancer, we conducted a meta-analysis of two studies on prostate cancer. Eight key genes were identified to be differentially expressed with progression. After gene co-expression analysis based on data from the GEO database, we obtained a co-expressed gene list which included 725 genes. Gene Ontology analysis revealed that these genes are involved in actin filament-based processes, locomotion and cell morphogenesis. Further analysis of the gene list should provide important clues for developing new prognostic markers and therapeutic targets.
Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China
Xie, Xiang-Quan,Zheng, Kui-Cheng,Wu, Bing-Shan,Chen, Tie-Hui,Lai, Shan-Rong,Lin, Zai-Sheng,Aoki, Kazuo The Korean Society for Preventive Medicine 2014 Journal of Preventive Medicine and Public Health Vol.47 No.5
Objectives: In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increased risk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogen I:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthy dietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developing gastric cancer than those in Nanjing do.
장기간의 크레아틴 섭취가 역도선수 신장 기능에 미치는 영향
선주상 ( Zhou Xiang Shan ),안효작 ( Hyo Jak Ahn ),염동철 ( Dong Cheol Yeom ),김창근 ( Chang Keun Kim ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.31 No.1
이 연구의 목적은 장기간 크레아틴 섭취가 역도선수의 신장기능에 미치는 영향을 알아보는데 있다. 연구 대상자는 평소 꾸준히 크레아틴을 섭취해 온 역도 국가대표선수 남녀 57명으로, 집단은 크레아틴 섭취 기간에 따라 1년 미만(n=10), 1년-3년 (n=15), 3년-5년(n=16), 5년 이상(n=16)으로 구분하였다. 신장기능을 평가하기 위해 혈청과 뇨에서 관련 변인(크레아틴, 크레아티닌, 뇨산, 시스타틴-C)을 분석하였다. 실험결과, 혈청 및 뇨에서 크레아틴, 크레아티닌, 뇨산 그리고 시스타틴-C는 모두 집단 간에 유의한 차이를 나타내지 않았다. 또한, 측정된 변인들은 혈액이나 뇨에서 모두 정상 농도범위를 유지했다. 그러나 뇨에서 크레아티닌과 뇨산은 정상 농도범위 보다 약간 높게 나타났으며, 혈청에서 사구체여과율은 정상범위 보다 약간 낮게 나타났다. 요약하면, 혈청과 뇨에서 분석한 변인들은 1년 미만에서 5년 이상의 크레아틴 섭취기간에 따른 집단 간에 차이를 보이지 않았다. 그러나 모든 집단에서 뇨 크레아티닌과 뇨산 수준은 정상수준보다 높았고, 사구체여과율은 더 낮은 수준을 보였다. 그러므로, 이러한 결과들을 확인하기 위한 후속연구가 필요할 것으로 사료된다. The aim of the present study was to investigate the effect of a long term creatine supplementation on renal function in weight lifters. Fifty seven weight lifters who have been supplemented creatine was participated in the experiment, and divided into four groups of under 1 yr (n=10), 1 to 3 yrs (n=15), 3 to 5 yrs (n=16), and over 5 yrs (n=16) by the period of creatine intake. Serum and urine creatine, creatinine, uric acid, and cystatin-C were analysed to evaluate renal function. There was no significant differences among the groups, not only by the measurement of serum creatine, creatinine, uric acid, cystatin- C, but also in urine as well. All measured valuables to evaluate renal function maintained normal concentration either in blood or in urine. But urine creatinine and uric acid level were maintained higher than normal concentration, and GFR level in serum was lower than normal level in all groups. In summary, there were no difference among the different durations of creatine supplementation of under one year to more than five years in the parameters measured in serum and urine. However urine creatinine and uric acid level were maintained slightly higher, and GFR level in serum was slightly lower in all groups. Therefore, it is highly recommended further research to confirm these findings in the future.
Zhou, Zhi-Xiang,Li, Dan,Guan, Shan-Shan,Zhao, Chen,Li, Ze-Lin,Zeng, Yi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Cervical cancer is the second most common cause of cancer related death of women. Persistent HPV infection, especially with high-risk types such as HPV16 and HPV18, has been identified to be the primary cause of cervical cancer. E6 and E7 are the major oncoproteins of high-risk HPVs, which are expressed exclusively in HPV infected tissues, and thereby represent ideal therapeutic targets for immunotherapy of cervical cancer. Materials and Methods: In this work, we used recombinant adenovirus expressing coden-optimized HPV16 E6 and E7 fusion protein (Ad-ofE6E7) to prime dendritic cells (DC-ofE6E7), to investigate the ability of primed DC vaccine in eliciting antitumor immunity in vitro and vivo. Results: Our results indicated that DC-ofE6E7 vaccine co-culturing with splenocytes could strongly induce a tumor-specific cytotoxic T lymphocyte (CTL) response and kill the TC-1 cells effectively in vitro. Moreover, DC-ofE6E7 vaccine induced protective immunity against the challenge of TC-1 cancer cells in vivo. Conclusions: The results suggested that the HPV16 ofE6E7 primed DC vaccine has potential application for cervical cancer immunotherapy.
Zhao, Jun-Qiang,Sun, Fang-Jie,Liu, Shan-Shan,Yang, Jun,Wu, Yu-Quan,Li, Gui-Shan,Chen, Qing-Yong,Wang, Jia-Xiang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Aim: Connexin 43 (Cx43) and E-cadherin are important biomarkers related with cancer. Their expression at protein and mRNA levels was here investigated in 50 primary lung carcinoma tissues and 20 samples of adjacent normal tissue of Chinese patients with non-small cell lung cancer (NSCLC). Methods: Protein and mRNA expression were evaluated by ABC immunohistochemistry and RT-PCR. Results: (1) The positive expression rates of Cx43 and E-cadherin protein were higher in the adjacent normal tissues than those in the primary lung carcinoma tissues; (2) the positive expression rates of Cx43 and E-cadherin protein decreased with NSCLC progression; (3) the expression of E-cadherin protein was not related with the pathological type of NSCLC; and (4) the relative quantity of the Cx43 or E-cadherin mRNA expression was correlated with the the histological type, clinical stage, cancer cell differentiation and the lymph node metastasis. Conclusion: The data suggested that the Cx43 and E-cadherin are reduced with NSCLC progression, and might be important biomarkers for judging the metastasis and prognosis.