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( Wu Zhou ) 성균관대학교 유교문화연구소 2013 儒敎文化硏究(中文版) Vol.0 No.19
儒家天道觀的特質,與其固有的道論、氣論和象論的獨特內涵有關,進一步來看,也跟中國古代社會基於其環境特徵的獨特的農耕文明有關。農耕文明亟須之基本認識方法爲物候學觀察,這種方法的泛化就是“取象比類”。農耕要靠天吃飯,對於氣候資源高度依賴,對於氣候波動則高度敏感;中華文明核心區域裡的東亞季風性氣候,就在儒家天道觀當中得到了深刻映現,與此種天道觀相容的“陰陽五行”的編碼模式,就是運用物候學方法和反映東亞季風性氣候的結果。 The specialty of Confucian viewpoint on natural law is related to the special intension of Dao theory and Qi theory and phenomenon theory. And also the specialty of Confucian viewpoint on natural law is related to the special agriculture civilization because of the environment of ancient china. The phenometry is the basic cognitional method in the agriculture civilization. Then the phenomenon theory usually basing on analogy has been the wide-ranging apply of the phenometry. Obviously, the farming practices rely on the climate resources and the natural condition. Then the features of East Asian monsoonal climate in the principal area are deeply reflected in the Confucian viewpoint on natural law. The encoded models of Yin yang and five elements that is compatible to the Confucian natural law viewpoint are the results of the apply of phenometry and the reflects of the features of East Asian monsoonal climate. [Article in Chinese]
Weishi Yu,Yuequn Wang,Yongqing Li,Yun Deng,Zequn Wang,Wuzhou Yuan,Dali Li,Chuanbing Zhu,Xueying Zhao,Xiaoyang Mo,Wen Huang,Na Luo,Yan Yan,Karen Ocorr,Rolf Bodmer,Xiushan Wu 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.5
The Bric-a-brac, Tramtrack, Broad-complex (BTB) domain is a protein-protein interaction domain that is found in many zinc finger transcription factors. BTB containing proteins play important roles in a variety of cellular functions including regulation of transcription, regulation of the cytoskeleton, protein ubiquitination, angiogenesis, and apoptosis. Here, we report the cloning and characterization of a novel human gene, KLHL31, from a human embryonic heart cDNA library. The cDNA of KLHL31 is 5743 bp long, encoding a protein product of 634 amino acids containing a BTB domain. The protein is highly conserved across different species. Western blot analysis indicates that the KLHL31 protein is abundantly expressed in both embryonic skeletal and heart tissue. In COS-7 cells, KLHL31 proteins are localized to both the nucleus and the cytoplasm. In primary cultures of nascent mouse cardiomyocytes, the majority of endogenous KLHL31 proteins are localized to the cytoplasm. KLHL31 acts as a transcription repressor when fused to GAL4 DNA-binding domain and deletion analysis indicates that the BTB domain is the main region responsible for this repression. Overexpression of KLHL31 in COS-7 cells inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). KLHL31 also significantly reduces JNK activation leading to decreased phosphorylation and protein levels of the JNK target c-Jun in both COS-7 and Hela cells. These results suggest that KLHL31 protein may act as a new transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions.