企業의 中高年齡層 問題와 그 對策에 관한 硏究

楊雲燮 군산대학교 산업개발연구소 1988 産業開發硏究 Vol.7 No.-

合理的 經營을 爲한 少數精銳主義

楊雲燮 全北大學校 1978 論文集 Vol.20 No.-

In this thesis, the writer has deaf with "A principle of selected minority for rational management," After the world War Ⅱ, in Korea, We were stagnant in a vicious circle of poverty, as prof, R, Nurkse said. But according to the industrialization, Well-educated manpower could be employed in low-efficiency and low-cost monagement methods were adopted. That is to say, up to now, the enterprises were run in low-wages, low-efficiency and low-Costs, therefore, the superfluous manpowers and individual inefficiency were failed to notice, But since the 1970's, espacially in recent years, new Change took place in structual conditions in management, That is high-wages, Labor-famine, Liberalization of Capital and intensificational of international competetions etcs. so it must be considered a measure to counter these problems. Under the above Circumstances the writer emphasized here the adoption of selected minority to rationalize the management. And he has researched the following points in the study. In the second chapter of this study, he tried to explaine the meaning of "A principle of selected minority." In the third chapter of this study, he introduced briefly some substances. In the fourth capter of thi study, the writer studied various methods. And he also mentioned some problems to be found while this subject is practiced.

아급성 괴사성 림프절 염에서 결핵균 및 비결핵성 미코박테륨에 대한 연구

조민선,한운섭 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Objectives : Subacute necrotizing lymphadenitis is a self-limiting disorder that typically affects cervical lymph nodes of young women. Although autoimmune reaction and a viral etiology have been suggested, the definite cause has been uncertain. We evaluated the association of M. tuberculosis and non-tuberculous mycobacterium with this disorder. Materials and Methods : From 1994 to 2002, Clinicopathological findings of 38 cases were revie-wed. Multiplex nested PCR was done using DNA extracted from paraffin-embedded tissue. Sequen-cing analysis was done to the cases showing positive band. Results : 3 cases among 38(7.89%) showed amplified non-tuberculous mycobacterium DNA. Two cases are M. gordonae and one is M. fortuitum by sequencing analysis. All cases revealed no positive band for M. tuberculosis. Negative control cases showed no bands for both mycobacte-riums. Conclusion : Although 7.89% of cases showed amplified non-tuberculous mycobacterium DNA, more study is needed to confirm the association of non-tuberculous mycobacterium with subacute necrotizing lymphadenitis. 목적 : 아급성 괴사성 림프절염의 원인으로서 결핵균 및 비결핵성 미코박테륨의 가능성에대해 알아보고자 하였다. 대상 및 방법: 1994년부터 2002년까지 아급성 괴사성 림프절염으로 진단된 38예를 대상으로 임상 및 병리조직학적인 소견을 검색하고, 파라핀 포매조직을 이요하여 결핵균 및 비결핵성 미코박테륨에 대해 multiplex nested PCR을 시행하고 양성인 예에 대해 유전자 염기서열분석을 시행하였다. 결과: 남녀 비가 6.6대 1 여자에게 주로 발생하였고 평균 나이는 30.0세였다. 37명의 환자가 경부림프절에서 발생하였다. 전체 38예 중 3예(7.89%)가 비결핵성 미코박테륨에 양성인 밴드를 보였고, 결핵균에 대해서는 모두 음성이었다. 음성 대조군은 결핵균 및 비결핵성 미코박테륨에 대해 모두 음성이었다. 유전자 염기서열 분석에서 2예는 M. gordonae 였고 1예는 M. fortuitum 이었다. 결론: 아급성 괴사성 림프절염 38예 중 3예가 비결핵성 미코박테륨에 대해 양성 반응을 보였으나 확실한 연관성을 증명하기 위해서는 더 많은 예가 양성을 보여야 한다고 생각한다.

肝吸蟲感染 마우스의 膽管系 早期 變化

閔弘基,韓雲燮 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.2

The objective of this sutdy was to obtain further information on the relation-ship between oncogenesis of cholangiocellular carcinoma of the liver and the infection with a liver fluke, Clonorchis sinensis in the earlier stage of the infec-tion. A group of 24 BALB/C male mice were used. Approximately 500 metacercariae were given orally to each mouse. Three mice were killed on the scheduled day, 3rd, 5th, 7th, 10th, 15th, 20th, 25th and 28th day after infection, respectively and histopathologic changes of the bile ducts were examined using hematoxylin and eosin stain method. The histopathologic findings observed were summarized as follows ; 1) Mice killed on the 3rd day showed a mild epithelial hyperplasia with the formation of papillae and adenomatous tissue proliferation. Bile ducts were dilated and the stroma was infiltrated by inflammatory cells, mainly eosinophils and polymorphonuclear leucocytes. Occasionally mitotic figures and atypia of epithelial cells were seen. Worms were found in the distal peripheral smaller branches of the bile duct. 2) Mice killed on the 7th day gave a mild connective tissue proliferation in addition to more striking pictures in the bile ducts. Chronic mononuclear leucocytes appeared in the stroma. 3) Bile duct chagnges including epithelial hyperplasia, adenomatous tissue for-mation, connective tissue proliferation and inflammatory cell infiltration were greater in the degrees in mice killed on the 10th day after infection. Mucinous cell metaplasia and collagen fiber proliferation were also observed. 4) From the 15th day throughout the 28th day after infection, mice showed the most striking pictures of peithelial hyperplasia, adenomatous tissue formation and mucinous cell metaplasia. The stroma demonstrated the excessive eosinophil and chronic mononuclear leucocyte infiltrations, while polymorphonuclear leucocytes were decreased.

임신성 융모 종양의 Immunoperoxidase 방법에 의한 HCG, HPL 및 SP-1의 분포에 관한 면역조직화학적 연구

정미경,한운섭,김옥경 梨花女子大學校 醫科大學 醫科學硏究所 1987 EMJ (Ewha medical journal) Vol.10 No.3

Fourty-six cases of gestational trophoblastic neoplasms (32 cases of hydatidiform mole; 4 cases of invasive mole; 10 cases of choriocarcinoma) and five cases of normal pregnancy as control group were studied for the distribution and intensity of human chorionic gonadotropin(HCG), human placental lactogen(HPL) and regnancy specific beta-1 glycoprotein(SP-1) by immunoperoxidase method. The following results were obtained. 1) The HGC was seen in the syncytiotropholasts, but not cytotrophoblasts of normal placental tissue and hydatidiform mole in all 3 grades. However, in the invasive mole and choriocarcinoma, the HCG was also seen in the cytotrophoblasts. 2) The HPL and SP-1 were only seen in the syncytiotrophoblasts in all those trophoblastic neoplasms. 3) The more malignancy was progressed, the more intensity of the HCG in the syncytiotrophoblasts was increase. Especially, it was severe intensity of positivity in the choriocarcinoma. 4) Intensity of the HPL in the syncytiotrophoblast had the tendency of increase in the invasive mole. But, it was variable in the choriocarcinoma. 5) Intensity of the SP-1 in the syncytiotrophoblast had the tendency of increase in the grade Ⅱ of hydatidiform mole. But thereafter, it was decreased or variable in more aggressive trophoblastic neoplasms, In conclusion, the HCG, HPL and SP-1 were present in the syncytiotrophoblasts of normal placental tissue and various trophoblastic neoplasms. And, the more severe hyperplasia and undifferentiation of trophoblasts were seen, the more intensity of the HCG was increased, suggesting that the HCG can be a useful tumor marker of prognosis in gestational trophpblastic neoplasms.

사용후핵연료 차세대관리공정 장비의 내방사선 요건 분석

김성영,송태길,윤지섭,정운관,여화연 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.1

For hot operation of advanced spent fuel conditioning process(ACP), the analysis of radiation-resistant Requirements effect and the system design process are required to design equipment to operate to operate reliably in a gamma radiation environment such as hot cell. To analysis the effects of radiation for ACP, we used the SCALE codes which were certified by Nuclear Regulatory Commission(NRC). The source term was calculated which reflects the features of target nuclear fuels using ORIGEN-S, a module of the SCALE code, and the gamma dose rates were calculated by using the QADS modules, considering the geometry of process equipment respectively. the results are shows that the value was maximum 3.03 ㏉/h from the rod storage box in hot cell, maximum 0.6 ㏉/h from the metallizer, and maximum 72.0 ㏉/h from the vol-oxidizer. Considering those values, the design methods for shielding and repositioning the major equipments and components should be induced, and, the preventive maintenance for components before failure actually occurs should be minimized the effects of radiation.

Monocrotaline으로 유발한 백시의 폐동맥고혈압에서 TGF-β와 PDGF의 발현

조민선,조상호,양우익,한운섭 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.8

위암과 식도암이 병발된 다발성 원발성 악성종양 1예

박사영,이나영,이효진,이선영,최진혁,이순남,심강섭,성순희,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

Multiple primary cancer means that more that two cancers occur independently in an individual. Recently, the incidence of multiple primary cancer has increased with lengthened survival, of cancer patients, development of new diagnostic technique and increased clinical evaluation. We report a patient who had adenocarcinoma of stomach combined with squamous cell carcinoma of esophagus simultaneously.

백혈구 제거용 필터의 평가(Ⅱ)

한규섭,권석운,한복연,조한익,김상인 大韓血液學會 1990 大韓血液學會誌 Vol.25 No.1

Immunocytochemical staining of p16^ink4a protein as an adjunct test in equivocal liquid-based cytology

Shin, Eun Kyoung,Lee, Sa Ra,Kim, Mi Kyoung,Kang, Eun Ji,Ju, Woong,Lee, Shi Nae,Han, Woon Sup,Kim, Seung Cheol Wiley Subscription Services, Inc., A Wiley Company 2008 Diagnostic cytopathology Vol.36 No.5

<P>For cervical cancer screening, HPV-DNA test is expensive and is not easily available in all clinical situations. Thus, we investigated the role of p16<SUP>ink4a</SUP> immunostaining as another adjunct test to diagnose cervical neoplasia in equivocal liquid based cytology. Eighty-seven patients were randomly selected for this study (3 patients with normal, 84 patients with abnormal including 24 ASCUS, 30 LSIL, and 30 HSIL). We performed p16<SUP>ink4a</SUP> immunostaining on ThinPrep® slide and on each case from the corresponding cervical biopsy tissues. High-risk HPV-DNA testing was also performed on all the subjects. We found that the immunoreactivity of p16<SUP>ink4a</SUP> is strongly correlated with the grade of cytologic and histologic diagnoses as well as with Hybrid Capture 2. In comparing the p16<SUP>ink4a</SUP> immunostaining with the Hybrid Capture 2 for accuracy of the diagnosis of CIN II/III or a higher-grade disease in the case of ASCUS/LSIL on ThinPrep®, no significant differences were observed. Our data implies that p16<SUP>ink4a</SUP> immunocytochemical staining in liquid-based cytology specimens might be used as a good adjunct test to predict cervical histology in equivocal ThinPrep® tests. Diagn. Cytopathol. 2008;36:311–316. © 2008 Wiley-Liss, Inc.</P>