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경영컨설팅 분야 캡스톤디자인 수업 사례 연구: H 대학 재직자 중심 학과 사례를 중심으로
임욱빈(Leem, Wook-Bin),황영아(Hwang, Young-Ah) 한국경영교육학회 2021 경영교육연구 Vol.36 No.6
[연구목적] 본 연구는 경영컨설팅 분야의 캡스톤디자인 수업운영 모형을 개발하여 적용하고 그 효과를 검증함으로써 경영컨설팅 분야 캡스톤디자인 수업 운영에의 시사점을 도출하고자 수행되었다. [연구방법] 본 연구는 캡스톤디자인의 개념, 운영체계 및 절차에 관한 문헌 고찰을 토대로 산업체 멘토를 선정하여 15주로 구성된 캡스톤디자인 수업을 설계하고, 수업준비, 수업, 종료 단계에 따른 학습자, 교수자, 산업체 멘토의 역할을 포함한 수업운영 세부 절차를 마련하였다. 이후 설계된 수업운영모형을 적용하여 수업을 진행하였으며, 수업성과 및 만족도 분석을 통해 수업의 효과를 검증하였다. [연구결과] 설계된 수업모형에 따라 학습자들은 3팀으로 나누어 팀별 주제 설정, 과제계획서 제출, 프로젝트 수행, 프로젝트 평가 등을 수행하였으며, 교수자와 산업체 멘토의 프로젝트 진행 지원과 피드백이 이루어졌다. 수업 운영 결과 기존 습득한 전문지식을 바탕으로 실무에서 요구하는 실제적인 역량 함양, 선행학습 내용의 종합적 적용 측면에서 캡스톤디자인 수업의 효과가 확인되었다. [연구의 시사점] 본 연구는 경영컨설팅 분야의 캡스톤디자인 수업에 있어 학습자, 교수자, 멘토의 역할을 체계적으로 제시하는 수업모형을 제시했다는 점에서 의의를 가지며, 향후 경영컨설팅 분야 수업설계의 기초자료로서 활용될 수 있을 것이다. [Purpose] This study was conducted to derive implications by developing and applying a teaching and learning model in the field of management consulting using capstone design, and verifying its effectiveness. [Methodology] In this study, a 15-week capstone design class was designed by selecting industrial mentors based on a literature review on capstone design. After that, the class was conducted by applying the designed class model, and the effectiveness of the class was verified through the class performance and satisfaction analysis. [Findings] According to the designed class model, the learners were divided into three teams to select a topic, submit a task plan, perform a project, and evaluate the project. Support and feedback from instructors and industry mentors were provided. As a result of the class operation, the effectiveness was confirmed in terms of developing the competency required in practice and comprehensive application of the contents of prior learning based on the previously acquired professional knowledge. [Implications] This study has significance in that it systematically presented a teaching model for the capstone design class in the field of management consulting.
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민순,김미승,임욱빈 대한기초간호자연과학회 2000 Journal of korean biological nursing science Vol.2 No.2
To determine the optimal rotational shift system, the effect of the direction of the rotational work shifting on the nocturnal rhythm of plasma melatonin were investigated in nursing students. Two groups of nine volunteers participated as experimental subjects, and two nursing students participated as a control group. The directions of the rotational work shift were as follows : CW(clockwise)-shift were rotated in the direction of day shift(3 days), evening shift(3 days), off duty(1 day) and night shift(5 days), and CCW(counterclockwise)-shift were done in the reverse direction. Plasma melatonin concentrations was measured by radioimmunoassay. The results were as follows : The plasma melatonin levels were kept low at night and in the following morning in the CW night shift workers, whereas the level started to increase at 05 : 00 hr in two workers of four CCW shift workers. These result suggests that the shift rotation in the CW direction is more acceptable in terms of the adaptation of hormonal rhythms. These results indicate that the CCW rotation of shift work is somewhat better than CCW rotation for the adaptation to shift work on hormonal aspects in nurses.
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치매간호중재 프로그램이 경증 치매노인의 Na, K, Ca, Cl, P, Cholesterol의 혈중농도 및 17-KS, 17-OHCS의 뇨배설량에 미치는 영향
나현주,조명숙,임욱빈 대한기초간호자연과학회 2002 Journal of korean biological nursing science Vol.4 No.2
This study was conducted for the evaluation of the effect of Dementia prevention nursing program on Urinary 17-KS, 17-OHCS, and Blood Na, Cl, K, Ca, P, cholesterol. The sample for the present study was composed of 16 demented elderly in D care center for the eldery in K city. The Dementia prevention nursing program consisted of concept memory training, music therapy, and art therapy. The program was performed twice a week and about ninety minutes was consumed for one session. The program had been administered for 8 weeks. We checked Urinary 17-KS, 17-OHCS, and Blood Na, Cl, K, Ca, P, cholesterol befor and after the program. Statistical analysis was performed by using descriptive statistics and Wlicoxon signed rank test of SAS system for window 6.12. The result were follows : 1. Urinary 17-KS 17-KS score increased significantly after intervention(p=0.005). 2. Urinary 17-OHCS 17-KS score increased significantly after intervention(p=0.00l). 3. Blood Na, Cl, K, Ca, P, cholesterol Na(p=0.0002), Cl(p=0.0001) K(p=0.0001), Ca(p=0.0028) decreased significantly after intervention. The results show that Dementia prevention nursing program increases Urinary 17-KS, the Dementia 17-OHCS, and decreases Blood Na, Cl, K, Ca, P, cholesterol. In conclusion, prevention nursing program can be used for the effective measure to decrease stress of the Demented elderly.
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( Wook-bin Lee ),( Won Young Choi ),( Dong-hyun Lee ),( Hyeran Shim ),( Jeongsil Kim-ha ),( Young-joon Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.2
Upon viral infection, the 2’, 5’-oligoadenylate synthetase (OAS)-ribonuclease L (RNaseL) system works to cleave viral RNA, thereby blocking viral replication. However, it is unclear whether OAS proteins have a role in regulating gene expression. Here, we show that OAS1 and OAS3 act as negative regulators of the expression of chemokines and interferon-responsive genes in human macrophages. Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein-9 nuclease (Cas9) technology was used to engineer human myeloid cell lines in which the OAS1 or OAS3 gene was deleted. Neither OAS1 nor OAS3 was exclusively responsible for the degradation of rRNA in macrophages stimulated with poly(I:C), a synthetic surrogate for viral double-stranded (ds)RNA. An mRNA sequencing analysis revealed that genes related to type I interferon signaling and chemokine activity were increased in OAS1<sup>-/-</sup> and OAS3<sup>-/-</sup> macrophages treated with intracellular poly(I:C). Indeed, retinoic-acid-inducible gene (RIG)-I- and interferon-induced helicase C domain-containing protein (IFIH1 or MDA5)-mediated induction of chemokines and interferon-stimulated genes was regulated by OAS3, but Toll-like receptor 3 (TLR3)- and TLR4-mediated induction of those genes was modulated by OAS1 in macrophages. However, stimulation of these cells with type I interferons had no effect on OAS1- or OAS3- mediated chemokine secretion. These data suggest that OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages. [BMB Reports 2019; 52(2): 133-138]
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Wook-Bin Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Lithospermum erythrorhizon (L. erythrorhizon), used in traditional medicine, is a potent wound healing, anti-inflammatory and antioxidant plant. However, the effect of L. erythrorhizon on retinal degenerative diseases and allergic rhinitis (AR) is still unknown. First, we explored the protective effects of L. erythrorhizon in in vitro and in vivo retinal degeneration. We found that ethanol extract of L. erythrorhizon (EELE) and the dichloromethane fraction of L. erythrorhizon (MCLE) significantly increased cell viability under glutamate/BSO-induced excitotoxicity/oxidative stress in R28 cells. Treatment with EELE and MCLE reduced the intracellular reactive oxygen species (ROS) and the levels of apoptotic proteins, such as cleaved PARP and cleaved caspase-3. Furthermore, oral administration of EELE and MCLE in an in vivo optic nerve crush mouse model decreased RGC cell death and increased retinal thickness. The major compound between EELE and MCLE was found to be lithospermic acid A (LAA), which has been shown to prevent the elevation of ROS in R28. Second, we investigated the protective action of EELE in ovalbumin (OVA)-induced AR models. EELE administration alleviated the nasal symptoms such as rubbing and sneezing, markedly reduced both serum OVA-specific IgE and IgG1 levels. EELE also ameliorated inflammatory cell infiltration and nasal mucosa inflammation in OVA-induced AR. We found that EELE markedly decreased IL-4 expression and degranulation of basophils. Therefore, EELE have protective effects against retinal degenerative diseases and allergic rhinitis.
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TE-TRAP : New Marker System for Gamma Irradiated Sorghum (Sorghum bicolor L.)
Seung Bin Im,Jaihyunk Ryu,Sang-Wook Jeong,Soon-Jae Kwon,Joon-Woo Ahn,Dong Sub Kim,Hee-bong Lee,Si-Yong Kang 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
The transposable element is a DNA sequence that can be changed its position within the genome, sometimes it can create or reverse mutations and altering the cell's genome size. Target region amplification polymorphism (TRAP) is a rapid and efficient PCR-based marker technique, which uses bioinformatics tools and expressed sequence tag (EST) database information to generate polymorphic markers around targeted candidate gene sequences. TE-TRAP is a new marker system which used terminal inverted repeat (TIR) instead of targeted candidate gene sequences. Sorghum holds a good potential plant organism for transposon tagging due to its small genome size, low amount of repetitive DNA and co-linearity with other cereal genomes, which allows the use of information derived from sorghum in other cereal grasses. IS2868 of sorghum accession was treated Gamma irradiation on seed. To define availability and utilization of TE-TRAP, twenty-one accessions were used to evaluate the genetic diversity and underlying relationships. One-thousand thirty-three TE-TRAP markers were amplified by thirty-one primer combination. Altogether, 712 (62.8%) markers were observed polymorphic segregation, whereas 421 (37.2%) showed monomorphic patterns. To estimate genetic differentiation of population by various gamma radiation doses, the analysis of molecular variance (AMOVA) was performed using 4 to 5 different radiation doses population of M1 sorghum individuals. This study and marker system will provide valuable information to assist radiation mutation breeding.
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Lee, Wook-Bin,Kang, Ji-Seon,Yan, Ji-Jing,Lee, Myeong Sup,Jeon, Bo-Young,Cho, Sang-Nae,Kim, Young-Joon Public Library of Science 2012 PLoS pathogens Vol.8 No.4
<▼1><P>Trehalose 6,6′-dimycolate (TDM), a cord factor of <I>Mycobacterium tuberculosis</I> (Mtb), is an important regulator of immune responses during Mtb infections. Macrophages recognize TDM through the Mincle receptor and initiate TDM-induced inflammatory responses, leading to lung granuloma formation. Although various immune cells are recruited to lung granulomas, the roles of other immune cells, especially during the initial process of TDM-induced inflammation, are not clear. In this study, Mincle signaling on neutrophils played an important role in TDM-induced lung inflammation by promoting adhesion and innate immune responses. Neutrophils were recruited during the early stage of lung inflammation following TDM-induced granuloma formation. Mincle expression on neutrophils was required for infiltration of TDM-challenged sites in a granuloma model induced by TDM-coated-beads. TDM-induced Mincle signaling on neutrophils increased cell adherence by enhancing F-actin polymerization and CD11b/CD18 surface expression. The TDM-induced effects were dependent on Src, Syk, and MAPK/ERK kinases (MEK). Moreover, coactivation of the Mincle and TLR2 pathways by TDM and Pam3CSK4 treatment synergistically induced CD11b/CD18 surface expression, reactive oxygen species, and TNFα production by neutrophils. These synergistically-enhanced immune responses correlated with the degree of Mincle expression on neutrophil surfaces. The physiological relevance of the Mincle-mediated anti-TDM immune response was confirmed by defective immune responses in Mincle<SUP>−/−</SUP> mice upon aerosol infections with Mtb. Mincle-mutant mice had higher inflammation levels and mycobacterial loads than WT mice. Neutrophil depletion with anti-Ly6G antibody caused a reduction in IL-6 and monocyte chemotactic protein-1 expression upon TDM treatment, and reduced levels of immune cell recruitment during the initial stage of infection. These findings suggest a new role of Mincle signaling on neutrophils during anti-mycobacterial responses.</P></▼1><▼2><P><B>Author Summary</B></P><P>Tuberculosis is one of the world's most pernicious diseases. <I>Mycobacterium tuberculosis</I> (Mtb), the causative agent of tuberculosis, has a lipid-rich cell wall that contains immunostimulatory properties. One of the lipid cell wall components, trehalose 6,6′-dimycolate (TDM), is a Mincle ligand and an immunogenic factor of Mtb that induces inflammatory responses leading to granuloma formation. Defining the major target and cellular functions of TDM may be requisite for delaying or preventing mycobacterial TDM-induced inflammation. Here, we demonstrated that neutrophils are important for the early phase of TDM-induced lung inflammation. Neutrophils are recruited during the initial stage of TDM-induced lung inflammation and Mincle is required for neutrophil access to TDM-challenged sites by enhancing neutrophil integrin expression, cytoskeleton remodeling, and cell adhesion. Furthermore, neutrophils aggravate TDM-induced lung inflammation by producing proinflammatory cytokines/chemokines. These findings open new perspectives for the role of Mincle signaling on neutrophils during TDM-induced inflammatory responses.</P></▼2>
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