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강건하고 정확한 방사기저함수를 위한 정규화 파라미터의 최적화
김원해(Wonhae Kim),박도현(Dohyun Park),최동훈(Dong-Hoon Choi) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
This study aims to optimization of regularization parameter in radial basis function to construct robust and accurate meta-model. Regularization parameter is one of the factors that affect accuracy of a radial basis function. The selection of appropriate regularization parameter can improve accuracy of radial basis function. However it is hard to know appropriate regularization parameter in advance because it depends on the problem. In this study, we suggest construction of robust and accurate meta-model by finding the optimal regularization parameter which minimized generalized cross-validation error expressed as a closed form solution.
Lee, Wonhae,Kim, Ki Ra,Singaravelu, Gunasekaran,Park, Byung-Jae,Kim, Do Han,Ahnn, Joohong,Yoo, Yung Joon WILEY-VCH 2006 Proteomics Vol. No.
<P>Proper folding and maintenance of the native structure are central to protein function and are assisted by a family of proteins called chaperones. Calreticulin and calnexin are ER resident chaperones well conserved from worm to human. Calreticulin/calnexin knock-out mice exhibit a severe phenotype, whereas in Caenorhabditis elegans, calreticulin [crt-1(jh101)]- and calnexin [cnx-1(nr2009)]-null mutant worms exhibit only a mild phenotype, suggesting the possible existence of alternative chaperone machinery that can compensate for the deficiency of calreticulin and/or calnexin. In order to rapidly identify the compensatory chaperone components involved in this process, we analyzed the proteome of crt-1(jh101) mutants and [crt-1(jh101);cnx-1(nr2009)] double mutants. When grown at 20°C, we found that five proteins were up-regulated and two proteins were down-regulated in crt-1(jh101) mutants; nine proteins were up-regulated and five proteins were down-regulated in [crt-1(jh101);cnx-1(nr2009)] double mutants. In addition, elevation of the cultivation temperature to 25°C, which is still permissive to growth but causes specific defects in mutants, led to the identification of several additional proteins. Interestingly, the consistent increment of heat shock protein-70 family members (hsp70) together with protein disulfide isomerase (PDI) at all the examined conditions suggests the possible compensatory function imparted by hsp70 and PDI family members in the absence of calreticulin and/or calnexin.</P>
Soo-Ung Lee,송현옥,Wonhae Lee,Gunasekaran Singaravelu,Jae-Ran Yu,박우윤 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.5
Calcineurin is a Ca2+/Calmodulin activated Ser/Thr phos-phatase that is well conserved from yeast to human. It is composed of catalytic subunit A (CnA) and regulatory subunit B (CnB). C. elegans homolog of CnA and CnB has been annotated to tax-6 and cnb-1, respectively and in vivo function of both genes has been intensively studied. In C. elegans, calcineurin play roles in various signaling path-ways such as fertility, movement, body size regulation and serotonin-mediated egg laying. In order to understand additional signaling pathway(s) in which calcineurin func-tions, we screened for binding proteins of TAX-6 and found a novel binding protein, HLH-11. The HLH-11, a member of basic helix-loop-helix (bHLH) proteins, is a pu-tative counterpart of human AP4 transcription factor. Pre-viously bHLH transcription factors have been implicated to regulate many developmental processes such as cell pro-liferation and differentiation, sex determination and myo-genesis. However, the in vivo function of hlh-11 is largely unknown. Here, we show that hlh-11 is expressed in phar-ynx, intestine, nerve cords, anal depressor and vuvla mus-cles where calcineurin is also expressed. Mutant analyses reveal that hlh-11 may have role(s) in regulating body size and reproduction. More interestingly, genetic epistasis suggests that hlh-11 may function to regulate serotonin-mediated egg laying at the downstream of tax-6.
김승빈(Seungbin Kim),신지혁(Jihyeok Shin),강지훈(Jihoon Kang),김원해(Wonhae Kim),이용석(Yong-Seok Lee) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11
Creep behavior of solder ball in electronic packaging is one of the main concerns. Solder alloy can reach 50% of its melting point easily when application is operated. As a result, manufacturers should consider solder creep because creep behavior is dominant over 0.4Tm of solder alloy. In this research, we made quarter model of ball-grid-array electronic package through finite element analysis. Simulation cases consisted of 9 cases according to solder ball position arrangement, and creep analysis was performed with a cycle of thermal profile -45℃ ~125℃. Therefore, we suggested which case is the optimum arrangement for creep fatigue life and mechanical reliability of ball-grid-array packaging.
루트킷 탐지 도구(Gibraltar) 성능 향상을 위한 자동화된 커널 메모리 자료 구조 추출에 관한 연구
최원하 ( Wonha Choi ),이하윤 ( Hayoon Yi ),조영필 ( Yeongpil Cho ),백윤흥 ( Yunheung Paek ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1
하이퍼바이저를 이용한 가상화 검사(Virtual Machine Introspection)의 하나인 Gibraltar[2]는 자동으로 무결성 명세서를 생성할 수 있고, 보안 위협이 높아지고 있는 데이터 영역에 대해서도 방어가 가능하다는 점에 존재하는 어떤 보안 도구보다 효과적인 시스템으로 여겨지고 있다. 본 연구에서는 루트킷 탐지 도구인 Gibraltar 를 Linux/ARM 3.14 버전에서 구현하고, 커널 메모리 자료 구조 추출 자동화 툴을 개발함으로써 기존 연구의 문제점을 해결하여 성능을 개선하였다. 이를 바탕으로 향후 Gibraltar 연구의 추가 개선 방향을 제시한다.