양성 갑상선 결절에서 티록신 억제 요법의 효과

윤석기,김철희,김영선,변동원,서교일,유명희 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

외래에서 항암화학요법을 받는 암환자들의 영양불량 위험도 연구

김원경,박미선,이영희,허대석 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

Although it is well known that cancer patients suffer from malnutrition, there are few published studies on malnutrition in outpatients receiving chemotherapy in Korea. This study aimed to evaluate nutritional risk in oncology outpatients receiving chemotherapy and to show the baseline data to set up nutritional management programs for cancer patients. This is a retrospective observational analysis on 1,962 patients referred for nutritional education before or during chemotherapy at Seoul National University Hospital Cancer Center from January 2006 to May 2007. According to a malnutrition screening tool, the proportion of patients having malnutrition risk was 23.0%. In the case of upper gastrointestinal cancer, more than 50% of patients were assessed as being at the risk of malnutrition. They showed more than 7% weight loss compared to their usual body weight and poor oral intake; energy intake was less than 100% of Basal Energy Expenditure (BEE) and protein intake was less than or equal to 0.77 g/㎏/d. However, only 6.3% of breast cancer patients had risk of malnutrition and their oral intake was better; energy intake was 121% of BEE, and protein intake was 0.90 g/㎏/d. Outpatients receiving chemotherapy had different nutritional risk depending on their cancer site. Nutritional management program should be conducted differently, depending on the cancer site and upper gastrointestinal cancer patients at high risk of malnutrition should basically have nutritional assessment and intervention.

한국어 처리 시스템을 위한 시소러스의 구현

강원석 安東大學 1996 安東大學 論文集 Vol.18 No.1

A natural language system needs the dictionary for analysis of natural language. Because the dictionary effects output of the system, we must design the good dictionary. However, the designed dictionary may not be used to other domain or systems. In this thesis, we design a large scale thesaurus prototype which can be used to other domain or systems with a little transformation. This thesaurus enables to extract the super and sub-concept of the given concept. It makes it easy to construct the Korean processing system by providing the information used in the system.

마우스 Myeloma Cell P3-X63-Ag8.653 및 T Cell Hybridome DO11.10에서의 Programmed Cell Death 유발 특성 비교

임석원,정용훈,최용,한승룡,조양자 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2

This study was aimed to prove that the death of HGPRT myeloma V653 by aminopterin treatment is due to PCD. This PCD was also compared with a relatively well-defined dexamethasone-induced PCD of T-cell hybridoma DO11.10. And these PCD systems were further characterized by inhibiting protein synthesis with cycloheximide, inhibiting mRNA synthesis with actinomycin-D, increasing intracellular calcium with calcium ionophore A23187. Induction of c-myc, an universal apoptosis gene, was also compared between these 2 systems. Viability of V653 cell was decreased by aminopterin-treatment in a dose-dependent manner. After treatment of aminopterin, this decrease of viability began in 6 hours and was accelerated in 12-18 hours. DNA fragmentation of V653 was detectable at 3 hours of incubation and peaked in 12-18 hours. Patterns of decrease in cell viability and increase in DNA fragmentation of dexamethasone-treated DO11.10 cells was similar to that of aminopterin-treated V653 cell, but the progress was much slower. The decrease in cell viability and increase in DNA fragmentation of aminopterin-treated V653 cells were inhibited by protein synthesis inhibitor cycloheximide, and RNA synthesis inhibitor actinomycin-D. In contrast the decrease in cell viability and increase in DNA fragmentation of dexamethasone-treated DO11.10 cell were accelerated by cycloheximide and actinomycin-D additions. Ca^2+ ionophore A23187 addition to aminopterin-treated V653 cells and dexamethasone-treated DO11.10 accelerated the decrease in cell viability and the increase in DNA fragmentation of both cells. In northern blot analysis, induction of c-myc gene was observed in aminopterin-treated V653 cell reached peak at 2hours and thern decreased drastically. Induction of c-myc gene in dexamethasone-treated DO11.10 cells was much slower and the fold of gene induction was much lower than that of aminopterin-treated V653 cell. Ultrastructural changes during the death process were observed by using electron microscope. Dilatation of rough endoplasmic reticulum(RER) and detachment of ribosomes were the earliest ultrastructural changes, which were observed in 30 minutes after death induction. The results of this study suggest that aminopterin-induced selective elimination of fusion partner V653 myeloma cell is due to PCD, and that this process requires de novo protein and RNA synthesis in which a Ca^2+ -mediated signal transduction pathway is involved.

밀도분포법을 이용한 부재의 연결구조 최적화

한석영,유재원 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.4

Most engineering products contain more than one component. Failure occurs either at the connection itself or in the component at the point of attachment of the connection in many engineering structures. The allocation and design of connections such as bolts, spot-welds, adhesive etc. usually play an important role in the structure of multi-components. Topology optimization of connection component provides more practical solutions in design of multi-component connection system. In this study, a topology optimization based on density distribution approach has been applied to optimal location of fasteners such as T-shape, L-shape and multi-component system. From the results, it was verified that the number of iteration was reduced, and the optimal topology was obtained very similarly comparing with ESO method. Therefore, it can be concluded that the density distribution method is very suitable for topology optimization of multi-component structures.

항진균성 항생물질을 생산하는 Streptoverticillium sp. NA-4083의 분리 및 동정

임대석,윤상균,이명섭,윤원호,김창한 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.6

전국 각지의 토양에서 441균주의 방선균을 분리한 결과 Trichophyton mentagrophytes, Trichophyton rubrum, Nanniza otae 및 Pyricularia oryzae 등의 진균에 광범위한 항진균활성을 나타내는 방선균 NA-4803을 선발하여 그 균주의 동정을 실시하였다. 분리균주 NA-4803은 Gram 양성세균 4균주, Gram 음성세균 2균주, 효모 2균주, 곰팡이 5균주, 조류 1균주에 대해 약한 항균활성을 보이는 반면, 곰팡이 Trichophyton mentagrophytes, Trichophyton rubrum, Nanniza otae 및 Pyricularia oryzae에 대해서는 비교적 강한 항진균활성을 나타내었다. 분리균주 NA-4803은 생리적 특성, 항균활성, lectithinase 및 lipolytic 활성, 각종 유기물의 분해력, 항생물질에 대한 저항성, 온도, pH 및 화학저해제의 첨가에 따른 생육, 질소원의 이용성 및 탄소원의 이용성 등에 있어서 cluster group F에 속하며 Cluster No. 58에 해당하는 Streptoverticillium blastmyceticum과 가장 유사하게 비교·동정되었으나 nitrate 환원성의 양성반응, L-tyrosine 분해력의 음성반응 및 cephaloridine에 대한 저항성에 음성반응을 보였고, 탄소원 중 L-rhamnose와 inulin을 이용하는 것으로 보아 Streptoverticillium blastmyceticum과 다른 특성을 나타내었다. 따라서 분리균주 NA-4803은 Streptoverticillium sp. NA-4803으로 동정되었다. The aim of the present research program was to develop a strain of actinomycetes producing antifungal substance. Soil samples were collected from various sites in Korea and a number of actinomycetes were isolated from the soil samples by applying selective agar for actinomycetes. Among over 440 isolates, a strain (NA-4803) producing antifungal substance against Trichophyton spp. Nannizzia otae and Pyricularia oryzae was selected. The strain NA-4803 was identified as strain similar to Streptoverticillium blastmyceticum with respect to morphological and physiological characteristics, lecithinase and lipolytic activity, degradation of organic compounds, resistance to antibiotics and utilization of carbon and nitrogen sources. But it showed some differences such as positive reaction of nitrate reduction, negative reaction of L-tyrosine degradation, resistance to cephaloridine, and utilization of I rhamnose and inulin. The strain NA-4803 was named as Streptoverticillium sp. NA-4803.

가중치 적용과 개선된 시소러스 도구에 의한 개념 기반 문서분류기 TAXON의 개선

강원석 安東大學校 工業技術硏究所 1998 공업기술연구논문집 Vol.5 No.1

In this paper, we present the improved concept-based text categorization system(TAXON) with probability-based method. The system consists of a Korean morphological, analyzer, a thesaurus tool, a weight determinator, and a similarity measurer. The thesaurus tool finds the concepts of the terms extracted by the Korean analyzer. The weight determinator decides the weight of the concepts with the heuristic rules. Finally, the similarity measurer decides the category of the input text with comparing the concept-probability vectors of the input text and categories. In this paper, we use the heuristic rules to acquire the concept-probability vector included the weight on each concept, and use the improved thesaurus tool to get the concepts to more terms than ever. Therefore, we can get the more good categorization quality with the heuristic rules and the improved thesaurus tool.

E. coli와 Staphylococcus aureus가 精子運動性에 미치는 影響

金原錫 충남대학교 의과대학 지역사회의학연구소 1981 충남의대잡지 Vol.8 No.2

This study was carried out to investigate the effect of sperm motility by E. coli and Staphylococcus aureus which were possible cause of infertility by genitourinary tract infection. Human spermatozoa, from 42 cases of healthy medical students, were exposed to E. coli(30 cases) and Staphylococcus aureus(12 cases) varying dilutions from 10^4, 10^5, 10^6 colonies/ml. of normal saline and broth solution. Spermatozoal numerical motility scale devised by Emmens was checked at the serial time of hours in vitro. The following results were obtained: 1. Sperm motility of control groups among pure semen, semen with normal saline, semen with broth solution and semen with broth extract contained endotoxin were no significant differences. 2. A sinificantly decreased sperm motility ensued in E. coli experimental groups than those of control groups. And the more bacteria concentrated the more significant decrease of sperm motility was observed. 3. There were no significant differences between control group and experimental groups in Staphylococus aureus.

WTO 관세협상에 있어 무세화에 대한 연구

박원석 부산 외국어 대학교 2004 外大論叢 Vol.28 No.-

DDA of 2001 mandates negotiation of all non-agricultural products without a priori exclusions. Under this mandate, many countries have proposed each of their own submissions which show a variety of modalities such as general approach, cocktail approach and a sector-by sector approach. Some of these submissions suggest tariff elimination of fishery products, which cause serious concerns to the countries with weak competition in the fishery industry, including Korea. Despite their unreality, it is necessary for Korea to suggest its positions and actively respond to opposing approaches, because a supplementary sectoral zero- for-zero negotiation is expected after a formula approach negotiation. The motivation behind tariffs elimination of fishery products may be attributed to the competition policy. Korea's positions towards tariff-free approach for fishery products may be divided into three strategies. Its first strategy to an across-the-board basis is that it degrades the proposal into premature and unrealistic, because Korea should preserve its fishery, industry with no competition power. Second position to sectoral tariff elimination approach is that it basically agrees to eliminate tariffs on UR-agreed upon products and ITA products, but its agreement does not extend to specific items suggested by several countries or fishery products. Lastly, Korea has granted the LDC exports a GSP status, and 87 items out of WTO-recommended 116 items has enjoyed tariff free preference since January 2000. In addition, the scope of tariff free product from 13 trading partners for fishery products may be expanded. The tariff elimination proposals for fishery products cannot be easy to materialize due to three reasons (tariff revenue, industrial weakness, and fishery management policy). Korea needs to recognize that it should eliminate or adjust .tariffs on non-popular products, non-sensitive product, or non protective products, excluding some fishery products falling within HSK 03, 12, and 16. It also should consider expanding the market liberalization and zero-for-zero rate to avoid strong arguments from tariff elimination-proposing countries.

다국어 질의응답을 위한 한국어 해석 시스템 설계 및 구현

강원석,황도삼 한국컴퓨터교육학회 2004 컴퓨터교육학회 논문지 Vol.7 No.4

다국어 질의 응답 시스템은 여러 언어의 질의에 대한 응답을 하는 시스템이다. LASSO 시스템은 다국어 질의응답 시스템 중의 하나이다. 본 논문은 LASSO 시스템을 위한 한국어 해석 새스템의 설계 및 구현에 관한 것이다. 질의 응답을 위한 한국어 해석 시스템은 한국어 질의를 처리할 수 있는 대화체 처리 기술이 필요하다. 그리고 다양한 분야의 질으에 대한 응답을 할 수 있는 범용의 시스템이어야 한다. 본 논문의 한국어 해석 시스템은 이와 같은 사항을 만족하기 위하여 심도 깊은 대화체 처리 기술보다 실용성이 높은 휴리스틱 규칙을 활용하였다. 이시스템은 다국어 질의 응답 시스템의 한국어 인터페이스 역할을 하는 것으로 질의 응답 시스템의 목적에 맞게 설계, 구현되었다. 본 해석 시스템에 적용된 기술은 정보검색 분야와 한국어 해석 분야에 응용할 수 있다. Multi-lingual query answering system is the system which answers on the queries with several languages. LASSO[1] is the system that aims to answer the multi-lingual query. In this paper, we design and implement a Korean analysis system for LASSO. The Korean analysis system for query answering needs processing techniques of dialogue style. And the system must be practical and general so as to use on various domains. This system uses not dialogue processing techniques with high cost and low utility but heuristic rules with low cost and high utility. It is designed and implemented as a Korean interface of multi-lingual query answering system. The techniques of this system highly contribute to information retrieval and Korean analysis researches.