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남항우,이성원,이병주,권칠용,문연자,안성훈,우원홍 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1
The Sellaginella Tarmariscina is widely used in the traditional oriental herbal medicine for its anti-inflammatory, antioxidant effects. The effects of aqueous extracts of Sellaginella Tarmariscina on the viability and induction of apoptotic cell death were investigated in HL-60 cells. The cell viability after treating with extract of Sellaginella Tarmariscina was quantified by MTT assay. The results showed that could inhibit the proliferation of HL-60 cells and caused a 40% inhibition of HL-60 cells at concentrations of 400 ㎍/ml. The cancericidic effect of Sellaginella Tarmariscina was mediated by apoptosis. Thus, HL-60 cells exposed to Sellaginella Tarmariscina displayed the DNA fragmentation ladder and nucleus chromatin condensation characteristic for apoptosis. In conclusion, our results suggest that the extract of Sellaginella Tarmariscina may induce the apoptotic death in HL-60 cells.
김진호,이종식,김원일,정구복,윤순강,정연태,권순국 한국환경농학회 2002 한국환경농학회지 Vol.21 No.2
연구대상 시설재배지 토양의 물리성은 대부분이 모래의 비율이 높은 sandy loam이나 loam으로 투수성이 양호할 것으로 판단되나, P2나 S1에서는 미사의 비율이 높은 미사 loam으로 투수성 및 통기성이 상대적으로 낮은 것으로 판단된다. 토양의 화학성은 EC의 경우 표토의 대부분이 기준치에 도달하거나, 초과하는 경향이었고, 심토의 경우는 기준치 이하로 조사되었다. 또한 유기물 함량은 적정수준 2~3%보다 조사 대상 지점의 대부분에서 상회하였고, 심토의 일부분도 이 수준을 넘는 곳도 있었다. 조사 대상 지역의 수질 특성 중 시설재배지 지하수의 가장 중요한 염류 지표인 EC는 연평균 0.48 dS/m로 농업용수로서 작물에 미치는 영향은 없는 것으로 판단되나, 수질오염지표인 질산성 질소의 경우 19.1 mg/L 로 농업용수 수질 기준인 20 mg/L에 근접한 수준을 나타내었다. 특히 조사 대상 지점의 36.4%가 수질 기준을 초과하는 것으로 나타났다. 지하수중의 이온의 양과 영양염류의 양을 간접적으로 나타내는 전기전도도인 EC는 양이온인 경우 Mg^(2+), Ca^(2+), Na^+, K^+와 정의상관이 있었으며, 특히 2가 양이온인 Mg^(2+)와 Ca^(2+)간에는 고도의 정의상관을 보이고 있었다. 또한 EC와 음이온간에는 NO_3^-, Cl^-, SO_4^(2-), PO_4^(2-)와 상관을 보이고 있었다. 지하수의 오염지표인 NO_3-N의 경우에는 COD를 제외한 모든 이온들과 상관을 보이고 있었다. 특히 SO_4^(2-), Cl^-, Na^+, Ca^(2+), Mg^(2+)와는 고도의 정의 상관을 보여주고 있다. 이는 NO_3-N는 EC와 함께 지하수오염의 중요한 지표중의 하나임을 보여주고 있다. The objective of this study was to know the qualities of soil and shallow groundwater in plastic film house fields around Central Part of Korea. The study was conducted at 11 sites in Suweon, Hwasung, Pyungtaek, Yongin, and Chuncheon through May to August in 1999. Soil textures of plastic films house were mainly sandy loam or loam. Electric conductivity and organic matter content of surface soils mostly exceeded the critical levels for crop production. Average concentration of N0_3-N in the shallow groundwater was 19.1 mg/L, and it reached almost the limiting level of agricultural groundwater quality (20 mg/L). Moreover about 36% of survey sites exceeded the limiting level of agricultural groundwater quality. Sulfate concentrations also at some sites exceeded agricultural groundwater quality limit level (50 mg/L). Nitrate-N, one of the most important factors in the groundwater quality, had positive correlations with other ions in groundwater.
Approximating Construction of Evolution Operator
Kwun,Young-chel,Yu,Jong-Won 東亞大學校附設基礎科學硏究所 1985 基礎科學硏究論文集 Vol.2 No.1
X,Y를 實 또는 複素 Banach 空間이라 한다. Y가 X안에 稠密하고 連續的으로 들어가고 作用素 U(t,s):X→X, 0≤s≤t ≤T 가 다음 (a)∼(d)의 性質을 만족할때 作用素族 {U(t,s)}을 發展作用素라 한다. (a) U(t,s)는 0≤s≤t≤T인 s,t에서 X-强連續이고 U(s,s)=I, ∥U(t,s)∥x≤??이다 (b) U(t,r)=U(t,s)U(s,r), r≤s≤t. (c) (??)??=-A(s)y, y∈Y, 0≤s<T. (d) (d/ds)U(t,s)y=U(t,s)A(s)y, y∈Y, 0≤s≤t≤T. 本 論文에서는 T. Kato ([2],[3])가 밝힌 {A(t}+B(t)}에 대한 유일한 發展作用素가 存在한다는 事實을 이용하여 다음 定理 4.5를 밝혔다. 定理4.5. V(t,s)가 定理 4.3에서 構成된 發展作用素라면 V(t,s)는 近似階段函數 ??(t)+??(t)에 의하여 構成된 發展作用素 ??(t,s)의 極限으로도 構成할 수 있다.
P285 : Therapeutic effect of quercetin on atopic dermatitis in vivo and in vitro
( Won Jong Oh ),( Hyun Kyu Kim ),( Mi Sook Jeong ),( Ji Yun Kim ),( Seong Jun Seo ),( Chang Kwun Hong ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: The diarylheptanoid, Quercetin (QCT), isolated from the leaves of Acer ginnala Maxim that grows natively in Korea, has been known to exert anti-oxidative, anti-inflammatory, anti-cancer, and immune regulatory effects. Objectives: To evaluate the effects of QCT in atopic dermatitis (AD), we examined QCT in vivo and in vitro. Methods: To induce the AD-like skin lesions in NC/Nga mice, after 4% SDS application, 100mg Dermatophagoides farinae (D.farinae) ointment was treated on the shaved skin of dorsal skin and both ears, twice a week for 4 weeks. From the 5th week, QCT formulated cream was applied to the back of the mice for another 4 weeks. In vitro, we evaluated cytokine expression and NO production to use anti-CD3-activated T cells, RAW 264.7 cells and RBL-2H3 cells depending on the QCT-treated or not. Results: We confirmed that NC/Nga mice developed AD-like skin lesions after the repeated application of D.farinae. QCT-treated group of mice showed significantly decreased clinical skin severity scores, eosinophil count, total IgE and cytokines (IL-4, -5 and -13). In vitro, QCT decreased IL-2 and IL-4 levels in anti-CD3-activated T cells. Also, NO production and IL-1β, iNOS mRNA expression was downregulated in RWA 264.7 cell treated with QCT. In IgE stimulated RBL-2H3 cells, QCT also significantly downregulates TNF-a and IL-4. Conclusion: In conclusion, QCT might be useful for treating AD and possibly for skin allergies.
權元達 韓國農業政策學會 1977 농업경영정책연구 Vol.4 No.1
Since production and demand for farm products and their merchandising ratio has increased, the material Volume of farm products being marketed has come larger and larger. Accordingly the modernization structure of farm products also has been made. Specially Co-Op marketing system must be needed in view of the present lack of distribution facilities and weaknesses in marketing organization. Recently farm product marketing environment has been changed very rapidly. Mass production is expected owing to the creating of the production estates and specialization. The Demand for growing farm products such as cash crops, sericulture, livestock, and so forth, has increased and concentration of demand into the cities is getting marked. While the functions of the large terminal markets are reactive and large scale retail facilities have been established. Those facilities have made mass trade possible. Producers, consumers, and midlenem are highly adaptable to such marketing environment changes. Because Co-Op marketing is one type of the collection of multiple saling intention, the economy of scale is applicable to the marketing process. Co-Op marketing includes transportation marketing sales, selective Co-Op marketing, and saling devices, and collective sales. The principles of Co-Op marketing involves non-conditional consignment sales, average salings and common accounting. But these principles should be changed as the organization and economic functions of Agr Coop incereases. Theoretically the function of Agr Coop is to perform the economic functions required by the members through cooperative principle. But consolidated Agri-Coop functions generated by the principles of economy of scale and equalization of the member's status and specialization of production, will be possibly inferior to the general middlemen's systems in view of managerial aspects. Accordingly Co-Op marketing should be modified. Farm products marked by Agri-Coop was accounted 10% of the total marketed volume in 1965, but this ratio increased 21.3% in 1976. In value terms, the amount of Coop marketing in 1976 was 25 times of that of 1965. Sales on consignment took the main part of marketing. But there are many problems in Agri-Coop marketing such as systematic-marketing, consignment sales, minimizing of marketing margin, increasing of merchandising ratio and newly rised coop marketing proldems.
Efficacy and safety of topical application of epidermal growth factor (EGF) for Korean acne patient
( Won Jong Oh ),( Eun Jung Ko ),( Sun Young Choi ),( Kwang Ho Yoo ),( Beom Joon Kim ),( Chang Kwun Hong ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Commonly prescribed medications for acne vulgaris are oral antibiotics and retinoids. However, those have clinical limitation due to its resistance and teratogenicity, respectively. In that EGF helps reducing sebum secretion and enhances skin moisturizing, topicalapplication of EGF is implied as a new treatment modality for acne vulgaris. Objectives: We aim to evaluate the clinical efficacy and safety of topical recombinant human (rh) EGF in treating facial acne vulgaris. Methods: Twenty three Korean with mild acne vulgaris has applied topical rhEGF cream (Trouble control EGF) on the face twice daily for four weeks. Acne lesion counts were scored by investigator’s global assessment, while efficacy and satisfaction were evaluated by subjects. Skin sebum output, hydration and redness level were also measured at each visit. Results: Skin sebum level, transepidermal water loss, skin redness statistically decreased and acne lesions were significantly reduced. No severe side effects were observed during the study. Conclusion: Topical rhEGF seems to be an effective and safe adjuvant treatment option for mild acne vulgaris.
권굉보,송선교,김홍진,이원종,심민철 영남대학교 의과대학 1986 Yeungnam University Journal of Medicine Vol.3 No.1
본 저자들은 Abdominal aorta와 iliac artery의 혈전성 패색에 의해 양측 하지의 동통, 창배 및 미약한 위축과 성불능이 있는 Leriche 증후군 1례를 Dacron graft를 사용하여 Aortobifemoral graft를 시술하여 좋은 결과를 얻었기에 문헌고찰과 함께 보고하는 바이다. Leriche syndrome is a chronic disorder mostly in male and is a specific symptom complex due to thrombotic obliteration of the aortic bifurcation as result of a atherosclerotic change. The symptoms include 1) extreme liability to fatigu of both lower limbs ; 2) symmetric atrophy of both lower limbs ; 3) pallor of the legs and feets ; 4) inability to maintain stable erection. There are several methods for surgical management of this disorder ; 1) thromboendarterectomy with or without sympathectomy ; 2) aortoiliac bypass graft ; 3) aortofemoral bypass graft. Here we report a case of Leriche syndrome which was successfully managed with arotobifemoral bypass graft with Dacron and reviewed literatures on it brifly.