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Keyong Ho Lee,Won Ho Yoon 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.5
Exo-polysaccharide isolated from the culture of Grifola frondosa was modified by sodium periodate (NaIO₄) and sodium chlorite (NaClO₂) to delete polysaccharide part and phenolic compound, respectively, and was investigated what effect has each part of exo-polysaccharide against 2,2’-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress in porcine kidney epithelial cells (LLC-PK1). Oxidative stress on LLC-PK1 cell was measured by cell viability, lipid peroxidation, superoxide dismutase (SOD), and glutathione peroxidase (GSH-px) activity. Exposure of LLC-PK1 cells to 1 mM AAPH for 24 hr resulted in significant decrease in cell viability, SOD, and GSH-px action, and significant increase in lipid peroxidation. The treatment of exo-polysaccharide and NaIO₄ modified sample protected LLC-PK1 cells from AAPHinduced cell damage such as cell viability, lipid peroxidation, SOD, and GSH-px activity in a dose dependant manner (10, 100, and 500 ㎍/㎖). However, the treatment of NaClO₂ modified sample did not affect for cell viability, lipid peroxidation, SOD, and GSH-px activity. The antioxidant activity of exo-polysaccharide was significantly decreased on AAPH-induced LLC-PK1 cell system when phenolic compound was deleted. The antioxidant activity was significantly correlated with the content of phenolic compound of exo-polysaccharide.
루테인과 후코이단 병용 처리에 의한 AAPH 유도 세포 손상 억제
이경호 ( Keyong Ho Lee ),윤원호 ( Won Ho Yoon ) 한국식품영양학회 2010 韓國食品營養學會誌 Vol.23 No.3
This study was designed to investigate the protective effect of the combination of fucoidan and lutein against AAPH-induced oxidative stress in THP-1 cells. The combination of fucoidan and lutein existed significant antioxidant effect on AAPH-damaged THP-1 cells by using lipid peroxidation and cellular antioxidant capacity assay. Fucoidan(1㎍/㎖) and lutein(10㎍/㎖) did not affect at all the viability of THP-1 cells, but protected the AAPH-damage of THP-1 cells at the same concentration. The viability of THP-1 cells was 0% with 1 mM AAPH alone, the protective effect of fucoidan(1㎍/㎖) and lutein(10㎍/㎖) was 37% and 36%, respectively. The combination of fucoidan(1㎍/㎖) and lutein(10㎍/㎖) exhibited significant inhibitory effect of lipid peroxidation using TBARS assay and cellular antioxidant capacity using DCFH-DA assay. In lipid peroxidation, the TBARS value of 1mM AAPH alone was 0.8±0.03nM MDA, its of the combination of fucoidan(1㎍/㎖) and lutein(10㎍/㎖) was 0.2±0.05nM MDA. In cellular antioxidant capacity, the combination of fucoidan(1㎍/㎖) and lutein(10㎍/㎖) exhibited significant cellular antioxidant capacity of 76%, whereas quercetin(10μM) as positive control exhibited the cellular antioxidant capacity of 32%. These results indicate that the cotreatment of fucoidan and lutein protects against AAPH-induced THP-1 cell damage by inhibiting lipid peroxidation, increasing cellular antioxidant capacity.
김하경 ( Ha-keyong Kim ),유새연 ( Sae-yeon Yoo ),윤주혜 ( Joo-hye Yoon ),정제원 ( Je-won Jung ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
커스터마이징 제품에 대한 니즈가 늘어감에 따라 화장품 시장도 맞춤형 화장품에 대한 수요가 증가하고 있다. 하지만 제작 이전의 진단 과정은 제공되지 않아 구매 실패로 이어지는 사례가 많다. 따라서 고객 맞춤 제품을 제작하기에 앞서 전용 진단 기기를 제공하여 셀프 진단 서비스를 구현하고자 한다. 이에 따라 본 논문은 피부 진단 기기를 이용하여 피부를 측정하고, 측정 결과 기반의 피부 분석을 통해 사용자에게 맞는 맞춤형 화장품을 제조하는 기기를 개발하여 서비스를 제공하고자 한다. 본 서비스는 집에서 빠르고 간편하게 본인의 피부를 진단하고 분석된 결과를 참조하여 자신과 가장 적합한 천연화장품을 바로 만들어줌으로써 소비자의 시간·공간적 제약을 없애는 것을 목표로 한다.
이현철 ( Hyun Cheol Lee ),이숙경 ( Suk Keyong Lee ),이흥렬 ( Heung Ryul Lee ),이원우 ( Won Woo Lee ),김덕하 ( Duck Ha Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.5
Prurigo pigmentosa is a chror ic pruritic inflammatory dermatosis characterized by erythematous papules in a reticulated pattern that resolve leaving a reticulated, mottled hyperpigmentation and rapidly response to dapsone therapy. Most cases that have been reported are from Japan. We report two cases of prurigo pigmentosa in a 21 year-old female and a 23-year-old female. Histopathologic findings of erythematous papules showed exocytosis, spongiosis, liquefaction degeneration of basal cell layer and perivascular lymphohistiocytic infiltration on the upper dermis. We treated them with dapsone, 100mg daily, which resulted in a remarkable regression of the ery thematous papules and improvenien of pruritus. (Kor J Dermatol 1995;33(5): 945-949)
조현홍,서정일,이경희,김태년,정문관,이현우,최원희,양창헌 영남대학교 의과대학 1992 Yeungnam University Journal of Medicine Vol.9 No.2
십이지장으로 분비되고 위내로 역류될 수 있는 bile acid가 위점막에 끼치는 영향을 알아보기 위해 체중 200-250gm전후의 Sprague-Dawley흰쥐를 사용하여 pH3인 염산과 TCDA 15mM혼합용액을 위장내에 주입하고 같은 산도의 염산을 위장내로 투여한 대조군과 비교 조사한 결과 다음과 같은 성적을 얻었다. TCDA에 의한 위점막 손상은 TCDA 투여후 75분이 지난 후 제일 저명하게 나타났고 15 분, 30분, 120분 및 150분에는 뚜렷한 변화를 관찰할 수 없었다. TDCA 투여후 75분에 나타나는 소견으로는 점막과 점막하조직의 울혈, 혈관 확장, 임파선 확장, 부종 등을 나타내었으며 시간이 경과함에 따라 혈관 확장 및 부종은 점차 소실되는 소견을 나타내었다. 이상의 결과로 보아 TCDA가 급성 위점막 손상을 일으킬 수 있지만 만성적 위점막 손상에 대해서는 여러 조건하에서 더 많은 연구가 있어야 할 것으로 사료된다. To investigate the effect of bile acid on gastric mucosa, we performed biologic test using Sprague-Dawley rat. Mixture solution of TDCA 15mM and HCl of pH 3 was given into stomach to one group and HCl of pH 3 was given into stomach to another group. The significant gastric mucosal change was vasodilatation and edema, that was disappeared progressively. These findings suggest the bile acid can damage gastric mucosa.
윤원호,최재훈,이경호,김창한,Yoon, Won-Ho,Choi, Jae-Hoon,Lee, Keyong-Ho,Kim, Chang-Han 한국식품과학회 2005 한국식품과학회지 Vol.37 No.1
본 연구는 폐기되는 차나무 열매를 이용하여 향균활성과 항종양활성을 비교하고 이용가능성에 대하여 탐색하고자 하였다. 항균활성과 항종양활성을 알아보기 위하여 70% 에탄올과 물 추출물의 활성을 측정하였다. 항균활성은 식중독균과 몇 종의 병원균, 효모, 곰팡이 등 17균주에 대하여 추정하였고, 항종양 활성은 6종류의 인체 암세포주, 1종류의 정상세포주에 대하여 조사하였다. 차나무 잎, 종자와 과피의 항균활성을 비교한 결과는 종자의 70% 에탄올과 물 추출물에서 효모에 대하여 항균활성이 높게 나타났다. 특히, candida albicans, Cryptococcus neoformans에 대하여 항균활성을 보였다. 종자 물 추출물을 $80,\;100^{\circ}C$에서 30분, $121^{\circ}C$에서 15분간 열처리 후 항균활성을 검색한 결과 가열온도에 따른 차이는 크게 나타나지 않았다. 항종양 활성을 검색하기 위하여 MTI assay를 통해 활성을 측정하였다. 과피 추출물에서 전혀 활성이 없었지만 종자 추출물에서는 큰 활성을 나타내었다. 극성용매인 70% 에탄올과 물 추출물의 종양세포 증식억제효과가 높게 나타났으며 그중에서 물 추출물이 70% 에탄올 추출물 보다 높게 항종양 활성이 나타났다. 차나무 종자로부터 추출한 활성물질의 종양세포와 정상 세포에 대한 세포독성을 MTT assay로 비교한 결과 $50{\mu}g/mL$의 농도에서 난소암 세포인 SK-OV-3는 70%의 억제율을 나타낸 반면 정상세포에서는 10% 미만으로 나타나 정상세포보다 종양세포에 대하여 보다 큰 선택 독성을 나타내는 것으로 보인다. Antimicrobial and antitumor activities of Camellia sinensis L seed extracts were investigated. Seed extracts showed antifungal activities against Candida albicans IFO 1594 and Cryptococcus neoformans. Inhibition zone of 20 mm was shown by 70% ethanol extract against C. albicans IFO 1594 at 100 mg/mL. Antifungal activity of seed extract was not decreased by heating at 80 and $100^{\circ}C$ for 30 min or at $121^{\circ}C$ for 15 min, indicating heat-stability of seed component. Growth-inhibitory effects were observed in 70 and 10% of tumor cell line SK-OV-3 and normal ceil line NIH/3T3 at $50{\mu}g/mL$, respectively.
Ha, Eun-Suk,Hwang, Soo-Hyun,Shin, Kwang-Soon,Yu, Kwang-Won,Lee, Keyong-Ho,Choi, Joo-Sun,Park, Woo-Mun,Yoon, Taek-Joon The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.2
Previously, we reported that water-extracted Acanthopanax senticasus exhibited anti-meta-static activity by stimulating the immune system. In this study, we fractionated glycoproteins (EN-SP) from the soluble protein layer (GF-AS) of A. senticasus and determined their basic chemical properties. We also investigated the anti-tumor and immunostimulating activities of the fractionated glycoprotein, EN-SP. We found that intravenous (i.v.) administration of GF-AS dramatically inhibited metastasis of colon26-M3.1 carcinoma cells to the lung in a dose-dependent manner. In vitro analysis showed GF-AS to enhance the proliferation of splenocytes. GF-AS also stimulated peritoneal macrophage, which was followed by the production of various cytokines such as IL-1$\beta$, TNF-$\alpha$, IL-12 and IFN-${\gamma}$. Furthermore, the production of these cytokines was partially blocked when peritoneal macrophage was cultured with the polyclonal antibodies against GF-AS. The depletion of NK cells by rabbit anti-asialo GM1 serum partly abolished the inhibitory effect of GF-AS on lung metastasis of colon26-M3.1 cells. Using gel filtration, EN-SP, an active glycoprotein fraction, is isolated from GF-AS. While both GF-AS and EN-SP stimulated the proliferatation of splenocytes of normal mice, EN-SP showed higher anti-metastatic activity and more potently stimulated the proliferation of splenocytes compared to GF-AS. These results suggest the use of EN-SP, the fractionated glycoprotein from A. senticasus, can be used as a therapeutical reagent to prevent or inhibit tumor metastasis.
편마비 환자의 보행훈련 시 기능적 전기자극 병용이 척수신경원의 흥분성 변화에 미치는 효과
강양훈,윤세원,서삼기,박경순,김용억,김태열,Kang, Yang-Hoon,Yoon, Se-Won,Seo, Sam-Ki,Park, Keyong-Soon,Kim, Yong-Eok,Kim, Tae-Youl 대한물리치료학회 2007 대한물리치료학회지 Vol.19 No.1
Purpose: The purpose of this study were to analysis the effect on change of spinal neuron excitability during gait training of hemiplegia patients by the functional electrical stimulation. Methods: Thirty six hemiplegia patients participated in this study. Stimulation conditions of FES were pulse rate 35pps, pulse width $250{\mu}s$, and on-time 0.3 second, treatment hour was 30 min. and treatment period was once a day for five days a week through six weeks. For functional evaluations before and after treatment, Modified Ashworth Scale (MAS), active range of motion (AROM), Hmax threshold, H/Mmax ratio were measured and the following conclusions were obtained. Results: Functional evaluation showed significant changes in experimental group as MAS(p<0.01), AROM(p<0.001), compared to control group. In spinal neuron excitability evaluation, change of Hmax threshold was significantly reduced in both non weight bearing (p<0.001) and bearing condition (p<0.05), H/Mmax ratio was significantly reduced in non weight bearing (p<0.05) and bearing condition (p<0.05). Conclusion: In conclusion, application of FES to hemiplegia patients in recovery stage during gait training improved mitigation of muscular spasticity, balance adjustment and moving ability and it was interpreted that it was caused by mitigation of muscular spasticity by the spinal neuron excitability.
IEEE 802.16e 시스템에서 망 지원을 이용한 효율적인 펨토셀 스캐닝 방안
최재인(Jae-In Choi),남진규(Jin-Kyu Nam),서원경(Won-Keyong Seo),조유제(You-Ze Cho) 한국통신학회 2011 韓國通信學會論文誌 Vol.36 No.1
본 논문에서는 IEEE 802.16e 기반의 펨토셀 환경에서 이동단말이 매크로셀에서 펨토셀로 핸드오버를 수행할 때 발생하는 긴 스캐닝 지연 시간과 큰 배터리 소모를 줄이고자 한다. IEEE 802.16e 시스템에서는 이동단말이 핸드오버를 수행할 때 인접한 기지국들을 스캐닝 해서 적절한 후보 기지국들을 선정하는데, 펨토셀이 도입되면 인접한 펨토셀의 수만큼 추가적으로 스캐닝 동작을 수행하여야 한다. 따라서 이동단말의 스캐닝 지연 시간 및 배터리 소모가 증가하는 문제가 발생한다. 이러한 문제를 해결하기 위해 본 논문에서는 삼각 측위법과 펨토셀의 모니터링 메커니즘을 이용하여 이동단말의 위치로부터 가장 근접한 하나의 펨토셀을 찾는 방안을 제안한다. 이동단말은 선정된 하나의 펨토셀에 대해서만 스캐닝 동작을 수행하기 때문에 스캐닝 지연 시간 및 배터리 소모를 줄일 수 있다. 시뮬레이션을 통해 제안 방안으로 동작할 경우 실제 이동단말의 위치에서 가장 근접한 펨토셀을 찾을 수 있는 확률이 높음을 확인하였으며 스캐닝 대상 펨토셀을 줄임으로써 기존 방안보다 스캐닝 지연 시간이 현저히 줄어들었음을 확인하였다. The femtocell is a miniaturized Base Station (BS) with low-cost and low-power using general broadband access network as backhaul. It is expected not only to improve indoor coverage but also to reduce a service charge. However, in IEEE 802.16e femtocells, when the Mobile Station (MS) scans neighbor BSs for handover, it takes a long time due to too many number of femto BSs. Also the size of the neighbor advertisement message that will be periodically sent by a serving BS is increased as the number of target femto BSs for scanning increases. In this paper, we proposed an efficient femtocell scanning scheme, using a triangulation mechanism and a femto BS monitoring scheme to reduce the number of scanning operations and the size of the neighbor advertisement messages. The proposed scheme can avoid wasting air resources and reduce scanning overheads by minimal scanning operation. The simulation results showed that the proposed scheme could improve scanning performance and avoid wasting air resources, compared with the conventional scheme of the IEEE 802.16e system.