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High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26.
Won, Eun Young,Xie, Yong,Takemoto, Chie,Chen, Lirong,Liu, Zhi Jie,Wang, Bi Cheng,Lee, Daeyoup,Woo, Eui Jeon,Park, Sung Goo,Shirouzu, Mikako,Yokoyama, Shigeyuki,Kim, Seung Jun,Chi, Seung Wook Wiley-Blackwell 2013 Acta crystallographica. Section D, Biological crys Vol.69 No.6
<P>Dual-specificity phosphatases (DUSPs) play an important role in regulating cellular signalling pathways governing cell growth, differentiation and apoptosis. Human DUSP26 inhibits the apoptosis of cancer cells by dephosphorylating substrates such as p38 and p53. High-resolution crystal structures of the DUSP26 catalytic domain (DUSP26-C) and its C152S mutant [DUSP26-C (C152S)] have been determined at 1.67 and 2.20 ? resolution, respectively. The structure of DUSP26-C showed a novel type of domain-swapped dimer formed by extensive crossover of the C-terminal α7 helix. Taken together with the results of a phosphatase-activity assay, structural comparison with other DUSPs revealed that DUSP26-C adopts a catalytically inactive conformation of the protein tyrosine phosphate-binding loop which significantly deviates from that of canonical DUSP structures. In particular, a noticeable difference exists between DUSP26-C and the active forms of other DUSPs at the hinge region of a swapped C-terminal domain. Additionally, two significant gaps were identified between the catalytic core and its surrounding loops in DUSP26-C, which can be exploited as additional binding sites for allosteric enzyme regulation. The high-resolution structure of DUSP26-C may thus provide structural insights into the rational design of DUSP26-targeted anticancer drugs.</P>
Case Report : Crohn`s Disease in a Patient Undergoing Hemodialysis Caused by IgA Nephropathy
Bi Ro Kim,Jae Won Yang,Joung Wook Choi,Young Sub Kim,Jong Myeong Yu,Seung Ok Choi,Byoung Geun Han 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.5
IgA nephropathy is usually localized to the kidney, however, it can accompany systemic disease, including gastrointestinal disease, skin disease, connective tissue disease, and malignant tumor. In some patients with IgA nephropathy which manifested as an extraintestinal symptom of Crohn`s disease, recovery of renal function was achieved following treatment of Crohn`s disease. The pathophysiology of each disease remains unclear. According to some studies, however, immunological, genetic, and environmental factors may be involved in a complex manner. In patients receiving renal replacement therapy for treatment of renal dysfunction due to IgA nephropathy, occurrence of Crohn`s disease as an extrarenal symptom has not been reported. We experienced a case of Crohn`s disease which developed in a patient receiving hemodialysis for treatment of end-stage renal disease due to IgA nephropathy.
Quality Attributes of White-Salted Noodles
Won-Jae Lee,Dan-Bi Woo,Mee-Ryung Lee 경상대학교 농업생명과학연구원 2015 농업생명과학연구 Vol.49 No.1
Noodles have been a part of our diet for a long time. In Asia, white-salted, Cantonese and instant fried types of noodles are widely consumed. White-salted noodles, also called Udon noodles, are consumed as wet or dried form. White-salted noodles are deeply favored in Korea and Japan and more consumption of Cantonese noodles are observed in other Asian countries. The quality attributes of white-salted noodles are predominantly dependant by wheat flour components, such as starch, protein and pigments, as wheat flour, water and salt are main raw materials of white-salted noodles. In several studies, the ratio between amylose and amylopectin is a key determinant of textural properties of white-salted noodles; hardness of white-salted noodles did have a significant (p<0.05) increase when amylose content in wheat flour was increased. The textural properties of white-salted noodles was not affected much by the protein content, especially protein content of flour was in the range of 10% ~ 13%. It seems that starch plays more important role than protein in the textural properties of white-salted noodles. Carotenoids and flavonoids pigment are major contributors of color of white-salted noodles.