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Imad Abdelhamid El Haci,Wissame Mazari,Fawzia Atik-Bekkara,Fayçal Hassani,Mohamed Gherib 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.2
This scientific work involves a phytochemical study of a medicinal plant endemic to the south of Algeria: Limoniatrum feei Girard (Batt.). The study of the antioxidant effects and the evaluation of the cytotoxicity were reported. Polar organic extracts: methanol, ethanol and acetone of L. feei presented considerable levels of phenols and flavonoids. These levels were ranged from 127.07 to 262.11 mg GAE/g and 84 to 157.88 mg CEQ/g, respectively. Considerable antioxidant activity of polar organic extracts of L. feei was revealed. In the DPPH scavenging method, methanolic extract expressed an IC50 of about 3.2 μg/mL which is comparable to that of the ascorbic acid (2.48 μg/mL). The same extract expressed strong antioxidant power against hydroxyl radical with an IC50 of about 36.33 μg/mL, which is higher than that of the ascorbic acid (61.83 μg/mL). In the test of the β-carotene bleaching, acetone extract expressed a remarkable antioxidant power comparable to the positive control (IC50: 5.85 μg/mL and 4.26 μg/mL, respectively). A low cytotoxic activity against human red blood cells was exerced by the methanol extract of L. feei, this could explaine the safety uses of this plant by indigenous populations.
Corruption and the Multinational Corporations: Antecedents to Bribery in a Foreign Country
Wissam AlHussaini,Byung Il Park,Zafar U Ahmed 한국외국어대학교 지식출판콘텐츠원 글로벌경영연구소 2014 글로벌경영연구 = Journal of global business research Vol.26 No.2
This research aims at determining the host country-specific antecedents which prompt MNCs to break the hyper-norm of anti-corruption and pay bribes abroad. Using anomie theory conjectures, antecedents are divided into opportunities and conditions. Data on more than 1000 MNCs operating in 26 countries was obtained from the World Bank’s Business Environment and Enterprise Performance Survey (BEEPS). A Multi-level model was constructed and hierarchical linear modeling (HLM) was used to determine the effect of country-level and firm-level antecedents on the MNC bribery activity. The results show that opportunities including achievement of competitive advantage, host countries’ transition periods, and natural resource abundance have positive significant effects on MNCs’ propensity to pay bribes. Additionally, host country conditions, such as the law’s rigidity and legal system incompetence, also have a significant positive impact on an MNC’s propensity to pay bribes. This study advances the literature on corruption in several directions. First, it studies the phenomenon from supply side (i.e. the bribe-payer). Second, it adopts the use of anomie theory which is still a novel approach for studying corruption. Third, it uses the MNC as the unit of analysis rather than country or local firms. Finally, it goes beyond recent studies by focusing on the host country’s rather than home country’s effect on a firm’s bribery activity.
Nebras Nasir Al-Dabbagh,Wissam Hamid Al-Janabi,Mohammed Baqur Sahib Al-Shuhaib 대한미생물학회 2019 Journal of Bacteriology and Virology Vol.49 No.4
The infection with Candida spp. for oral cavity is being increasingly reported. However, its variations have not yet been specifically described in periodontitis. The present study was conducted to use an uniplex 26S rRNA- based amplicons to detect and discriminate Candida using only one pair of ribosomal primers. A total of 50 patients with chronic periodontitis was involved in the study. Pure Candida colonies were isolated from 23 patients and genomic DNA was extracted, and PCR was conducted. Direct DNA sequencing followed by comprehensive phylogenetic analyses were performed to confirm the identity of Candida colonies. Results indicated that the ration of Candida-infected patients was 46%, with a high prevalence of C. albicans, followed by remarkably lower ratios of C. parapsilosis, C. glabrata, C. kefyr, and C. dubliniensis respectively. Phylogenetic analyses indicated obvious discrimination amongst the analyzed Candida species as each observed species occupied a distinctive phylogenetic position. The current results reported a simple, efficient, and low-cost detection of five species of Candida without the need for other costly techniques of molecular screening. The current findings may help dentists to easily take a snapshot of the patterns of Candida infection in periodontitis cases to assess the nature and grade of infection.
El Ezzi, Asmahan Ali,Zaidan, Wissam Rateeb,El-Saidi, Mohammed Ahmed,Al-Ahmadieh, Nabil,Mortenson, Jeffrey Benjamin,Kuddus, Ruhul Haque Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background: The aim of the study was to investigate any associations between benign prostate hyperplasia (BPH) and single nucleotide polymorphisms (SNPs) in the VDR gene (FokI, BsmI, ApaI and Taq${\alpha}$I loci) and the CYP17 gene (MspA1I locus), as well as TA repeat polymorphism in SRD5A2 gene among Lebanese men. Materials and Methods: DNA extracted from blood of 68 subjects with confirmed BPH and 79 age-matched controls was subjected to PCR/PCR-restriction fragment length polymorphism analysis. The odds ra=tio (OR) of having a genotype and the relative risk (RR) of developing BPH for having the genotype were calculated and the alleles were designated risk-bearing or protective. Results: Our data indicated that the A and B alleles of the VDR ApaI and BsmI SNPs were highly associated with increased risk of BPH (p=0.0168 and 0.0002, respectively). Moreover, 63% of the controls compared to 43% of the subjects with BPH were homozygous for none of the risk-bearing alleles (p=0.0123) whereas 60% of the controls and 28% of the subjects with BPH were homozygous for two or more protective alleles (p<0.0001). Conclusions: For the first time, our study demonstrated that ApaI and BsmI of the VDR gene are associated with risk of BPH among Lebanese men. Our study also indicated that overall polymorphism profile of all the genes involved in prostate physiology could be a better predictor of BPH risk.
Song, Daesub,Ha, Gunwoo,Serhan, Wissam,Eltahir, Yassir,Yusof, Mohammed,Hashem, Farouq,Elsayed, Elsaeid,Marzoug, Bahaaeldin,Abdelazim, Assem,Al Muhairi, Salama American Society for Microbiology 2015 Journal of clinical microbiology Vol.53 No.4
<P>We present here a rapid immunochromatographic assay for the detection of Middle East respiratory syndrome coronavirus (MERS-CoV) antigen in the nasal swabs of dromedary camels. The assay is based on the detection of MERS-CoV nucleocapsid protein in a short time frame using highly selective monoclonal antibodies at room temperature. The relative sensitivity and specificity of the assay were found to be 93.90% and 100%, respectively, compared to that of the UpE and open reading frame 1A (Orf1A) real-time reverse transcriptase PCR (RT-PCR). The results suggest that the assay developed here is a useful tool for the rapid diagnosis and epidemiological surveillance of MERS-CoV infection in dromedary camels.</P>
Ghassan Ghssein,Ali Salami,Lamis Salloum,Pia Chedid,Wissam H Joumaa,Hadi Fakih 대한소아소화기영양학회 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.3
Purpose: Acute gastroenteritis (AGE) is a major cause of morbidity and remains a major cause of hospitalization. Following the Syrian refugee crisis and insufficient clean water in the region, this study reviews the etiological and epidemiological data in Lebanon.Methods: We prospectively analyzed demographic, clinical and routine laboratory data of 198 children from the age of 1 month to 10 years old who were admitted with the diagnosis of AGE to a private tertiary care hospital located in the district of Nabatieh in south Lebanon.Results: Males had a higher incidence of AGE (57.1%). Pathogens were detected in 57.6% (n=114) of admitted pa-tients, among them single pathogens were found in 51.0% (n=101) of cases that consisted of: Entamoeba histolytica26.3% (n=52), rotavirus 18.7% (n=37), adenovirus 6.1% (n=12) and mixed co-pathogens found in 6.6% (n=13). Breast-fed children were significantly less prone to rotavirus (p=0.041). Moreover, children who had received the rota-virus vaccine were significantly less prone to rotavirus (p=0.032).Conclusion: Our findings highlight the high prevalence of E. histolytica infection as the major cause of pediatric gastro-enteritis in hospitalized children, during the summer period likely reflecting the insanitary water supplies and lack of hygiene. Moreover the 42.4% of unidentified causative pathogens should prompt us to widen our diagnostic laboratory arsenal by adopting new diagnostic technologies.
Ghssein, Ghassan,Awada, Rana,Salami, Ali,Bahmad, Hisham F.,Awad, Ali,Joumaa, Wissam H.,Roz, Ali El The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.4
Purpose: Campylobacter species are currently the most common cause of bacterial gastroenteritis. In Lebanon, Campylobacter infection occurrence is underdiagnosed owing to the lack of specific culture and rapid test kits, particularly among children. This study aimed to evaluate the prevalence, laboratory findings, and clinical characteristics of Campylobacter infection in hospitalized children with acute gastroenteritis in South Lebanon. Methods: We conducted a 6-month retrospective cohort study between January and June 2018, including 291 children aged between 1 month and 12 years, who were admitted to a tertiary healthcare center in South Lebanon. The medical files of the patients were reviewed to retrieve the required clinical information, including clinical and laboratory data. Results: The prevalence of campylobacteriosis agents in pediatric patients with acute gastroenteritis is 12.02%. Patients infected with Campylobacter had more severe acute gastroenteritis than Campylobacter-negative patients and often presented with high-grade fever, diarrhea episodes more than six times per day, diarrhea lasting for more than five days, and dehydration. Indeed, children with high-grade fever (≥38.5℃) were five times more likely to test positive for Campylobacter than those with low-grade fever. In addition, the results showed a higher Vesikari score for the majority of Campylobacter-positive patients with severe acute gastroenteritis compared to a moderate profile for Campylobacter-negative patients. Conclusion: The present study findings highlight that Campylobacter infection is frequent among children with acute gastroenteritis. Therefore, the detection of Campylobacter should be carried out for the diagnosis of human gastroenteritis in Lebanon, along with the detection of routine enteropathogens.
Ghssein, Ghassan,Salami, Ali,Salloum, Lamis,Chedid, Pia,Joumaa, Wissam H,Fakih, Hadi The Korean Society of Pediatric Gastroenterology 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.3
Purpose: Acute gastroenteritis (AGE) is a major cause of morbidity and remains a major cause of hospitalization. Following the Syrian refugee crisis and insufficient clean water in the region, this study reviews the etiological and epidemiological data in Lebanon. Methods: We prospectively analyzed demographic, clinical and routine laboratory data of 198 children from the age of 1 month to 10 years old who were admitted with the diagnosis of AGE to a private tertiary care hospital located in the district of Nabatieh in south Lebanon. Results: Males had a higher incidence of AGE (57.1%). Pathogens were detected in 57.6% (n=114) of admitted patients, among them single pathogens were found in 51.0% (n=101) of cases that consisted of: Entamoeba histolytica 26.3% (n=52), rotavirus 18.7% (n=37), adenovirus 6.1% (n=12) and mixed co-pathogens found in 6.6% (n=13). Breast-fed children were significantly less prone to rotavirus (p=0.041). Moreover, children who had received the rotavirus vaccine were significantly less prone to rotavirus (p=0.032). Conclusion: Our findings highlight the high prevalence of E. histolytica infection as the major cause of pediatric gastroenteritis in hospitalized children, during the summer period likely reflecting the insanitary water supplies and lack of hygiene. Moreover the 42.4% of unidentified causative pathogens should prompt us to widen our diagnostic laboratory arsenal by adopting new diagnostic technologies.
Tariq Al-Najjar,Mohammad Wahsha,Mwaffaq Al-Khushman,Maroof Khalaf,Kyle Hardage,Wissam Hayek,Khalid Abu Khadra,Adina Paytan 한국해양과학기술원 2021 Ocean science journal Vol.56 No.4
To assess the utility of the seagrass (Halophila stipulacea) for biomonitoring of metal pollution, seagrass samples were collected from four sites along the Jordanian coast of the Gulf of Aqaba between April and July 2017. Concentrations of trace metals (Cr, Mn, Fe, Ni, Zn, and Pb) in leaves, rhizomes, and roots were compared to published data on sediment trace metal and organic carbon content at the same sites to assess the degree of their fidelity in recording local trace metal pollution. The results of this study indicated that the roots of the seagrass H. stipulacea accumulated higher metal concentrations of Cd, Pb, Cr, Ni, Zn, Mn, and Fe than rhizomes and leaves. Concentrations in H. stipulacea varied significantly between sites for Mn, Fe, Zn, Cd, and Pb but not for Cr and Ni. Higher levels of seagrass trace metals in the Hotels Area and Old Phosphate Port sampling sites compared to other sampled sites are likely related to the sites' proximity to tourist and boating activity and city infrastructure which may contribute to metals accumulating in the tissues of this seagrass. In contrast to other studies, when all the data are considered, no clear trend between sediment metal concentration and seagrass metals is observed, suggesting physiological control on metal uptake by H. stipulacea and thus limiting the utility of H. stipulacea for biomonitoring of pollution.