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Whoon Jong Kil,Tabitha Pham,Sabbir Hossain,Juan Casaigne,Kellie Jones.,Mohammad Khalil 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.1
Deep inspiration breathing hold (DIBH) compared to free-breathing (FB) during radiotherapy (RT) has significantly decreased radiation dose to heart and has been one of the techniques adopted for patients with breast cancer. However, patients who are unable to make suitable deep inspiration breath may not be eligible for DIBH, yet still need to spare the heart and lung during breast cancer RT (left-sided RT in particular). Continuous positive airway pressure (CPAP) is a positive airway pressure ventilator, which keeps the airways continuously open and subsequently inflates the thorax resembling thoracic changes from DIBH. In this report, authors applied CPAP instead of FB during left-sided breast cancer RT including internal mammary node in a patient who was unable to tolerate DIBH, and substantially decreased radiation dose the heart and lung with CPAP compared to FB.
Whoon Jong Kil,Kevin Camphausen,In Hye Cho 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.2
Although surgery is the mainstay of local treatment for skin cancer, definitive radiation therapy (RT) has been also applied for patients who are unable to tolerate surgery. Definitive RT regimens usually consist of daily treatment for 4–7 weeks. Such protracted daily RT regimens, however, would not be feasible for non-compliant patients or patients who are unable to make multiple daily trips for weeks. Without treatment, however, skin cancers can continuously progress and cause distressing symptoms. A cyclical hypofractionated RT (QUAD Shot: 14 Gy in 4 fractions, twice-daily treatments with 6 hours interval on 2 consecutive days) can be a practical RT regimen for those patients. In this report, we present the successful treatment course of repeated QUAD Shots in a 79-year-old patient with neglected skin cancer that was disfiguring his face yet declined definitive surgery and protracted RT. We also evaluated and compared biologically equivalent doses between QUAD Shots and conventionally fractionated protracted RT regimens.
( Sung Whoon Han ),( Hong Rok Lim Kim ),( Chang Sun Kim ) 한국운동영양학회 2011 Physical Activity and Nutrition (Phys Act Nutr) Vol.15 No.1
The purpose of this study was to examine the effects of various levels of oxygen (O2) intake on biological muscle damage and oxidative stress after exhaustive maximal exercise. Ten male participants underwent exhaustive exercise by treadmill running three times, and various levels of O2 intake were administered to subjects using the counter balance method at 1-week intervals. O2 intake patterns were divided into three patterns based on the concentration of O2: 21% O2 (air) group, 30% O2 group, and 90% O2 group. Blood samples were collected before as well as 0, 30, and 90 minutes after exercising. From the blood, muscle damage indices (creatine phosphokinase; CPK, lactate dehydrogenase; LDH) and oxidative stresses indices (malondialdehyde; MDA, superoxide dismutase; SOD) were analyzed. Based on the results, although the index of CPK and LDH, showed no significant differences in interaction effect according to the concentration of O2 (p > .05), LDH showed a larger reduction rate in the 30% and 90% groups than in the 21% group (p < .001). The MDA index of the 30% and 90% groups was significantly lower than that of the 21% group after 30 and 90 minutes of exercise (p < .001). The SOD index showed a significant difference in interaction effect; SOD of the 90% group was lower compared to the 21% and 30% groups 30 minutes after exercise (p > .05). These results suggest that although intake of high density O2 after exhaustive exercise does not affect muscle damage, it might reduce oxidative stress.
Kil, Whoon Jong,Pham, Tabitha,Hossain, Sabbir,Casaigne, Juan,Jones, Kellie,Khalil, Mohammad The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.1
Deep inspiration breathing hold (DIBH) compared to free-breathing (FB) during radiotherapy (RT) has significantly decreased radiation dose to heart and has been one of the techniques adopted for patients with breast cancer. However, patients who are unable to make suitable deep inspiration breath may not be eligible for DIBH, yet still need to spare the heart and lung during breast cancer RT (left-sided RT in particular). Continuous positive airway pressure (CPAP) is a positive airway pressure ventilator, which keeps the airways continuously open and subsequently inflates the thorax resembling thoracic changes from DIBH. In this report, authors applied CPAP instead of FB during left-sided breast cancer RT including internal mammary node in a patient who was unable to tolerate DIBH, and substantially decreased radiation dose the heart and lung with CPAP compared to FB.
Kil, Whoon Jong,Camphausen, Kevin,Cho, In Hye The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.2
Although surgery is the mainstay of local treatment for skin cancer, definitive radiation therapy (RT) has been also applied for patients who are unable to tolerate surgery. Definitive RT regimens usually consist of daily treatment for 4-7 weeks. Such protracted daily RT regimens, however, would not be feasible for non-compliant patients or patients who are unable to make multiple daily trips for weeks. Without treatment, however, skin cancers can continuously progress and cause distressing symptoms. A cyclical hypofractionated RT (QUAD Shot: 14 Gy in 4 fractions, twice-daily treatments with 6 hours interval on 2 consecutive days) can be a practical RT regimen for those patients. In this report, we present the successful treatment course of repeated QUAD Shots in a 79-year-old patient with neglected skin cancer that was disfiguring his face yet declined definitive surgery and protracted RT. We also evaluated and compared biologically equivalent doses between QUAD Shots and conventionally fractionated protracted RT regimens.