공간 데이터베이스에서 질의 최적화를 위한 공간 분할 기법

이미란,황환규 강원대학교 정보통신연구소 2002 정보통신논문지 Vol.6 No.-

It is important to calculate the query result size for query optimization in spatial databases. When processing queries to the database, the computing cost of the query result size satisfying query conditions is so expensive. To solve the problem, the query result size estimation based on the summary data approximating the distribution and characteristics of the spatial data is very efficient. In this paper, we propose a spatial partitioning technique based on Maxdiff(V,A) whose performance is evaluated very efficient in one dimensional database. This paper proves the proposed partitioning technique is superior to previous ones through experiments.

영산강 하구역의 해양환경 변화

文美姬,曺炷煥,李文燦 조선대학교 기초과학연구소 1991 自然科學硏究 Vol.14 No.1

In order to research the physico-chemical elements, such as water temperature, salinity, dissolved oxygen, chemical oxygen demand, PO_4-P, transparency and suspended solids, were studied in the Yeongsan river estuary during a decade from 1980 to 1989. The variation of water temperature in the investigated areas was within the range of 2.22∼29.10℃. The salinity varied within the range of 5.87∼33.45‰ throughout the research period, and showed its maximum walue in February and its minimum in August. The salinity was clearly stratified between the surface and the bottom in summer. The salinity of the seaward water was greatly decreased temporarily as low as 5.87‰, in extreme case duo to influx of fresh water. The dissolved oxygen content was reduced in seaward water, but the sporadical oxygen saturated portions were appeared in the plankton-rich areas of the enclosed water. COD increased greately after the enclosure and was particularly high in summer. The concentration of SS and transparency were 48.6mg/l and 0.55m, respectively in 1980, but after the enclosure of the dam these changed remarkly to 8.65mg/l, 2.19m in 1984 as the result of reduced run off of the silt, clay matters and water. The relation coefficient between the concentration of SS and the transparency was calculated as S=86.4982-71.4837T(r=-0.9502) in 1980, but this was changed after the enclosure of the dam to S=22.0384-6.186T(r=-0.6879) in 1984. The concentration of PO_4-P decreased generally after the enclosure of the dam, and large amounts of nutrients discharged across the dam whenever there were bulk outflow of water. The PO_4-P was appeared low in spring in the enclosed water due to flourishing of phytoplanktons.

인터넷 카페에 게시된 예비 과학교사들의 과학교육론에 대한 질문 분석

김인환,이미영 大邱大學校 師範大學 附設 敎育硏究所 2010 學校敎育硏究 Vol.5 No.2

본 연구는 임용시험을 준비하는 예비과학교사들의 학습 중 온라인상에서 이루어지는 과학교육론에 대한 질문의 내용 영역별 빈도, 질문의 수준, 질문의 형태, 질문의 출처 등을 분석하였다. 질문의 내용 영역별 빈도 분석 결과는 과학철학과 과학교육사상 영역에 관한 질문이 20.7%로 가장 많았고, 질문의 수준별 분석에서는 내용에 대한 이해 수준에 심도있는 질문들이 54.9%로 많았으며, 질문의 형태별 분 석에서는 직접적 정보 요청 질문이 42.9%로 가장 많은 부분을 차지하였다. 또 질문의 출처 분석에서는 기출문제를 통한 질문이 42.9%로 가장 많게 나타났다. 이러한 분석 결과 를 바탕으로 과학교육론 학습지도의 기초 자료를 제공하고자 하였다. The purpose of this study is to investigate the preservice teachers' questions on the science education posted in the internet cafe, which includes the frequency of questions on theory of science education on each part, the level of questions, the question types, the source of questions, and to provide the base data for the science teaching methodology. The conclusion and suggestions based on the result of the study are the followings. (1) As the result of analysis of the frequency of questions on each part of the theory of science education, the ones which got the most were on science knowledge, 20.7% of the science philosophy and science education ideology, science teaching & learning according to theory of learning, scientific methodology, psychology and learning theory, meaning of science assessment and charters. These are proved to be closely related with trend and frequency of teachers' examination. Accordingly, deep explanation on these parts is required. (2) According to the questions on the theory of science education many preservice science teachers ask 54.9% of the questions on understanding level among knowledge, understanding, application. Hence, we can conclude they feel difficulty on understanding. Therefore, the explanation on understanding is required when teaching the theory of science education. (3) The analysis of types of questions on the theory of science education shows that direct information request questions and convergent questions occupied the most. Learners who are prepared with somewhat theoretical knowledge are thought to study by themselves and check where they are missing and ask the exact parts. (4) According to the analysis of the questions on the source, questions on past examinations took much part, which suggests that questions who are preparing for the teacher' examination refer to the past examinations rather than texts for acquiring knowledge. Hence, grasping the types of past examinations and remembering the gist of the questions, and teaching similar contents inclusively would be a better teaching methodology. (5) To activate internet cafe is required as preservice teachers who are preparing for the teachers' examination do not have the regular learning hours.

회귀분석(regression analysis)을 이용한 개인별 혈중알콜농도의 감소율 계산

홍성욱,권미아,최혜진,박용훈,인상환,김동우,정주연,우상희,박혜성 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

방사선 치료후 시간경과에 따른 염색체이상 빈도의 변화

송명재,하성환,이춘자,김희근,김미숙 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.1

임파구의 염색체이상 빈도로부터 피폭자의 흡수선량을 구하는 방법은 사고로 인해 급성피폭을 받는 경우 유용하게 사용될 수 있다. 그러나 방사선 피폭 후 시간이 경과함에 따라 불안정 염색체이상을 가진 임파구는 감소하게 된다. 이에 방사선 치료후 시간 경과에 따른 불안정 염색체이상 빈도의 변화를 규명하고자 한다. 전골반에 50.4 Gy의 방사선 치료를 받은 총 20명의 자궁경부암 또는 자궁내막암 환자를 대상으로 41개의 검체를 얻었다. 채혈의 시기는 방사선 치료후 1일 3주, 6주, 12주, 24주, 52주, 104주, 156주, 208주, 520주로 하였다. 이들 말초혈액의 임파구에 대해 전혈미세배양을 실시한 후 임파구의 불안정 염색체이상을 관찰하여 Ydr, Qdr, Qdra를 얻었다. Ydr 값은 방사선 치료가 끝난 직후부터 3주까지 plateau를 보였고 이후 감소하는 경향이었다. Ydr의 평균값은 치료후 3주에 0.29에서 급격히 감소하여 2년후 0.05로 감소하였으며 이후 5년까지 서서히 감소하였다. 회귀분석을 실시한바 Ydr = 0.259×exp(-0.0429T)+0.0560×exp(-0.00106T)(time in weeks)로 나타났다. Qdr값은 치료 직후부터 24주까지 1.51 전후로 거의 변화가 없었으며 이후 감소하여 52주 이후에는 1.17 전후로 거의 일정하였다. Qdra 값은 치료 직후부터 12주까지 1.10 전후이며 이후 감소하여 52주 이후에는 0.81 전후였다. 피폭 후 시간경과에 따른 Ydr 값의 감소는 두 component exponential 모델을 잘 맞고 이 식을 이용하여 생물학적 선량측정이 가능하다. Qdr 값 및 Qdra 값은 피폭후 시간경과가 짧은 경우 피폭선량을 추정하는 지료로 사용할 수 있다. It is good method to use frequency of chromosome aberration in lymphocytes for a biological dosimetry in cases of accidental exposure to radiation. But in cases of past edposure, biological dosimetry is limited because the friquency of aberration decreases by time after exposure. To provide a basic data for estimationof past radiation exposure, the changing pattern of frequency of unstable chromosome aberration by time interbal after exposure was studied. Observation was made on peripheral lymphocytes of 41 blood samples from 20 patients treated for uterine cervical carcinoma and endometrial caricinoma. The patients received 50.4 Gy radiation to whole pelvis. Elapsed times after the completion of radiation therapy were 1 day, 3, 6, 9, 12, 24, 52, 104, 156, 208, 260 and 520 weeks. All the blood sample were microcultured. The Ydr, Qdr and Qdra were calculated form frequency of unstable aberration. Ydr did not decrease for 3 weeks after radiation therapy, and thereafter, decreased very rapidly and reached 0.05 at two years after radiation therapy and decreased very slowly until 5 years after radiation therapy. Relationship between unstable chromosome aberration and time interval after radiation therapy was described as Ydr = 0.2590.259×exp(-0.0429T)+0.0560×exp(-0.00106T)(time in weeks) Qdr remained constant at 1.51 until 24 weeks after radiation therapy and then decreased to 1.17 at 52 weeks. Therafter, it did not change. Qdra remained constant at 1.10 for 12 weeks after radiation therapy and decreased to 0.81 at 52 weeks. Thereafter, it remanined constant. Two superimposed exponential Ydr disappearance rate wuggests that it is possible to calculate the past exposure dose. When the elapsed time after exposure is short, Qdr and Qdra are useful papameters for biological dosimetry for past radiation exposure.

Aspergillus sp. ISR 균주를 통한 콜레스테롤 합성저해제 lovastain의 생산

박상은,조미현,신동화,황승환,박천석 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-

본 연구에서 한국 토양에서 분리된 lovastatin 생산 균주인 Aspergillus sp. ISR 균주를 이용하여 여러 배지 조성 성분이 lovastatin의 생산에 미치는 영향을 관찰하였다. 탄소원으로는 lactose보다 glycerol 5%가 가장 효과적이었으며 질소원과 인산염의 경우는 기본 RPM배지 조성과 농도에서 보다 효과적인 것을 발견하지 못하였다. 복합영양원으로 rapeseed meal 보다는 대두박이 보다 효과적이어서 저렴한 배지원으로 사용이 가능할 것으로 사료된다. 최종적으로 최적화된 배지를 사용하여 52 mg·L^(-1)의 lovastatin을 생산할 수 있었고 이는 기존의 RPM 배지보다 수율이 4.5배 증가한 것이다. 좀 더 효과적인 lovastatin의 생산을 위하여 회분식 발효에 대한 연구와 분자유전학적인 연구를 통한 고생산 균주의 제조에 대한 연구가 진행중이다. Effects of various nutritional components on the production of lovastatin were investigated in the Aspergillus sp. ISR. Among various carbon (C) sources, glycerol was determined to be the most effective C source at the concentration of 5% (v/v). In case of nitrogen sources, 0.2% (w/v) KNO_(3) efficiently induced the lovastatin production in Aspergillus sp. ISR. Interestingly, the addition of soybean meal into the production medium enhanced the lovastatin production compared to the rapeseed meal. Conclusively, Aspergillus sp. ISR produced 52 mg·L^(-1) of lovastatin in the optimized medium containing 5% (v/v) glycerol, 0.2% (w/v) KNO_(3), 0.3% (w/v) KH_(2)PO_(4), and 0.3% (w/v) soybean meal, which was 4.5 times higher than the amount produced using the standard RPM (rapeseedmeal production medium).

유방암종에서 p53, cyclin D1 및 cathersin D 단백발현의 의의

문경래,김환정,이미자,기근홍,서재홍,양정원,조현진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma. Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma. Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis. Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.

반코마이신 내성 장구균 감염에 대한 quinupristin-dalfopristin 치료 경험

추은주,최상호,조영환,정선미,김백남,김남중,김미나,김양수,우준희,류지소 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.1

VRE 감염이 중환자에서 급속히 증가하고 있으나 이에 대한 확실한 치료제가 없어 새로운 항생제에 대한 활발한 연구가 있는데 그 중 하나가 quinupristin/dalfopristin이고, 저자들은 중증 환자들의 VRE 감염에 대해 quinupristin/dalfopristin를 투여하여 치료한 임상적 경험을 하였기에 문헌고찰과 함께 보고하는 바이다. Vancomycin-resistant enterococci (VRE) was first recognized in 1992 in Korea. VRE infection have been increasingly reported in immunosuppressed patients over the past decade and have become one of major nosocomial pathogens. Clinicians carings for patients with VRE infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin is active in vitro againt vancomycin-resistant E. faecium (VREF), with a MIC_(90) of 1.0㎍/mL. We studied the clinical efficacy and safety of this agent in the treatment of VREF infection. Patients were included if they had signs and symptoms of active infection including bacteremia, intra-abdominal infection, and wound infection. A total of 13 patients with VREF infection were enrolled. A favorable clinical response (cure or improvement) occured in 10 of 11 evaluable patients. The only adverse events related to quinupristin/dalfopristin were arthralgia and myalgia, which occurred in 2 of 13 patients. These results suggest that quinupristin/dalfopristin is effective and safe as treatment for VREF infections in critically ill patients with serious underlying conditions.

인체 지방 및 간장조직 중 유기염소제류의 확인 및 정량기법 체계화

이상기,양자열,인상환,김기욱,이수연,오승민,김미영,정규혁 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

Selection of strains with high sucrose content in soybean

Mi-Kyung Sung,Min-Whan Kim,Hyung-Jin Seo,Jong-Il Chung 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Sucrose, raffinose, and stachyose are major soluble sugars in soybean seeds. Sucrose is the major source of energy for fermentation and contributes to the sweetness of soybean foods. The soyfood and animal feed markets prefer soybean cultivars with high sucrose because they provide high levels of energy and better tasting food and feed. The objective of this study is to select soybean lines with high sucrose content. A total of 295 soybean genotypes including 13 current cultivars, 34 germplasms, and 248 breeding lines were planted at the field. After harvesting, sucrose contents for 295 genotypes were measured through HPLC method. Wide variation was detected among the 295 genotypes in sucrose content. The sucrose content ranged from 15.1 to 39.0 g. kg-1 in 13 current cultivars. The highest sucrose content was identified in “Dayangkong” (39.0 g. kg-1), whereas was lowest in “Seomoktae” (15.1 g. kg-1). The sucrose content ranged from 9.6 to 47.6 g. kg-1 in 34 germplasms. The sucrose content ranged from 0.9 to 46.4 g. kg-1 in 248 breeding lines.