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Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses
Wes Spiller,Keum Ji Jung,Ji Young Lee,지선하 대한심장학회 2020 Korean Circulation Journal Vol.50 No.2
Cardiovascular disease (CVD) is considered a primary driver of global mortality and is estimated to be responsible for approximately 17.9 million deaths annually. Consequently, a substantial body of research related to CVD has developed, with an emphasis on identifying strategies for the prevention and effective treatment of CVD. In this review, we critically examine the existing CVD literature, and specifically highlight the contribution of Mendelian randomization analyses in CVD research. Throughout this review, we assess the extent to which research findings agree across a range of studies of differing design within a triangulation framework. If differing study designs are subject to non-overlapping sources of bias, consistent findings limit the extent to which results are merely an artefact of study design. Consequently, broad agreement across differing studies can be viewed as providing more robust causal evidence in contrast to limiting the scope of the review to a single specific study design. Utilising the triangulation approach, we highlight emerging patterns in research findings, and explore the potential of identified risk factors as targets for precision medicine and novel interventions.
Jae-Hwan Han,R. Wes Harrison 한국농업경제학회 2006 農業經濟硏究 Vol.47 No.4
This study conducted a national survey to investigate the effects of consumers’risk/benefit perceptions on their labeling preferences and willingness to buy biotech meat depending on labeling policy. The study examined that various attribute perceptions associated with biotechnology are key factors to explain consumers’ labeling preferences and willingness to buy biotech meat. The responding sample is somewhat biased toward the Caucasian and higher-educated. Results indicate that consumers are less likely to purchase biotech meat under a mandatory labeling policy. In addition, the study suggests that educating consumers about GM foods might be a viable strategy to mitigate their concerns about unknown health risks and adverse environmental effects.
Consumer Valuation of Genetically Modified (GM) Potatoes with Benefit Disclosure
( Jae Hwan Han ),( R. Wes Harrison ) 한국농업경제학회 2007 KOREAN JOURNAL OF AGRICULTURAL ECONOMICS(KJAT) Vol.48 No.3
This study conducted a national survey to investigate the effects of consumers’ risk/benefit beliefs on the level of a premium of GM potatoes with more nutritious value. The study found that the qualitative factors, such as benefits of GM foods to the health and environment and positive evaluation about GM foods, have a significant, positive influence on the premium level for GM potatoes. However, unexpectedly, the findings show that risks of GM food and morality have the reasonable signs, but have an insignificant effect on the premium level for GM potatoes.
Consumer Valuation of Genetically Modified(GM) Potatoes with Benefit Disclosure
Jae-Hwan Han,R. Wes Harrison 한국농업경제학회 2007 農業經濟硏究 Vol.48 No.4
This study conducted a national survey to investigate the effects of consumers’ risk/benefit beliefs on the level of a premium of GM potatoes with more nutritious value. The study found that the qualitative factors, such as benefits of GM foods to the health and environment and positive evaluation about GM foods, have a significant, positive influence on the premium level for GM potatoes. However, unexpectedly, the findings show that risks of GM food and morality have the reasonable signs, but have an insignificant effect on the premium level for GM potatoes.
( Jae Hwan Han ),( R. Wes Harrison ) 한국농업경제학회 2006 KOREAN JOURNAL OF AGRICULTURAL ECONOMICS(KJAT) Vol.47 No.3
This study conducted a national survey to investigate the effects of consumers’risk/benefit perceptions on their labeling preferences and willingness to buy biotech meat depending on label-ingpolicy. The study examined that various attribute perceptions associated with biotechnology are key factors to explain consumers’ labeling preferences and willingness to buy biotech meat. The responding sample is somewhat biased toward the Caucasian and higher-educated. Results indicate that consumers are less likely to purchase biotech meat under a mandatory labeling policy. In addition, the study suggests that educating consumers about GM foods might be a viable strategy to mitigate their concerns about unknown health risks and adverse environmental effects.
Sung Yong Park,Young Mo Yoon,M. Wes Schilling,Koo Bok Chin 한국축산식품학회 2009 한국축산식품학회지 Vol.29 No.5
This study was conducted to investigate the effects of heating, fiber type used in solid-phase microextraction (SPME, two phase vs three phase) and storage time on the volatile compounds of porcine M. longissimus dorsi (LD). Volatile compounds were measured using a gas chromatography and mass spectrometry (GC/MS) with a quadrupole mass analyzer. Among the volatile compounds identified, aldehydes (49.33%), alcohols (24.63%) and ketones (9.85%) were higher in pre-heated loins (100oC/30 min), whereas, alcohols (34.33%), hydrocarbons (22.84%) and ketones (16.88%) were higher in non-heated loins. Heating of loins induced the formation of various volatile compounds such as aldehydes (hexanal) and alcohols. The total contents of hydrocarbons, alcohols, and carboxylic acids were higher in two phase fibers, whereas those of esters tended to be higher in three-phase fibers (p<0.05). Most volatile compounds increased (p<0.05) with increased storage time. Thus, the analysis of volatile compounds were affected by the fiber type, while heating and refrigerated storage of pork M. longissimus dorsi increased the volatile compounds derived from lipid oxidation and amino acid catabolism, respectively. This study was conducted to investigate the effects of heating, fiber type used in solid-phase microextraction (SPME, two phase vs three phase) and storage time on the volatile compounds of porcine M. longissimus dorsi (LD). Volatile compounds were measured using a gas chromatography and mass spectrometry (GC/MS) with a quadrupole mass analyzer. Among the volatile compounds identified, aldehydes (49.33%), alcohols (24.63%) and ketones (9.85%) were higher in pre-heated loins (100oC/30 min), whereas, alcohols (34.33%), hydrocarbons (22.84%) and ketones (16.88%) were higher in non-heated loins. Heating of loins induced the formation of various volatile compounds such as aldehydes (hexanal) and alcohols. The total contents of hydrocarbons, alcohols, and carboxylic acids were higher in two phase fibers, whereas those of esters tended to be higher in three-phase fibers (p<0.05). Most volatile compounds increased (p<0.05) with increased storage time. Thus, the analysis of volatile compounds were affected by the fiber type, while heating and refrigerated storage of pork M. longissimus dorsi increased the volatile compounds derived from lipid oxidation and amino acid catabolism, respectively.
Maintenance-based prognostics of nuclear plant equipment for long-term operation
Zachary Welz,Jamie Coble,Belle Upadhyaya,Wes Hines 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.5
While industry understands the importance of keeping equipment operational and well maintained, theimportance of tracking maintenance information in reliability models is often overlooked. Prognosticmodels can be used to predict the failure times of critical equipment, but more often than not, thesemodels assume that all maintenance actions are the same or do not consider maintenance at all. Thisstudy investigates the influence of integrating maintenance information on prognostic model predictionaccuracy. By incorporating maintenance information to develop maintenance-dependent prognosticmodels, prediction accuracy was improved by more than 40% compared with traditional maintenanceindependent models. This study acts as a proof of concept, showing the importance of utilizing maintenance information in modern prognostics for industrial equipment.
Park, Sung-Yong,Yoon, Young-Mo,Schilling, M. Wes,Chin, Koo-Bok Korean Society for Food Science of Animal Resource 2009 한국축산식품학회지 Vol.29 No.5
This study was conducted to investigate the effects of heating, fiber type used in solid-phase microextraction (SPME, two phase vs three phase) and storage time on the volatile compounds of porcine M. longissimus dorsi (LD). Volatile compounds were measured using a gas chromatography and mass spectrometry (GC/MS) with a quadrupole mass analyzer. Among the volatile compounds identified, aldehydes (49.33%), alcohols (24.63%) and ketones (9.85%) were higher in pre-heated loins ($100^{\circ}C$/30 min), whereas, alcohols (34.33%), hydrocarbons (22.84%) and ketones (16.88%) were higher in non-heated loins. Heating of loins induced the formation of various volatile compounds such as aldehydes (hexanal) and alcohols. The total contents of hydrocarbons, alcohols, and carboxylic acids were higher in two phase fibers, whereas those of esters tended to be higher in three-phase fibers (p<0.05). Most volatile compounds increased (p<0.05) with increased storage time. Thus, the analysis of volatile compounds were affected by the fiber type, while heating and refrigerated storage of pork M. longissimus dorsi increased the volatile compounds derived from lipid oxidation and amino acid catabolism, respectively.