성견에서 악관절원판 절제가 악관절에 미치는 영향에 관한 실험적 연구

윤원석,김기환,우기선 단국대학교 치의학연구소 1995 논문집 Vol.7 No.1

The purpose of this study was to observe changes of TMJ after unilateral diskectomy. 7 dogs of 12kg weight ( control : 1, experimental : 6 ) were used. Left side of experimental group was diskectomized. The experimental animals were sacrified on 2, 12, and 22 weeks. Bilateral excised TMJ were fixed in 10% neutral formalin, decalcified with 8% formic acid, and 4-8um paraffin sections were stained with Hematoxylin-Eosin staining and Masson's Trichrome staining. The specimens were examined with light microscope. The results were as follows 1. Hyperplasia of articular zone and proliferating zone increased but hypertropic zone and erosive zone decreased in the non-surgical site. These features were assumed to mean adaptations of subchondral bone by change from chondral bone to bone. 2. Articular zone and hypertropic zone were increased but proliferating zone was decreased in surgical site of 22 weeks. It was assumed that stimulations in mandibular condyle accelerate shift from proliferating zone to hypertropic zone. Erosive zone was decreased a little. 3. Remodelling of subchondral bone was seen until to 22weeks of surgical site, but barely seen in non-surgical site. 4. There were more active bone remodelling at the inner part of trabecules in both them surgical and non-surgical site.

사람唾液의 Cl 血型分泌型에 關한 硏究

朴淳元,韓元東 大韓法醫學會 1979 대한법의학회지 Vol.3 No.1

Moon and Wiener had demonstrated new blood factor "Cl" with anti-Cl lectin prepared from extracts of seeds of Korean Clerodendron trichotomum THUNBERG by absorption of selected human red blood cells. After that, Moon et al. had reported that Cl type specific substance in distributed in human saliva, too. Therefore, human saliva can be classified into two type, secretor of Cl (Sc) and non-secretor of Cl (nSc). To study on the frequency of Sc and nSc, relation with ABH type secretor and hereditary pattern of Cl secretors, agglutination inhibition test of anti-Cl lectin was carried out with human saliva by standard method, and the results can be summarized as follows; 1. Cl positive type can be classified secretor and non-secretor of Cl by human saliva, but Cl negative type is reacted as only non-secretor of Cl. 2. The secretor status of Cl is quite different from ABH secretor. 3. It appears that the inheritance of the saliva type of Cl follows the Mendelian law with the non-secretor of Cl transmitted through recessive genes.

RAPD(Random Amplified Polymorphic DNA)법을 이용한 한약재의 판별 연구

김대원,김도균,안선경,조동욱 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

Conventionally, identification and classification methods of natural products include the morphological survey and assay of chemical disposition. Using these methods, however, is not satisfying for the precise identification of natural products because they are often variable in the compositions, genomic DNA analysis such as RAPD, RFLP and Amp-FLP can be adopted for this purpose. In this study, various ginsengs and bear gall bladder were tested for the development of genetic identification and classification method. Varieties of ginsengs such as, P. ginseng, P. quinquefolium, P. japonicus and P. notohinseng, were genetically analyzed by RAPD. Also, DNA isolated form Bear blood and gall bladder, Ursus thibetanus, Ursus americanus and Ursus arctors, were analyzed by the same method. The results demonstrated that the identification and classification of bear gall bladder and various ginsengs were possible by RAPD analysis. Therefore, this method was thought to be used as a additional method for the identification of other natural products.

동기 MPSK 신호 심볼 오류 확률의 빠른 계산을 위한 간단한 근사식

윤동원,황선태 대전대학교 산업기술연구소 1998 산업기술연구소 論文集 Vol.9 No.2

The symbol error probability for the coherent detection of M-ary PSK signals in AWGN can be evaluated exactly for M = 2 (BPSK) and M = 4 (QPSK). The MPSK symbol error rate(SER) bounds used in the past are simple to calulate, but not particularly accurate. More recently, very tight bounds have been proposed, but they are not true bounds since they are based on an arbitrary truncation of an infinite series expansion. In this paper to obtain the simple and accurate lower bound for coherent MPSK SER in AWGN, we consider the SER for MPSK in Nakagami fading case first. Then as the Nakagami fading index m approaches to the infinite, we obtain the SER for MPSK in AWGN. Here, new lower bound that is simple and very tight is derived.

사람睡液의 Cl血型 分泌型에 關한 硏究

朴淳元 大韓法醫學會 1988 대한법의학회지 Vol.12 No.1

Moon and Wiener had demonstrated new blood factor "Cl" with anti-Cl lectin prepared from extracts of seeds of Korean Clerodendron trichotomum THUNBERG by absorption of selected human red blood cells. After that, Moon et al. had reported that Cl type specific substance is distributed in human saliva, too. Therefore, human saliva can be classified into two types, secretor of Cl(Sc) and non-secretor of Cl(nSc). To study on the frequency of Sc and nSc, relation with ABH type secretor and hereditary pattern of Cl secretors, agglutination inhibition test of anti-Cl lectin was carried out with human saliva by standard method, and the results can be summarized as follows: 1. Cl positive type can be classified secretor and non-secretor of Cl by human saliva, but Cl negative type is reacted as only non-sectetor of Cl. 2. The secretor status of Cl is quite different from ABH secretor. 3. It appears that the inheritance of the saliva type of Cl follows the Mendelism law with the non-secretor of Cl transmitted through recessive genes.

유전실험법에 의한 가교폴리에틸렌의 절연특성 평가

김원종,임윤희,심낙순,심재선,방영근 三陟大學校 産業科學技術硏究所 2003 産業科學技術硏究論文集 Vol.8 No.1

In this paper, we estimated the insulation properties of cross-linked polyethylene (XLPE) for ultra-high voltage cable. we have studied the dielectric characteristics of XLPE due to frequency and temperature variation. The dielectric characteristics were measured in the temperature range from 25[℃] to l20[℃]. Also we measured in the voltage range of l[V] to 20[V] according to the step voltage application method. From FT-IR spectrum as an analysis of physical properties, a strong absorption in wavenumbers 700 to 730[cm^(-1)] 1456[cm^(-1)] and 2700 to 3000 [cm^(-1)] observed by the methyl group(CH₂). From the analysis of DSC. the crystalline melting points of the specimen observed in the temperature 60[℃] and 106.58[℃].

韓國産 植物凝集素 Vicia pallida Turcz.의 凝集活性에 關한 硏究

朴淳元,文國鎭 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

After Stillmark's report on agglutination of human and animal red blood cell (RBC) by plant extracts, numerous studies on phytagglutinin was performed. Phytagglutinin was divided into species-specific phytagglutinin, type-specific phytagglutinin and pan-phytagglutinin. Therefore, the author performed agglutination test with human RBC and with ficinated RBC, and agglutinating inhibition test with human saliva and various sugar solution, by using extract of Korean native Vicia pallida. The results could be summarized as follows; 1) Human RBC was divided into agglutinating group and not agglutinating group by extracts of Vicia pallida, and it was designated the former as Vp (+) type and the latter as Vp(-) type. The distribution of Vp(+) type was 78.80% and Vp(-) type was 21.20% in 1,118 of Korean blood samples. 2) There were no differences in the distribution of Vp (+) and Vp (-) type frequencies between male and female, among ABO blood groups and MN blood groups. 3) No appreciable difference was noted in the distribution of Vp group among tested patient groups. 4) Agglutinating activity of ficinated RBCs with extracts of Vicia pallida was decreased. 5) Agglutinating activity of extracts of Vicia pallida was not inhibited by human saliva. 6) Agglutinating activity of extracts of Vicia pallida were inhibited by dextrose, D-mannose, and lactose.

성견에서 악관절원판 절제가 악관절에 미치는 영향에 관한 실험적 연구

윤석원,김기환,우기선 단국대학교 치의학연구소 1995 단국대치의학연구소논문집 Vol.7 No.1

비만 개선 효과를 지닌 탄수화물 및 지방 흡수 억제 기능성 식이조성물 개발

윤유식,최선미,홍순복,홍정미,김정원,이홍석,홍성길 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

In a previous study, we developed a new food additive as an egg yolk antibody (IgY) against carbohydrate digestion enzymes for the regulation of blood glucose level and weight control. The IgY delayed and decreased the increment of blood glucose level after administration of sucrose in human being by 30% in 20∼30 min. We also developed a lipase inhibitor as a water extract of two kinds of herb, Platycodon grandiflorum and Solanum melongena. Twenty three volunteers were subjected to the intake of the egg yolk IgY plus the herbal extracts for 50 days. In average, the treated subjects appeared to lose 1.96 ㎏ of body weight and 3.4 ㎏ of body fat mass during the treated period. Furthermore, Panniculus adiposus and breech size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of egg yolk IgY and natural herbal extract improve the obesity by the decrement of body weight and body fat mass.

임신여성을 제외한 성인에서의 B군 연쇄구균 감염에 관한 임상적 고찰

고경식,권선희,안우석,이원욱,김구엽,서환조 대한감염학회 1995 감염 Vol.27 No.4

목적:B군 연쇄구균은 최근 보고에 의하면 만성 기저질환(당뇨병, 악성종양등)이 있는 성인에서 감염빈도 및 사망률, 이환율이 증가하고 있는 추세이며 그 중요성이 대두되고 있다. 이에 저자들은 B군 연쇄구균 감염의 임상양상, 기저질환(위험인자)을 알아보고, B군 연쇄구균 항균제 감수성등을 규명하고자 하였다. 방법:1986년 1월부터 1993년 12월까지 경희대학교 부속병원에서 B군 연쇄구균이 배양된 274예를 대상으로 의무기록지를 검토하였다. 결과: 1) 전체 연구대상은 274예로 98예(35.8%)가 남자였고, 176예(64.2%)가 여자였다. 이들의 연령분포를 보면 신생아군에서 감염이 많이 발생하였다 이후 감소추세를 보이다가 20대 이상에서 다시 증가 하는 추세를 보였다. 2) 감염 양상은 274명중 명확한 감염이 156명(56.9%), 추정감염이 55명(20.1%), 비감염이 63명(23.0%)이었다. 임신을 제외한 18세 이상의 성인은 231명으로 남자가 83명, 여자가 148명이었고 남여 비율은 1:1.78이었다. 이중 133예(57.6%)에서 명확한 감염이었고, 46명(19.9%)에서 추정 감염, 52명(22.5%)에서 비감염이었다. 명확한 감염환자 133명중 31명(23.3%)이 병원내 감염이였다. 3) 18세 이상의 성인 231명에서 Group B Streptococcus가 분리 동정된 감염 부위는 자궁 경부 77예(33.3%), 요 73예(31.6%), 객담및 상기도 39예(16.9%), 농 24예(10.4%)등이었다. 4) 명확한 감염을 가지고 있었던 성인 133명의 임상양상은 요로 감염 37명(28%), 자궁 경부염 37명(28%), 피부, 연조직 감염 23명(17%), 폐렴 10명(8%), 패혈증 8명(6%)등이었다. 5) 명확한 감염을 가지고 있었던 성인 133명중 92명(69%)에서 한가지 이상의 만성 기저질환이 있었으며, 이중 당뇨병 32%, 뇌 혈관 질환 21%, 고혈압 19%, 신부전 12%, 악성종양 5%등을 차지하였다. 6) 항균제 감수성 검사(251예)에서 penicillin 98.4%, cephalothin 99.6%, cefamandol 98.8%, erythromycin 96.0%, clindamycin 89.4%, oxacillin 88.8%, lincomycin 87.8%, methicillin 86.8%, minocycline 49.4%, trimethoprim-sulfamethoxazole 15.5%의 감수성을 보였다. 7) 명확한 성인 감염 133명중 6명(4.5%)이 사망하였다. 결론:B군 연쇄구균은 만성 기저질환이 있는 성인에서 감염 빈도가 높고, 치명적인 결과를 초래할수 있으므로 감염 예방 및 조기 발견, 적절한 항균제 감수성 검사에 따라 조기 치료로 사망률을 줄여야 할것으로 생각된다. Background: Several reports have suggested that the incidence of diseases caused by Group B streptococcus is increasing in nonpregnant adults, particularly those with serious underlying diseases. The objectives of this study were to define the clinical manifestations, underlying conditions(risk factors) of definite group B streptococcal diseases in nonpregnant adults and to obtain antimicrobial sensitivity of these infections. Methods: We analyzed the records of 274 cases of the Group B streptococcus isolated in Kyung-Hee University hospital between 1986 and 1993. Results: 1) Total Group B streptococcal isolates were 274 cases : Of these cases, 7 percent were 1 month of age or younger, 3 percent were older than 1 month but younger than 18 years of age, and 91 percent were 18 or older. 2) Men and nonpregnant women accounted for 87 percent (n=231) : 133 cases (57.6%) with definite infection, 46 cases(19.9%) with possible infection, and 52 cases(22.5%) with no infection. 31 cases of 133 (23.3%) nonpregnant adult with definite infection apeared to have acquired the disease nosocomially. 3) In the 133 nonpregnant adult patients, the most common clinical diagnosis were urinary tract infection(28%), and cervicitis(28%). 4) In the 133 nonpregnant adult patients, the underlying diseases or conditions were diabetes mellitus(32%), cerebrovascular accident(21%), hypertension(19%), renal failure(12%), and malignant neoplasm(5%), Sixty-nine percent of the cases had one or more underlying diseases. 5) In the antimicrobial sensitivity tests, 98.4% of isolates were sensitive to penicillin, 99.6% to cephalothin, 98,8% to cefamandol, 96.0% to erythromycin, 89.4% to clindamycin, and 49.4% to minocycline. 6) The case mortality rate was 4.5%(6 of 133). Conclusion:We found group B streptococcal infection to be a significant and apparently increasing cause of definite diseases in nonprognant adults, particularly in those with serious underlying diseases. Recognizing these infections early in the groups with serious underlying diseases will be helpful in lowering mortality.