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Antioxidative and Anti-inflammatory Activities of Litsea japonica Leaves
( Weon Jong Yoon ),( Se Chan Kang ),( Young Min Ham ),( Kil Nam Kim ),( Weon Hyuk Yang ),( Hee Jung Kim ),( Soo Yeong Park ),( Yong Hwan Jung ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
We investigated the antioxidative and anti-inflammatory properties of an 80% ethanol extract and solvent fractions of Litsea japonica leaves. The extract and the CH2Cl2, EtOAc, and BuOH fractions showed antioxidant potential, based on radical-scavenging activity. In LPS-stimulated RAW 264.7 cells, the CH2Cl2 fractions inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production. Additionally, the CH2Cl2 fractions inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. These results show that the CH2Cl2 fractions of L. japonica strongly inhibited the production of NO and PGE2 and the induction of iNOS and COX-2 in LPS-stimulated cells. Thus, we propose that CH2Cl2 fractions may inhibit NO and PGE2 production primarily through the regulation of iNOS and COX-2 gene expression. This study suggests the L. japonica may be a natural source of effective antioxidant and anti-inflammatory agents.
Antioxidative and Anti-inflammatory Activities of Litsea japonica Leaves
Yoon, Weon-Jong,Kang, Se-Chan,Ham, Young-Min,Kim, Kil-Nam,Yang, Weon-Hyuk,Kim, Hee-Jung,Park, Soo-Yeong,Jung, Yong-Hwan The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
We investigated the antioxidative and anti-inflammatory properties of an 80% ethanol extract and solvent fractions of Litsea japonica leaves. The extract and the $CH_2Cl_2$, EtOAc, and BuOH fractions showed antioxidant potential, based on radical-scavenging activity. In LPS-stimulated RAW 264.7 cells, the $CH_2Cl_2$ fractions inhibited nitric oxide (NO) and prostaglandin $E_2(PGE_2)$ production. Additionally, the $CH_2Cl_2$ fractions inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. These results show that the $CH_2Cl_2$ fractions of L. japonica strongly inhibited the production of NO and $PGE_2$ and the induction of iNOS and COX-2 in LPS-stimulated cells. Thus, we propose that $CH_2Cl_2$ fractions may inhibit NO and $PGE_2$ production primarily through the regulation of iNOS and COX-2 gene expression. This study suggests the L. japonica may be a natural source of effective antioxidant and anti-inflammatory agents.
( Weon Ju Lee ),( Yoon Hyuk Choi ),( Bo Ae Kim ),( Chan Ik Park ) 한국피부장벽학회 2012 한국피부장벽학회지 Vol.14 No.2
Dry skin is a relatively common disorder, especially in the elderly. The condition is associated with generalized pruritus and herbal medicines such as Coptis chinensis and Houttuynia cordata have been proven to be safe and effective for skin dryness and pruritus. The purpose of this study was to evaluate the clinical efficacy of moisturizers containing herbal medicines on senior dry skin patients with pruritus. Twenty six patients were treated with these moisturizers and clinical efficacies, as measured by the score of subjective symptom and objective signs about pruritus, transepidermal water loss (TEWL) and hydration capacitance respectively, were assessed after topical application of the moisturizers. As results, the scores of clinical signs and TEWL showed statistically significant improvements after treating with two types of moisturizers on the senior dry skin and no local or systemic side effect occurred. Topical application of these moisturizers was found to be effective and safe for senior patients suffering from dryness and pruritus. And those results were confirmed by the rheological data of loss angle increasing with the addition of Houttuynia cordata extract and decreasing from 15.8 to 12.1 with the addition of Coptis chinensis extract. About 23% reduction of loss angle means that elasticity of moisturizer increases and physically optimized skincare barrier of moisturizer can be formed to keep dry senior skin effectively moisturized.
Do Weon Lee,Du Hyun Ro,Myung Chul Lee,Hyuk-Soo Han 대한정형외과학회 2024 Clinics in Orthopedic Surgery Vol.16 No.1
Background: Rectangular tunnel and graft have been recently designed to closely resemble the native anatomy in anterior cruciate ligament reconstruction (ACLR). This study was performed to compare the short-term clinical outcomes between rectangular and round femoral tunnels in ACLR using quadriceps tendon-patellar bone (QTPB) autografts. Methods: A total of 78 patients who underwent primary ACLR with QTPB autografts performed by three senior surgeons and had at least 1 year of postoperative follow-up were retrospectively reviewed. Patients who underwent rectangular tunnel ACLR (n = 40) were compared to those treated with the conventional round tunnel ACLR (n = 38). Outcomes including knee stability, clinical scores, quadriceps strength, associated complications, postoperative knee range of motion, and cross-sectional area of the graft were assessed. Results: Significant improvements in knee stability and clinical scores were observed after surgery in both groups (all p < 0.001). The postoperative measurements of knee stability and clinical scores were not significantly different between the two groups. Knee extension strength deficit at 60°/sec was significantly less in the rectangular tunnel group than in the round tunnel group at postoperative 6 months (41.7% vs. 48.9%, p = 0.032). The cross-sectional area of the partial-thickness QTPB graft was approximately 60% of the full-thickness QTPB graft. Conclusions: In the short-term, rectangular tunnel ACLR was comparable to round tunnel ACLR with QTPB autograft despite the smaller cross-sectional area. Additionally, the rectangular tunnel ACLR allowed partial-thickness grafting technique, which could subsequently reduce early donor site morbidity.
Trichophyton verrucosum infection in Korea: Analysis on 224 patients from 1976 to 2015
( Dong Hyuk Eun ),( Jun Hong Park ),( Sun Young Moon ),( Yong Hyun Jang ),( Seok-jong Lee ),( Do Won Kim ),( Yong Jun Bang ),( Jae Bok Jun ),( Weon Ju Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Trichophyton (T.) verrucosum is a dermatophyte causing ringworm in cattle, distributed worldwide. It can be responsible for various inflammatory lesions of skin and scalp. In Korea, kerion celsi caused by T. verrucosum was first reported at 1986 in the southeast province of Korea. Since then, many patients infected with T. verrucosum have been reported in Young-nam province. There are few long-term studies about epidemiological characteristics of T. verrucosum. Objectives: To investigate the clinical and epidemiological characteristics of T. verrucosum infections in Korea. Methods: A total of 224 patients were diagnosed as T. verrucosum infection by fungal culture from 1976 to 2015. The data were based on a retrospective survey of medical records. Results: The annual incidence of patients with T. verrucosum infection had been increasing since the report in 1986. The number of patients showed a peak in 1988. After 2000, the number of patients had been decreasing. Female to male ratio showed a 1.2-fold predominance of female infection. And more than 15-year-old group was 59.4% of total patients. T. verrucosum infection was most commonly seen in spring and was found predominantly in patients living in rural areas. Face was most frequently involved, followed by arms. Conclusion: These findings provide useful information for understanding of T. verrucosum infection and future dermatophytosis prospects.