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Wen-Shing Sun,Chuen-Lin Tien,Jui-Wen Pan,Tsung-Hsun Yang,Chih-Hsuan Tsuei,Yi-Han Huang 한국광학회 2013 Current Optics and Photonics Vol.17 No.5
The design of the LEDs lighting in general household illumination was proposed and compared with the fluorescent lighting in this study. Using the LED as a light source would promote energy saving lighting for household illumination purposes. We used the LightTools and DIALux software to design and simulate different standards of illuminance, different correlated color temperatures and different color rendering indices for household environments. The power consumption and efficiency of traditional illuminated light sources and an LED light source with the same standard of illuminance for lighting the household environment were analyzed and compared with each other. Finally, our results show the advantages of using white-light LEDs for lighting and household illumination.
A Low-cost Optimization Design for Minimizing Chromatic Aberration by Doublet Prisms
Wen-Shing Sun,Chuen-Lin Tien,Ching-Cherng Sun,Ching-Chun Lee 한국광학회 2012 Current Optics and Photonics Vol.16 No.4
A low-cost optimal double-prism method is proposed by using the developed MATLAB program to correct chromatic aberration. We present an efficient approach to choose a couple of low-cost glasses to obtain a low aberration double prism. The doublet prisms were made of two lead-free glasses. The relative partial dispersion of the two lead-free glasses is identical and their Abbe numbers are different greatly. The proposed design aims to minimize chromatic aberration, such as in apochromats, for paraxial ray tracing. Finally, an optimization design for real ray tracing can be evaluated by the chromatic aberration curve with a minimal area.
A practice on performance testing for web-based systems Hyperlink testing for web-based system
Chang, Wen-Kui,Hon, Shing-Kai 한국품질경영학회 2000 The Asian Journal on Quality Vol.1 No.1
This paper investigates the issue of performance testing on web browsing environments. Among the typical non-functional characteristics, index of link validity will be deeply explored. A framework to certify link correctness in web site is proposed. All possible navigation paths are first formulated to represent a usage model with the Markov chain property, which is then used to generate test script file statistically. With collecting any existing failure information followed by tracing these testing browsed paths, certification analysis may be performed by applying Markov chain theory. The certification result will yield some significant information such as: test coverage, reliability measure, confidence interval, etc. The proposed mechanism may provide not only completed but also systemic methodologies to find any linking errors and other web technologies errors. Besides, an actual practice of the proposed approach to a web-based system will be demonstrated quantitatively through a certification tool.
Bidirectional Hybrid DWDM-PON for HDTV/Gigabit Ethernet/CATV Applications
Hai-Han Lu,Wen-Shing Tsai,Tzu-Shen Chien,Shih-Hung Chen,Yu-Chieh Chi,Che-Wei Liao 한국전자통신연구원 2007 ETRI Journal Vol.29 No.2
A new scheme for bi-directional HDTV/Gigabit Ethernet/CATV transmission over a hybrid densewavelength- division-multiplexing passive optical network (DWDM-PON) is proposed and demonstrated. It is based on injection-locked vertical-cavity surface-emitting lasers and distributed-feedback laser diodes as transmitters. Services with 129 HDTV channels, a 1.25 Gbps Gigabit Ethernet connection, and 77 CATV channels are successfully demonstrated over 40 km single-mode fiber links. Good performance of bit error rate, carrier-to-noise ratio, composite second order, and composite triple beat is achieved in our proposed bidirectional DWDM-PON.
Hwang,Gwo Haur,Shen,Wen Zen,Tenqchen,Shing 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1
In this paper, a complete PLA break fault ATPG system, PLABEK, is proposed. PLABEK contains four main parts : 1) break fault collapsing; 2) pruning algorithm based test pair generation; 3) serial fault-injection parallel-bit-operation event-driven break fault simulation; and 4) testability-measure-based fault ordering. Experimental results show that PLABEK can generate complete compact test sequences for PLA's break faults very fast.
( Byung Su Yoo ),( Jin Joo Park ),( Dong Ju Choi ),( Seok Min Kang ),( Juey Jen Hwang ),( Shing Jong Lin ),( Ming Shien Wen ),( Jian Zhang ),( Junbo Ge ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.4
Background/Aims: Hyponatremia is a well-known risk factor for poor outcomes in Western studies of heart failure (HF) patients. We evaluated the predictive value of hyponatremia in hospitalized Asian HF patients. Methods: The Clinical Characteristics and Outcomes in the Relation with Serum Sodium Level in Asian Patients Hospitalized for Heart Failure (the COAST) study enrolled hospitalized patients with systolic HF (ejection fraction < 45%) at eight centers in South Korea, Taiwan, and China. The relationship between admissionsodium level and clinical outcomes was analyzed in 1,470 patients. Results: The mean admission sodium level was 138 ± 4.7 mmol/L, and 247 patients (16.8%) had hyponatremia defined as Na+ < 135 mmol/L. The 12-month mortality was higher in hyponatremic patients (27.9% vs. 14.6%, p < 0.001), and hyponatremia was an independent predictor of 12-month mortality (hazard ratio, 1.72; 95% confidence interval, 1.12 to 2.65). During hospital admission, 57% of hyponatremic patients showed improvement without improvement in their clinical outcomes (p = 0.620). The proportion of patients with optimal medical treatment was only 26.5% and 44.2% at admission and discharge, respectively, defined as thecombined use of angiotensin-converting-enzyme inhibitor/angiotensin receptor blocker and β-blocker. Underuse of optimal medical treatment was more pronounced in hyponatremic patients. Conclusions: In hospitalized Asian HF patients, hyponatremia at admission is common and is an independent predictor of poor clinical outcome. Furthermore, hyponatremic patients receive less optimal medical treatment than their counterparts.
Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.