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Wen-juan Shan,Wei Tang 한국펄프·종이공학회 2019 펄프.종이기술 Vol.51 No.2
In view of the characteristics of strong multivariable coupling in a cross-directional (CD) basis weight control system, a multivariable block-decoupling control strategy and a real-time decomposition algorithm are proposed in this paper. Based on a model of the CD basis weight profile, a system non-square interaction matrix with high dimensionality was analyzed by experimental studies and numerical computation. Along the diagonal of the interaction matrix, the matrix block method was adopted to reduce the system dimensions and convert it into a square system. The multivariable control system with high dimensionality is divided into several subsystems. According to the structure of each subsystem, a new constraint on the control variables was introduced to satisfy the triangular decomposition of the subsystem. Based on the multi-actuator parallel control strategy, the correlation between the subsystems was eliminated, and a high-dimensional multivariable decoupling control problem was transformed into a group single loop control general problem. The relative gain matrix of the new system was calculated to verify the decoupling effect in theory, and the real-time performance of the technique was demonstrated by results from an implementation on an actual project of a paper mill.
Wen-juan Shan,Bing Liu,Wei Tang 한국펄프.종이工學會 2022 펄프.종이기술 Vol.54 No.4
Due to the multi-variable, time-delay, and nonlinear characteristics of the pulp washing process, it is difficult to accurately measure and optimize the process. An asymmetrical nonlinear control system can be decomposed into a group of low-dimensional subsystems, which brings great convenience to the analysis and design of the system. In this paper, the concept of symmetry is used to simplify nonlinear optimal control problems, and datadriven theory is used to solve optimal policy problems. This paper proposes a data-driven operating model optimization method to model and optimizes the pulp washing process. The most important quality indicators of pulp washing performance are the alkali residue in washing pulp and the Baumé degree of the extracted black liquor. Considering the difficulty of modeling, online measurement of these indicators, two-step neural network, and multiple logistic regression were used to build a prediction model for soda water and Baumé degree. The mathematical model of the washing process can be identified, and the indicators meet the production requirements. With the goal of better product quality, low cost, and low energy consumption, based on the optimized operation mode database, the ant colony optimization (ACO) algorithm was used to solve the multi-objective problem. Theoretical analysis and practical application were carried out, and the optimal control system of the pulp washing process was designed. The actual results showed that the pulp output was increased by 20%, and the water consumption was reduced by nearly 30%. This method is effective during pulp washing.
Head-on Collision Between Two Envelope Solitary Waves in a Granular Medium
Wen-Qing Du,Jian-An Sun,Juan-Fang Han,Wen-Shan Duan,Yang-Yang Yang,Xin Jiang 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.75 No.11
We investigated the head-on collision between two envelope solitary waves. Head-on collisions between two envelope solitary waves are first discussed in one-dimension (1D) granular chains. The interesting result is that no phase shift or phase delay detected after the head-on collision between two envelope solitary waves. The maximum amplitude during the head-on collision between two envelope solitary waves is also found to be less than the sum of the amplitudes of the two envelope solitary waves, but is larger than the amplitude of the either of the envelope solitary waves.
Effect of Dilution Water on Pulp Consistency in Cross-directional Basis Weight Control
Wen-juan Shan,Wei Tang 한국펄프·종이공학회 2019 펄프.종이기술 Vol.51 No.2
Cross-directional basis weight of paper based on hydraulic headbox is adjusted by the opening of dilution water valve. In order to achieve uniform concentration distribution of paper sheet, a research on the effect of dilution water added to the mainstream on concentration and flow was studied by experimental set-up and mathematical modeling in this paper. Based on the numerical simulation results, a scale model of headbox was derived to predict the water content distribution and pulp consistency distribution. Results show that these models could accurately predict the experimental flow characteristics of a pulp suspension with dilution water added. Compared with slice regulation, the inverse response problem and its improvement method were discussed. By parameters improvement of pulp consistency model, the reverse response on both sides can be well eliminated or balanced when the dilution water was adopted to cross-directional profile control system. It ensures that the influence range of a single dilution water valve is controllable, which improves the adjustment accuracy of cross-directional profile control and thus improves the paper quality.
KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer
Juan Zhou,Wei-Rong Chen,Li-Chao Yang,Jun Wang,Jia-Yuan Sun,Wen-Wen Zhang,Zhen-Yu He,San-Gang Wu 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3
Purpose The study aimed to search and identify genes that were differentially expressed in breast cancer, and their roles in cancer growth and progression. Materials and Methods The Gene Expression Omnibus (Oncomine) and The Cancer Genome Atlas databases (https://cancergenome.nih.gov/) were screened for genes that were expressed differentially in breast cancer and were closely related to a poor prognosis. Gene expressions were verified by quantitative real-time polymerase chain reaction, and genes were knocked down by a lentivirus-based system. Cell growth and motility were evaluated and in vivo nude mice were used to confirm the in vitro roles of genes. Markers of epithelial-to-mesenchymal transition and the associations of KIF11 with the classical cancer signaling pathways were detected by Western blot. Results A series of genes expressed differentially in patients with breast cancer. The prognosis associated with high KIF11 expression was poor, and the expression of KIF11 increased significantly in high stage and malignant tumor cells. Inhibiting KIF11 expression in lentivirussuppressed cells revealed that KIF11 inhibition significantly reduced cell viability and colony formation, inhibited migration and invasion, but promoted apoptosis. The sizes and weights of KIF11-inhibited tumors in nude mice were significantly lower than in the negative controls. Western blot showed that E-cadherin in breast cancer was significantly upregulated in KIFinhibited cells and tumor tissues, whereas N-cadherin and vimentin were significantly downregulated. BT549 and MDA231 cells with KIF11 knockdown exhibited decreased ERK, AMPK, AKT, and CREB phosphorylation. Conclusion KIF11 acts as a potential oncogene that regulates the development and progression of breast cancer.
ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China
Wen, Yuan-Yuan,Pan, Xiong-Fei,Loh, Marie,Tian, Zhi,Yang, Shu-Juan,Lv, Si-Han,Huang, Wen-Zhi,Huang, He,Xie, Yao,Soong, Richie,Yang, Chun-Xia Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: We designed a multicenter 1:1 matched case-control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P<0.05). Conclusions: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findings may offer insight into further similar large gene-environment and gene-gene studies in this region.
Genomic Screening for Targets Regulated by Berberine in Breast Cancer Cells
Wen, Chun-Jie,Wu, Lan-Xiang,Fu, Li-Juan,Yu, Jing,Zhang, Yi-Wen,Zhang, Xue,Zhou, Hong-Hao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Berberine, a common isoquinoline alkaloid, has been shown to possess anti-cancer activities. However, the underlying molecular mechanisms are still not completely understood. In the current study, we investigated the effects of berberine on cell growth, colony formation, cell cycle distribution, and whether it improved the anticancer efficiency of cisplatin and doxorubicin in human breast cancer estrogen receptor positive (ER+) MCF-7 cells and estrogen receptor negative (ER-) MDA-MB-231 cells. Notably, berberine treatment significantly inhibited cell growth and colony formation in the two cell lines, berberine in combination with cisplatin exerting synergistic growth inhibitory effects. Accompanied by decreased growth, berberine induced G1 phase arrest in MCF-7 but not MDA-MB-231 cells. To provide a more detailed understanding of the mechanisms of action of berberine, we performed genome-wide expression profiling of berberine-treated cells using cDNA microarrays. This revealed that there were 3,397 and 2,706 genes regulated by berberine in MCF-7 and MDA-MB-231 cells, respectively. Fene oncology (GO) analysis identified that many of the target genes were involved in regulation of the cell cycle, cell migration, apoptosis, and drug responses. To confirm the microarray data, qPCR analysis was conducted for 10 selected genes based on previously reported associations with breast cancer and GO analysis. In conclusion, berberine exhibits inhibitory effects on breast cancer cells proliferation, which is likely mediated by alteration of gene expression profiles.