Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats

Weiyue Hu,Lingling Wang,Guizhen Du,Quanquan Guan,Tianyu Dong,Ling Song,Yankai Xia,Xinru Wang 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.5

Background: Obesity has become one of the most serious issues threatening the health of humankind, and we conducted this study to examine whether and how celastrol protects against obesity. Methods: We fed male Sprague-Dawley rats a high-fat diet and administered celastrol to obese rats for 3 weeks. By recording body weight (BW) and other measures, we identified the effective dose of celastrol for obesity treatment. Feces were collected to perform 16S rRNA sequencing, and hypothalami were extracted for transcriptome sequencing. We then treated leptin knockout rats with celastrol and explored the changes in energy metabolism. Male Institute of Cancer Research (ICR) mice were used to test the acute toxicity of celastrol. Results: We observed that celastrol reduced BW and promoted energy expenditure at a dose of 500 μg/kg BW but that food intake was not changed after administration. The diversity of the gut microbiota was improved, with an increased ratio of Bacteroidetes to Firmicutes, and the gut microbiota played an important role in the anti-obesity effects of celastrol. Hypothalamic transcriptome analysis showed a significant enrichment of the leptin signaling pathway, and we found that celastrol significantly enhanced energy expenditure, which was mediated by the leptin signaling pathway. Acute lethal toxicity of celastrol was not observed at doses ranging from 0 to 62.5 mg/kg BW. Conclusion: Our study revealed that celastrol decreased the BW of obese rats by enhancing energy expenditure but not by suppressing food intake and that this effect was mediated by the improvement of the gut microbiota and the activation of the hypothalamic leptin signaling pathway.

Assembly of the Superconducting Tokamak EAST

Weiyue Wu,Daming Gao,Jie Yu,Peide Weng,Songtao Wu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III

EAST is a new machine, Experimental Advanced Superconducting Tokamak, being built in CASIPP. Steady-state operation is a main mission for this machine and the superconducting magnets were all poloidal field and toroidal field systems, constituting an engineering mission to establish the technology basis of chosen to be full superconducting Tokamak to investigate a future fusion device. The parameters of EAST are: the main radius is 1.7 m and the minor radius is 0.4 m, with a maximum toroidal magnetic field of 3.5 Tesla at the plasma center. The plasma current is 1 MA, the pulse length is 1000 s, elongation is about 1.6 . 2.0, and triangularity is about 0.4 . 0.6. The EAST device has a large number of components to be assembled at the main building since June 18, 2003. These include: support structure, cryostat, thermal shields, vacuum vessel, toroidal field magnets, poloidal field magnets, current leads and joints, cooling tubes and insulators, first wall and other auxiliary systems. In this device the required assembly should maintain gaps and insulation blocks between toroidal field magnets, thermal shields and vacuum vessel. It was required to meet the tolerances for accurate positioning of the components in the radial, toroidal, poloidal and vertical directions, to ensure that the machine satisfied the requirements and to minimize subsequent corrective operations. This paper presents a brief description of the device in terms of design, fabrication, testing and assembly.

Are Longer and More Negative Online Reviews More Helpful? - The Mediating Role of Consumers' Perceived Usefulness of Reviews

Weiyu Zhang,Xinyue Li,Moon-Seop Kim 강원대학교 경영경제연구소 2023 Asia-Pacific Journal of Business Vol.14 No.1

Purpose - This study investigates how review length and sentiment impact consumers' purchase intentions, using real online reviews as the data source. The study aims to understand how the length and tone of a review affect a potential buyer's decision-making process when considering a purchase. Design/methodology/approach - A 2 (comment length: long vs. short) × 2 (comment sentiment: positive vs. negative) × 2 (product type: practical vs. hedonic) experiment was conducted. Findings - Results indicate that longer reviews have a greater impact on consumers' perceived usefulness compared to short reviews, but do not affect purchase intentions. Review sentiment is found to have a stronger impact than review length, especially for negative sentiment. The study also suggests that consumers pay more attention to reviews of practical products, and that reviews have less influence on hedonic products. Research implications or Originality - The implications of these findings are relevant for both merchants managing reviews and consumers reviewing products.The results of this research could help businesses and marketers optimize their online review strategies to maximize their impact on consumer behavior.

What are the Key Location Factors for McDonald's, KFC and Starbucks stores in China?

Weiyu Zhang,권종욱,Miao wang 한국무역경영학회 2022 한국무역경영연구 Vol.- No.26

Since Chinese retail industry foreign investment mainly distributed in urban areas, there were significant differences in number of shops in different cities. Previous researches on FDI mainly focused on national and regional level, which could not explain this phenomenon. So, it is imperative to conduct researches to determine which factors attracted more foreign investment in retail industry. Based on distributed data of Starbucks, KFC and McDonald shops in 296 cities in China mainland, this paper explores their location determining factors. Apart from traditional market size and economic agglomeration effect, the number of university students in each city is also a key driving factor. Although the number of university students is a negative variable in distribution of Starbucks shops, it is a positive variable in distribution of KFC shops. In addition, results of this research show that location of Starbucks and KFC are not affected by the open policy system, which is different from location of McDonald's. The implication for this paper is explained from two perspectives. Firstly, theoretically, this paper promotes the discussion on FDI location determinants from city level, and provides significant reference for establishing location model of foreign investment in China on macro-level. Secondly, from practical point of view, this paper offers some suggestions on attracting foreign investment for city managers, and provides a few advices on location for other retail brands and potential investors on the three brands.

Urban Determinants of Japanese Convenience Store Investment in Mainland China

Zhang, Weiyu,권종욱 부산대학교 중국연구소 2022 Journal of China Studies Vol.25 No.2

In recent years, research on convenience stores has gradually increased because the growth of the large-scale retail industry has slowed down, and many industry giants have refocused their attention on the neighborhood market. In the past ten years, the rapid expansion of chain convenience store brands in mainland China has shown huge regional differences in economic phenomena. Specifically, there are great differences in the number of chain convenience store stores in different cities. At the same time, we noticed that the survival rate of stores of local Chinese brands and convenience stores of Japanese brands is very different. Because previous research theories on the location determinants of FDI have focused too much on the national and regional levels, they have had to be limited in explaining why one city has more FDI than another. On the other hand, research on the determinants of retail location has focused too much on the streets within a city or within a city. There are some limitations in explaining the economic phenomena we mentioned earlier. Therefore, this study compiles the literature on the locational determinants of FDI and models retail store location, and identifies research gaps in these two areas. This paper attempts to analyze the location strategies of Japanese brand convenience stores for the convenience store industry investors' reference and, at the same time, tries to promote the fusion of the theory of location determinants of FDI theory and the modeling theory of retail location. Through the multiple regression analysis of the data of convenience stores in 162 cities with a population of more than one million in China, this study shows that with the development of the times, only by subdividing the geographical population can we better grasp the science of location selection. For example, the location of Japanese brand convenience stores should try to avoid the group of college students with the highest national sentiment. Theoretically, this study is helpful to promote FDI research at the city level and attract more scholars to pay attention to the city level. This study provides a macro perspective for convenience store location research and helps to establish a more scientific convenience store location model. In practice, the results of this study have certain reference significance for investors who want to join and invest in the convenience store industry and for traversing branding in China's local industry.

The Combined Tensile and Torsional Behavior of Irregular Fibers

He, Weiyu,Wang, Xungai The Korean Fiber Society 2002 Fibers and polymers Vol.3 No.1

Most fibers are irregular, and they are often subjected to combined loading conditions during processing and enduse. In this paper polyester and wool fibers under the combined tensile and torsional loads have been studied for the first time using the finite element method (FEM). The dimensional irregularities of these fibers are simulated with sine waves of different magnitude and frequency. The breaking load and breaking extension of the fibers at different twist or torsion levels are then calculated from the finite element model. The results indicate that twist and level of fiber irregularity have a major impact on the mechanical properties of the fiber and the effect of the frequency of irregularity is relatively small.

FLYING PEACE CHEERING VICTORY

Fan Weiyu 한국콘텐츠학회 2018 ICCC International Digital Design Invitation Exhib Vol.2018 No.5

상사무례가 직무열의 및 반생산적 과업행동에 미치는 영향

방유옥(Weiyu Fang),전재균(Jae-Kyoon Jun) 한국자료분석학회 2022 Journal of the Korean Data Analysis Society Vol.24 No.5

직장 내 무례는 국내외 기업 구성원 사이에서 이슈가 되고 있다. 한 조사에 따르면 직장 내 무례를 경험하지 못한 조직구성원을 찾아보기가 어려운 것이 현실이다. 이 가운데도 특히 상사에 의한 무례가 가장 높은 비중을 차지하고 있다. 본 연구는 중국 외식업체 종사원을 대상으로 상사무례가 직무열의 및 반생산적 과업행동에 미치는 영향을 분석하고자 한다. 반생산적 과업행동은 세 가지 유형인 고객에 대한 반생산적 과업행동, 조직에 대한 반생산적 과업행동, 조직구성원에 대한 반생산적 과업행동으로 구분하여 조사하였다. 조사 기간은 2022년 2월 1일부터 3월 28일까지 걸쳐서 진행하였다. 총 400부의 설문지를 배부하여 382부의 설문지가 회수되었으며, 이중 응답이 불성실한 21부를 제외한 361부를 최종 분석에 이용하였다. 분석 결과를 요약하면 다음과 같다. 첫째, 상사무례는 직무열의에 유의한 부(-)의 영향을 미치는 것으로 나타났다. 이는 상사로부터 무례를 경험할수록 부하직원의 직무에 대한 열정은 감소하게 됨을 의미한다. 둘째, 직무열의는 세 가지 유형의 반생산적 과업행동에 모두 유의한 부(-)의 영향을 미쳤다. 이는 직무열의가 약할수록 세 가지 유형의 반생산적 과업행동은 더욱 높아지는 것을 나타낸다. 이러한 분석 결과를 기초로 연구의 이론적, 실무적 시사점을 제시하여 외식업체 조직문화를 향상시키기 위한 방안을 제안하였다. Incivility in the workplace has become an issue among domestic and foreign corporate members. According to a survey, it is difficult to find members of an organization who have not experienced incivility in the workplace. Among them, in particular, incivility by the supervisor accounts for the highest proportion. This study aims to analyze the effect of commercial practices on job engagement and counterproductive work behavior for employees of Chinese restaurant companies. The counterproductive work behavior was investigated by dividing it into three types: counterproductive work behavior for customers(CWB-C), counterproductive work behavior for organizations(CWB-O), and counterproductive work behavior for organizational employees(CWB-I). The investigation period was conducted from February 1 to March 28, 2022. A total of 400 questionnaires were distributed, and 382 questionnaires were collected, of which 361 were used for the final analysis, excluding 21 were dishonest. The summary of the analysis results are as follows. First, it was found that supervisor’s incivility had a significant negative (-) effect on job engagement. This means that as you experience incivility from your supervisor, your subordinates' enthusiasm for the job decreases. Second, job engagement had a significant negative (-) effect on all three types of counterproductive work behavior. This indicates that the weaker the job engagement, the higher the three types of counterproductive work behavior. Based on these analysis results, a plan to improve the organizational culture of restaurants was proposed by presenting theoretical and practical implications of the study.

High expression of ring finger protein 115 contributes to the progression of colorectal cancer via WNT/β-catenin pathway

Wu Weiyu,Zhang Xuelian,He Feng,Wu Longxiang 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.3

Background Colorectal cancer (CRC) is one of the most common malignancies worldwide, with the second highest incidence among men and the third incidence among women. Objective To uncover the expression of RNF115 in human colorectal cancer (CRC) tissues and cell lines, investigate its effects on CRC progression, and further explore the mechanisms. Results TCGA database showed the high transcript per million (TPM) in human CRC tissues and its relationship with poor prognosis. RNF115 was highly expressed in CRC tissues and cell lines. RNF115 contributed to the growth of CRC cells via mediating cell cycle and colony formation. RNF115 knockdown also stimulated the apoptosis of CRC cells by increasing Bax and cleaved caspase-3 expression levels. Mechanistically, RNF115 affected the proliferation and apoptosis via targeting WNT/β-catenin pathway in CRC cells. Conclusion RNF115 was highly expressed in human CRC tissues and cell lines and correlated with poor prognosis. RNF115 contributed to the growth of CRC cells via mediating cell cycle and colony formation, and also induced the apoptosis of CRC cells via targeting WNT/β-catenin pathway. RNF115 could serve as a target for CRC treatment.

체육계열 대학생의 전공 선택 동기가 전공 만족도 및 취업준비행동에 미치는 영향

왕유월(Wang, Weiyue) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.17

목적 본 연구는 체육계열 대학생을 대상으로 전공선택동기가 전공만족도 및 취업준비행동에 미치는 영향을 파악하여 취업준비행동 향상을 위한 실증적 기초자료를 제공하기 위해 시행되었다. 방법 이를 위하여 경기도 용인 소재의 Y대학에 재학 중인 체육계열 대학생에게 설문지에 자기평가기입법으로 응답하여 최종 133부의 설문지를 분석처리 하였다. 자료처리는 Windows Program SPSS Statistics Version 22.0으로 p<.05로 설정하여 빈도 분석, t-test, 상관관계분석과 다중회귀분석을 실시하였다. 결과 체대생의 성별에 따른 전공선택동기의 차이 검증 결과, 외재적 동기(p=.016)에서 유의한 차이가 나타났으며, 전공만족도의 차이 검증 결과, 유의한 차이가 나타나지 않았으며, 취업준비행동의 차이 검증 결과, 비공식적 준비(p=.037)에서 유의한 차이가 나타났다. 전공선택동기가 전공만족도에 미치는 영향 분석 결과, 내재적 동기는 수업만족과 사회인식만족에 유의한 영향을 미치며, 외재적 동기는 수업만족, 관계만족, 사회인식만족에 유의한 영항을 미치는 것으로 나타났다. 전공선택동기가 취업준비행동에 미치는 영향을 검증한 결과, 외재적 동기요인이 비공식 준비행동과 적극적 준비행동에 유의한 영향을 미치며, 내재적 동기요인이 공식적 준비행동에 유의한 영향을 미치는 것으로 나타났다. 전공선택동기의 내재적 동기와 외재적 동기는 전공만족도와 취업준비행동에 정(+)적 영향을 미치고 있음을 검증하였다. 결론 전공만족도 향상을 통해 취업준비행동을 향상시키는 것은 만족스러운 대학생활 및 취업에 있어 매우 중요하다고 할 수 있다. Objectives This study was conducted to provide empirical basic data for improving the employment preparation behavior of physical education undergraduate students. Methods The subject of this study is a physical education undergraduate student enrolled in Y University. For the period from November 15 to December 20, 2019, the final 133 questionnaires that were answered by the self-evaluation method were analyzed with Windows Program SPSS Statistics Version 22.0. Results Differences in major selection motives according to gender were found in extrinsic motivation (p=.016), and differences in job preparation behavior were found in informal preparation (p=.037). Intrinsic motivation has a significant effect on class satisfaction and social cognition satisfaction, and extrinsic motivation has a significant effect on class satisfaction, relationship satisfaction, and social cognition satisfaction. Extrinsic motivational factors have a significant effect on informal preparation behaviors and active preparation behaviors, and intrinsic motivational factors have a significant effect on formal preparation behaviors. Conclusions Improving employment preparation behavior through improvement of major satisfaction is very important and can be done for satisfactory university life and employment.