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Ming‑Wei Wu,Jhewn‑Kuang Chen,Mo‑Kai Tsai,Pei Wang,Tien‑Lin Cheng,Bo‑Huan Lin,Po‑Hsing Chiang,Annadurai Dhinakar 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.1
The selective laser melted (SLM) Ti–6Al–4V cellular solid is a promising material in biomedical and other applications. The mechanical properties of the SLM Ti–6Al–4V cellular material are predominantly controlled by the design of the cellular structure. The objective of this study was to investigate the uniaxial compressive properties and compressive fatigueperformance of the SLM Ti–6Al–4V cellular solid with a new cuboctahedron unit cell reinforced by four diagonal strutsand two horizontal struts along the X and Y axes. The infuences of hot isostatic pressing (HIP) on the various mechanicalproperties were also examined. The results showed a smoother stress–strain curve and fewer stress oscillations in the HIPspecimen than in the SLM specimen. The HIP process slightly decreased the yield strength of the SLM sample from 55 to52 MPa. Under uniaxial compressive stress, the SLM and HIP specimens exhibited layer-by-layer fracture and diagonalshear fracture, respectively. Furthermore, the HIP treatment signifcantly increased the fatigue performance and improved thefatigue endurance ratio at 106cycles from 0.15 to 0.35. The HIP treatment contributed to several positive efects, includingphase transformation from brittle α′ to α + β, the elimination of strut porosity and residual stress, an increase in lath size,and a better combination of strength and ductility, thereby improving the fatigue performance. The efects of stress mode onthe fracture mechanism were also clarifed using in situ observation in combination with digital image correlation.
Kuo, Yuh-Chi,Wu, Chia-Lin,Tasi, Wei-Jern,Wang, Jir-Yenn,Chang, Shi-Chung,Lin, Ching-Yuang,Shiao, Ming-Shi 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang₃,Ching-Yung Lin⁴,and Ming-Shi Shiao⁴¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang²,Ching-Yung Lin³,and Ming-Shi Shiao⁴.¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan. Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps sinensis in the Bronchoalveolar Lavage Fluids Cells. Proceedings of international Symposium on East-West Medicine, Seoul. 44-64, 1999.-Cordyceps sinensis is a major parasitic fungus on larva of Lepidoptera. It is one of the well know fungi used in traditional Chinese medicine for treatment asthma, lung and kideney diseases. Many fungi belonging to the genus Cordyceps have been demonstrated to produce natural products with various biological activities. Reported biological activities of genus cordyceps include:(a)inhibition of DNA and RNA synthesis;(b)enhancement of cell differentiation;(c)restruction of cytoskeleton;(d)inhibition of protein kinase activity;(e)antitumor activity on bladder, colon, lung carcinoma as well as fibroblastoma;(f)inhibition of the infection and revers transciptase activity of human immunodeficiency virus type 1; and(g) inhibition of methylation of nucleic acid. Thus, it is suggested that the extracts of Cordyceps sp. Contain antitumor, antiviral, and many other biological activities. In our previous studies, we proved that C. sinensis contains the antitumor and immunomodulatory agents. In the present studies, effects of C. sinensis on bronchoalveolar lavage fluids(BAL)cells were demonstrated. The crude methanolic extracts of C. sinensis were fractionated into 15 fractions by silica gel column chromatography. Effects of various fraction on BAL cells proliferation and lipopolysaccharide(LPS) stimulated interleukin-1β(IL-8),platelet activating factor(PAF), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8) production on BAL cells were determined. The result indicated that the CS-19-22 fraction suppressed BAL cells proliferation activated by LPS. The median inhibitory concentration(IC50) was 6㎍/ml. The CS-19-22 fraction also decreased IL-1β,PAF,IL-6, TNF-αand IL-8 production.The results of revers transcription-polymerase chain reaction(RT-PCR) demonstrated that the CS-19-22 fraction did not affect IL-1β,PAF,IL-6, TNF-α,and IL-8 mRNAs expression in BAL cells activated by LPS. By contrast, it inhibited the IL-10 mRNA expression but enhanced IFN-γand IL-12 mRNAs expression in activated BAL cells. Moreover, the CS-19-22 fraction blocked PAF-induced platelet aggregation. It is unlikely that cytotoxicity was involved. Because no cell deths were observable. We hypothesize that inhibitory mechanisms of CS-19-22 on BAL cells proliferation may be related to the impairments of gene expression and production of cytokines in BAL cells. The explanation of C. sinensis antiasthma function may involved the following(1)C.sinenesis contained immunomodulatory agents that stimulated IFN-γand IL-12 expression in TH1cells.(2)Enhanced secretion of IFN-γand IL-12 will inhibit the Tγcells immune responses Ex. Decreasing of IL-6 and IL-10 production.(3) The impairments of cytokines production in TH2 cells suppressed th BAL cells proliferation then more cytokines production Ex.IL-1β,PAF,IL-6,TNF-αand IL-8 in activated BAL cells were decreased. (4)The suppression of TH2cells immune responses will inhibit the growth and differentiation of B cells then IgE production will be decreased. (5)Reduced production of IgE will decreased asthma attack occurring in individuals. However, the results of the present study suggested that C. sinensis may also have acted to treat asthma in part by inhibiting BAL cells proliferation and cytokine gene expression and production. Future, experiments with treatment of animals with asthma with C. sinensis will be necessary to defined whether C. sinensis can reduce asthma injury. Plans are underway for the isolation of pure principal growth inhibitors and their mechanisms of action are subjected for further study.
Wei Ji,Wei Zhao,Rong‑Chen Liu,Xiao‑Bo Jiao,Kai Han,Zhong‑Yi Yang,Mei‑Ying Gao,Rui Ren,Xiu‑Juan Fan,Ming‑Xia Yang 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.6
Flower color variegation has been observed in many plant species. However, pink flowers on the white-blooming hawthorn trees found by our group earlier have never been reported. To better understand the differentially expressed genes (DEGs) in variegated hawthorn flowers, white and pink flowers at different developmental stages (S1 and S2) underwent transcriptome sequencing separately. Approximately 34.28 Gb of high-quality data were obtained and assembled into 100,013 unigenes with an average length of 706.93 bp. These unigenes were further subjected to functional annotation and biochemical pathway analysis, and DEGs of two types of hawthorn flowers at different developmental stages were studied. Based on the enrichment analysis of DEGs, eight anthocyanin-modified enzyme genes or other enzyme genes that indirectly affect anthocyanin synthesis (5AT, 3GGT , and AI, β-Glu, two Aux/IAAs, two PODs), eight structural genes (UFGT, DFR, CHI, two F3Hs, and three PALs), and three transcription factors (one MYB and two bHLHs) were also identified. We randomly selected 15 genes, and the trends in the expression levels of these genes in the organs of white and pink flowers at different developmental stages were verified by quantitative real-time PCR. Mass sequence data obtained by RNA-seq of variegated hawthorn flowers provided basic sequence information and a unique opportunity to uncover the genetic mechanisms under-lying flower color variegation.
Ming Zhao,Ming Zhao,Bin Tong,Zinan Kang,Yanfang Wu,Wei Ding,Baoming Feng 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.5
The synthesis of PdP nanoparticles (NPs) using triphenylphosphine as a phosphorus precursor was investigated. The electrocatalytic performance of PdP NPs in hydrogen evolution reaction in an alkaline medium was measured. It can be concluded that when the current density is 10 mA cm -2, the overpotential produced by Pd3P0.95 NPs is 75mV which is 185mV lower than that produced by commercial Pd/C. The mass activity of Pd3P0.95 NPs is more than twice as high as that of commercial Pd/C. The work indicates that PdP nanomaterials could be a potential catalyst for water splitting.
Wei-Ming Chiang,Fu Jen Wang,Kusnandar 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.2
Following the machine tool with demands of high-speed, high-precision machining and multi-axis, the heat generation of machine tool will lead to thermo growth of spindle, thermal error, etc. Therefore, the machine tool oil cooler has been frequently adopted for thermal management of heat generation for machine tool. However, it will be quite challenging to develop high-precision machining without suitable temperature control scheme. And, the machine tool oil cooler with on-off control is difficult to control the oil temperature accurately. Therefore, in this paper, the machine tool oil cooler with hot-gas bypass temperature control scheme and inverter temperature control scheme based on the PID control logic have been proposed to solve the oil temperature control problem for machine tool oil cooler. Furthermore, the temperature control performance (i.e. thermo growth of spindle, oil temperature control accuracy, and EER) of hot-gas bypass temperature control scheme and inverter temperature control scheme has been compared by means of experiment. The experimental results shows that the inlet oil temperature control accuracy can be maintained ±0.2 °C during spindle operation by using the hot-gas bypass temperature control scheme (HGB cooler) and inverter temperature control scheme (INV cooler). Furthermore, the thermo growth of spindle of HGB cooler is about 14 % smaller than the INV cooler because of hot-gas bypass temperature control scheme with thermal compensation function. However, the total power consumption of HGB cooler is about 0.18 kW higher than the INV cooler. Hence, the energy efficiency ratio (EER) of INV cooler reveals about 10.9 % higher than the HGB cooler at steady state. Furthermore, when oil flow rate declined to about half, the temperature difference between initial and final steady state temperature of the spindle is increased around 94.3 %, and the thermo growth of spindle is increased 58.7 %.
WEAKLY POSITIVE IMPLICATIVE BCI-ALGEBRAS
Wei, Shi-Ming,Jun, Young-Bae Korean Mathematical Society 1995 대한수학회논문집 Vol.10 No.4
We introduce the concept of weakly positive implicative ideals in BCI-algebras and give some characterization of weakly positive implicative BCI-algebras and weakly positive implicative ideals.
Temperature control scheme using hot-gas bypass for a machine tool oil cooler
Wei-Ming Chiang,Win-Jet Luo,Fu Jen Wang 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.3
Accurate temperature control that addresses heat generation is crucial given the development of high-accuracy high-speed machining process. Heat generation leads to a thermal error of machine tools. Therefore, developing high-accuracy machining without appropriate temperature control scheme is challenging. Machine tool coolers for forced convection cooling can effectively control heat generation. However, temperature control accuracy cannot be achieved because the temperature control scheme for machine tool oil cooler encounters nonlinear and time-varying problems with time delay characteristic. This study presents a novel temperature control scheme, namely, Proportional–integral–derivative (PID) control logic based on Smith predictive method. MATLAB simulation software was utilized to determine the specifications of outlet temperature control using hot-gas bypass scheme of high-precision oil cooler with refrigerant R-32. Simulation results revealed that the proposed control scheme present better temperature control accuracy than the traditional PID control. The proposed control scheme can also effectively solve the abovementioned problems through on-site experimental results. The steadystate error of the oil outlet temperature of the high-precision-type machine tool oil cooler can be controlled within 0.1 °C by using the proposed control hot-gas bypass scheme.