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In Vitro Biological Characterization of DCUN1D5 in DNA Damage Response
Guo, Wei,Li, Guo-Jun,Xu, Hong-Bo,Xie, Jie-Shi,Shi, Tai-Ping,Zhang, Sheng-Zhong,Chen, Xiao-Hong,Huang, Zhi-Gang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Background: Novel prognostic biomarkers or therapeutic molecular targets for laryngeal squamous cell carcinoma (LSCC) are an urgent priority. We here sought to identify multiple novel LSCC-associated genes. Methods: Using high-density microarray expression profiling, we identified multiple genes that were significantly altered between human LSCCs and paired normal tissues. Potential oncogenic functions of one such gene, DCUN1D5, were further characterized in vitro. Results: Our results demonstrated that DCUN1D5 was highly expressed in LSCCs. Overexpression of DCUN1D5 in vitro resulted in 2.7-fold increased cellular migration, 67.5% increased invasive capacity, and 2.6-fold increased proliferation. Endogenous DCUN1D5 expression was decreased in a time-dependent manner after genotoxic stress, and silencing of DCUN1D5 by siRNA decreased the number of cells in the S phase by 10.2% and increased apoptosis by 11.7%. Conclusion: Our data suggest that DCUN1D5 in vitro might have vital roles in DNA damage response, but further studies are warranted to assess its significance in vivo.
A new approach for the simulation of cementitious materials
Wei Guo Yang,Hong Jun Xiang,김정한,박귀태 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.1
Cementitious materials can be considered as consisting of particulate elements on the levels of the microstructure and mesostructure. The mechanical properties of cementitious granular materials were studied by a numerical approach. First, an ellipsoid-based method was developed to generate single aggregate particles of arbitrary shape. The HADES toolbox was then used to form a material structure from aggregate (HADES is a concurrent, algorithm-based program that is designed to simulate the mixing or flow of granular material of arbitrary shape). Afterwards, an interfacial transition zone (ITZ) between the aggregate particles and the cement paste was enriched and a special tool, Gmsh, was used for forming a mesh of aggregate, cement paste, and ITZ. Finally, the mesh data was transferred into the finite element code FEAP to predict the mechanical properties of the material. Based on these processes, a simulation of concrete was used as an example of a typical cementitious granular material. Additionally, a parameter study was conducted to highlight the influence of aggregate on the mechanical properties. The simulation shows that the method is feasible and effectively predicts the elastic modulus of three-phase cementitious granular materials (cement paste, ITZ and aggregate).
Guo-Wei Fan,Xue-Ying Lv,Ying Song,Huan-Yu Zhao,Liu Zhang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
Nonparallel ground track imaging of optical remote sensing satellite is an efficient imaging mode which could realize one-time transit imaging of complex observation tasks due to its fast and flexible imaging capability, and has attracted more attentions in the earth observation field recently. In this paper, an off-line attitude trajectory planning and on-line moving horizon attitude tracking control scheme based on optimal control idea is designed to satisfy the imaging requirement of high-performance attitude control oriented to nonparallel ground track imaging. Considering the entire satellite attitude adjustment of the drift angle, based on the geometric relationship of sapce vectors and the coordinate transformation principle, the three-axis attitude calculation of the precise pointing of key feature targets in the interested ground curve strip is conducted. Taking the attitude orientation as the constraint, the pseudospectral method is used following the established agile satellite control model to design the optimal trajectory of the attitude manever and the feedforward control torque of actuator for nonparallel ground track imaging. A moving horizon tracking control law based on the nonlinear error control model is designed to realize the highprecision attitude tracking control. The feasibility and effectiveness of the proposed control scheme are illustrated by numerical and imaging simulations.
Wei Yao,Yu Guo,Yi-Fei Wu,Jian Guo 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.2
This paper investigates the tracking control for multi-link flexible joint manipulator system with disturbance, uncertain stiffness and input saturation. A robust adaptive dynamic surface control scheme is developed with an auxiliary dynamic system. The auxiliary dynamic system is employed to handle input saturation. To compensate for disturbance, an adaptive law for disturbance upper bound estimation is designed. The value of uncertain stiffness is updated by another adaptive law. It is proved that the proposed control scheme can realize precise tracking of link angles and guarantee the uniform ultimate boundedness of all the signals in the closed-loop by appropriately choosing the parameters to be designed. Finally, simulation results demonstrate the effectiveness of the proposed control method.
Percutaneous Osteoplasty for the Management of a Femoral Head Metastasis: a Case Report
Wei-Guo Wang,Chun-Gen Wu,Yi-Feng Gu,Ming-Hua Li 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.6
Percutaneous osteoplasty (POP) as a technical extension of percutaneous vertebroplasty (PVP) has been used to treat malignant disease that affects the skeletal system. POP has demonstrated good outcome for pain relief and functional improvement. Few studies have reported on the efficiency of POP to treat malignancies located in the femoral head. We designed a pilot study with the use of POP to treat intractable pain caused by a femoral head metastatic tumor in a 43-year-old man. During the follow-up period, the patient experienced sustained pain relief and improvement of quality of life that persisted for more than three months.
Wei Wei,Tao Xu,Xiaoxue Wang,Chengshan Wang,Lingxu Guo,Jun Lin,Tianchu Li 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.2
The increasing penetration of distributed energy resources on the distribution networks have brought a number of technical impacts where voltage and thermal variations have been identified as the dominant effects. Active network management in distribution networks aims to integrate distributed energy resources with flexible network management so that distributed energy resources are organized to make better use of existing capacity and infrastructure. This paper propose active solutions which aims to solve the voltage and thermal issues in a distributed manner utilizing a collaborative approach. The proposed algorithms have been fully tested on a distribution network with distributed generation units.
The K+/H+ antiporter AhNHX1 improved tobacco tolerance to NaCl stress by enhancing K+ retention
Wei-Wei Zhang,Jing-Jing Meng,Jin-Yi Xing,Sha Yang,Feng Guo,Xin-Guo Li,Shu-Bo Wan 한국식물학회 2017 Journal of Plant Biology Vol.60 No.3
High salinity is the one of important factors limiting plant growth and crop production. Many NHX-type antiporters have been reported to catalyze K+/H+ exchange to mediate salt stress. This study shows that an NHX gene from Arachis hypogaea L. has an important role in K+ uptake and transport, which affects K+ accumulation and plant salt tolerance. When overexpressing AhNHX1, the growth of tobacco seedlings is improved with longer roots and a higher fresh weight than the wild type (WT) under NaCl treatment. Meanwhile, when exposed to NaCl stress, the transgenic seedlings had higher K+/H+ antiporter activity and their roots got more K+ uptake. NaCl stress could induce higher K+ accumulation in the roots, stems, and leaves of transgenic tobacco seedlings but not Na+ accumulation, thus, leading to a higher K+/Na+ ratio in the transgenic seedlings. Additionally, the AKT1, HAK1, SKOR, and KEA genes, which are involved in K+ uptake or transport, were induced by NaCl stress and kept higher expression levels in transgenic seedlings than in WT seedlings. The H+-ATPase and H+-PPase activities were also higher in transgenic seedlings than in the WT seedlings under NaCl stress. Simultaneously, overexpression of AhNHX1 increased the relative distribution of K+ in the aerial parts of the seedlings under NaCl stress. These results showed that AhNHX1 catalyzed the K+/H+ antiporter and enhanced tobacco tolerance to salt stress by increasing K+ uptake and transport.
Wei-Guo Pan,Jie-nan Hong,Rui-Tang Guo,Wen-long Zhen,Hong-lei Ding,Qiang Jin,Cheng-gang Ding,Shi-yi Guo 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
MnOx–CuOx/TiO2 and MnOx–CuOx/Al2O3 catalysts were prepared by sol–gel method and used for low temperature selective catalytic reduction of NO with NH3. The results showed that MnOx–CuOx/TiO2 had better catalytic activity and SO2 resistance than MnOx–CuOx/Al2O3 in the temperature range of 100–250 ℃. The properties of the catalysts were characterized by using XRD, N2 adsorption, temperature programmed reduction (H2-TPR) and temperature programmed desorption (NH3-TPD). It was found that the support has a great impact on the acidity of catalyst; TiO2 and Al2O3 can promote the formation of Lewis acid sites and Bro¨ nsted acid sites respectively.
Mechanical behavior of rock-coal-rock specimens with different coal thicknesses
Guo, Wei-Yao,Tan, Yun-Liang,Yu, Feng-Hai,Zhao, Tong-Bin,Hu, Shan-Chao,Huang, Dong-Mei,Qin, Zhe Techno-Press 2018 Geomechanics & engineering Vol.15 No.4
To explore the influence of coal thickness on the mechanical behavior and the failure characteristics of rock-coal-rock (RCR) mass, the experimental investigation of uniaxial compressive tests was conducted first and then a systematic numerical simulation by particle flow code (PFC2D) was performed to deeply analyze the failure mechanical behavior of RCR specimens with different coal thicknesses in conventional compression tests. The overall elastic modulus and peak stress of RCR specimens lie between the rock and the coal. Inter-particle properties were calibrated to match the physical sample strength and the stiffness response. Numerical simulation results show that the deformation and strength behaviors of RCR specimens depend not only on the coal thickness, but also on the confining pressure. Under low confining pressures, the overall failure mechanism of RCR specimen is the serious damage of coal section when the coal thickness is smaller than 30 mm, but it is shear failure of coal section when the coal thickness is larger than 30 mm. Whereas under high confining pressures, obvious shear bands exist in both the coal section and the rock section when the coal thickness is larger than 30 mm, but when the coal thickness is smaller than 30mm, the failure mechanism is serious damage of coal section and shear failure of rock section.