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Influence of Corrosion on Anchoring Bond Behavior of Jointed Rock Mass
Wantao Ding,Zhongrong Wang,Xinghang Huang,Lei Chen,Yingjie Zheng 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
In order to investigate the effect of corrosion on bond behavior of anchored jointed rock masses, based on the migration law of pitting corrosion obtained by laboratory tests and the concept of strength reduction, the anchoring pull-out test of jointed rock mass was simulated by using Discrete Element Method (DEM). The results show that for uncorroded rock specimens, due to the existence of joints, there are significant differences for granular displacement and bond failure on both sides of the rock bolt during pull-out process, and phenomenon of eccentric tension also appears; for corroded rock specimens, the reduction rate of bond strength and slip ratio of single and double joint specimens decrease linearly with the increase of pitting corrosion rate. The decreasing rate gets fast with the increase of joints, but it is not a multiple relationship. Compared with the test with uncorroded specimens, when the pitting corrosion rate is 15%, the maximum pull-out load of the single-joint specimen with joint angel of 45° is reduced by 17.8%, and the slip value is reduced by 14.6%; the maximum pull-out load of the double-joint specimen is reduced by 31.9%, and the slip value is reduced by 24.9%. The numerical test results are in good agreement with the laboratory test results. The research results can provide reference for the selection and optimization of the design parameters of anchoring support structure of jointed rock mass under the erosion environment in the future.
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An External Parameter Optimize Method for 3D Optical Measurement System
Heyao Ma,Wantao He,Xianglin Meng,Dan Li 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.5
A simple and effective external parameter calibration and optimize method based on epipolar geometry for improving the accuracy and stabilization of 3D optical measurement system are present. First, the internal parameters of two cameras are calibrated using the planar calibration method. Then using the parameters as initial value calibrates the external parameter of the 3D optical measurement system in every view. Optimization result is computed through minimizing epipolar line error of the same pair of points in every view. Experimental results show that the measurement precision is high and stable in the measurement volume.
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Experiment Study on Efficient Flank Milling of Ti6AL4V Thin-walled Components
Yanyan Guo,Huayan Zhong,Wantao He,Guangfu Tao 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.7
Flank milling is a method of line contact machining and also is an important method in machining aerospace structures components, turbine blades and so on. In this paper, flank milling of Ti6AL4V is conducted with carbide tools on CNC machining center. First, acquired cutting force signals are analyzed in time domain and frequency domain based on Matlab software to obtain the distribution of cutting force energy. Second, the flank milling force experimental formulas are established by means of regression analysis. Finally, the influence of cutting parameters such as feed per tooth, the axial depth of cut, cutting width and cutting speed on cutting force is studied. The curves between cutting parameters and cutting force are obtained by analyzing the flank milling experiment. This research has certain guiding significance in selecting cutting parameters for flank machining Ti6AL4V.
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mRNA nanodelivery systems: Targeting strategies and administration routes
Mujie Yuan,Zeyu Han,Yan Liang,Yong Sun,Bin He,Wantao Chen,Fan Li 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention and treatment of various refractory diseases. To function efficiently in vivo and overcome clinical limitations, mRNA demands safe and stable vectors and a reasonable administration route, bypassing multiple biological barriers and achieving organ-specific targeted delivery of mRNA. Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ. In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized. The importance of passive targeting, especially endogenous targeting, and active targeting in mRNA nano-delivery is emphasized, and different cellular endocytic mechanisms are discussed. Most importantly, based on the above content and the physiological structure characteristics of various organs in vivo, the design strategies of mRNA NPs targeting different organs and cells are classified and discussed. Furthermore, the influence of administration routes on targeting design is highlighted. Finally, an outlook on the remaining challenges and future development toward mRNA targeted therapies and precision medicine is provided.
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