Juvenile Patient with LEOPARD Syndrome: Clinical Profile of a Genetically Confirmed Case

Pengjie Wan,Ying Cheng,Zhuo Chen,Ji Chen 대한피부과학회 2023 Annals of Dermatology Vol.35 No.2

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Study on an Improved Quantum PSO Algorithm for Solving Complex Optimization Problem

Mengxing Li,Zhuo Wan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.8

Particle swarm optimization (PSO) algorithm is a population-based search algorithm by simulating the social behavior of birds within a flock. It is a simple and efficient optimization algorithm. But it exists the low computational speed and easy falling into local optimal solution in solving the complex problem. So the quantum theory, adaptive inertia weight, disturbance factor and diversity mutation strategy are introduced into the PSO algorithm in order to propose an improved PSO(IWDMDQPSO) algorithm in this paper. In the IWDMDQPSO algorithm, the quantum theory is used to change the updating mode of the particles for guaranteeing the simplification and effectiveness of the algorithm. The adaptive inertia weight is used to improve the premature convergence of the algorithm. The disturbance factor is used to avoid the premature of the algorithm. The diversity mutation strategy is used to improve the global searching ability and computation speed. Finally, the famous benchmark functions are selected to prove the performance and effectiveness of the proposed IWDMDQPSO algorithm. The experiment results show that the proposed IWDMDQPSO algorithm takes on better solving accuracy and higher computation speed in solving the complex function. So it has a remarkable optimization performance.

Strain-rate effects on interaction between Mode I matrix crack and inclined elliptic inclusion under dynamic loadings

Ying Li,Wan-Chao Qiu,Zhuo-Cheng Ou,Zhuo-Ping Duan,Feng-Lei Huang 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6

The strain rate effects on the interaction between a Mode I matrix crack and an inclined elliptic matrix-inclusion interface under dynamic tensile loadings were investigated numerically, and the results are in agreement with previous experimental data. It is found, for a given material system, that there are the first and the second critical strain rates, by which three kinds of the subsequent crack growth patterns can be classified in turn with the increasing strain rate, namely, the crack deflection, the double crack mode and the perpendicular crack penetration. Moreover, such a crack deflection/penetration behavior is found to be dependent on the relative interfacial strength, the inclined angle and the inclusion size. In addition, it is shown that the so-called strain rate effect on the dynamic strength of granule composites can be induced directly from the structural dynamic response of materials, not be entirely an intrinsic material property.

Research on an Improved ACO Algorithm Based on Multi-Strategy for Solving TSP

Mengxing Li,Zhuo Wan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.9

Ant colony optimization (ACO) algorithm is a metaheuristic inspired by the behavior of real ants in their search for the shortest path to food sources. The ACO algorithm takes on these characteristics of robust, positive feedback distributed computing, easy fusing with other algorithms. But the basic ACO algorithm has some deficiencies of premature and stagnation phenomenon in the evolution process, and is easily trapped into local optimal solution. And it is difficult to explore other solutions in the neighbor space. So a improved ACO(DPSEMACO) algorithm based on dual population strategy, bi-directional dynamic adjust evaporation factor strategy of the pheromone and parallel strategy is proposed to solve the traveling salesman problem(TSP). In the DPSEMACO algorithm, the ants are divided into the two subpopulations by borrowing the mutual cooperation mechanism of biological community, which evolve separately and exchange information timely. The bi-directional dynamic adjusting evaporation factor strategy of the pheromone is used to change the corresponding path pheromone of different subpopulations in order to avoid to trap into a local optimum. The parallel strategy can avoid falling into a local optimum. And the DPSEMACO algorithm can expand the search space and improve the overall searching performance by repeated changing the pheromone of the each subpopulation and adaptive adjusting evaporation factor. Finally, in order to prove the optimization performance of the proposed DPSEMACO algorithm, some classic TSP instances are selected from the TSPLIB in this paper. And some existing methods are selected to compare the optimization performance with the proposed DPSEMACO algorithm. The experimental results demonstrate that the proposed DPSEMACO algorithm is feasible and effective in solving TSP, and takes on a good global searching ability and high convergence speed.

Strain-rate effects on interaction between Mode I matrix crack and inclined elliptic inclusion under dynamic loadings

Li, Ying,Qiu, Wan-Chao,Ou, Zhuo-Cheng,Duan, Zhuo-Ping,Huang, Feng-Lei Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6

The strain rate effects on the interaction between a Mode I matrix crack and an inclined elliptic matrix-inclusion interface under dynamic tensile loadings were investigated numerically, and the results are in agreement with previous experimental data. It is found, for a given material system, that there are the first and the second critical strain rates, by which three kinds of the subsequent crack growth patterns can be classified in turn with the increasing strain rate, namely, the crack deflection, the double crack mode and the perpendicular crack penetration. Moreover, such a crack deflection/penetration behavior is found to be dependent on the relative interfacial strength, the inclined angle and the inclusion size. In addition, it is shown that the so-called strain rate effect on the dynamic strength of granule composites can be induced directly from the structural dynamic response of materials, not be entirely an intrinsic material property.

Clone and Identification of Bifunctional Δ12/Δ15 Fatty Acid Desaturase LKFAD15 from Lipomyces kononenkoae

Zhang Yan,Liang Zhuo,Jiang Mulan,Wan Xia,Gon Yangmin,Zhang Yinbo,Huang Fenghong 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.2

In modern diet of human being, the ω-6/ω-3ratio of dietary fatty acid was shifted much towards ω-6series. In this work, a fatty acid desaturase (FAD) gene lkfad15 was cloned and identified from oleaginous yeast Lipomyces kononenkoae. Function analysis results shown that LKFAD15 is a novel Δ12/Δ15 bifunctional FAD which could not only produce linoleic acid and α-linolenic acid use just oleic acid as substrate but also adjust the ω-6/ω-3 fatty acids ratio to the WHO recommended ratio. Phylogenetic analysis of LKFAD15 suggested it is a specific intermediate product of gene evolution derives from independent gene duplication events.

Prognostic Values of Various Clinical Factors and Genetic Subtypes for Diffuse Large B-cell lymphoma Patients: A Retrospective Analysis of 227 Cases

Zhou, De,Xie, Wan-Zhuo,Hu, Ke-Yue,Huang, Wei-Jia,Wei, Guo-Qing,He, Jing-Song,Shi, Ji-Min,Luo, Yi,Li, Li,Zhu, Jing-Jing,Zhang, Jie,Lin, Mao-Fang,Ye, Xiu-Jin,Cai, Zhen,Huang, He Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Aim: To analyze the significance of different clinical factors for prognostic prediction in diffuse large B-cell lymphoma (DLBCL) patients. Methods: Two hundred and twenty-seven DLBCL patients were retrospectively reviewed. Patients were managed with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen or rituximab plus the CHOP (RCHOP) regimen. Results: Lactate dehydrogenase (LDH), ${\beta}2$-microglobulin (${\beta}2$-M), B symptoms, Ann Arbor stage and genetic subtypes were statistically relevant in predicting the prognosis of the overall survival (OS). In the CHOP group, the OS in patients with germinal center B-cell-like (GCB)(76.2%) was significantly higher than that of the non-GCB group (51.9%, P=0.032). With RCHOP management, there was no statistical difference in OS between the GCB (88.4%) and non-GCB groups (81.9%, P=0.288). Conclusion: Elevated LDH and ${\beta}2$-M levels, positive B symptoms, Ann Arbor stage III/IV, and primary nodal lymphoma indicate an unfavorable prognosis of DLBCL patients. Patients with GCB-like DLBCL have a better prognosis than those with non-GCB when treated with the CHOP regimen. The RCHOP treatment with the addition of rituximab can improve the prognosis of patients with DLBCL.

Molecular Characteristics and Resistant Mechanisms of Imipenem-Resistant Acinetobacter baumannii Isolates in Shenyang, China

Jing Ping Zhang,Wan Zhu,Su Fei Tian,Yun Zhuo Chu,Bai Yi Chen 한국미생물학회 2010 The journal of microbiology Vol.48 No.5

The investigation was carried out to elucidate the molecular characteristics and resistant mechanisms of imipenem-resistant Acinetobacter baumannii. Thirty-seven isolates were collected from January 2007 to December 2007. The homology of the isolates was analyzed by both pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). The genes of β-lactamases, adeB, and class 1 integron were polymerase chain reaction amplified. Genotype analysis of the 37 A. baumannii isolates by PFGE revealed the circulation of four PFGE types (A-D) ; the A- and B-type accounted for 48.6% and 40.5%, respectively. MLST showed the existence of three allelic profiles. The agar dilution method was carried out to determine the MIC of imipenem, in the absence or presence of carbonyl cyanide m-chlorophenylhydrazone (CCCP, 10 μg/ml). The MICs of the strains to imipenem were between 16 μg/ml and 128 μg/ml. When CCCP was added, a MIC decrease of at least four-fold was observed in 20 isolates, which belonged to the A- or C-type. AdeB and blaPER-1 genes were each detected in 35 isolates, blaOXA-23 gene in 34 isolates and blaOXA-58-like gene in 24 isolates. All isolates harbored blaOXA-51-like genes. No isolates carried the blaIMP-1 gene. Integron was detected in 25 isolates, which mediated the resistance to aminoglycosides and rifampin. The epidemiologic data suggested that the increasing infection of A. baumannii in our hospital was mainly caused by the inter-hospital spread of two epidemic clones. The AdeABC efflux system may be the important factor that leads to the high level of imipenem-resistance in PFGE A-type.

Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats

Xing Li,Xiaoping Wan,Zhaoxia Wang,Yanan Liang,Zhuo Jia,Xu Zhang,Limin Liao 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.2

Purpose: The present study determined the effects of saphenous nerve stimulation (SNS) at different stimulation frequencies on bladder reflex and explored a possible action mechanism of tibial nerve stimulation (TNS) on bladder activity in cats. Methods: Two bipolar nerve cuff electrodes were implanted on the saphenous nerve and the contralateral tibial nerve in 13 cats, respectively. Multiple cystometrograms were obtained to determine the effects of single SNS at different frequencies and that of combined SNS and TNS on the micturition reflex by infusing normal saline. Results: SNS at 1 Hz significantly reduced the bladder capacity (BC) to 59.8%±7.7% and 59.3%±5.8% of the control level at the intensity threshold (T) and 2T, respectively (P<0.05), while that at 20 Hz significantly increased the BC to 130.6%±4.2% of the control level at 6T (P<0.05). The TNS and SNS at 20 Hz did not significantly change the BCs at 1T (P>0.05), while combined stimulation at 1T significantly increased the BC to 122.7%±1.9% of the control level and induced an inhibitory effect which was similar to that TNS at 2T. Conclusions: The current study revealed that SNS reduced and increased BC depending on different stimulation frequencies. The combined SNS and TNS maximized the clinical efficacy at a low intensity. Also, SNS may be a potential therapeutic mechanism of TNS.

Identification and Heterologous Expression of a Δ4-Fatty Acid Desaturase Gene from Isochrysis sphaerica

( Bing Guo ),( Mu Lan Jiang ),( Xia Wan ),( Yang Min Gong ),( Zhuo Liang ),( Chuan Jiong Hu ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.10

The marine microalga Isochrysis sphaerica is rich in the very-long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (EPA, C20:5ω-3) and docosahexaenoic acid (DHA, C22:6ω-3) that are important to human health. Here, we report a functional characterization of a Δ4-fatty acid desaturase gene (FAD4) from I. sphaerica. IsFAD4 contains a 1,284 bp open reading frame encoding a 427 amino acid polypeptide. The deduced amino sequence comprises three conserved histidine motifs and a cytochrome b5 domain at its N-terminus. Phylogenetic analysis indicated that IsFad4 formed a unique Isochrysis clade distinct from the counterparts of other eukaryotes. Heterologous expression of IsFAD4 in Pichia pastoris showed that IsFad4 was able to desaturate docosapentaenoic acid (DPA) to form DHA, and the rate of converting DPA to DHA was 79.8%. These results throw light on the potential industrial production of specific polyunsaturated fatty acids through IsFAD4 transgenic yeast or oil crops.