Time-varying multi-objective region iterative learning motion control

Wan Xu,Tingwei Chen,Di Xiao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.1

In the multi-axis motion control field, the point-to-point multi-objective learning algorithm, taking target point tracking accuracy as the major control objective, limits the optimization of other control objectives such as motion distance and energy consumption of the system. Therefore, this paper initially proposes multi-objective region iterative learning control algorithm, extending point-to-point tracking to region-to-region tracking and further optimizing other performance indexes via flexibly setting the region size on the grounds of the tracking requirements. In view that the fixed weight coefficient of each object in the multi-objective iterative learning algorithm is not suitable for occasions with dynamic control requirements, this paper further presents time-varying multi-objective region iterative learning control algorithm and unifies point-to-point tracking and region-to-region tracking under one algorithm framework. In addition, by means of designing time-varying weight matrix, strengthening major control objectives, weakening minor control objectives and satisfying the ever-changing control requirements, experimental results show that time-varying multi-objective region iterative learning algorithm is capable of flexibly adjusting the weight size of each objective in line with various control needs so that the control system is endowed with higher tracking accuracy in trajectory tracking segment as well as lower energy consumption and shorter motion distance in region tracking segment, thus having good flexibility.

Pancreatic Cancer Incidence and Mortality Patterns in China, 2009

Chen, Wan-Qing,Liang, Di,Zhang, Si-Wei,Zheng, Rou-Shou,He, Yu-Tong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Objective: To estimate the incidence and mortality rates for pancreatic cancer in China. Methods: After checking and reviewing the cancer registry data in 2009 from 72 cancer registry centers, we divided cancer registry areas into urban and rural areas. Incidence/mortality rates, age-specific incidence/mortality rates, age-standardized incidence/mortality rates, proportions, and cumulative incidence/mortality rates for pancreatic cancer were calculated. Results: The total number of newly diagnosed pancreatic cancer cases and deaths in 2009 were 6,220 and 5,650, respectively. The crude incidence rate in all cancer registry areas was 7.28/100,000 (males 8.24, females 6.29). The age-standardized incidence rate by Chinese standard population (ASR) was 3.35/100,000, with ranking at 7th among all cancers. Pancreatic cancer incidence rate was 8.19/100,000 in urban areas whereas it was 5.41/100 000 in rural areas. Cancer mortality rate in all cancer registry areas was 6.61/100,000 (males 7.45; females 5.75), with ranking at 6th among all cancers, and 7.42/100 000 in urban but 4.94/100000 in rural areas. Conclusions: Pancreatic cancer incidence and mortality rates have shown a gradual increase in China. Owing to the difficulty of early diagnosis, identification of high-risk population and modification of risk factors are important to reduce the burden of pancreatic cancer.

Long-Term Outcomes of Stenting on Non-Acute Phase Extracranial Supra-Aortic Dissections

Jiang, Yeqing,Di, Ruoyu,Lu, Gang,Huang, Lei,Wan, Hailin,Ge, Liang,Zhang, Xiaolong The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.3

Objective : Extracranial supra-aortic dissections (ESADs) with severe stenosis, occlusion and/or pseudoaneurysm presents potential risk of stroke. Endovascular stenting to reconstruct non acute phase ESADs (NAP-ESADs) is an alternative to anticoagulant or antiplatelet therapy. However, its feasibility, safety and efficacy of stenting in NAP-ESADs is unclear. This study aims to investigate the long-term outcomes of the feasibility, safety and efficacy of stenting in NAP-ESADs. Methods : Seventy-four patients with 91 NAP-ESAD vessels with severe stenosis, occlusion and/or pseudoaneurysm presents potential risk of stroke who underwent stent remodeling were enrolled into this respective study from December 2008 to March 2020. Technical success rate, complications, clinical and angiographic results were harvested and analyzed. Results : Success rate of stent deployment was 99% (90/91) with no procedural mortality or morbidity. Transient ischemic attack occurred in three patients during operation (4.1%, 3/74). Asymptomatic embolisms of distal intracranial vessels were found in two patients (2.7%, 2/74). One hundred and forty-two stents deployed at 85 carotid (135 stents) and six vertebral (seven stents) vessels. Six stent types (Wingspan, 28/135, 20.7%; Solitaire, 10/135, 7.4%; Neuroform, 8/135, 5.9%; LVIS, 2/135, 1.5%; Precise, 75/135, 55.6%; Acculink, 12/135, 8.9%) were deployed at carotid arterial dissection while two types (Wingspan, 5/7, 71.4%; Solitaire 2/7, 28.6%) at vertebral arterial dissection. Digital subtracted angiography (56%, 51/91), computational tomography angiography (41.8%, 38/91) and high resolution magnetic resonance imaging (2.2%, 2/91) were adopted for follow up, with a mean time of 17.2±15.4 months (5-77). All patient modified Rankin Scale scores showed no increase at discharge or follow-up. Angiographically, dissections in 86 vessels in 69 patients (94.5%, 86/91) were completely reconstructed with only minor remnant dissections in four vessels in four patients (4.4%, 4/91). Severe re-stenosis in the stented segment required re-stenting in one patient (1.1%, 1/91). Conclusion : Stent remodeling technique provides feasible, safe and efficacious treatment of ESADs patients with severe stenosis, occlusion and/or pseudoaneurysm.

MicroRNA-362 Inhibits Cell Proliferation and Invasion by Directly Targeting SIX1 in Colorectal Cancer

Jin’e Wan,Jian Yang,Cuixia Qiao,Xiaomei Sun,Aiting Di,Lize Zhang,Dandan Wang,Gang Zhao 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.5

Purpose: Colorectal cancer (CRC) is the third most common cancer in China and poses high morbidity and mortality. In recentyears, increasing evidence has indicated that microRNAs played important functions in the occurrence and development of tumors. The purpose of this study was to identify the biological mechanisms of miR-362 in CRC. Materials and Methods: Quantitative real-time PCR was carried out to assess the expression of miR-362 and SIX1. The Kaplan-Meier method was employed to evaluate the 5-year overall survival of CRC patients. The proliferative and invasive abilities of CRCcells were assessed by MTT and transwell assays. Results: miR-362 was significantly decreased in CRC tissues and cell lines, compared to the normal tissues and normal cells. Asignificant connection was confirmed between the overall survival of 53 CRC patients and low expression of miR-362. Downregulationof miR-362 inhibited the proliferation and invasion through binding to the 3'-UTR of SIX1 mRNA in CRC. Additionally, wediscovered that SIX1 was a direct target gene of miR-362 and that the expression of miR-362 had a negative connection with SIX1expression in CRC. SIX1 could reverse partial functions in the proliferation and invasion in CRC cells. Conclusion: miR-362 may be a prognostic marker in CRC and suppress CRC cell proliferation and invasion in part through targetingthe 3'-UTR of SIX1 mRNA. The newly identified miR-362/SIX1 axis provides insight into the progression of CRC.

Bidirectional Regulation of Manganese Superoxide Dismutase (MnSOD) on the Radiosensitivity of Esophageal Cancer Cells

Sun, Guo-Gui,Hu, Wan-Ning,Wang, Ya-Di,Yang, Cong-Rong,Lu, Yi-Fang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

The mitochondrial antioxidant protein manganese superoxide dismutase (MnSOD) may represent a new type of tumor suppressor protein. Overexpression of the cDNA of this gene by plasmid or recombinant lentiviral transfection in various types of cancer leads to growth suppression both in vitro and in vivo. We previously determined that changes in MnSOD expression had bidirectional effects on adriamycin (ADR) when combined with nitric oxide (NO). Radiation induces free radicals in a manner similar to ADR, so we speculated that MnSOD combined with NO would also have a bidirectional effect on cellular radiosensitivity. To examine this hypothesis, TE-1 human esophageal squamous carcinoma cells were stably transfected using lipofectamine with a pLenti6-DEST plasmid containing human MnSOD cDNA at moderate to high overexpression levels or with no MnSOD insert. Blastidicin-resistant colonies were isolated, grown, and maintained in culture. We found that moderate overexpression of MnSOD decreased growth rates, plating efficiency, and increased apoptosis. However, high overexpression increased growth rates, plating efficiency, and decreased apoptosis. When combined with NO, moderate overexpression of MnSOD increased the radiosensitivity of esophageal cancer cells, whereas high MnSOD overexpression had the opposite effect. This finding suggests a potential new method to kill certain radioresistant tumors and to provide radioresistance to normal cells.

방한 중국인들의 의료관광동기가 만족도 및 재방문의도에 미치는 영향 - 대구광역시를 중심으로 -

적반반 ( Pan Pan Di ),홍경완 ( Kyung Wan Hong ) 대한관광경영학회 2015 觀光硏究 Vol.30 No.3

의료기술의 발달로 인간의 수명이 늘어나면서 건강한 삶에 대한 욕구가 커지자, 웰빙과 로하스의 바람을 타고 ‘건강하게 잘 먹고 잘 살자’는 인식이 확산되기 시작하였고, 현재는 하나의 문화코드로 자리 잡게 되었다· 이러한 시대적 흐름의 변화에 따라 관광산업에 있어서도 관광과 건강을 접목한 상품이 나타나기 시작했고, 초기단계에서는 헬스 투어리즘의 개념으로 다루어 졌다· 하지만 이제 단순한 헬스 케어의 범위를 넘어서 질병의 치료에서부터 건강과 휴양프로그램을 포함하는 폭넓은 의미의 건강치료를 위해 다른 장소를 방문하고 여행하는 의료관광의 개념으로 발달하였다· 이러한 트렌드에 발 맞추어 본 연구에서는 대구광역시를 찾는 중국인 관광객들의 의료관광동기를 조사하였다· 구체적으로 의료관광동기가 전반적 만족과 재방문의도에 미치는 영향을 조사하였으며, 또한 전반적 만족이 재방문의도에 미치는 영향도 조사하였다· 표본추출은 대구 의료병원에서 일하는 중국 직원을 통해 대구 지역에 있는 방문율이 높은 병원 10곳과 중국의 여행사 3곳을 통하여 의료관광 완료 후 귀가하는 중국 의료관광객을 대상으로 중국어 설문지 총 200부를 배부하여 조사하였다· 조사결과 의료관광동기는 총 2요인(문화체험, 의료건강)으로 나타났으며, 2요인 모두 전반적 만족과 재방문 의도에 정의 영향을 미치는 것으로 나타났다· 문화체험요인이 전반적 만족에 미치는 영향이 의료건강보다 큰 것으로 나타났으며, 반면에 의료건강요인은 재방문의도에 문화적 체험보다 큰 영향을 미치는 것으로 나타났다· 이와 같은 연구결과를 바탕으로 대구중심권 병원들은 의료를 중심으로 주변 대구관광권의 패키지화, 그리고 경증환자를 위한 맞춤형 의료서비스를 도입하여야 할 것이다· The primary purpose of this study was to examine the relationships between medical tourism motivation, satisfaction and the revisit intention of Chinese visitors. In this study, the theories of medical tourism motivation and satisfaction have been adopted to explain Chinese visitors’ revisit intention. In order to collect the data needed for this study, an on-site questionnaire was developed. Chinese and Korean language versions of the questionnaire were prepared. A systematic sample of subjects was obtained from Chinese visitors who have been to Korea. Data were collected through on-site surveys by face-to-face interviews conducted over 15 days in 2014. Three hypotheses were examined to represent the relationships between medical tourism motivation, satisfaction and revisit intention. The proposed hypotheses suggested that there are significant and positive relationships between medical tourism motivation, satisfaction and revisit intention. A statically significant and positive relationship between medical tourism motivation and satisfaction suggested that motivation influences the level of the visitor’s satisfaction. At the same time, motivation influences the level of revisit intention. The result suggested that medical tourism motivation played an important role in the process of making satisfaction judgments. The findings of this study offer several managerial implications for Korean directors who make policy related to medical tourism. For example, the results of the evaluation can be used as background for allocating budgets and other management resources.

Size-Controlled Silver Nanoparticles Confined in Ordered Mesoporous Silica and Their Enhanced Catalytic Activities

Xiaofei Zhou,Jiawei Wan,Yefeng Liu,Di Liu,Hong Wang,Xiaoyong Lai,Yanzhao Zou,Guo Lin,Jian Chen 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.9

A cooperative assembly route has been developed, by which silver nanoparticles with controlled sizes are incorporated into the channels of ordered cubic mesoporous silica (KIT-6) with different pore sizes (4.3–6.4 nm). The samples were characterized by XRD, TEM, FT-IR, UV-Vis and N2 physisorption. The pore wall of mesoporous silica can efficiently confine the growth of silver nanoparticles within the channels and their average sizes decreased with the pore size reduction of KIT-6. Catalytic activities of the resultant Ag/KIT-6-x (x stands for hydrothermal temperature) composite for reducing harmful organic dye Rhodamine B (Rh B) by sodium borohydride (NaBH4) were investigated. All the Ag/KIT-6 composite samples show great catalytic activities, among which Ag/KIT-6-80 with higher loading and smaller size of Ag nanoparticles exhibits higher catalytic activity than those of Ag/KIT-6-60 and Ag/KIT-6-100.

The Beneficial Effects of Electroacupuncture at PC6 Acupoints (Neiguan) on Myocardial Ischemia in ASIC3 / mice

Ying-Wang,Yi-guo Chen,Wan-shuang Zhao,Di Li,Ya-han Xu,Meng-di Li,Jin Chen,Zhi-jun Kou,Qi-ge Wang,Nsoa dimitri Joseph 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.3

This study aims to investigate the possible mechanisms of electroacupuncture (EA) at PC6to improve myocardial ischemia (MI) by regulating the cardiac transient outward potassiumcurrent channel (Ito). According to the random number table, the mice were dividedinto six groups of six mice each: control group, MI group, PC6, LU7 (Lieque-point), ST36(Zusanli-point), and nonacupoint group. Mice in the control group were injected with saline(20 mg/kg, 24 hours interval), and the other ASIC3 / mice were injected subcutaneouslytwice with isoproterenol (ISO) (20 mg/kg, 24 hours interval). In thepreexperiment, 5 mg/kg, 10 mg/kg, 20 mg/kg, and 30 mg/kg of ISO were used, andthe results showed that 5 mg/kg and 10 mg/kg of ISO both could induce acute MI, butshorter duration of sustained MI. On the other hand, an injection of 30 mg/kg can makethe mice experience arrhythmia or die immediately, and EA was operated at PC6, LU7,ST36 acupoints, and nonacupoint in the mice of PC6, LU7, ST36, and nonacupoint groups,respectively, after injecting twice. Then Western blotting techniques (Western Blot) wereused to analyze the protein expressions of Kv1.4, Kv4.2, Kv4.3, and KchIP2. The results ofthis experiment showed that the protein expressions of Kv1.4, Kv4.2, Kv4.3, and KChIP2 inMI group were significantly lower than those in the control group (p < 0.01). Comparedwith MI group, the results of PC6, LU7, and ST36 groups obviously increased (p < 0.05). Furthermore, the expressions of PC6 group were higher than LU7 group and ST36 group(p < 0.05). And electrocardiogram’s T-waves showed obvious pathological changes inthe MI group compared to the control group (p < 0.01). After EA, the abnormal T-waves voltage of ECG in PC6, LU7, and ST36 groups was improved (p < 0.05). In addition, therate change of PC6 group was larger than that of both LU7 and ST36 groups (p < 0.05). But the T-waves voltage of the nonacupoint group was not significantly different than thatof the MI group (p > 0.05).

Seismic Behavior of Low-rise Concrete Shear Wall with Single Layer of Web Reinforcement and Inclined Rebars: Restoring Force Model

Jian-Wei Zhang,Wen-Bin Zheng,Wan-Lin Cao,Hong-Ying Dong,Wan-Di Li 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.3

In order to study the restoring force model of low-rise concrete shear wall with single layer of web reinforcement and inclined rebars, a series of specimens were investigated by quasi-static tests. Based on the fitting of experimental data and theoretical analysis, the restoring force model considering four characteristic points (crack point, yield point, peak point and failure point) and degradation of unloading stiffness was established. The hysteretic rule of restoring force model was determined by analyzing characteristic of hysteresis curve for cyclic loading tests. The results show that skeleton curves and hysteresis curves calculated by the restoring force model are in good agreement with the test curves, which can provide reference for the elastic-plastic dynamic analysis of low-rise concrete shear walls with single layer of web reinforcements and inclined rebars. Shaking table tests of two low-rise concrete shear walls were also conducted to investigate dynamic performance and the seismic damage mechanism of low-rise concrete shear wall with single layer of web reinforcement and inclined rebars. Research on dynamic nonlinear simplified model of SAP2000 shows thatthe proposed restoring force model can be used to analyze the elastic and elastic-plastic dynamic response for the low-rise concrete shear wall with single layer of web reinforcement and inclined rebars.

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Sun, Guo-Gui,Wang, Ya-Di,Lu, Yi-Fang,Hu, Wan-Ning Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Altered expression or function of manganese superoxide dismutase (MnSOD) has been shown to be associated with cancer risk but assessment of gene polymorphisms has resulted in inconclusive data. Here a search of published data was made and 22 studies were recruited, covering 20,025 case and control subjects, for meta-analyses of the association of MnSOD polymorphisms with the risk of prostate, esophageal, and lung cancers. The data on 12 studies of prostate cancer (including 4,182 cases and 6,885 controls) showed a statistically significant association with the risk of development in co-dominant models and dominant models, but not in the recessive model. Subgroup analysis showed there was no statistically significant association of MnSOD polymorphisms with aggressive or nonaggressive prostate cancer in different genetic models. In addition, the data on four studies of esophageal cancer containing 620 cases and 909 controls showed a statistically significant association between MnSOD polymorphisms and risk in all comparison models. In contrast, the data on six studies of lung cancer with 3,375 cases and 4,050 controls showed that MnSOD polymorphisms were significantly associated with the decreased risk of lung cancer in the homozygote and dominant models, but not the heterozygote model. A subgroup analysis of the combination of MnSOD polymorphisms with tobacco smokers did not show any significant association with lung cancer risk, histological type, or clinical stage of lung cancer. The data from the current study indicated that the Ala allele MnSOD polymorphism is associated with increased risk of prostate and esophageal cancers, but with decreased risk of lung cancer. The underlying molecular mechanisms warrant further investigation.