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Image Watermarking Scheme Based on Scale-Invariant Feature Transform
( Wan-li Lyu ),( Chin-chen Chang ),( Thai-son Nguyen ),( Chia-chen Lin ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.10
In this paper, a robust watermarking scheme is proposed that uses the scale-invariant feature transform (SIFT) algorithm in the discrete wavelet transform (DWT) domain. First, the SIFT feature areas are extracted from the original image. Then, one level DWT is applied on the selected SIFT feature areas. The watermark is embedded by modifying the fractional portion of the horizontal or vertical, high-frequency DWT coefficients. In the watermark extracting phase, the embedded watermark can be directly extracted from the watermarked image without requiring the original cover image. The experimental results showed that the proposed scheme obtains the robustness to both signal processing and geometric attacks. Also, the proposed scheme is superior to some previous schemes in terms of watermark robustness and the visual quality of the watermarked image.
Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system.
Wan, Chen-rei,Chung, Seok,Kamm, Roger D Pergamon Press [etc.] 2011 Annals of biomedical engineering Vol.39 No.6
<P>The differentiation process of murine embryonic stem cells into cardiomyocytes was investigated with a compliant microfluidic platform which allows for versatile cell seeding arrangements, optical observation access, long-term cell viability, and programmable uniaxial cyclic stretch. Specifically, two environmental cues were examined with this platform--culture dimensions and uniaxial cyclic stretch. First, the cardiomyogenic differentiation process, assessed by a GFP reporter driven by the α-MHC promoter, was enhanced in microfluidic devices (?FDs) compared with conventional well-plates. The addition of BMP-2 neutralizing antibody reduced the enhancement observed in the ?FDs and the addition of exogenous BMP-2 augmented the cardiomyogenic differentiation in well plates. Second, 24 h of uniaxial cyclic stretch at 1 Hz and 10% strain on day 9 of differentiation was found to have a negative impact on cardiomyogenic differentiation. This microfluidic platform builds upon an existing design and extends its capability to test cellular responses to mechanical strain. It provides capabilities not found in other systems for studying differentiation, such as seeding embryoid bodies in 2D or 3D in combination with cyclic strain. This study demonstrates that the microfluidic system contributes to enhanced cardiomyogenic differentiation and may be a superior platform compared with conventional well plates. In addition to studying the effect of cyclic stretch on cardiomyogenic differentiation, this compliant platform can also be applied to investigate other biological mechanisms.</P>
Chen, Jian,Chen, Jie,Ding, Hong-Yan,Pan, Qin-Shi,Hong, Wan-Dong,Xu, Gang,Yu, Fang-You,Wang, Yu-Min Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Background: The statistical methods to analyze and predict the related dangerous factors of deep fungal infection in lung cancer patients were several, such as logic regression analysis, meta-analysis, multivariate Cox proportional hazards model analysis, retrospective analysis, and so on, but the results are inconsistent. Materials and Methods: A total of 696 patients with lung cancer were enrolled. The factors were compared employing Student's t-test or the Mann-Whitney test or the Chi-square test and variables that were significantly related to the presence of deep fungal infection selected as candidates for input into the final artificial neural network analysis (ANN) model. The receiver operating characteristic (ROC) and area under curve (AUC) were used to evaluate the performance of the artificial neural network (ANN) model and logistic regression (LR) model. Results: The prevalence of deep fungal infection from lung cancer in this entire study population was 32.04%(223/696), deep fungal infections occur in sputum specimens 44.05%(200/454). The ratio of candida albicans was 86.99% (194/223) in the total fungi. It was demonstrated that older (${\geq}65$ years), use of antibiotics, low serum albumin concentrations (${\leq}37.18g/L$), radiotherapy, surgery, low hemoglobin hyperlipidemia (${\leq}93.67g/L$), long time of hospitalization (${\geq}14$days) were apt to deep fungal infection and the ANN model consisted of the seven factors. The AUC of ANN model($0.829{\pm}0.019$)was higher than that of LR model ($0.756{\pm}0.021$). Conclusions: The artificial neural network model with variables consisting of age, use of antibiotics, serum albumin concentrations, received radiotherapy, received surgery, hemoglobin, time of hospitalization should be useful for predicting the deep fungal infection in lung cancer.
Pancreatic Cancer Incidence and Mortality Patterns in China, 2009
Chen, Wan-Qing,Liang, Di,Zhang, Si-Wei,Zheng, Rou-Shou,He, Yu-Tong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Objective: To estimate the incidence and mortality rates for pancreatic cancer in China. Methods: After checking and reviewing the cancer registry data in 2009 from 72 cancer registry centers, we divided cancer registry areas into urban and rural areas. Incidence/mortality rates, age-specific incidence/mortality rates, age-standardized incidence/mortality rates, proportions, and cumulative incidence/mortality rates for pancreatic cancer were calculated. Results: The total number of newly diagnosed pancreatic cancer cases and deaths in 2009 were 6,220 and 5,650, respectively. The crude incidence rate in all cancer registry areas was 7.28/100,000 (males 8.24, females 6.29). The age-standardized incidence rate by Chinese standard population (ASR) was 3.35/100,000, with ranking at 7th among all cancers. Pancreatic cancer incidence rate was 8.19/100,000 in urban areas whereas it was 5.41/100 000 in rural areas. Cancer mortality rate in all cancer registry areas was 6.61/100,000 (males 7.45; females 5.75), with ranking at 6th among all cancers, and 7.42/100 000 in urban but 4.94/100000 in rural areas. Conclusions: Pancreatic cancer incidence and mortality rates have shown a gradual increase in China. Owing to the difficulty of early diagnosis, identification of high-risk population and modification of risk factors are important to reduce the burden of pancreatic cancer.
Design and Implementation on Spatial Science and Technology Information Database of CSI
Chen, Xiu Wan,Deng, Zheng Quan,Lu, Zhi Gao,Ma, Jia,Lin, Jia Yuan,Zhang, Wen Jiang,Luo, Tianfu,Liu, Baofu 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1
Remote Sensing technology, which is characterized by producing imagery an multi-platform, different temporal and spatial resolution, has greatly improved mankind's capability of acquisition, processing and application of spatial information. The increase of spatial data sources and the development, applications and industrialization of spatial information technology are urging the need of spatial data sharing and exchanging. Based an a brief introduction an the China Spatial Information Network (CSI) and its database system, the CSI Spatial Science and Technology Information Database (SSTID) management system was designed and implemented in this paper.
The Safety Management & Liability on GMO Products in China
Chen I-wan 원광대학교 법학연구소 2010 의생명과학과 법 Vol.4 No.-
The paper reviews how China’s policy of providing the devel opment of genetic engineering of crops with high priority massive fundin g absolute support was formed. China’s existing legal framework and go vernment management regulations of GMO and its safety. Most importan t developments in R&D, trials, commercialize planting of GM crops and consequences. Sino-American trade conflicts over massive imports of GM products and consequences. A series of serious facts raising great concern about GM food safety in China. Reveals that China’s national st andard does not establish any standard on the glyphosate maximum allo wed residue level of GM soybeans, soy milk and powder, toufu and all other soybean products. Spread of illegal grown unapproved GM rice. T he commercialization of GM Bt-cotton in fact is a failure but how it wa s glorified into a "success"! Suspicious animal abnormality phenomena a nd its possible link with GM suspect corn. Reactions of the concerned departments to such cases. Suspicious widespread trend of deteriorating human reproduction capabilities of young men and women in China. All of this shows that The present GMO safety legal framework is incompl ete, not effective and lack of comprehensive. Reveals how the Ministry of Agriculture resists further regulation restrictions on GM safety. A ge neral conclusion: Providing unconditional massive funding absolute supp ort to the promotion of GM technology is a fatal strategic mistake! Different to most other researchers, the author has crossed into the f ield of studying GMO safety from two other fields, (1) disaster preventi on, and (2) science & technology innovation sociology. From angles of studies in disaster prevention, when studying the issu e of GMO safety, the author focuses on what aspects already cause or have the potential of causing the most serious and widespread disaster s to human health and the environment in China, their reasons, and pos sible preventative measures. From angles of studies in science & technology innovation sociology, when studying the issue of GMO safety, the author focuses on the follo wing questions: Is genetic engineering a science & technology innovatio n? Is it promoting advance in science, or reverse? Is it promoting other science & technology innovation in the concerned fields, or is it suppre ssing other science & technology innovation in the concerned fields? O r, in other words, is it blocking science advancement? The present paper can not cover all these respects, but, for the first time, provides scholars outside China a detailed review of the overall s ituation of genetic engineering, especially the development and commer cialization planting of GM crops, massive volume imports of GM crops, their management, liabilities and consequences showing up in China.
Chen, Wan,Ahmad, Ishtiaq,Chang, KyungHi SpringerOpen 2017 Eurasip Journal on Wireless Communications and Net Vol.2017 No.-
<P>In the Republic of Korea, a Long Term Evolution (LTE)-based public safety (PS)-LTE network is being built using 718 similar to 728 MHz for uplink and 773 similar to 783 MHz for downlink. However, the same bands are also assigned to the LTE-based high-speed railway (LTE-R) network, so great concerns and practical researches on co-channel interference (CCI) management schemes are urgently required. In this paper, performance is analyzed and evaluated by considering the cases of non-RAN (radio access network) sharing and LTE-R RAN sharing by PS-LTE user equipments (UE). Since a train control signal requires high reliability and low latency in order to fulfill its mission-critical service (MCS) requirements, we give higher priority to LTE-R UE during resource allocation under the LTE-R RAN sharing by PS-LTE UEs. In addition, interference management schemes are more effective for the coexistence of PS-LTE and LTE-R networks under RAN sharing environment. In this paper, we utilize enhanced inter-cell interference coordination (eICIC) and further enhanced ICIC (FeICIC) schemes to mitigate the interference from PS-LTE network to LTE-R network while improving the LTE-R eNodeB (eNB) resource utilization by offloading more PS-LTE UEs to LTE-R network. Moreover, a coordinated multipoint (CoMP) transmission scheme is considered among LTE-R eNBs to enhance LTE-R cell edge user performance. By employing FeICIC along with coordinated scheduling (CS) CoMP, the best throughput performance can be achieved under the case of RAN sharing.</P>
Chen Wang,Kai Zhang,Chen Zhongjun,Heng Cai,Wan Honggui,Ping-Kai Ouyang 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.3
Lysine decarboxylase (LDC) exhibits a significant role in cadaverine (1,5-pentanediamine, diaminopentane) production from lysine. In this study, an error-prone PCR and DNA shuffling were performed to improve the activity of LDC from Hafnia alvei AS1.1009 for cadaverine production. A sensitive high-throughput screening strategy based on a pH indicator was established for directed evolution of LDC. Several improved mutants were obtained from directed evolution and LDCV147F/E583G mutant showed highest activity to catalyze lysine to cadaverine. This mutant showed 1.62-fold high LDC activity when compared to wild-type. Further analysis by site-directed mutagenesis reveled that only the mutant E583G was sufficient for higher catalytic activity. Wild type LDC and mutant LDCE583G were purified by an improved method including hydrophobic chromatography. These purified enzymes were characterized and the kinetic parameters were compared between LDCE583G and WT LDC. Vmax of LDCE583G was 1.32-fold higher than that of WT LDC. Use of LDCE583G mutant showed 1.48-fold improved productivity of cadaverine when compared to wild type. The concentration of cadaverine in E. coli JM109/pTrc99a-ldc2-41 was 63.9 g/L with conversion yield of 93.4% during 5 h. These results indicate that the mutation has positive effects on improving LDC activity and a potential candidate for cadaverine production.