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Developing a deeper insight into reproductive biomarkers
Wahid, Braira,Bashir, Hamid,Bilal, Muhammad,Wahid, Khansa,Sumrin, Aleena The Korean Society for Reproductive Medicine 2017 Clinical and Experimental Reproductive Medicine Vol.44 No.4
The development of biomarkers of reproductive medicine is still in its infancy because many black boxes are still present in reproductive medicine. Novel approaches to human infertility diagnostics and treatment must be developed because reproductive medicine has lagged behind in the implementation of biomarkers in clinical medicine. Despite the dearth of the available literature, the current rapid pace of publications suggests that this gap will soon be filled therefore; this review is a $pr\acute{e}cis$ of the research that has been done so far and will provide a basis for the development of biomarkers in reproductive medicine.
Expression of CYP1A1 and GSTP1 in Human Brain Tumor Tissues in Pakistan
Wahid, Mussarat,Mahjabeen, Ishrat,Baig, Ruqia Mehmood,Kayani, Mahmood Akhtar Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Most of the exogenous and endogenous chemical compounds are metabolized by enzymes of xenobiotic processing pathways, including the phase I cytochrome p450 species. Carcinogens and their metabolites are generally detoxified by phase II enzymes like glutathione-S-transferases (GST). The balance of enzymes determines whether metabolic activation of pro-carcinogens or inactivation of carcinogens occurs. Under certain conditions, deregulated expression of xenobiotic enzymes may also convert endogenous substrates to metabolites that can facilitate DNA adduct formation and ultimately lead to cancer development. In this study, we aimed to test the association between deregulation of metabolizing genes and brain tumorigenesis. The expression profile of metabolizing genes CYP1A1 and GSTP1 was therefore studied in a cohort of 36 brain tumor patients and controls using Western blotting. In a second part of the study we analyzed protein expression of GSTs in the same study cohort by ELISA. CYP1A1 expression was found to be significantly high (p<0.001) in brain tumor as compared to the normal tissues, with ~4 fold (OR=4, 95%CI=0.43-37) increase in some cases. In contrast, the expression of GSTP1 was found to be significantly low in brain tumor tissues as compared to the controls (p<0.02). This down regulation was significantly higher (OR=0.05, 95%CI=0.006-0.51; p<0.007) in certain grades of lesions. Furthermore, GSTs levels were significantly down-regulated (p<0.014) in brain tumor patients compared to controls. Statistically significant decrease in GST levels was observed in the more advanced lesions (III-IV, p<0.005) as compared to the early tissue grades (I-II). Thus, altered expression of these xenobiotic metabolizing genes may be involved in brain tumor development in Pakistani population. Investigation of expression of these genes may provide information not only for the prediction of individual cancer risk but also for the prevention of cancer.
Study on Microstructure and Mechanical Properties of Laser Welded AlMg7 Alloy Thin Sheets
Wahid Muhamad Furkon,이광진 대한용접·접합학회 2021 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2021 No.5
Laser welding has been used commonly for welding aluminum alloys in the various industry, because a low localized heat input and high welding speeds can be produced with small distortion of welded assemblies. In this study, non-heat-treatable alloys of AlMg7 thin sheets were laser-welded with various welding powers of 1.50, 1.75, and 2.00 kW and travelling speeds of 8, 9, 10, and 11 mpm. The cross-sectional observation on these various lap joints were conducted using optical microscope (OM) and electron back-scatter diffraction (EBSD) in order to investigate the microstructures including the melting pool, heat affected zone (HAZ), and base metals (BM) regions. The tensile test was performed to evaluate the mechanical properties of lap-joints of AlMg7 thin sheets and find the optimum welding conditions. The sound joints with high tensile strength have been affected with their microstructures after laser welding will be elaborated in detail.
CORRELATION BETWEEN TESTICLE MEASUREMENTS AND LIBIDO AND SEMEN QUALITY IN RAMS
Wahid, S.A.,Yunus, J.M. Asian Australasian Association of Animal Productio 1994 Animal Bioscience Vol.7 No.2
A study was conducted at Ijok, Malaysia, to determine the relationship of testicular measurements with libido and semen quality in tropical and imported temperate breeds of sheep. Ten rams each of Malin (M), Siamese Longtail (L), Cross of Merino with Border Leicester (C), Dorset (D) and Suffolk (S) were used for the study. Libido, semen volume and semen quality were recorded monthly for a year together with testicular length, width and circumference. The results showed that there were breed differences in volume and quality of semen where the tropical breeds had better semen compared to the temperate breeds. There was positive and significant correlation between testicle length and semen volume in all the breeds. Testicular length was found to be positively and significantly correlated with motility and sperm concentration in the tropical breeds (L and M). The relationship between libido and testicle measurements in the tropical breeds was not significant (p<0.05). There was variable relationship between the testicular measurements and libido in the temperate breeds where the relationship was significant and negative in breeds C and D and highly significant and positive in S. It was evident that the long testicles influenced the quality of the semen whereas testicles with greater circumference influenced the libido of the rams.
Wahid Ul Rehman,Kriti Gupta,Felix Bast 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.3
Bryum is recognized as a cosmopolitan genus of mosses in the family Bryaceae that contains the largestdiversity of mosses. Although there are around 100 species of moss species reported from Antarctica todate, the actual species diversity remains elusive, as the continent remains one of the least exploredhabitats globally. Here, we describe a new species of Bryum from the Larsemann Hills, Eastern Antarctica,with several synapomorphic characters, including unbranched plant body, ovate-lanceolate leaves,reflexed leaf margins with slightly serrulate apex, and percurrent coasta. In nuclear ribosomal DNA internaltranscribed spacer 1 phylogram, our isolate did not cluster with any known species of this genus. The closest BLASTn hit was found to be Bryum pseudotriquetrum, but our isolate had several distinctsynapomorphic traits. Based on morphological and molecular data, a new moss species, Bryum bharatiensesp. nov. is formally proposed herein. Besides, two new taxonomic records are also presented inthis study, viz. Bryoerythrophyllum recurvirostrum from Larsemann Hills and Coscinodon lawianus fromSchirmacher Oasis.