Proproliferative Functions of Drosophila Small Mitochondrial Heat Shock Protein 22 in Human Cells

Wadhwa, R.,Ryu, J.,Gao, R.,Choi, I.-K.,Morrow, G.,Kaur, K.,Kim, I.,Kaul, S.C.,Yun, C.-O.,Tanguay, R.M. The American Society for Biochemistry and Molecula 2010 The Journal of biological chemistry Vol.285 No.6

Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis

Wadhwa, Deepti,Bey, Afshan,Hasija, Mukesh,Moin, Shagufta,Kumar, Arun,Aman, Shazia,Sharma, Vivek Kumar Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.5

Purpose: Cigarette smoking is a major risk factor in periodontal diseases. The pathogenesis of periodontal diseases may be affected by alterations of the inflammatory response by smoke. Nitric oxide (NO) is a gaseous, colorless, highly reactive, short-lived free radical with a pivotal role in the regulation of various physiological and pathological mechanisms in the body. It is important in host defense and homeostasis, on the one hand, whereas, on the other hand, it modulates the inflammatory response in periodontitis, leading to harmful effects. The aim of this study was to assess the levels of NO in both the serum and saliva of smokers and nonsmokers having chronic periodontitis and to compare them with periodontally healthy controls. Methods: Sixty subjects participated in the study and were divided into three groups: group I, healthy nonsmoking subjects; group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis. Each group consisted of twenty subjects. The biochemical estimation of NO in the collected serum and in the saliva was performed using the Griess colorimetric reaction. Results: The results showed that the mean value of the salivary and serum NO was greater in group II than in group I, and also greater in group III than in group II. Conclusions: NO appears to play an important and rather complex role in the immuno-inflammatory process and in the remodeling and maintenance of osseous structures. It is therefore logical that modulation of this mediator has potential for the treatment of a number of inflammatory conditions including periodontal disease.

Dynamic System Modeling for Closed Loop Supply Chains System

Wadhwa, Subhash,Madaan, Jitendra Korean Institute of Industrial Engineers 2008 Industrial Engineeering & Management Systems Vol.7 No.1

The need for holistic modeling efforts for returns that capture the extended closed loop supply chain (CLSC) system at strategic as well as operational level has been clearly recognized by the industry and academia. Strategic decision-makers need comprehensive models that can guide them in efficient decision-making to increase the profitability of the entire forward and return chain. Therefore, determination of a near optimal design configuration, which includes the environmental, economical and technological capability factors, is important in strategic decision-making effort that affect the profitability of the closed loop supply chain. In this paper, we adopted an improved system dynamics methodology to tackle strategic issues that affect various performance measures, like market, time/cost, environment etc., for closed loop supply chains. After studying real life implementation issues in CLSC design, we presented guidelines for the PBM (Participative Business Modeling) methodology and presented its extension for the strategic dynamic system modeling of return chains. Finally, we demonstrated the measurement of operational performance by extending SD (system dynamic) application to closed loop supply chain management.

Dynamic System Modeling for Closed Loop Supply Chains System

Subhash Wadhwa,Jitendra Madaan 대한산업공학회 2008 Industrial Engineeering & Management Systems Vol.7 No.1

The need for holistic modeling efforts for returns that capture the extended closed loop supply chain (CLSC) system at strategic as well as operational level has been clearly recognized by the industry and academia. Strategic decision-makers need comprehensive models that can guide them in efficient decision-making to increase the profitability of the entire forward and return chain. Therefore, determination of a near optimal design configuration, which includes the environmental, economical and technological capability factors, is important in strategic decision-making effort that affect the profitability of the closed loop supply chain. In this paper, we adopted an improved system dynamics methodology to tackle strategic issues that affect various performance measures, like market, time/cost, environment etc., for closed loop supply chains. After studying real life implementation issues in CLSC design, we presented guidelines for the PBM (Participative Business Modeling) methodology and presented its extension for the strategic dynamic system modeling of return chains. Finally, we demonstrated the measurement of operational performance by extending SD (system dynamic) application to closed loop supply chain management.

Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms

Ravisha Wadhwa,Divya Vohora,Manoj Kumar,Sushama Talegaonkar 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.2

Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is emerging, raising certain questions regarding the effect of blockade of serotonin reuptake in the bone metabolism. Clinical studies have reported an association of SSRI antidepressants which with increase in fracture and decrease in bone mineral density. This review focus on recent evidence that evaluate the association of SSRIs with the risk of fracture and bone mineral density and also the probable mechanisms that might be involved in such effects.

Migration, Social Relations, and Shifting Identities

Megha Wadhwa 대한일어일문학회 2016 대한일어일문학회 학술대회 발표논문 요지집 Vol.2016 No.4

Design and Investigation of Junctionless DGTFET for Biological Molecule Recognition

Girish Wadhwa,Priyanka Kamboj,Jeetendra Singh,Balwinder Raj 한국전기전자재료학회 2021 Transactions on Electrical and Electronic Material Vol.22 No.3

This work utilizes the dielectric modulated detection technique within a junctionless tunnel fi eld-effect transistor (JLTFET) to detect various charged and neutral biomolecules. The electrostatic properties of the proposed dielectric modulated junctionless double gate JLTFET (DM-JL DGTFET) are observed and analyzed to determine the biomolecules like uricase(k = 1.54), Glucose oxidase (k = 3.46), APTES (k = 3.57), keratin (k = 8) and gelatin (k = 14) lipid, carbohydrate, nucleic acid (DNA and RNA), and protein, etc. The SiO 2 (gate oxide) is etched and a cavity is shaped under the gate electrode in which the analytes are injected and thus the eff ective dielectric of the gate oxide is modulated. The injected charge or neutral analytes of the various biomolecules in the immobilized states are responsible to change the electrostatic characteristics of the DM-JL DGTFET device by varying the gate capacitance. The drain current, I ON /I OFF , subthreshold slope, and sensitivity of the DM-JL DGTFET are estimated to recognize the biomolecules. The DM-DGJLTFET shows noticeable sensitivity outcomes 15.2 × 10 11 for the charged biomolecules, especially the positively charged analytes.

Some remarks on results of Pant and Pant along with generalization for hybrid mappings

Kamal Wadhwa,Ved Prakash Bhardwaj 원광대학교 기초자연과학연구소 2017 ANNALS OF FUZZY MATHEMATICS AND INFORMATICS Vol.14 No.3

In the present note, we pose some remarks on results of Pant and Pant [23]. After resolving some errors; we provide their results using common limit in the range property. Further, we generalize their results for hybrid pairs of mappings in fuzzy metric space. we also provide some examples for the validity of our results.

Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis

Deepti Wadhwa,Afshan Bey,Mukesh Hasija,Shagufta Moin,Arun Kumar,Shazia Aman,Vivek Kumar Sharma 대한치주과학회 2013 Journal of Periodontal & Implant Science Vol.43 No.5

Purpose: Cigarette smoking is a major risk factor in periodontal diseases. The pathogenesis of periodontal diseases may be affected by alterations of the inflammatory response by smoke. Nitric oxide (NO) is a gaseous, colorless, highly reactive, shortlived free radical with a pivotal role in the regulation of various physiological and pathological mechanisms in the body. It is important in host defense and homeostasis, on the one hand, whereas, on the other hand, it modulates the inflammatory response in periodontitis, leading to harmful effects. The aim of this study was to assess the levels of NO in both the serum and saliva of smokers and nonsmokers having chronic periodontitis and to compare them with periodontally healthy controls. Methods: Sixty subjects participated in the study and were divided into three groups: group I, healthy nonsmoking subjects;group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis. Each group consisted of twenty subjects. The biochemical estimation of NO in the collected serum and in the saliva was performed using the Griess colorimetric reaction. Results: The results showed that the mean value of the salivary and serum NO was greater in group II than in group I, and also greater in group III than in group II. Conclusions: NO appears to play an important and rather complex role in the immuno-inflammatory process and in the remodeling and maintenance of osseous structures. It is therefore logical that modulation of this mediator has potential for the treatment of a number of inflammatory conditions including periodontal disease. Purpose: Cigarette smoking is a major risk factor in periodontal diseases. The pathogenesis of periodontal diseases may be affected by alterations of the inflammatory response by smoke. Nitric oxide (NO) is a gaseous, colorless, highly reactive, shortlived free radical with a pivotal role in the regulation of various physiological and pathological mechanisms in the body. It is important in host defense and homeostasis, on the one hand, whereas, on the other hand, it modulates the inflammatory response in periodontitis, leading to harmful effects. The aim of this study was to assess the levels of NO in both the serum and saliva of smokers and nonsmokers having chronic periodontitis and to compare them with periodontally healthy controls. Methods: Sixty subjects participated in the study and were divided into three groups: group I, healthy nonsmoking subjects;group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis. Each group consisted of twenty subjects. The biochemical estimation of NO in the collected serum and in the saliva was performed using the Griess colorimetric reaction. Results: The results showed that the mean value of the salivary and serum NO was greater in group II than in group I, and also greater in group III than in group II. Conclusions: NO appears to play an important and rather complex role in the immuno-inflammatory process and in the remodeling and maintenance of osseous structures. It is therefore logical that modulation of this mediator has potential for the treatment of a number of inflammatory conditions including periodontal disease.

Geophysical investigations for deciding alignment of head race tunnel and location of lake tapping at Koyna hydroelectric project, Maharashtra, India

R. S. Wadhwa,M. S. Chaudhari,V. Chandrasekhar,A. Saha,R. Mukhopadhyay 한국암반공학회 2003 한국암반공학회 학술대회 및 세미나 자료집 Vol.- No.-