Ginsenosides protect striatal neurons in a cellular model of Huntington's disease

Wu, Jun,Jeong, Hye Kyoung,Bulin, Sarah Elizabeth,Kwon, Sung Won,Park, Jeong Hill,Bezprozvanny, Ilya Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.8

<P>Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is a widely used herbal medicine. Ginsenosides, the active ingredients of ginseng, are the main components responsible for many beneficial actions of ginseng. In the present study, we tested 10 different ginsenosides in the previously developed in vitro Huntington's disease (HD) assay with primary medium spiny striatal neuronal cultures (MSN) from the YAC128 HD mouse model. We found that nanomolar concentrations of ginsenoside Rb1 and Rc effectively protected YAC128 medium spiny neurons from glutamate-induced apoptosis and that Rg5 was protective at micromolar concentration. The other seven ginsenosides tested were not effective or exerted toxic effects in MSN cultures. From further experiments, we suggested that neuroprotective effects of ginsenosides Rb1, Rc, and Rg5 could correlate with their ability to inhibit glutamate-induced Ca<SUP>2+</SUP> responses in cultured MSN. From these results we concluded that ginsenosides Rb1, Rc, and Rg5 offer a potential therapeutic choice for the treatment of HD and possibly other neurodegenerative disorders. © 2009 Wiley-Liss, Inc.</P>

Geometric Imperfection Distributions of Existing Reticulated Shells: Theoretical and Experimental Analysis

Wu Jun,Luo Yongfeng,Wang Lei 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.5

Geometric imperfection is one of the most disadvantageous factors that impair mechanical behaviors of existing reticulated shell structures. However, the available consistent mode methods and statistical methods which usually applied in designing structures can hardly estimate the actual geometric imperfection distribution for existing structures, because these methods use the assumed imperfections. In this paper, a Markov Random Field (MRF) theoretical model of existing reticulated shells is established by introducing the theory of probabilistic graphical model. The unit of graphic model named node clique are proposed to deduct the geometric state function of reticulated shells, based on the local Markov property. Then the inversion function along with its iterative equation is established to predict geometric imperfection distribution of existing reticulated shells. The MRF method makes the predicted distribution of the numerical model as consistent as possible with its corresponding actual structure, and only a few measurement nodes are needed as known conditions. An experimental structure of K6 single-layer reticulated shell is built to verify the proposed theory by comparing the calculated geometric imperfection distribution results with the actual measured data. Meanwhile, the signifi cance level of the calculated results between MRF and traditional stochastic method is analyzed, which shows MRF method can eff ectively predict the geometric imperfections of single layer reticulated shells.

NOTE FOR THE TRIPLED AND QUADRUPLE FIXED POINTS OF THE MIXED MONOTONE MAPPINGS

Wu, Jun,Liu, Yicheng Korean Mathematical Society 2013 대한수학회보 Vol.50 No.3

In this paper, to include more generalized cases, the authors present a modified concept for the tripled and quadruple fixed point of the mixed monotone mappings. Also, they investigate the existence and uniqueness of fixed point of the ordered monotone operator with the Matkowski contractive conditions in the partial ordered metric spaces. As the direct consequences, the existence of coupled fixed point, tripled fixed point and quadruple fixed point are explored at the common framework and some previous results in [T. G. Bhaskar and V. Lakshmikan-tham, Fixed point theory in partially ordered metric spaces and applications, Nonlinear Anal. 65 (2006), 1379-1393; V. Berinde and M. Borcut, Tripled fixed point theorems for contractive type mappings in partially ordered metric spaces, Nonlinear Anal. 74 (2011), no. 15, 4889-4897; E. Karapinar and N. V. Luong, Quadruple fixed point theorems for nonlinear contractions, Computers and Mathematics with Applications (2012), doi:10.1016/j.camwa.2012.02061] are improved. Finally, some fixed point theorems are proved.

Sequential fusion to defend against sensing data falsification attack for cognitive Internet of Things

Wu, Jun,Wang, Cong,Yu, Yue,Song, Tiecheng,Hu, Jing Electronics and Telecommunications Research Instit 2020 ETRI Journal Vol.42 No.6

Internet of Things (IoT) is considered the future network to support wireless communications. To realize an IoT network, sufficient spectrum should be allocated for the rapidly increasing IoT devices. Through cognitive radio, unlicensed IoT devices exploit cooperative spectrum sensing (CSS) to opportunistically access a licensed spectrum without causing harmful interference to licensed primary users (PUs), thereby effectively improving the spectrum utilization. However, an open access cognitive IoT allows abnormal IoT devices to undermine the CSS process. Herein, we first establish a hard-combining attack model according to the malicious behavior of falsifying sensing data. Subsequently, we propose a weighted sequential hypothesis test (WSHT) to increase the PU detection accuracy and decrease the sampling number, which comprises the data transmission status-trust evaluation mechanism, sensing data availability, and sequential hypothesis test. Finally, simulation results show that when various attacks are encountered, the requirements of the WSHT are less than those of the conventional WSHT for a better detection performance.

Development of Sustainable Accessory Design Using Convertible Techniques

( Wujun Tang ),( Sumin Koo ) 한국패션비즈니스학회 2021 패션 비즈니스 Vol.25 No.6

This research aimed to analyze the features of convertible accessories, develop sustainable accessory designs using convertible techniques, and evaluate the designs developed through a consumer satisfaction survey and in anticipation of commercialization. Through a review of literature and design cases, convertible accessories were classified; and six convertible accessory designs were developed into practical products. A survey on the convertible designs was conducted to evaluate their aesthetic, functional, and symbolic aspects, ease of use, usefulness, and the intention of consumers to purchase and use the products. In addition, a survey was performed to understand the differences in fashion leadership and eco commitment and behavior. The data were analyzed using descriptive analysis methods, a series of t-test, and ANOVA using the SPSS 25.0 software. There were 335 participants; mostly adult women aged between 20 and 60 years and living in China, one of the world's largest accessory markets. The participants showed high interest to use and purchase the developed designs. There were significant differences in aesthetics, functionality, symbolism, attitude, ease of use, usefulness, usage, and purchase intention for the developed convertible accessories among people with different levels of fashion leadership, environmental commitment, and behavior. The results of this study will help designers develop convertible accessories with a better understanding of consumer perceptions and attitudes towards convertible accessories.

Development and Evaluation of Wearable Bags and Consumer Innovativeness

( Tang Wujun ),( Koo Sumin ) 한국패션비즈니스학회 2020 패션 비즈니스 Vol.24 No.6

Wearable bags are body-worn bags, integrated with clothing or accessories, and they can liberate the wearer’s hands, offering enhanced mobility. The main purposes of this research were: a) to analyze wearable bag design cases ranging from historical costumes to contemporary fashion; b) to develop wearable bag designs using various defined design methods, styles, and features and prototypes; and c) to evaluate people’s satisfaction with the developed wearable bags and their differences among people with different innovativeness levels. Thus, the wearable bag design cases involved in this study were researched and collected from previous literature searches. then, the wearable bag designs were developed and prototyped. Next. an evaluation survey was conducted using questions that assessed satisfaction with overall design and function, use and purchase intention, and consumer innovativeness. The results are expected to enhance the understanding of wearable bags and provide guidelines for designers who develop wearable bags. The results indicated that 80% or more of the surveyed people were satisfied with the design and function of the developed wearable bags. They perceived that the bags were easy to use and useful, and wanted to use and purchase them. Consumers with high social, functional, and hedonic innovativeness were more satisfied and perceived these wearable bags as easier to use and more useful and wanted to use and purchase them more than consumers with low innovativeness. This study can be helpful to designers developing wearable bags by providing a better understanding of wearable bags and consumer perceptions.

Ion-Exchange Synthesis and Enhanced Visible-Light Photoactivity of Graphene/Hexagonal CuS/Ag2S Nanocomposites

BIN ZENG,WUJUN ZENG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.1

Graphene loaded hexagonal CuS/Ag2S nanoplates have been successfully synthesized. Scanning electron microscopy and transmission electron microscopy observations show that hexagonal CuS/Ag2S nanoplates are tightly anchored onto graphene. The experimental results show that these nanocomposites have a highly visible-light photocatalytic performance. The high visible photocatalytic activities can be attributed to direct photoinduced interfacial charge transfer in the hexagonal CuS/Ag2S nanoplates and the further electrons transfer from CuS/Ag2S to graphene.

Graphene Decorated with Hierarchical CuS Nanoplates: Enhanced Photocatalytic Performance

BIN ZENG,Wanfeng Liu,WUJUN ZENG,Can Jin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.3

Graphene decorated with hierarchical CuS nanoplates (CuS NP-G) was synthesized using a microwave method to be used as a photocatalytic material. The incorporation of graphene into hierarchical CuS nanoplates was confirmed by structural, morphological and optical characterizations. The photocatalytic performance of the nanocomposite was evaluated. This study confirmed that the introduction of graphene was an effective way not only to improve the structural stability and service durability of the composite, but also to improve its solar photocatalytic activity by promoting the electron transfer and charge separation of hierarchical CuS nanoplates.

CARBON NANOTUBES/GRAPHENE THREE-DIMENSIONAL NETWORKS ARCHITECTURE LOADING WITH Ni AND ITS ADSORPTION PROPERTIES

BIN ZENG,YOUXIN LUO,QIYUAN LIU,WUJUN ZENG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.2

The composite of carbon nanotubes/graphene networks loaded-Ni (CNTs/GR-Ni) were suc-cessfully synthesized by spray drying and post-calcinating method for the ¯rst time. The syn-thesized products were systematically studied by X-ray di®raction, scanning electron microscopyand transmission electron microscopy. The result showed the hybrid of CNTs and graphenecomposed the 3D network structure and Ni nanoparticles were attaching on their surface. Adsorption performance evidenced that the obtained nanocomposite possessed high adsorptione±ciency and excellent separation property.

A New Theoretical Equation to Estimate Poisson’s Ratio for Coated Bi-axial Warp Knitted Fabrics under Bias Tensile Loading

Jianwen Chen,Han Zhou,Bing Zhao,Wujun Chen,Mingyang Wang,Zhihong Xu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.12

Tensile tests of seven bias angles with a 15 o increment with respect to the warp direction are conducted on a typical coated bi-axial warp knitted fabric (BWKF). By utilizing the Digital Image Correlation technique, the experimental results are processed, and detailed responses of strain contours and Poisson’s ratios are determined for some specific strain levels, and an extraordinary M-shaped relationship between Poisson’s ratio and bias angle is revealed. Then, the tested Poisson’s ratios are compared with corresponding theoretical predictions from the original theory for ordinary anisotropic materials, discrepancies and their possible causes are analyzed. Finally, the original theory used for Poisson’s ratio predication of ordinary anisotropic materials is modified for application to the BWKFs by considering the unique local valley at 45 o caused by structural differences and possible yarn movements. The modified theoretical equation could exhibit the Mshaped relationship between Poisson’s ratio and bias angle, and is validated due to the high similarity between the predictions and experimental results. This investigation could provide some new insights into the orientation-dependence, Poisson’s effect and complex deformation mechanism of BWKFs.