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Vitaly Zhalimov,Yuliya Gritsyna,Oleg Morenkov 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.3
Adjuvants are often required to improve the potentially low immunogenicity of vaccines. In this study, it is proposed to use an emulsion based on fluorocarbons as an adjuvant. Since this emulsion adsorbs only a small range of proteins, apolipoprotein A-I (ApoAI) was used as an anchor. Antigen and ApoAI were combined by creating a fusion construct. Results showed that the combined use of a perfluorocarbon emulsion and ApoAI during immunization significantly increases the specific antibody titer in mice and in its effectiveness this system is close to the incomplete Freund’s adjuvant.
Primo Vascular Node in the Bone Marrow and Longevity
Vitaly Vodyanoy,Oleg Pustovyy,Ludmila Globa 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.1
Background: Intra-organic bone marrow node is predicted to be a part of the primo vascular system that plays a critical role in hematopoiesis and generation and regeneration of other cells. Two models of cell regeneration were suggested, one involving DNA synthesis and the other pertaining to DNA recycling. Objectives: The aim of this work is to extract a primo node from bone marrow, characterize its structure, understand its biochemistry and cell composition, and suggest a cell regeneration mechanism. Methods: Primo nodes were sampled from segmented halves of the rat femur. We used immunohistochemistry and high-resolution fluorescent microscopy to analyze 1200 samples obtained from 42 rats and 190 primo nodes. Results: Primo nodes in the bone marrow have an oval or round structure of about one millimeter in diameter, which is encompassed by a fine capsule, having incoming and outgoing vessels filled with the extracellular matrix and hematopoietic, mesenchymal, endothelial stem cells, as well as cells of the megakaryocyte family found in other primo nodes. Conclusion: Our findings imply that bone marrow nodes are intra-organic primo vascular nodes, and they provide ways and approaches for further investigation. Bone marrow nodes are simple to examine ex vivo in a variety of environments to assess cell regeneration mechanisms, wound healing, and organism rejuvenation and lifespan. Further research into these and other intra-organic nodes in animals and humans could lead to new regenerative medicine and longevity strategies that have yet to be discovered.
Low Latitude Plasma Blobs: A Review
Vitaly P. Kim,Valery V. Hegai 한국우주과학회 2016 Journal of Astronomy and Space Sciences Vol.33 No.1
In recent years, there has been renewed activity in the study of local plasma density enhancements in the low latitude F region ionosphere (low latitude plasma blobs). Satellite, all-sky airglow imager, and radar measurements have identified the characteristics of these blobs, and their coupling to Equatorial Plasma Bubbles (EPBs). New information related to blobs has also been obtained from the Communication/Navigation Outage Forecasting System (C/NOFS) satellite. In this paper, we briefly review experimental, theoretical and modeling studies related to low latitude plasma blobs.
Vitaly P. Kim,Valery V. Hegai 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.2
In this paper we study the transmission of the electrostatic field due to coulomb charges of an individual thundercloud into the midlatitude ionosphere, taking into account the total geomagnetic field integrated Pedersen conductivity of the ionosphere. It is shown that at ionospheric altitudes, a typical thundercloud produces an insignificant electrostatic field whereas a giant thundercloud can drive the horizontal electrostatic field with a magnitude of ~270 μV/m for nighttime conditions.
On the Variability of the Ionospheric F2-Layer During the Quietest Days in December 2009
Vitaly P. Kim,Valery V. Hegai 한국우주과학회 2016 Journal of Astronomy and Space Sciences Vol.33 No.4
December 2009 was one of the quietest (monthly Ap=2) months over the last eight decades. It provided an excellent opportunity to study the day-to-day variability of the F2 layer with the smallest contribution due to geomagnetic activity. With this aim, we analyze hourly values of the F2-layer critical frequency (foF2) recorded at 18 ionosonde stations during the magnetically quietest (Ap=0) days of the month. The foF2 variability is quantified as the relative standard deviation of foF2 about the mean of all the “zero-Ap” days of December 2009. This case study may contribute to a more clear vision of the F2-layer variability caused by sources not linked to geomagnetic activity. In accord with previous studies, we find that there is considerable “zero-Ap” variability of foF2 all over the world. At most locations, foF2 variability is presumably affected by the passage of the solar terminator. The patterns of foF2 variability are different at different stations. Possible causes of the observed diurnal foF2 variability may be related to “meteorological” disturbances transmitted from the lower atmosphere or/and effects of the intrinsic turbulence of the ionosphere-atmosphere system.
Vitaly P. Kim,Valery V. Hegai 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.2
In this paper we study the transmission of the electrostatic field due to coulomb charges of an individual thundercloud into the midlatitude ionosphere, taking into account the total geomagnetic field integrated Pedersen conductivity of the ionosphere. It is shown that at ionospheric altitudes, a typical thundercloud produces an insignificant electrostatic field whereas a giant thundercloud can drive the horizontal electrostatic field with a magnitude of ~270 μV/m for nighttime conditions.