http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
SIMON VANDER ELST,FILIP DE RYNCK 한국행정학회 2013 International Review of Public Administration Vol.18 No.2
This article assesses and explains the performance of the Belgian network of the Crossroads Bank for Enterprises (CBE), representing the mandated “network administrative organization form” (Kenis and Provan,2009). We address the following questions: To what degree is the mandated network able to reduce the complexity that arises from the fragmented nature of public service delivery? Does the hierarchical nature of the mandate help to obtain the desired production, process, and regime performance? What is the impact of the hybrid nature of the arrangement on the performance? Could this analysis help us to improve the performance assessment of types of networks? To cope with these questions, we apply the framework of Voets et al. (2010) to the case of the CBE. Although partly successful and effective, the network did not generate the desired outputs. Explanations for the lack of performance are found in the complex process of interacting network dimensions.
Marc Vander Ghinst,Myriam Remmelink,Anne-Laure Mansbach,Sergio Hassid,Georges Choufani 대한이비인후과학회 2012 Clinical and Experimental Otorhinolaryngology Vol.5 No.2
Objectives. There is a classical distinction based on clinical criteria between acquired and congenital cholesteatomas. To determine if these two types of lesions show different immunohistochemical features, we have studied the expression patterns of three distinctive galectins (animal lectins implied especially in cellular proliferation and apoptosis) in both types of cholesteatomas and compared it to their expression patterns in external auditory canal skin. Methods. Our study is based on nine acquired and eight congenital cholesteatomas, obtained from children during ear surgery. Six specimens of normal adult auditory meatal skin served as control. Specimens were analyzed by immunohistochemistry using monoclonal antibodies with galectin-1 and galectin-3, and a polyclonal antibody with galectin-7. Results. We did not observe any differences in the galectin distribution pattern between congenital and acquired pediatric cholesteatomas. Compared to the control group, cholesteatomas present some particular features. There was no expression of galectin-1 and a lower expression of galectin-3 in the epithelium. Furthermore, we observed a preferentially nuclear distribution of galectin-7 in cholesteatomas, whereas it is essentially cytoplasmic in the control group. Conclusion. The data reported in this study suggest, on the basis of a lesser marked galectin-3 in cholesteatomas epithelium compared with an external auditory canal skin, that an immature keratinocytes population is at the origin of these lesions and that galectin-3 and galectin-7 play a part in the capacity as apoptosis modulators. Our study does not establish a difference in the galectin expressions of congenital and acquired cholesteatomas, but it constitutes however an additional argument in favor of the “undifferentiated” origin of keratinocytes in cholesteatomas.
Why the fire ant drives basic and applied research
Robert K. Vander Meer 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04
Insect neuropeptides are involved in most physiological processes in insects, such as diuresis, ecdysis, and pheromone biosynthesis. The peptides perform these functions as ligands for G-protein coupled receptors (GPCRs) that trigger specific biochemical functions. Our research in this area has focused on the Pheromone Biosynthesis Activating Neuropeptide (PBAN) and its GPCR in fire ants. I will show that PBAN is involved in fire ant pheromone production and interestingly, also in important functions of all colony life stages. Since many neuropeptides play critical roles in insect development and reproduction, the peptide hormones and their receptors are viewed as promising targets for novel biologically-based control. These possibilities will be illustrated. Secondly, the use of venom alkaloids, cuticular hydrocarbons, and pheromones as useful taxonomic characters will be illustrated using Solenopsis species in the USA and in South America.
Robert A. Orlando,Amanda M.,Lucy A. Hunsaker,Carolina R.,Robert E. Royer,David L. Vander Jagt,Dorothy J. Vander Jagt 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a primary choice of therapy for diseases with a chronic inflammatory component. Unfortunately, long-term NSAID therapy is often accompanied by severe side effects, including cardiovascular and gastrointestinal complications. Because of this, there is critical need for identification of new and safer treatments for chronic inflammation to circumvent these side effects. Inflammatory diseases have been successfully remedied with natural herbs by many cultures. To better understand the potential of natural herbs in treating chronic inflammation and to identify their mechanism of action, we have evaluated the anti-inflammatory activities of 20 medicinal herbs commonly used in the Hispanic culture. We have established a standardized method for preparing aqueous extracts (teas) from the selected medicinal herbs and screened for inhibition of tumor necrosis factor-α-induced activation of nuclear factor κB (NF-κB), which is the central signaling pathway of the inflammatory response. A number of herbal teas were identified that exhibited significant anti-inflammatory activity. In particular, tea from the herb commonly called laurel was found to be an especially potent inhibitor of NF-κB-dependent cyclooxygenase-2 gene expression and prostaglandin E2 production in cultured murine macrophages. These findings indicate that laurel tea extract contains potent anti-inflammatory compounds that function by inhibiting the major signal transduction pathway responsible for inducing an inflammatory event. Based on these results, laurel may represent a new, safe therapeutic agent for managing chronic inflammation.
Effect of NH_4CI on NO_3Uptake and in vivo NR Activity Redbean Seedings
Kwon, Oh-Yong,Oh, Hee-Mock,Leo, Beek C. Vander 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.1
窒酸鹽을 亞窒酸으로 轉換시키는 最初 物質代謝過程은 暗發芽에서 窒酸鹽을 주어 植物을 培養하므로써 in vivo에서 쉽게 證明될 수 있다. 이러한 物質代謝過程에서 7일간 자라게 한 幼植物을 材料로 하여 NH_4Cl의 影響을 究明할 目的으로 NO_3^-吸收와 NRA를 測定하였다. NRA는 低濃度의 NH_4Cl(0.01mM)에 의해서 큰 減少現象(46%)을 보이나, 基質의 濃度가 極히 낮은 (0.01mM) 境遇에는 增加現象을 보이며, pH6.4에서 크게 나타났다. 뿌리와 Epicotyl에 存在하는 單位生體量當 NRA는 큰 差異가 없으나 뿌리 全體에 있는 NRA는 Epicotyl의 2∼3倍에 이른다. Ca(NO_3)_2 濃度에 따르는 NO_3^-吸收는 低濃度(0.1∼2.5mM)와 高濃度(5mM이상)에서 2가지 吸收樣相을 보이며, 低濃度에서 Km=1.41mM로 barley(Km=0.11mM)에 比해 작은 Affinity를 나타내고, NO_3^- efflux는 2.5mM NH_4Cl로 處理했을 때에 2時間 經過後 36%의 減少를 보였다. 結果的으로 低濃度의 NH_4Cl(0.01mM)에 의한 NO_3^- uptake의 增加는 NRA 誘導의 增加를 보이지 않았으며, 極히 낮은 基質濃度(0.01mM)에서 약간의 增加를 보였을 뿐이다. 이것은 NH_4Cl이 NO_3^- uptake와 NRA에 미치는 影響이 相互 別個의 것으로 推定된다.
Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations
Park, Ji Wan,McIntosh, Iain,Hetmanski, Jacqueline B,Jabs, Ethylin Wang,Kolk, Craig A Vander,Wu-Chou, Yah-Huei,Chen, Philip K,Chong, Samuel S,Yeow, Vincent,Jee, Sun Ha,Park, Beyoung Yun,Fallin, M Danie Springer Science and Business Media LLC 2007 Genetics in medicine Vol.9 No.4
Two New C-Glucosyl Benzoic Acids and Flavonoids from Mallotus nanus and Their Antioxidant Activity
Phan Van Kiem,Nguyen Thi Mai,Chau Van Minh,Nguyen Huu Khoi,Nguyen Hai Dang,Nguyen Phuong Thao,Nguyen Xuan Cuong,Nguyen Hoai Nam,Nguyen Xuan Nhiem,Yvan Vander Heyden,Joëlle Quetin-Leclercq,김교남,장해동,김영호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.2
Two new 2-C-β-D-glucopyranosyl benzoic acid derivatives named mallonanosides A (1) and B (2) were isolated from the methanolic extract of the leaves of Mallotus nanus along with five known flavonoids, kaempferin (3), juglanin (4), quercitrin (5), myricitrin (6), and rhoifolin (7). Their structures were established on the basis of spectral and chemical evidence. Their antioxidant activities were shown to depend on the number of hydroxyl groups, and the location and species of sugar moiety.