Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation InVivo

V?ronique, Calleja,Alcor, Damien,Laguerre, Michel,Park, Jongsun,Vojnovic, Borivoj,A.Hemmings, Brian,Downward, Julian,J.Parker, Peter,Larijani, Banafsh? 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

La question du genre et des TNIC au prisme du dialogue de la sociologie et de la sémiotique

Hélène Bourdeloie,Véronique Julliard 고려대학교 응용문화연구소 2013 에피스테메 Vol.0 No.9

This contribution studies the seniors’ practices in relation with Digital Information and Communication Technologies (DICT) and gendered identities that are built through these practices. We make the hypothesis that Sex is a determining factor and that Gender structures practices as well as representations. The authors congujate sociological and semiotic approaches upon two fields: firstly, two groups of persons over 60 years, which one has followed a training to DICT, secondly, the Social Networking Service (SNS) Quintonic. The study reveals that beyond gender divisions, the seniors’ practices make sense in the system of Gender-which distributes centers of interests between men and women-, participating in the construction of gendered identities. Furthermore, the SNS, because of their expressive dimensions, allow gender norms’ interpretations. These interpretations question gendered identities. Cette contribution étudie les pratiques des seniors liées aux technologies numériques de l’information et de la communication (TNIC) et les identités de genre qui s’élaborent via ces pratiques, l’hypothèse étant que le sexe est là un facteur déterminant et que le genre structure tant les pratiques que les représentations. Les auteures font ici dialoguer des approches sociologique et sémiotique sur deux terrains : deux groupes de seniors âgés de 60 ans, dont l’un a suivi une formation aux TNIC, et le réseau socionumérique (RSN) Quintonic. Il ressort de l’étude qu’au-delà de leur sexuation, les pratiques des seniors prennent sens dans le système du genre-qui distribue les centres d’intérêt entre les sexes-, et participent à la construction des identités de genre. Par ailleurs, certaines TNIC, telles qu’un RSN, de par leurs dimensions éditoriale et expressive, donnent lieu à des interprétations des normes de genre, interprétations susceptibles de redessiner les identités de genre traditionelles.

Relevant design parameters for a reactor used in P removal with ZVI-based materials

Pauline Lanet,Véronique Deluchat,Michel Baudu 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-

Phosphate (P) retention onto zero valent iron (ZVI) particles and on iron oxyhydroxides has been widelyinvestigated as a treatment process for domestic wastewater. Since such a process is less expensive andrequires less maintenance than typical biological and physicochemical methods, it could provide a viablepath to reaching high P removal capacities. This manuscript provides up-to-date information on P retentionmechanisms, with the main ones being adsorption, precipitation and co-precipitation. The majorexperimental parameters affecting these mechanisms and ZVI reactivity are summarized. Through areview of batch studies and continuous reactor experiments, the P retention capacities of ZVI-basedmaterials have been collated and compared according to test operating conditions, such as pH, initialadsorbate concentrations or hydrodynamic conditions. ZVI and its byproducts have already demonstratedhigh P retention capacities (up to 264 mg P/g ZVI). Methodological recommendations are providedto design reactor for phosphorus removal in wastewater treatment plants.

Safety Results and Analysis of Eribulin Efficacy according to Previous Microtubules-Inhibitors Sensitivity in the French Prospective Expanded Access Program for Heavily Pre-treated Metastatic Breast Cancer

Renaud Sabatier,Véronique Diéras,Xavier Pivot,Etienne Brain,Henri Roché,Jean-Marc Extra,Audrey Monneur,Magali Provansal,Carole Tarpin,François Bertucci,Patrice Viens,Christophe Zemmour,Anthony Gonçalv 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose Eribulin is approved for advanced breast cancers refractory to anthracyclines and taxanes. Efficacy according to sensitivity to previous therapies has been poorly explored. Materials and Methods Safety data were collected prospectively and we retrospectively collected efficacy data from the five French centres that participated in the Eribulin E7389-G000-398 expanded access program. Our main objectives were exploration of safety and analysis of eribulin efficacy (progression- free survival [PFS] and overall survival [OS]) according to sensitivity to the last microtubule-inhibiting agent administered. Results Median eribulin treatment duration was 3.3 months for the 250 patients included in this prospective single-arm study. Two hundreds and thirty-nine patients (95.6%) experienced an adverse event (AE) related to treatment including 129 (51.6%) with grade  3 AEs. The most frequently observed toxicities were cytopenias (59.6% of included patients), gastrointestinal disorders (59.2%), and asthenia (56.4%). The most frequent grade 3-4 AE was neutropenia (37.2% with 4.8% febrile neutropenia). Median PFS and OS were 4.6 and 11.8 months, respectively. Patients classified as responders to the last microtubule-inhibiting therapy had a longer OS (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.51 to 0.94; p=0.017), and tended to display a better PFS (HR, 0.78; 95% CI, 0.58 to 1.04; p=0.086). OS improvement was still significant in multivariate analysis (adjusted HR, 0.53; 95% CI, 0.35 to 0.79; p=0.002). Conclusion This work based on a prospective study suggests that identification of patients likely to be more sensitive to eribulin could be based on their previous response to microtubules inhibitors.

Genome of Bifidobacteria and Carbohydrate Metabolism

Pauline Bondue,Véronique Delcenserie 한국축산식품학회 2015 한국축산식품학회지 Vol.35 No.1

In recent years, the knowledge about bifidobacteria has considerably evolved thanks to recent progress in molecular biol-ogy. The analysis of the whole genome sequences of 48 taxa of bifidobacteria offers new perspectives for their classifica-tion, especially to set up limit between two species. Indeed, several species are presenting a high homology and should bereclassified. On the other hand, some subspecies are presenting a low homology and should therefore be reclassified intodifferent species. In addition, a better knowledge of the genome of bifidobacteria allows a better understanding of the mech-anisms involved in complex carbohydrate metabolism. The genome of some species of bifidobacteria from human but alsofrom animal origin demonstrates high presence in genes involved in the metabolism of complex oligosaccharides. Thosespecies should be further tested to confirm their potential to metabolize complex oligosaccharides in vitro and in vivo.

18F-FDG PET/CT Imaging of Peritoneal Fibrosis Mimicking Persistent Metastatic Ovarian Carcinoma

Leroy-Freschini Benjamin,Lindner Véronique,Boisramé Thomas,Demarchi Martin 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.5

A 65-year-old woman was addressed for clinical and biological suspicion of ovarian cancer relapse. 18F-FDG PET/CT revealed massive peritoneal carcinomatosis. Post-chemotherapy PET/CT showed complete metabolic response in initial localizations albeit three new 18F-FDG uptakes appeared in the mesentery and in the retro-hepatic space. Close follow-up (including PET/ CT scan) and surgical examination of the abdominal cavity confirmed the absence of malignancy and the benign nature of these lesions, which appeared to be peritoneal fibrosis mimicking persistent carcinomatosis.

Les carrières «motiles» en univers bureaucratique : le cas des administrateurs territoriaux

Hae-Ok Pyun,Frank Bournois,Véronique Chanut 한국정부회계학회 2015 정부회계연구 Vol.13 No.2

2008년과 2011년 글로벌 금융위기 이후 조직 형태 및 고용관계가 많은 변화를 겪고 있 다. 이로 인해 기존의 경력보다는 유동적인 경력 (motile carear)현상이 두드러진다. Arthur와 Rousseau (The boundaryless career, 1996)가 주장한 조직 형태가 사회 환경 의 영향을 받는 것과 같이 경력 형태도 조직 형태의 영향을 받는다고 주장하고 있다. 다시 말해 사회 환경이 불안정하면 할수록, 조직 형태가 관료형태보다는 좀더 유동적인 형태를 취하게 되고, 조직 형태가 유동적이면 유동적일 수로, 구성원의 경력 형태도 더욱 더 유동 적이 된다. 그러나, 본 연구에서는 Arthur와 Rousseau의 기존 연구와 달리 조직 형태가 관 료적임에도 불구하고 구성원들의 경력이 유동적이라는 점을 제시하고 있다. 함축하면 관료 조직에서도 유동적 경력이 있을 수 있다는 것이다. Depuis les années 1970 et surtout les crises 2008 et 2011, l’environnement socio-économique transforme les formes organisationnelles et tout particulièrement, les relations entre salariés et employeurs. Il en résulte, entre autres, la mise en cause des carrières traditionnelles au profit de différentes formes de carrières, notamment des carrières motiles. Pour Arthur, Rousseau et al. (The boundaryless career, 1996), la diversification des formes de carrières est liée à celle des formes organisationnelles et les carrières motiles concernent le plus souvent l’organisation organique. Grâce au soutien de l’Association des Administrateurs Territoriaux de France, notre étude sur 1 125 parcours professionnels d’administrateurs territoriaux démontre que ce phénomène touche également l’organisation bureaucratique.

Dynamics and diversity of mosquito vectors of Japanese encephalitis virus in Kandal province, Cambodia

Sebastien Boyer,Borin Peng,Senglong Pang,Véronique Chevalier,Veasna Duong,Christopher Gorman,Philippe Dussart,Didier Fontenille,Julien Cappelle 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.4

The Japanese encephalitis virus (JEV) is one of the main causes of encephalitis in Asia, including Cambodia. An understanding of the interactions between JEV hosts and vectors (Diptera: Culicidae) remains rare in the context of expanding urbanization. The relative abundance, species diversity and population dynamics of potential JEV vectors were studied between August 2015 and July 2016 on a peri-urban and rural pig farm in Kandal province, Cambodia, where JEV is circulating. Five similar environments in the two farms were selected for mosquito trapping: pig farm, cattle house, river/canals, household/ponds and paddy fields. The main objective was to describe the distribution and the dynamics of the main JEV vector mosquito species. In total, 83,013 mosquitoes from 20 species were caught in rural and peri-urban areas, and 82.3% of the mosquitoes were potential JEV vector species. In peri-urban areas, Culex (Cx.) gelidus was the most abundant species, followed by Cx. vishnui subgroup and Cx. tritaeniorhynchus. In rural areas, the same species were dominant: Cx. vishnui subgroup, Cx. gelidus and Cx. tritaeniorhynchus. The vast majority of mosquitoes (95.9%) were collected in close proximity to pigs and cattle. In conclusion, JEV vectors were present at all study sites and throughout all months of the year, supporting a continuous circulation of JEV in Cambodia.

Elderly CADASIL patients with intact neurological status

Ruiting Zhang,Elisa Ouin,Lina Grosset,Karine Ighilkrim,Jessica Lebenberg,Stéphanie Guey,Véronique François,Elisabeth Tournier-Lasserve,Eric Jouvent,Hugues Chabriat 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.3

Background and Purpose Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most devastating cerebral small vessel diseases. However, despite its progression with aging, some patients remain neurologically intact (Nint) even when they get older. Their main characteristics are poorly known. We aimed to delineate their clinical, imaging, and molecular features. Methods Individuals aged over 65 years were selected from a cohort of 472 CADASIL patients. Subjects who had no focal deficit, cognitive impairment, or disability were considered Nint. Their demographic, genetic, clinical, and imaging features were compared to those with permanent neurological symptoms (Nps). Results Among 129 patients, 23 (17.8%) individuals were considered Nint. The frequency of vascular risk factors and NOTCH3 cysteine mutations in epidermal growth factor-like repeat (EGFr) domains 7-34 did not differ between Nint and Nps patients but Nint patients had less stroke events and were more likely to have migraine with aura. The number of lacunes and microbleeds and degree of brain atrophy were lower in the Nint group, but the volume of white matter hyperintensities did not differ between the two groups. Conclusions Nearly one in five CADASIL patients can remain Nint after the age of 65 years. Their clinical and imaging profile differed from that of other age-matched CADASIL patients. The location of NOTCH3 mutation inside or outside EGFr domains 1-6 cannot fully explain this discrepancy. The factors involved in their relative preservation of brain tissue from severe damage despite aging remain to be determined.

Combined Measures of Psychomotor and Cognitive Alterations as a Potential Hallmark for Bipolar Depression

Alison Robin,Anne Sauvaget,Thibault Deschamps,Samuel Bulteau,Véronique Thomas-Ollivier 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.12

Objective The current study aimed to examine whether specific features of psychomotor retardation (PMR) and cognitive functioning established different profiles in unipolar (UD) and bipolar depression (BD). Methods Two groups of age-matched patients with UD (n=54) and BD (n=20) completed the Montgomery-Asberg Depression Rating Scale (MADRS/60), the Montreal Cognitive Assessment (MoCA/30), and the Salpêtrière Retardation Rating Scale (SRRS/60). We analyzed the group effect and then performed intra-group analyses. Results The BD patients have higher SRRS score, and lower MoCA score than UD despite no difference on the level of depression between UD and BD. Our results show that PMR can be predicted by the level of depression in UD and by the cognitive alteration and onset of disease in BD. Conclusion PMR is a relevant marker of depression. Our results highlight the importance of concomitant evaluation of psychomotor and cognitive functions in the distinction of UD and BD symptoms.