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Determination of Chemical Structures of Biologically Active Substances
Masakazu Uramoto 건국대학교 동물자원연구센터 1992 국제 심포지움 Vol.- No.3
Recently, techniques in structure determination of organic compounds by utilization of instrumental analyses have been developed remarkably. Especially, nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) have been used as powerful tools for structure analysis. Various measuring techniques in NMR and MS, which were utilized for the structure analysis of bio-active microbial metabolites, were described. It was shown that appropriate application of instrumental measurement was important in each situation of the procedure of the structure analysis.
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Takeda, Koichi,Watanabe, Hideo,Uramoto, Naohiko,Nomiyama, Hiroshi,Matsuzawa, Hirofumi,Nasukawa, Tetsuya,Nagano, Tohru,Murakami, Akiko,Takeuchi, Hironori,Kanayama, Hiroshi,Kobayashi, Mei,Aono, Masaki,I 한국정보처리학회 2004 정보처리학회지 Vol.11 No.2
Malignant Melanoma of the Nipple: A Case Report
Yoshika Nagata,Manabu Yoshioka,Hidetaka Uramoto,Yosuke Tsurudome,Sohsuke Yamada,Takeshi Hanagiri,Fumihiro Tanaka 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1
Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy. We herein report a patient who underwent surgical resection of a primary malignant melanoma of the nipple. An elastic soft nodule was observed on the left nipple, and no abnormal lesions were identified in the breast. Eventually, a malignant melanoma was diagnosed from the clinical and cytological evaluation findings. This bulky tumor was classified as a stage IIIC nodular melanoma, with a thickness of 12 mm. The patient received adjuvant chemotherapy and exhibits no evidence of recurrence 7 years after surgery.
Machida, Yuichiro,Sagawa, Motoyasu,Tanaka, Makoto,Motono, Nozomu,Matsui, Takuma,Usuda, Katsuo,Uramoto, Hidetaka Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10
Background: The Glasgow Prognostic Score (GPS) is calculated from measured CRP and albumin levels. We here evaluated the significance of the GPS in patients with resected pulmonary adenocarcinoma. Materials and Methods: The present study included 156 patients with lung adenocarcinoma who underwent lobectomy at Kanazawa Medical University between 2002 and 2012. Classification was into three groups: those with normal albumin (>=3.5 g/dl) and C-reactive protein (CRP) (<=1.0 mg/dl) levels were classified as GPS 0 (n =136), those with low albumin (<3.5 g/dl) or elevated CRP (>1.0 mg/dl) levels as GPS 1 (n = 16), and those with low albumin (<3.5 g/dl) and elevated CRP (>1.0 mg/dl) levels as GPS 2 (n = 4). We retrospectively investigated relationships between the patient characteristics including the GPS, and disease-free survival and cancer-specific survival. Results: The pathological stages of the patients were as follows: IA (n=78, 50%), IB (n=31, 19.9%), IIA (n=20.0, 12.8%), IIB (n=9.0, 5.7%), and IIIA (n=18.0, 11.5%). Lobectomy was performed in all cases. The average GPS was 0.15 (0-2) and showed significant relationships with stage and tumor size. The 2-year survival rates in patients with GPS0, 1 and 2 were 81.4%, 38.4%, and 25.0%, respectively. Clear correlations were noted with both cancer-specific survival and disease-free survival. Furthermore, multivariate analysis revealed that GPS was a significant prognostic factor. Conclusions: The GPS could be a prognostic factor for patients with resected pulmonary adenocarcinoma.
The Structure Determination of a Herbicidal Compound, 3D5
Kim, Shin Duk,Ryoo, In Ja,Kim, Chang Jin,Uramoto, Masakazu,Yoo, Ick Dong 한국미생물 · 생명공학회 1993 Journal of microbiology and biotechnology Vol.3 No.1
The structure of herbicidal compound, 3D5, isolated from the culture broth of Streptomyces sp. 3D5, was elucidated as a 16-membered diene macrolide by the spectroscopic method. It was identical with bafilomycin D which has been known to be an insecticidal compound and an inhibitor of K^+-dependent ATPase. However, this is the first report which shows that bafilomycin D has a herbicidal activity.
박동진,이상화,박해룡,권오성,박상호,여수환,우라모토 마사카즈,김창진 한국산업미생물학회 2000 한국미생물·생명공학회지 Vol.28 No.3
Different actinomycete strains were isolated from natural lime caves of Ondal, Cheongok, Hwanseon and Yongyeon, which are located at Kangwon or Chungcheongbook province in Korea, and were identified to the genus level. Soil samples were collected at 6 sites inside and 2 sites outside of each natural lime cave. As the result, the strains belonging to genus Streptomyces and rare actinomycetes were isolated at the average of 2.1 and 3.4 strains per g soil on inside cave, whereas, which were isolated at the 6.0 and 1.8 strains per g soil on outside cave. However, the generic distribution of Streptomyces and rare actinomycetes isolated from outside cave was quite different from that of inside cave. It was shown that rare actinomycetes at natural lime caves is generally highly abundant than Streptomyces.