http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kang, Unwoo,Han, Ah-Reum,So, Yangkang,Jin, Chang Hyun,Ryu, Seung Mok,Lee, Dongho,Seo, Eun Kyoung American Society of Pharmacognosy 2019 Journal of natural products Vol.82 No.9
<P>Five new furanocoumarins, dahuribirin H (<B>1</B>), dahuribirin I (<B>2</B>), (2′<I>S</I>)-(+)-5-(2′-hydroxy-3′-methylbut-3′-enyloxy)-8-(3′′-methylbut-2″-enyloxy)psoralen (<B>3</B>), (2′<I>R</I>)-(+)-5-(2′,3′-epoxy-3′-methylbutoxy)-8-(3″-methylbut-2″-enyloxy)psoralen (<B>4</B>), and 5-methoxy-8-((<I>Z</I>)-4′-(3″-methylbutanoate)-3′-methylbut-2′-enyloxy)psoralen (<B>5</B>), along with 15 known compounds (<B>6</B>-<B>20</B>), were isolated from the roots of <I>Angelica dahurica</I>. The structures of the new compounds were elucidated by spectroscopic analysis, along with electronic circular dichroism calculations and Mosher ester analysis. Compounds <B>3</B>, <B>4</B>, <B>11</B>, <B>13</B>, and <B>16</B> reduced H<SUB>2</SUB>O<SUB>2</SUB>-induced cell death in HepG2 cells and attenuated reactive oxygen species (ROS) formation without showing cytotoxicity, suggesting that these compounds might have cytoprotective effects against H<SUB>2</SUB>O<SUB>2</SUB>-induced oxidative damage via ROS scavenging activities.</P> [FIG OMISSION]</BR>
Lee, Joohee,Kang, Unwoo,Seo, Eun Kyoung,Kim, Yeong Shik Elsevier 2016 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.34 No.-
<P><B>Abstract</B></P> <P>The dried flower buds of <I>Tussilago farfara</I> L. have been used in traditional medicine, mainly as an antitussive in the treatment of cough and other respiratory problems. In the present study, we investigated the anti-inflammatory signaling pathway via the upregulation of heme oxygenase-1 (HO-1) in response to tussilagonone (TGN), a sesquiterpene compound isolated from <I>T. farfara</I>. TGN induced HO-1 expression and nuclear factor-E2-related factor 2 (Nrf2) activation in RAW 264.7 cells. Nuclear translocation of Nrf2 by TGN also increased in a time- and dose-dependent manner, indicating that TGN induced HO-1 via the Nrf2 pathway. Consistent with the notion that HO-1 has anti-inflammatory properties, TGN suppressed inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and reduced the mRNA expression of proinflammatory cytokines, as well as nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. TGN inhibited the phosphorylation and degradation of inhibitory κB-α (IκB-α) and the nuclear translocation of nuclear factor (NF)-κB. However, a specific inhibitor of HO-1 reversed the TGN-mediated suppression of NO production and knockdown of HO-1 by small interfering RNA abrogated inhibitory effects of TGN on iNOS and COX-2 protein expression and NF-κB nuclear translocation. Furthermore, TGN reduced iNOS and COX-2 expression in a 12-<I>O</I>-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation mouse model. Taken together, these findings suggest an important role for TGN-induced HO-1 activation in regulating inflammatory responses. Moreover, TGN is a potent therapeutic candidate for targeting the crosstalk between Nrf2/HO-1 and the NF-κB signaling pathway in the prevention or treatment of inflammation-associated diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TGN up-regulates HO-1 expression via Nrf2 activation. </LI> <LI> TGN inhibits LPS-induced inflammatory responses. </LI> <LI> TGN suppresses LPS-stimulated activation of the NF-κB pathway. </LI> <LI> HO-1 induction contributes to the anti-inflammatory properties of TGN. </LI> <LI> TGN exerts anti-inflammatory effects in TPA-induced skin inflammation in mice. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Pyun, Haejun,Kang, Unwoo,Seo, Eun Kyoung,Lee, Kyunglim Elsevier 2018 Phytomedicine Vol.43 No.-
<P>Conclusion: DCL's therapeutic potential in allergic airway inflammation is based on its anti-inflammatory activity of suppressing the function of dTCTP.</P>
Identification of a New Fatty Acid from the Seeds of Coix lachryma-jobi var. ma-yuen
Han, Ah-Reum,Kil, Yun-Seo,Kang, Unwoo,Youn, I-Soo,Choi, Goeun,Lee, Yoo Jin,Nam, Joo-Won,Lee, Je-Hyun,Hong, Jongki,Lee, Sang Kook,Seo, Eun-Kyoung Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.4
A new secoiridoid glycoside from the fruits of <i>Cornus officinalis</i> (Cornaceae)
Park, Ji-Yeon,Han, Ah-Reum,Kil, Yun-Seo,Kang, Unwoo,Kim, Se-Hee,Nam, Sang-Jip,Seo, Eun Kyoung Taylor & Francis Health Sciences 2016 NATURAL PRODUCT RESEARCH Vol.30 No.13
<P>A new secoiridoid glycoside, 7-O-dimethyl butanedioate morroniside (1) was isolated from the fruits of Cornus officinalis (Cornaceae) along with the known compound, caffeoyltartaric acid dimethyl ester (2) which was isolated from the family Cornaceae for the first time. Their structures were elucidated by physical and spectroscopic data analysis, including 1D and 2D NMR, ESI-MS and CD experiments. [GRAPHICS] .</P>