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RISS 인기검색어
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- 저자 : Uebaba, (검색결과 3 건)
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Effect of Kampo Formulations on Visual Evoked Potentials
Uebaba,Kazuo,Cyong,Jong Chol,Xu,Feng Hao 慶熙大學校韓醫科大學韓醫學硏究所 1998 慶熙韓醫大論文集 Vol.21 No.1
For the assesslllent of pharmacological actions of Kampo formulation on cerebral higher function, visual evoked potentials(VEP) were measured before and after administration of 6 main Kampo formulation to 7 healthy male adults. As result, Mao-to induced a progressive significant prolongation of latency of P100 and continuous decrease of amplitude of N145(p<0.005 bypaired t-test same as following chages), while Shinbu-to induced time dependent significant prolongation of latency of N145 and transient decrease of amplitude of P100 and N145 at 60 minutes after administration. Shigyaku-san induced prolongation of latency of both of N75 and P100, transient decrease of N75 and continuous decrease of P100. Keishi-to showed a progressive prolongation of latency of P100, while Ninjin-to showed neither significant changes of latency or amplitude. Mao-to, Keishi-to, Shigyaku-san and Shinbu-to showed significant prolongation of latency, while Shimotu-to and Ninjin-to showed nonsignificant change of latency of VEP. Furthermore, Mao-to showed a progressive significant decrease of amplitude of VEP, in turn Shinbu-to showed a progressive significant increase, while Ninjin-to and Keishi-to showed no change of these parameters of VEP.
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박찬흠,노성수,송영옥,노정숙,Kazuo Uebaba,Takako Yokozawa,Feng Hao Xu 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.3
This study was conducted to compare the protective effects of astaxanthin (ASX) with Corni Fructus (CF) against diabetes-induced pathologies such as oxidative stress-induced inflammation and advanced glycation end product (AGE) formation in the liver of type 1 diabetic rats. ASX (50 mg/kg body weight/day) or CF (200 mg/kg body weight/day) was orally administered every day for 18 days to streptozotocin (STZ)-induced diabetic rats, and their effects were compared with nondiabetic and diabetic control rats. The administration of CF, but not ASX, decreased both the elevated serum and hepatic glucose concentration in diabetic rats. In diabetic rats, increased levels of AGE, reactive oxygen species, and lipid peroxidation were significantly decreased by treatment with both ASX and CF in the liver of diabetic rats. STZ treatment markedly augmented the protein expressions of AGE, and both ASX and CF efficiently attenuated these increases in hepatic protein expressions. In addition, oxidative stress and proinflammatory protein expressions were upregulated in the diabetic rats. On the contrary, these upregulations of protein expressions were decreased by the administration of ASX or CF. These results suggest that the inhibitory effect of ASX on diabetes-induced hepatic dysfunction could be derived from the blocking of AGE formation and further anti-inflammation and that CF exhibited beneficial effects through the attenuation of hyperglycemia, and thus the inhibition of AGE formation and the inflammatory responses. Therefore, ASX as well as CF may help prevent ongoing diabetes-induced hepatic injury.
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Suzuki, Nobutaka,Takimoto, Yuko,Suzuki, Riho,Arai, Takanari,Uebaba, Kazuo,Nakai, Masuo,Strong, Jeffry Michael,Tokuda, Harukuni Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Extract of Lentinula edodes mycelia (LEM) is currently utilized as an oral biological response modifier (BRM) medicine for cancer patients. However, its effectiveness for breast cancer patients with postoperative adjuvant hormone therapy has not yet been scientifically verified. In this study, we investigated the influence of LEM on the quality of life (QOL) and immune response in breast cancer patients undergoing postoperative adjuvant hormone therapy. Twenty patients were studied in total. They received only hormone therapy in the first 4 weeks followed by hormone therapy and LEM during the next 8 weeks. Laboratory tests, QOL score and peripheral blood cytokine production levels were evaluated during the study period. No changes in QOL or cytokines were noted after the first 4 weeks. In contrast, during the following combined therapy period, improvements were noted in QOL and cytokine levels. Although a future large-scale investigation is necessary to confirm these results, these data suggest that the concomitant use of LEM with postoperative adjuvant hormone therapy improves the QOL and immune function of patients.
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