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Level of Self-Efficacy of Science Teachers Towards Engaging Students
Upadhyaya, Indra Raj Education Research Institute Chungbuk National Uni 2019 한국교육논총 Vol.40 No.2
The study aimed at investigating the level of self-efficacy of science teachers towards student engagement. Although the general self-efficacy of teachers has been explored a lot but the efficacy of science teacher has not been explored more and student engagement is crucial towards understanding of science concepts. Therefore, the main purpose of the study was to find the self-efficacy of science teachers mainly towards three dimensions of student engagement (Behavioral, Cognitive and Emotional engagement). The study was carried with 150 secondary science teachers as Kathmandu. Secondary science teachers were found to be moderately high efficacious in all aspects of behavioral engagement of students except four aspects in which they showed moderate efficacy. Regarding the self-efficacy on cognitive engagement they were moderately efficacious in two aspects and were found to be moderately high efficacious in other all aspects. However, science teachers' self-efficacy was found to be moderately high. Teachers were found to be efficacious in making clasroom constructive, developing collaborative skill and high order thinking among the students. However in some aspects they were found less efficacious.
Cell Cycle Regulation and Induction of Apoptosis by β-carotene in U937 and HL-60 Leukemia Cells
Upadhyaya, K.R.,Radha, K.S.,Madhyastha, H.K. Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.6
In this communication, we report the efficacy of $\beta$-carotene towards differentiation and apoptosis of leukemia cells. Dose ($20{\mu}M$) and time dependence (12 h) tests of $\beta$-carotene showed a higher magnitude of decrease (significance p < 0.05) in cell numbers and cell viability in HL-60 cells than U937 cells but not normal cell like Peripheral blood mononuclear cell (PBMC). Microscopical observation of $\beta$-carotene treated cells showed a distinct pattern of morphological abnormalities with inclusion of apoptotic bodies in both leukemia cell lines. When cells were treated with $20{\mu}M$ of $\beta$-carotene, total genomic DNA showed a fragmentation pattern and this pattern was clear in HL-60 than U937 cells. Both the cell lines, on treatment with $\beta$-carotene, showed a clear shift in $G_1$ phase of the cell cycle. In addition the study also revealed anti-oxidant properties of $\beta$-carotene since there was reduction in relative fluorescent when treated than the control at lower concentration. Collectively this study shows the dual phenomenon of apoptosis and differentiation of leukemia cells on treatment with $\beta$-carotene.
Upadhyaya, Chandrama Prakash,Venkatesh, Jelli,Gururani, Mayank Anand,Asnin, Leonid,Sharma, Kavita,Ajappala, Hemavathi,Park, Se Won Kluwer Academic Publishers 2011 Biotechnology letters. Vol.33 No.11
<P>Salt-tolerance was studied in transgenic potato. It was conferred by overexpression of ascorbate pathway enzyme (D-galacturonic acid reductase, GalUR). As genetic engineering of the GalUR gene in potato enhances its ascorbic acid content (L-AsA), and subsequently plants suffered minimal oxidative stress-induced damage, we now report on the comprehensive aptness of this engineering approach for enhanced salt tolerance in transgenic potato (Solanum tuberosum L. cv. Taedong Valley). Potatoes overexpressing GalUR grew and tuberized in continuous presence of 200 mM of NaCl. The transgenic plants maintained a higher reduced to oxidized glutathione (GSH:GSSG) ratio together with enhanced activity of glutathione dependent antioxidative and glyoxalase enzymes under salinity stress. The transgenics resisted an increase in methylglyoxal that increased radically in untransformed control plants under salinity stress. This is the first report of genetic engineering of ascorbate pathway gene in maintaining higher level of GSH homeostasis along with higher glyoxalase activity inhibiting the accumulation in methylglyoxal (a potent cytotoxic compound) under salt stress. These results suggested the engineering of ascorbate pathway enzymes as a major step towards developing salinity tolerant crop plants.</P>
Upadhyaya, Jitendra,Kim, Min-Ji,Kim, Young-Hoi,Ko, Sung-Ryong,Park, Hee-Won,Kim, Myung-Kon The Korean Society of Ginseng 2016 Journal of Ginseng Research Vol.40 No.2
Background: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. In this work, enzymatic hydrolysis of ginsenoside Rb1 was studied using enzyme preparations from cultured mycelia of mushrooms. Methods: Mycelia of Armillaria mellea, Ganoderma lucidum, Phellinus linteus, Elfvingia applanata, and Pleurotus ostreatus were cultivated in liquid media at $25^{\circ}C$ for 2 wk. Enzyme preparations from cultured mycelia of five mushrooms were obtained by mycelia separation from cultured broth, enzyme extraction, ammonium sulfate (30-80%) precipitation, dialysis, and freeze drying, respectively. The enzyme preparations were used for enzymatic hydrolysis of ginsenoside Rb1. Results: Among the mushrooms used in this study, the enzyme preparation from cultured mycelia of A. mellea (AMMEP) was found to convert ginsenoside Rb1 into compound K with a high yield, while those from G. lucidum, P. linteus, E. applanata, and P. ostreatus produced remarkable amounts of ginsenoside Rd from ginsenoside Rb1. The enzymatic hydrolysis pathway of ginsenoside Rb1 by AMMEP was $Rb1{\rightarrow}Rd{\rightarrow}F2{\rightarrow}$ compound K. The optimum reaction conditions for compound K formation from ginsenoside Rb1 were as follows: reaction time 72-96 h, pH 4.0-4.5, and temperature $45-55^{\circ}C$. Conclusion: AMMEP can be used to produce the human intestinal bacterial metabolite, compound K, from ginsenoside Rb1 with a high yield and without food safety issues.
Kumud Upadhyaya,Priya Kumari Sharma,Ansab Akhtar,Sangeeta Pilkhwal Sah 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.6
Ginger contains zingerone, an active constituent possessing antioxidant and neuroprotective properties. The present study was designed to explore the efficacy of the bioactive compound, zingerone, for treating behavioral and biochemical alterations in rats exposed to chronic restraint stress (CRS). Female Wistar rats were administered zingerone (25, 50, and 100 mg/kg p.o.) once daily for a period of 28 days while being exposed to CRS (6 h/day). Our results indicated that the stressed animals depicted depression-like behavior (reduced sucrose preference and increased immobility time) associated with increased lipid peroxidation (LPO) (cortex), decreased catalase (CAT) (hippocampus and cortex), and increased superoxide dismutase (SOD) (hippocampus and cortex). In addition, metabolic alterations were characterized by hyperglycemia and increased glycosylated hemoglobin in the CRS rats. However, no alterations were observed for learning and memory and in the levels of reduced glutathione. Repeated zingerone administration significantly reversed depression-like behavior elicited by CRS in rats. Furthermore, a significant antioxidant effect was exhibited by zingerone, as shown by decreased LPO and enhanced activity of SOD and CAT in chronically stressed rats. The findings of our study demonstrated that zingerone possesses protective actions against chronic stress-induced depressive-like behavioral, biochemical, and metabolic alterations and that its underlying mechanism may be attributed to its antioxidant properties. The results also signify its pharmacological and possible nutritional importance.
A Survey - Energy Efficient Routing Protocols in MANET
Jyoti Upadhyaya,Nitin Manjhi 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.5
The field of mobile ad hoc network (MANETs) has gained an important of the researchers and become very popular in last year’s. Mobile Ad hoc networks is a network that can change locations and configure itself; as it is infrastructure less and have no central administration. MANET nodes are mobile and battery powered and has limited energy resources. Life of nodes is directly proportional to the battery in the device operating at the node. Minimize energy consumption and maximize life of network is still an immerging issue of MANET. In order to enhance the lifetime of the Ad hoc network; various energy efficiency techniques are needed. This paper presents a survey on energy efficient routing protocols. These algorithms and methodologies modify routing protocol in order to reduce energy consumption and maximize life of network. These proposed methodologies also minimize energy consumption by selecting an energy efficient route.