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장우익 ( Jang U Ig ),안강현 ( An Gang Hyeon ),이종인 ( Lee Jong In ),김현수 ( Kim Hyeon Su ),김효열 ( Kim Hyo Yeol ),김수경 ( Kim Su Gyeong ),이동기 ( Lee Dong Gi ),배선우 ( Bae Seon U ),심영학 ( Sim Yeong Hag ),강명서 ( Kang Myeo 대한내과학회 1993 대한내과학회지 Vol.44 No.4
연구배경 : 종양표지자는 암외 진단, 임상적 병기구분 및 치료효과 판정에 유용하며, 위장관암에서 alphafetoprotein, carcinoembryonic antigen, CA 19-9, 및 CA 72-4 등이 중요한 지표로 사용되고 있으나 위암의 경우, 현재까지 만족할 만한 유용성을 가진 종양표지자는 없는 실정이다. 저자등은 위암에 대한 새로운 종양표지자로 CA 125의 역할을 규명하고자 위암을 비롯한 각종 위장관암에서 CA 125와 기존의 종양표지자와의 유용성을 검토하였다. 방법 : 대상은 위장관 악성종양 181예, 위장관 양성질환자 55예를 대상으로 하였으며 CA 72-4는 CIS ELSA CA 72-4 RIA kit, CA 19-9는 Abbott CA 19-9 RIA kit, CEA는 Abbott CEA kit, CA 125는 Centocor CA 125 RIA kit를 사용하여 측정하였으며, 각각의 정상치 한계는 4 U/ml, 37 U/ml, 5ng/ml그리고 35 U/ml로 하였다. 결과 : 1) CA 125는 양성 소화기 질환에서 93%의 높은 특이도를 보였으나 복수가 있는 간경변증의 경우 거의 전예에서 혈중 CA 125값이 증가하여 악성종양군과 감별이 어려웠다. 2) CA 125는 위암에서 민감도가 36%로 CA 72-4와 차이가 없었다. 3) CA 125는 췌담도암에 대한 민감도가 55%로 CA 19-9의 85%에 비해 낮았으며 두 종양표지자를 병합하여 사용한 경우 민감도의 증가(95%)를 볼 수 있었다. 4) 23예의 조기위암 환자에서 CA 125의 민감도는 9%로 낮았다. 5) Conventional image study 상으로 인지되지 않은 복강내 암종증 환자에 대한 CA 125의 민감도는 36%였다. 결론 : CA 125는 위암에서 기존의 종양표지자인 CA 72-4와 유용성의 차이를 보이지 않았으며 전이성 위암에서 높은 민감도를 나타내었다. 혈중 CA 125의 증가는 위장관의 악성 및 양성질환에 관계없이 복수의 유무와 밀접한 연관관계를 가지는 것으로 사료되며 통상적인 영상 진단법상으로 인지되지 않은 복강내 암종중의 예견에 있어서는 유용하지 않을 것으로 생각된다. Background: Detection of tumor markers could offer an accessible method for screening risk groups in order to achieve an early diagnosis of cansers, to contribute to and adequate staging, and to help evaluate effects of therapy. CA 125 is an antigenic determinant defined by murine monoclonal antibody OC 125, and synthesized by coelomic epithelial derivatives such as Mullerian epithelium and mesothelial tissues. CA 125 is regarded as useful tumor marker for non-musinous epithelial ovarian tumors. So we investigated whether CA 125 is reliable tumor marker for gastrointestinal malignancies and especially for detection of intraperitoneal carcinomatosis unrecognized by conventional imaging studies. And we compared CA 125 with other conventional tumor markers in the serodiagnosis of gastrointestinal malignancies. Methods: Serum CA 72-4, CA 19-9, CA 125 and CEA were determined radioimmunologically with monoclonal antibodies. A cut-off value of 4 U/ml, 37 U/ml, 35 U/ml and 5 mg/ml were used respectively. Results: The results are summarized as follows. 1) CA 125 had high specificity (93%) for benign gastrointestinal disease but was not useful to differetiate malignant ascites and benign ascites. 2) In gastric carcinoma, the sensitivity of CA 125 (36%) was not so different to that of CA 72-4(36%). 3) In pancreatobiliary carcinoma, the sensitivity of CA 125(55%) was inferior than that of CA 19-9 (85%), but combined use of these two tumor markers increases sensitivitu(95%) for the diagnosis. 4) The sensitivities of CA 125 for 23 early gastric cancer was 9%. 5) The sensitivities of CA 125 for the intraperitoneal carcinomatosis that was not recognized by conventional imaging studies was 36%. Conclustion: Our data indicates that CA 125 is not better in the serodiagnosis of gastrointestinal malignancies than other conventional tumor markers, and CA 125 has a little predictive value in the diagnosis of intraperitoneal carcinomatosis unrecognized by the conventional imaging studies. Serum CA 125 elevation in benign or malignant diseases closely correlated with the presence of ascites.
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장진성,배강국,김우곤,김선재,국일현,김성청,Jang, Jin-Seong,Bae, Gang-Guk,Kim, U-Gon,Kim, Seon-Jae,Guk, Il-Hyeon,Kim, Seong-Cheong 대한기계학회 2000 大韓機械學會論文集A Vol.24 No.2
Residual stress induced in U-bending and tube-to-tubesheet joint processes of PWR's row-1 heat exchanger tube was measured by X-ray method and Hole-Drilling Method(HDM). Compressive residual stresses(-) at the extrados surface were induced in U-bending, and its maximum value reached -319 MPa in axial direction at the position of $\psi$ = $0^{\circ}$. Tensile residual stresses(+) of $\sigma_{zz}$ = 45 MPa and $\sigma_{\theta\theta}$ = 25 MPa were introduced in the intrados surface at the position of $\psi$ = $0^{\circ}$. Maximum tensile residual stress of 170 MPa was measured at the flank side at the position of $\psi$ = $90^{\circ}$, i.e., at apex region. It was observed that higher stress gradient was generated at the irregular transition regions (ITR). The trend of residual stress induced by U bending process of the tubes was found to be related with the change of ovality. The residual stress induced by the explosive joint method was found to be lower than that by the mechanical roll method. The gradient of residual stress along the expanded tube was highest at the transition region (TR), and the residual stress in circumferential direction was found to be higher than the residual stress in axial direction.
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박혜영,배안,신성웅,윤우상 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3
본 연구에서 저자들은 공동사회모임에 참여한 환자와 지료자의 공동사회모임에 대한 반응을 알아보고, 일종의 집단정신치료로서 공동사회모임의 치료적 효과를 Yalon의 Q-sort 단축형 척도를 적용하여 평가하므로써 공도사회모임의 문제점을 진단, 보완하고, 집단치료로서의 치료적 기능을 활성화하고자 하였다. 평가대상이 된 10차례의 공동사회모임은 비교적 치료공동체가 부침기에 해당하는 기간에 열렸으며, 매회당 환자군 26.7명(±2.95)과 치료자군 8.5명(±1.43)이 참가했다. 그 결과 환자와 치료자 모두 공동사회모임을 긍정직으로 평가하였으며, 도움이 된 항목에 대하여 환자는 '서로간의 이해와 사랑', '자신에 대하 깨달음'이라고 답하였고, 치료자는 '솔직한 자기표현'과 '대화'가 도움이 되었다고 하였다. 또한 공도사회모임의 집단치료 치료요인의 모든 항목에서 치료자군에 비하여 환자군이 더 치료적이라고 평가하였으며, 특히 '보편성', '지침', '카타르시르'를 제외한 9개의 항목에서 통계적으로 유의한 차이가 있었다. 공동사회모임에서 활성화된 집단치료 치료요인으로서 환자와 치료자는 공통적으로 '실존적 인자'와 '보편성'이라고 압했으며, '외면적 대인간 학습'을 비활성화된 치료요인으로 평가하였다. This research was conducted to investigate the responses of the patients and the therapists who attend the community meeting, to evaluate the therapeutic effects fo community meeting as a group psychotherapy by applying short form scale of Yalom's Q-sort, to diagnose and complement the problems of the community meeting and to aim at activating the therapeutic function as the group psychotherapy. The community meeting was held by 10 times during the stage of oscillation of the community and 26.7 patients group(±2.95) and 8.5 therapists group(±1.43) attended the every meeting. Consequently, both patients group and therapists group evaluate the community meeting as positive, and on the item which is helpful to them, while patient group responds it is 'mutual understanding and love' and 'self-understanding', therapist group does it is 'frank self-expression' and 'conversation'. On all items of group psychotherapy facors in the community meeting, the patients group evaluates it is more therapeutic in comparison with the therapists group, especially there is a significant difference in nine items such as 'altruism', 'group cohesiveness', 'interpersonal input', 'interpersonal output', 'identification', 'instillation of hope', 'family reenactment', 'self-understanding' and 'existential awareness'. In addition, on the therapeutic factor which is activated group psychotherapy factor in the community meeting, both patients and therapists respond that it is 'existential awareness' and 'universality', and they evaluate 'interpersonal output' as an non-activated therapeutic factor.
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서주리,정윤,최종욱,배경융 한국전문가시스템학회 1994 학술대회 Vol.2 No.1
Every year many expert systems, possibly more than 1,000 systems are reported to have been developed or in development in the States and more than 200 systems in Japan. To the contrary, a very few expert systems are being developed or installed in Korea, even though many companies are planning to invest money into developing intelligent decision making softwares. In this paper, expert systems developed or in development stage in Korea are analyzed to derive critical factors which determine success or failure. Identification of critical factors is important in that system developers involved in expert system projects can utilize the list of critical factors to avoid possible problems. The critical factors identified in the survey research are user's involvement, domain selection, management support, quality of domain experts, and technical capability of developers. It was found that there is a significant difference in the list and priorities of the critical factors identified in this research and factors identified in the States. The difference may be explained by the progressional stage of expert system development in Korea and America. Expert systems in America is already well established technology in the stage of commercial products, while expert systems in Korea is still new and novel technology in beginning stage. Domain selection is not a serious problem in America, because they have solved many problems and consequently know what problems to solve, what problem not to solve. To the contrary, developers in Korea very often initiate development projects motivated by technical curiosity, rather than by user's requests. Therefore, problems they selected to solve can be inappropriate and then in the later stage of the development they confront resistance of domain experts and users.
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Bae, B. U.,Yoon, H. Y.,Euh, D. J.,Huh, B. G.,Song, C. H.,Park, G. C. Taylor Francis 2008 Heat transfer engineering Vol.29 No.8
<P> In a two-phase flow analysis, the interfacial area concentration (IAC) is a dominant factor governing the interfacial transfer of the momentum or energy. For a dynamic analysis with the implementation of IAC transport equation, a multi-dimensional computational fluid dynamics code was developed. The code is based on the two-fluid model and the simplified marker and cell algorithm by using the finite volume method, where the conventional approach for a single-phase flow has been modified in order to consider the term for a phase change. As benchmark problems of a single-phase flow and two-phase flow, a natural convection in a rectangular cavity and a subcooled boiling in an annulus channel were selected, respectively. In the calculation for the single-phase flow, the developed code predicted a reasonable behavior for a buoyancy-driven flow depending on the Rayleigh number. In the analysis of the subcooled boiling, the calculation results showed the robustness of code for the analysis of the boiling phenomena and void propagation, where they represented limitations of the one-dimensional IAC model. To conduct a multi-dimensional analysis for the two-phase flow, it is confirmed that the implementation of an IAC transport equation into the code is essential.</P>
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Bae, Dae-Kwon,Park, Dongsun,Lee, Sun Hee,Yang, Goeun,Kyung, Jangbeen,Kim, Dajeong,Shin, Kyungha,Choi, Ehn-Kyoung,Kim, Gonhyung,Hong, Jin Tae,Kim, Seung U.,Kim, Yun-Bae Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-
<P>Since multiple sclerosis (MS) is featured with widespread demyelination caused by autoimmune response, we investigated the recovery effects of F3.olig2 progenitors, established by transducing human neural stem cells (F3 NSCs) with Olig2 transcription factor, in myelin oligodendrocyte glycoprotein- (MOG-) induced experimental autoimmune encephalomyelitis (EAE) model mice. Six days after EAE induction, F3 or F3.olig2 cells (1 × 10<SUP>6</SUP>/mouse) were intravenously transplanted. MOG-injected mice displayed severe neurobehavioral deficits which were remarkably attenuated and restored by cell transplantation, in which F3.olig2 cells were superior to its parental F3 cells. Transplanted cells migrated to the injured spinal cord, matured to oligodendrocytes, and produced myelin basic proteins (MBP). The F3.olig2 cells expressed growth and neurotrophic factors including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF). In addition, the transplanted cells markedly attenuated inflammatory cell infiltration, reduced cytokine levels in the spinal cord and lymph nodes, and protected host myelins. The results indicate that F3.olig2 cells restore neurobehavioral symptoms of EAE mice by regulating autoimmune inflammatory responses as well as by stimulating remyelination and that F3.olig2 progenitors could be a candidate for the cell therapy of demyelinating diseases including MS.</P>
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Bae, S. U.,Han, Y. D.,Cho, M. S.,Hur, H.,Min, B. S.,Baik, S. H.,Lee, K. Y.,Kim, N. K. Springer Science + Business Media 2016 Annals of surgical oncology Vol.23 No.5
<P>The treatment strategy and benefit of extended lymph node dissection among patients with preoperatively diagnosed paraaortic lymph node metastasis (PALNM) in colon cancer remains highly controversial. In the current study, we analyzed the oncologic outcomes of patients who underwent extraregional lymph node dissection for colon cancer with isolated PALNM. From March 2000 to December 2009, the study group included 1082 patients who underwent curative surgery for colonic adenocarcinoma with pathological lymph node metastasis. Of 1082 patients who underwent curative surgery for colonic carcinoma, 953 (88.1 %) patients underwent regional lymphadenectomy, and 129 (11.9 %) patients underwent paraaortic lymph node dissection. Pathologic examination revealed N1 stage disease in 738 (68.2 %), N2 in 295 (27.3 %), and PALNM in 49 (4.5 %). Five-year overall survival (OS) and disease-free survival (DFS) rate were significantly better in the regional LNM group than in the PALNM group (OS 75.1 vs. 33.9 %, p < 0.001; DFS 66.2 vs. 26.5 %, p < 0.001). Five-year OS and DFS were not significantly different between the PALNM and resectable liver metastasis patients who underwent curative resection (OS 33.9 vs. 38.7 %, p = 0.080; DFS 26.5 vs. 27.6 %, p = 0.604). PALNM in colon cancer is associated with poorer survival than regional lymph node metastasis and showed comparable survival rates with metastasectomy for liver metastasis. Further studies evaluating the net benefit of upfront chemotherapy compared with initial resection for patients with potentially resectable PALNM are needed.</P>
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