Identrfication of Continuous Time-Delay Systems Using the Genetic Algorithm

Tomohiro,Zi-Jiang Yang,Teruo Tsuji 제어로봇시스템학회 1993 제어로봇시스템학회 국내학술대회 논문집 Vol.1993 No.10

Establishment of a canine mammary gland tumor cell line and characterization of its miRNA expression

Tomohiro Osaki,Yuji Sunden,Akihiko Sugiyama,Kazuo Azuma,Yusuke Murahata,Takeshi Tsuka,Norihiko Itoh,Tomohiro Imagawa,Yoshiharu Okamoto 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.3

Canine mammary gland tumors (CMGTs), which are the most common neoplasms in sexually intact female dogs, have been suggested as a model for studying human breast cancer because of several similarities, including relative age of onset, risk factors, incidence, histological and molecular features, biological behavior, metastatic pattern, and responses to therapy. In the present study, we established a new cell line, the SNP cell line, from a CMGT. A tumor formed in each NOD.CB17-Prkdcscid/J mouse at the site of subcutaneous SNP cell injection. SNP cells are characterized by proliferation in a tubulopapillary pattern and are vimentin positive. Moreover, we examined miRNA expression in the cultured cells and found that the expression values of miRNA-143 and miRNA-138a showed the greatest increase and decrease, respectively, of all miRNAs observed, indicating that these miRNAs might play a significant role in the malignancy of SNP cells. Overall, the results of this study indicate that SNP cells might serve as a model for future genetic analysis and clinical treatments of human breast tumors.

Association between Pelvic Parameters and Vaginal Delivery

Yamada Tomohiro,Yamato Yu,Hasegawa Tomohiko,Yoshida Go,Yasuda Tatsuya,Banno Tomohiro,Arima Hideyuki,Oe Shin,Mihara Yuki,Ushirozako Hiroki,Ide Koichiro,Watanabe Yuh,Hosino Hironobu,Matsuyama Yukihiro 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2

Study Design: Cross-sectional study. Purpose: To investigate the association between vaginal delivery and pelvic parameters and clarify the effect of parity on parameter fluctuations. Overview of Literature: During vaginal delivery, the sacroiliac joint widens and the sacrum nutates (nods). However, the association between these pelvic parameters and parity is unknown. Methods: As part of a 2016 health screening, 320 female volunteers underwent whole-spine radiographs. Age-matched healthy women were grouped according to the number of vaginal deliveries (0, 1–2, or ≥3). Demographic variables and spinopelvic parameters were compared among the three groups. Results: Of the 320 volunteers, 213 were enrolled (mean age, 71.1±7.2 years). The mean number of vaginal deliveries was 2.2. The average pelvic incidence (PI) was 55.6°±11.1° and was significantly higher in the 90 women with three or more vaginal deliveries than in the other two groups (p<0.001). The average sacral slope was 33.4°±11.1° and was significantly higher in the women with three or more vaginal deliveries than in the 18 who did not deliver vaginally (p<0.001). The 105 women with one or two vaginal deliveries had significantly higher PIs and sacral slopes than did those who did not deliver vaginally (p<0.001). Conclusions: This is the first study documenting an association between vaginal delivery and pelvic parameters. Bony birth canal realignment during vaginal delivery can affect postnatal PI. Our study helps in understanding the PI changes over a woman’s life span.

Limestone Related Problems for Foundations in Central Vietnam

( Tomohiro Yasuda ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

We conducted geological reconnaissance and exploratory drilling for a candidate plant site in Central Vietnam. The geological investigation reveals that the site is underlain by limestone. We identified typical limestone features, namely cavity, sinkhole, slump zone and Karst topography. It is concerned that foundation pressure may overstress cavities and cause collapse of cavities. That would result in new sinkhole or ground settlement, which may damage surrounding structures and buildings. Slump zones were observed below very stiff/dense overlying soils and immediately above limestone, where soils were very loose with SPT N-values of 5 or less. It is possible that slump zone expands by flowing loose soils into underlying cavities. The spread slump zone may cause sinkholes. Karst topography with depths varying from 40 to 70 metres is likely to cause several problems for pile foundation. Where piles are driven to the top of limestone, the pile lengths drastically vary in a short distance. When the piles are driven onto steeply inclined limestone surface and deep ditches, the piles can be damaged. Additionally, if the pile is supported on an overhang, its bearing capacity might be insufficient. To overcome limestone related problems, cavity probing and grout treatment for cavity and slump zone are required for proposed shallow and pile foundations. However, the probing and treatment are costly and time consuming. As the thorough probing and treatment are practically impossible, unexpected sinkhole or settlement remains unavoidable even after the probing and treatment. Consequently, we recommended relocating the site to avoid the limestone area.

Earthquake Damage in Sapporo City Examined from InSAR and Paleogeography - 2018 Hokkaido Eastern Iburi Earthquake -

( Tomohiro Nishimura ),( Sakae Mukoyama ),( Ken-ichi Honda ),( Kiyoyuki Shigeno ),( Akihiro Yokota ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

The Hokkaido Eastern Iburi Earthquake (Mw=6.6), which occurred in the early morning on September 6, 2018, resulted in extremely large number of landslides in Atsuma Town, Abira Town, Mukawa Town in Hokkaido. In addition, ground displacement occurred in a wide area including Kiyota Ward, Sapporo City, and many buildings were damaged. InSAR can extract small displacements of the ground surface over a wide area, regardless of the weather, and can quickly detect where the ground or a building may be damaged. We analyzed SAR before and 2 hours after the earthquake acquired by Sentinel-1 satellite within 24 hours after the earthquake, and identified areas where displacement is estimated to be large. As a result, significant displacements were estimated in Kiyota, Satozuka and Utsukushigaoka in Kiyota ward, Hiragishi in Toyohira ward, and Fushiko in Higashi ward, and it was predicted that the earthquake caused great damage. After SAR analisys, the aerial photograph interpretation and the detailed examination of the field survey were carried out for these areas. The damage situation by the ground displacement were found, checked the paleogeography, and the validity of the SAR analysis results was verified. The displacements area are concentrated on the artificial land where the old river channel and old valley are filled up, and the correlation between the damage and the old topography is considered to be very strong.

Modeling and Identification of Human Mind using a Robot Which Walks Together

Tomohiro Hayashi,Ai Sato,Michio Ohta 제어로봇시스템학회 2001 제어로봇시스템학회 국제학술대회 논문집 Vol.2001 No.10

Multi-Rod Constructs Can Increase the Incidence of Iliac Screw Loosening after Surgery for Adult Spinal Deformity

Tomohiro Banno,Tomohiko Hasegawa,Yu Yamato,Daisuke Togawa,Go Yoshida,Sho Kobayashi,Tatsuya Yasuda,Hideyuki Arima,Shin Oe,Yuki Mihara,Hiroki Ushirozako,Yukihiro Matsuyama 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.3

Study Design: A retrospective study. Purpose: To investigate the incidence of iliac screw loosening with a two-rod vs. multi-rod construct and the effect on clinical and radiographic outcomes after surgery for adult spinal deformity (ASD). Overview of Literature: Multi-rod construct is useful for preventing rod fracture in ASD surgery. However, limited information is available regarding the incidence of iliac screw loosening after corrective fusion surgery using a multi-rod construct. Methods: Total 106 patients with ASD (24 men and 82 women; mean age, 68 years) who underwent corrective fusion surgery using bilateral iliac screws and were followed up for at least 1 year were reviewed. The following variables were compared between patients who underwent surgery with a two-rod and multi-rod construct: age, sex, bone mineral density (BMD), fusion level, high-grade osteotomy, L5/S interbody fusion, screw loosening (upper instrumented vertebra [UIV], S1, and iliac), rod fracture, proximal junctional kyphosis, spinopelvic parameters, and Oswestry Disability Index (ODI) score. We also compared patients with and without iliac screw loosening in the multi-rod construct group. Results: Of the 106 patients, 55 underwent surgery with a conventional two-rod construct and 51 with a multi-rod construct (three rods in 16, four rods in 35). Iliac and UIV screw loosening was observed in 24 patients (21%) and 35 patients (33%), respectively. The multi-rod group showed significantly higher incidence of iliac and UIV screw loosening and lower incidence of rod fracture. Patients with iliac screw loosening had a lower BMD than those without screw loosening; however, no significant differences were observed in the spinopelvic parameters or the ODI score. Conclusions: The use of multi-rod constructs led to a higher incidence of junctional screw loosening than the use of conventional two-rod constructs, especially in patients with osteoporosis. Iliac screw loosening did not affect sagittal alignment or clinical outcome in the short term.

Reply to “Interstitial Cystitis – A Consequence of Weakened Uterosacral Ligaments Failing to Support Visceral Plexuses and Bladder Stretch Receptors and Therefore Potentially Curable?”

Tomohiro Ueda 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.4

.

Modeling of an ER Fluid’s Time Delay for Servo Systems

Tomohiro Terada,Ken’ichi Koyanagi,Toru Oshima 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

A particle type ER(Electro-Rheological) fluid damper in which viscosity was controlled for fast and precise positioning control have been developed in aprevious study. However, for improvement of control performance or new control demands of mechatronics devices using particle type ER fluids, it will be needed to further investigate are sponse time of the fluids. It is commonly said around 5-milliseconds, but, the formula structure of that delay has not been clear. This study aims to develop a functional damper(attenuators), that can control its viscous characteristics in real time using ER fluids as its working fluid. ER dampers in this case are useful to a ccomplish high precision positioning not to prevent high speed movement of the motor. To realize the functional damper that can be manipulated according to situation sortasks, the modeling and control of ER fluids are necessary. This paper investigates time delay affects of ER fluids and makes an in-depth dynamic model of the fluid by utilizing simulation and experiment. The mathematical model has a dead-time and first ordered delays of the fluid and the high voltage amplifier for the fluid.

Current new challenges in the management of ulcerative colitis

Tomohiro Fukuda,Makoto Naganuma,Takanori Kanai 대한장연구학회 2019 Intestinal Research Vol.17 No.1

Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract. Although the cause of UC is postulatedto be multifactorial in nature, including genetic predisposition, epithelial barrier defects, dysregulation of immune responses,and environmental factors, the specific pathogenesis of UC is still incompletely understood. In the treatment of UC so far, amethod of suppressing immunity and treating it has been mainstream. Immunosuppressant drugs, including thiopurines(azathioprine or 6-mercaptopurine), anti-tumor necrosis factor-α (anti-TNF-α) antibody (infliximab and adalimumab), andcalcineurin inhibitor, can be used in treat patients with corticosteroid-dependent and/or corticosteroid-refractory moderateto-severe UC. Recently, in addition to such a conventional therapeutic agent, golimumab, which is the first transgenic humanmonoclonal anti-TNF-α antibody to be fabricated, anti α-4/β-7 integrin antibody, and Janus kinase inhibitor have been reportedto novel immunosuppressant therapy. Furthermore, other treatments with unique mechanisms different from immunosuppression,have also been suggested, including fecal microbiota transplantation and Indigo naturalis, which is a Chinese herbalmedicine. We compared the features and efficacy of these new treatments. In this issue, the features and treatment options forthese new treatments is reviewed. (Intest Res 2019;17:36-44)