http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Association Between MDM2 SNP309 T>G and Risk of Gastric Cancer: A Meta-analysis
Tian, Xin,Tian, Ye,Ma, Ping,Sui, Cheng-Guang,Meng, Fan-Dong,Li, Yan,Fu, Li-Ye,Jiang, Tao,Wang, Yang,Ji, Fu-Jian,Fang, Xue-Dong,Jiang, You-Hong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Background: As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer. Methods: The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases. Results: It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected. Conclusion: The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.
Study on hair dryer thermal vibration massage to make shaving more comfortable
Tian, Zhixing,You, Kwang-Bock,Bae, Myung-Jin The International Promotion Agency of Culture Tech 2021 International Journal of Advanced Culture Technolo Vol.9 No.2
When shaving, it is easy to suffer shaving burns, that is, facial burn irritation during shaving. The reason is that the razor blade irritates the skin. The current solution is to make the razor sharper and use a razor with a blade heating function. Although these ways can increase the comfort of shaving, they will also greatly increase shaving costs. This paper proposes using a hairdryer to massage the skin before shaving to reduce skin irritation during shaving. This is a simple, practical and low-cost method. The hair dryer's heat, sound, and wind energy have a massage effect, and they can make shaving easier and more comfortable. For analyzing shaving effect, two evaluation methods are used, which are sound spectrum analysis and mos. The sound spectrum analysis is used to analyze the working status of the razor objectively. The MOS test can reflect the subjective feelings of the subject on the shaving's comfort. The results show that the hairdryer thermal vibration massage can make the beard easier to cut, thereby reducing the irritation of the razor to the skin and improving shaving comfort.
You-Hua Cai,Ze-Xin Liang,Shuang Li,Ming-Jun Zhu,Zhenqiang Wu,Shang-Tian Yang,Ju-Fang Wang 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6
There is an increasing worldwide interest in bioethanol production from agricultural, industrial, and urban residues for both ecological and economic reasons. The acid hydrolysis of cassava pulp to reducing sugars and their fermentation to ethanol were evaluated in a fibrousbed bioreactor with immobilized Δldh, a genetically engineered Thermoanaerobacterium aotearoense. A maximum yield of total reducing sugars of 53.5% was obtained after 8 h of hydrolysis at 85oC in 0.4 mol/L hydrochloric acid with a solid-to-liquid ratio of 1:20, which was optimized by using an orthogonal design based on preliminary experiments. In the FBB, the fed-batch fermentation, using glucose as the sole carbon source, gave a maximum ethanol production of 38.3 g/L with a yield of 0.364 g/g in 100 h; whereas the fed-batch fermentation, using xylose as the sole carbon source, gave 34.1 g/L ethanol with a yield of 0.342 g/g in 135 h. When cassava pulp hydrolysate was used as a carbon source, 39.1 g/L ethanol with a yield of 0.123 g/g cassava pulp in185 h was observed, using the fed-batch fermentation model. In addition, for repeated batch fermentation of cassava pulp hydrolysate carried out in the fibrous-bed bioreactor, long-term operation with high ethanol yield and volumetric productivity were achieved. The above results show that the acid hydrolysate of cassava pulp can be used for ethanol production in a fibrous-bed bioreactor, although some inhibition phenomena were observed during the process of fermentation.
Tian, Yu-Hua,Lee, Kwang-Wook,You, In-Jee,Lee, Seok-Yong,Jang, Choon-Gon Wiley Subscription Services, Inc., A Wiley Company 2008 Synapse Vol.62 No.8
<P>Butorphanol is a synthetic opioid agonist/antagonist analgesic agent that mainly exerts its effects through κ-opioid receptors. It has been demonstrated that κ-opioid receptors preferentially mediate the development of physical dependence upon butorphanol and the associated withdrawal syndrome. However, it is not fully understood whether or not nNOS-containing neurons in the various brain regions play an important role in butorphanol withdrawal. Therefore, this study was conducted to determine whether the selective nNOS inhibitor, 7-NI, modifies the development of butorphanol withdrawal and changes of nNOS expressions in different brain regions in physically butorphanol-dependent rats. The first part of the study focused on withdrawal behaviors in male Sprague-Dawley rats. Physical dependence was induced by a 72-h i.c.v. infusion with butorphanol (26 nmol/μl/h) and withdrawal was subsequently precipitated by i.c.v. challenge with naloxone (48 nmol/5 μl/rat) 2 h after termination of the butorphanol infusion. The butorphanol/7-NI coadministration group showed a significant decrease in several signs of withdrawal such as teeth chattering, as compared with the butorphanol-treated group. In the second part of the study, immunohistochemical analysis was performed to determine the expression of nNOS in the various brain regions. In the butorphanol/7-NI coadministration group, the number of cells labeled for nNOS was significantly lower in the various brain regions (including the caudate putamen, nucleus accumbens, and hippocampus) than in the butorphanol group. Therefore, 7-NI decreased in butorphanol-induced physical dependence and nNOS expression. Taken together, these findings suggest that the nNOS system is involved in the development of butorphanol-induced physical dependence, and 7-NI has potential clinical application as a candidate for the treatment of opioid withdrawal syndrome. Synapse 62:582–589, 2008. © 2008 Wiley-Liss, Inc.</P>
Tian, Hui,Shimakoshi, Hisashi,Park, Gyurim,Kim, Sinheui,You, Youngmin,Hisaeda, Yoshio The Royal Society of Chemistry 2018 Dalton transactions Vol.47 No.3
<P>A visible light induced three-component catalytic system with the cobalamin derivative (B12) as a catalyst, the cyclometalated iridium(iii) complex (Irdfppy, Irppy, Irpbt and [Ir{dF(CF3)ppy}2(dtbpy)]PF6) as a photosensitizer and triethanolamine as an electron source under N2 was developed. This catalytic system showed a much higher catalytic efficiency than the previous catalytic system using [Ru(ii)(bpy)3]Cl2 as the photosensitizer for the dechlorination reaction of 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethane (DDT). Noteworthy is the fact that the remarkable high turnover number (over ten thousand) based on B12, which ranks at the top among the reported studies, was obtained when Irdfppy was used as a photosensitizer. This photocatalytic system was also successfully applied to the B12 enzyme-mimic reaction, <I>i.e.</I>, the 1,2-migration of the phenyl group of 2-bromomethyl-2-phenylmalonate. The plausible reaction mechanism was proposed, which involved two quenching pathways, an oxidative quenching pathway and a reductive quenching pathway, to be responsible for the initial electron transfer of the excited-state photosensitizers during the DDT dechlorination reaction. Transient photoluminescence experiments revealed that the oxidative quenching of the photosensitizer dominated over the reductive quenching pathway.</P>
Vibration analysis of new drill string system with hydro-oscillator in horizontal well
Jia-lin Tian,Zhi Yang,You Li,Lin Yang,Chun-ming Wu,Gang Liu,Chang-fu Yuan 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.6
With the growth of oil and gas resource demand, the hydro-oscillator is widely used to enhance the Rate of penetration (ROP) and improve the efficacy in drilling various wells. The vibration model is the key issue of dynamics analysis and optimization of downhole tools. For the vibration analysis of the new drill string system with hydro-oscillator in the horizontal well, based on the design of the new hydro-oscillator and its operation conditions, the kinematics expressions are presented. Combined with the vibration force calculation results of the hydro-oscillator, the dynamics model of the new drill string system is established. Furthermore, the important features of vibration frequency, displacement, velocity and acceleration are discussed in the numerical example calculation results. By comparing the results of the calculation and experiment test, we can verify the correctness of the analysis model. With the hydro-oscillator vibration effect, the static friction between the drill string and wellbore is changed to the dynamic friction, so it can result in a significant increase in run length. At the same time, the ROP can be enhanced with the vibration effect. Moreover, with the parameters’ adjustment according to the operation conditions, the analysis method and model can also provide references to the study of similar downhole tools dynamics or mechanical properties.
He, Qiang,You, Hong,Li, Xin-Min,Liu, Tian-Hui,Wang, Ping,Wang, Bao-En Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
The high mobility group box-1 (HMGB1) protein and NALP3 inflammasome have been identified to play important roles in inflammation and cancer pathogenesis, but the relationships between the two and cancer remain unclear. The current study investigated the relationship between HMGB1 and the NALP3 inflammasome in THP-1 macrophages. HMGB1 was found unable to activate the NALP3 inflammasome and failed to induce the release of the IL-$1{\beta}$ and IL-18 in THP-1 macrophages. HMGB1 was also found significantly enhanced the activity of ATP to induce IL-$1{\beta}$ and IL-18 by the induction of increased expression of pro-IL-$1{\beta}$ and pro-IL-18. This process was dependent on activation of RAGE, MAPK p38 and NF-${\kappa}B$ signaling pathway. These results demonstrate that HMGB1 promotes the synthesis of pro-IL-$1{\beta}$ and pro-IL-18 in THP-1 macrophages by the activation of p38 MAPK and NF-${\kappa}B$ through RAGE. HMGB1 likely plays an important role in the first step of the release of the IL-$1{\beta}$ and IL-18, preparing for other cytokines to induce excessive release of IL-$1{\beta}$ and IL-18 which promote inflammation and cancer progression.