Effects of habitat fragmentation on the functional diversity of insects in Thousand Island Lake, China

Tian‐Hao Tu,Ji-Rui WANG,Jian-Qiang GU,Tian-Qi LI,Kun LV,Guo-Xin ZHOU,Zhi-Hong XU 한국곤충학회 2019 Entomological Research Vol.49 No.2

Due to habitat fragmentation, the loss of species diversity has been extensively studied. On the contrary, the effects of habitat fragmentation on functional diversity is still poorly understood. In the Thousand Island Lake, we conducted studies of insect functional diversity on a set of 29 isolated islands. We used 10 functional diversity indices from three aspects (functional richness, functional evenness and functional divergence) to respectively describe functional diversity of insects on sample islands. We found the following results: (i) The functional indices selected could reflect the functional diversity of sample islands and it is further proved that in general, three components of functional diversity were independent of each other; (ii) Sample islands could be divided into two categories, island JSD and the remaining islands; (iii) Functional richness increased with island area and shape index, but had no significant correlation with isolation. Likewise, both functional evenness and functional divergence had no significant correlation with island attributes. The conclusion to emphasize from our research is that: (i) habitat fragmentation reduced the biological functional diversity to some extent, further demonstrating the importance of habitat continuity in biodiversity protection; and (ii) for functional diversity protection of insects in a fragmented landscape, an island which has high approximate shape index values of at least hundred hectare magnitude order has a critical promoting effect.

Factors that Influence the Presciption of Antipsychotics for Patients with Schizophrenia in China

Tian-Mei Si,Liang Shu,Ke-Qing Li,Xie-He Liu,Qi-Yi Mei,Gao-Hua Wang,Pei-Shen Bai,Li-Ping Ji,Xian-Sheng Chen,Cui Ma,Jian-Guo Shi,Hong-Yan Zhang,Hong Ma,Xin Yu 대한정신약물학회 2011 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.9 No.3

Objective: To investigate the patterns of antipsychotic use in China and to analyze the factors that influence antipsychotic prescriptions. Methods: A standardized survey was conducted from May 20 to 24 2002 in five different regions of China with varying economic levels. The patterns of antipsychotic medication use were analyzed in a sample of 4,779 patients with schizophrenia. The survey gathered information on demographic characteristics, clinical profiles, and antipsychotic medications prescribed. Multiple logistic regression was used to analyze factors related to patterns of antipsychotic medication use. Results: A plurality of patients with schizophrenia was treated with clozapine (39%); this was followed by risperidone, sulpride,chlorpromazine, perphenazine, and haloperidol. More than 56.3% of patients were treated with only one atypical antipsychotic. The mean daily dose of chlorpromazine was 365±253 mg (mean±standard deviation), and 6.5% of patients were treated with depot injections of typical antipsychotic medications. A total of 73.7% (n=3,523) of patients with schizophrenia received monotherapy,24.8% (n=1,183) received two antipsychotics, 1.1% (n=52) received three antipsychotics, and one received four different antipsychotics. Patients often simultaneously received other classes of medications including anticholinergic agents, benzodiazepines,β-blockers, antidepressants, and mood stabilizers. Economic status and clinical symptoms were the main factors that contributed to the patterns of antipsychotic prescription. Conclusion: The present study suggests that atypical antipsychotic medications, especially clozapine, are the primary psychiatric treatments of choice in the management of schizophrenia in China. Moreover, the economic status and clinical profile of the patient are the major factors affecting the prescription of antipsychotic medication.

Plasma Membrane as the Target Site of Cholic Acid Analogs

Tian Hong Zhang,Zhen Qing Zhang,Chun Guang Liu,Jin Xiu Ruan 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

Although the mechanism is unknown, Calculus Bovis and its active components, cholic acid analogs (CAAs), have been used in China to treat a wide range of diseases. Based on the previous finding that the potency of CAA is strongly dependent on the intrinsic surface activity, this paper aimed to investigate the role of the plasma membrane in the pharmacological activity of CAAs. First, CAAs (0.1 mM) caused a surface activity-dependent depression on ATPase activity in the cell membrane extract, but it had no effects on other cellular extracts, suggesting an indispensable role of the membrane environment for pharmacological activity. Second, CAAs lowered the membrane fluidity of cultured Caco-2 cells with the same rank-order of potency sequence. Third, the hypothesis that any functional protein located on the membrane is influenced by changes in cellular membrane fluidity was supported by: ileal contraction that was induced by acetylcholine and mediated by the muscarinic receptor (M-receptor) or the relaxation induced by adrenaline and mediated by the β-adrenergic receptor (β-receptor) was inhibited by CAAs. They also had similar rank-order of potency and the effects on the plasma membrane. Collectively, the plasma membrane may be a target for the CAAs to exert the multiple pharmacological effects which are mediated by the alteration of the membrane mobility and the function of integral membrane proteins.

Development of biomarker for detecting silver nanoparticles exposure using a GAL4 enhancer trap screening in <i>Drosophila</i>

Tian, Hong,Eom, Hyun-Jeong,Moon, Sungjin,Lee, Jeongmi,Choi, Jinhee,Chung, Yun Doo Elsevier 2013 Environmental toxicology and pharmacology Vol.36 No.2

<P><B>Abstract</B></P> <P>Silver nanoparticles (AgNPs) have been widely used in commercial goods ranging from medical devices to home appliances. Their widespread application increase the risk related to their potential toxicity. Although several studies showed their acute hazardous effects on living animals, our understanding of chronic effects of AgNPs exposed by the environment we encounter in our everyday lives is still very limited. This is partly because of the lack of versatile animal model system for studying AgNPs effects on terrestrial animals including human. In this study, we used <I>Drosophila</I> model to study AgNPs toxicity in terrestrial animals, and found that long-term exposure of AgNPs, but not Ag ions, at low level (0.1 and 1μg/mL) significantly shortened the lifespan. By taking advantage of the power of <I>Drosophila</I> genetics, we also isolated a GAL4 enhancer trap line called <I>M95</I>, in which the expression of GAL4 is up-regulated in response to ingestion of AgNPs at concentrations as low as 0.1μg/mL. Interestingly <I>M95</I> flies showed significantly increased tolerance to both AgNPs treatment and dry starvation probably due to up-regulation of JNK signaling. These findings suggest not only that <I>M95</I> may be a very useful biomarker of AgNPs because of its high sensitivity and tolerance to AgNPs, but also that <I>Drosophila</I> may be a versatile terrestrial invertebrate model for studying the effects of AgNPs on human health.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Long-term exposure of AgNPs at low doses (0.1–1μg/mL) but not Ag ions affects lifespan of <I>Drosophila</I>. </LI> <LI> Isolation of a GAL4 enhancer trap line (<I>M95</I>) as a sensitive biomarker of AgNPs. </LI> <LI> <I>M95</I> flies are more sensitive to AgNPs and dry starvation compared to the control flies. </LI> <LI> AgNPs treatment up-regulates the JNK signaling in <I>Drosophila</I>. </LI> <LI> The basal level of p-JNK is elevated in <I>M95</I> compared to control. </LI> </UL> </P>

Study on the Decoupling Effects of Carbon Emission in Shandong Tourism

Tian, Hong,Sun, Fengzhi,Ding, Changan 한중경제문화학회 2015 한중경제문화연구 Vol.5 No.-

With the depth research in global climate change and the rapid development of tourism industry, tourism industry has been paid more and more attention to carbon emissions. Shandong Province is a major tourism province, the tourism industry not only has the high speed development, but also has expanded each year, the issue of tourism carbon emissions has become one of the important problems to be solved. By using Tapio model to analyze the decoupling relationship between economic growth and carbon emissions in Shandong Province tourism during 2000-2013, and decomposed the total decoupling indicator into the energy saving decoupling indicator and emission reduction decoupling indicator to study, the results showed that: the decoupling relationship between economic growth and carbon emissions in Shandong Province tourism was mainly weak decoupling, energy saving decoupling indicator was the main influence factor of the total decoupling indicators being weak decoupling state, emissions reduction decoupling indicator showed a weak influence on the total decoupling indicators being weak decoupling state. When Shandong Province develop the low-carbon tourism, efforts should be made to create a good institutional environment, to increase research and development of low carbon technology, to improve the level of low-carbon tourism facilities, to optimize energy consumption structure, to increase the proportion of the use of low carbon energy.

Association Between MDM2 SNP309 T>G and Risk of Gastric Cancer: A Meta-analysis

Tian, Xin,Tian, Ye,Ma, Ping,Sui, Cheng-Guang,Meng, Fan-Dong,Li, Yan,Fu, Li-Ye,Jiang, Tao,Wang, Yang,Ji, Fu-Jian,Fang, Xue-Dong,Jiang, You-Hong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer. Methods: The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases. Results: It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected. Conclusion: The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.

Research on elements forming intergranular phases of SmFe12-based alloys

Tian Hong Zhou,Yong-Rae Cho,Chul-Jin Choi,Jihoon Park 한국자기학회 2023 한국자기학회 학술연구발표회 논문개요집 Vol.33 No.1

Cultural Resources Development Potential Evaluation of Shandong Peninsula Blue Economic Zone

Tian, Hong 한중경제문화학회 2017 한중경제문화연구 Vol.8 No.-

The 13th “Five year plan” clearly puts forward the goal of making cultural industry become the pillar industry of national economy in the next five years, which means cultural industry becomes a new development momentum, and are attached much greater importance by the government. Cultural resources are the material basis for the cultural industry, to scientifically classify and evaluate the cultural resources is the key to transform cultural resource advantage into industrial advantage. Firstly, referring to the method of national tourist resources classification, the cultural resources in the Shandong peninsula blue economic zone can be divided into seven types, which are natural landscape culture resources, historical culture resources, folk customs culture resources, religious culture resources, festival events culture resources, literature and art, reality culture resources. Then, the development potential of cultural resources in the Shandong Peninsula Blue Economic Zone were evaluated using the multilevel grey method. The evaluation results showed that the development potential of the cultural resources in the Shandong Peninsula Blue Economic Zone is the highest and the development potential order of each type was W (natural)>W(historical)>W(folk)>W(literaryarts)>W(festivalevent)>W(Religion)>W(real), among which natural landscape culture resources and history culture resources has the greatest development potential, festival event culture resources and reality culture resources has a comparative advantage, literature and art resources has a advantaged talent and outstanding development characteristics, and festival events culture resources has great potential market demand and expected development benefits.

Gut microbiota metabolic characteristics in coronary artery disease patients with hyperhomocysteine

Tian Ran,Liu Hong-Hong,Feng Si-Qin,Wang Yi-Fei,Wang Yi-Yang,Chen Yu-Xiong,Wang Hui,Zhang Shu-Yang 한국미생물학회 2022 The journal of microbiology Vol.60 No.4

Hyperhomocysteine (HHcy) is known as a risk factor for coronary artery disease (CAD). Despite the knowledge that gut microbiota related metabolism pathway shares metabolites with that of Hcy, little has been shown concerning the association between HHcy and gut microbiota. To explore their relationship in the context of CAD, 105 patients and 14 healthy controls were recruited from one single medical center located in Beijing, China. Their serum and fecal samples were collected, with multi-omics analyses performed via LC/MS/ MS and 16S rRNA gene V3-V4 region sequencing, respectively. Participants from the prospective cohort were divided into CAD, CAD & HHcy and healthy controls (HC) groups based on the diagnosis and serum Hcy concentration. The results revealed significant different metabolic signatures between CAD and CAD & HHcy groups. CAD patients with HHcy suffered a heavier atherosclerotic burden compared to CAD patients, and the difference was closely associated to betaine-homocysteine S-methyltransferase (BHMT)-related metabolites and trimethylamine N-oxide (TMAO)-related metabolites. Dimethylglycine (DMG) exhibited a strong positive correlation with serum total Hcy (tHcy), and TMAO and trimethylysine (TML) were associated with heavier atherosclerotic burden. Multiple other metabolites were also identified to be related to distinct cardiovascular risk factors. Additionally, Clostridium cluster IV and Butyricimonas were enriched in CAD patients with elevated tHcy. Our study suggested that CAD patients with elevated tHcy were correlated with higher atherosclerotic burden, and the impaired Hcy metabolism and cardiovascular risk were closely associated with BHMT-related metabolites, TMAO-related metabolites and impaired gut microbiota homeostasis.

Deuterium Clusters Fusion Induced by the Intense Femtosecond Laser Pulse

Hong-Jie, Liu,Zhi-Jian, Zheng,Yu-Qiu, Gu,Bao-Han, Zhang,Yong-Joo, Rhee,Sung-Mo, Nam,Jae-Min, Han,Yong-Woo, Rhee,Kwon-Hae, Yea,Jia-Bin, Chen,Hong-Bin, Wang,Chun-Ye, Jiao,Ying-Ling, He,Tian-Shu, Wen,Xia ALLERTON PRESS INC 2007 CHINESE PHYSICS LETTERS Vol.24 No.2

<P>Neutrons (2.45 MeV) from deuterium cluster fusion induced by the intense femtosecond (30 fs) laser pulse are experimentally demonstrated. The average neutron yield 10<SUP>3</SUP> per shot is obtained. It is found that the yield slightly increases with the increasing laser spot size. No neutron can be observed when the laser intensity I < 4.3×10<SUP>15</SUP> W/cm<SUP>2</SUP>.</P>