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Quy Son Luu,Uyen Thi Do,Dokyung Kim,Jiwon Kim,Donghyeok Jo,Quynh Thi Nguyen,Youngbok Lee 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
This study introduces a facile method for synthesizing covalently bonded magnetic carbon nanoparticles(MCNs) in which carboxylic acid-functionalized activated carbon nanospheres (ACN-COOH) are connectedwith amine-terminated iron oxide nanoparticles (NPs) (Fe3O4-NH2) via a carbodiimide crosslinkingreaction. The adsorption characteristics of the developed magnetic nanoparticles (ACN-Fe3O4) wereinvestigated using a standard cationic dye (methylene blue, MB). Two additional MCNs (multi-coreand core@shell structures) were also prepared, and their adsorption performances were extensively compared. The developed ACN-Fe3O4 material thoroughly utilizes the strengths of activated carbon and Fe3O4themselves, exhibiting large specific surface areas (708.4 m2/g) and strong magnetic properties(40.3 emu/g), resulting in high adsorption capacity (349.5 mg/g) and recycling efficiency (76 % of adsorptionperformance after four cycles). In addition, a study of the mechanism reveals that pore-filling processesare dominant with minor contributions from electrostatic interactions, p–p interactions, and n–p interactions. The developed covalently bonded magnetic carbon nanoparticles (ACN-Fe3O4) can thusbe considered as competent adsorbents with the potential to compensate for the drawbacks of contemporaryMCNs, such as, low adsorption capacity, and weak magnetic properties.
Kim, Ji Won,Ha, Thi-Kim-Quy,Cho, Hyomoon,Kim, Eunhee,Shim, Sang Hee,Yang, Jun-Li,Oh, Won Keun Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.13
<P><B>Abstract</B></P> <P>Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high fatality of piglets, influencing the swine industry. Japanese horse chestnut (seed of <I>Aesculus turbinata</I>) contains many saponin mixtures, called escins, and has been used for a long time as a traditional medicinal plant. Structure-activity relationship (SAR) studies on escins have revealed that acylations at C-21 and C-22 with angeloyl or tigloyl groups were important for their cytotoxic effects. However, the strong cytotoxicity of escins makes them hard to utilize for other diseases and to develop as nutraceuticals. In this research, we investigated whether escin derivatives <B>1</B>–<B>7</B> (including new compounds <B>2</B>, <B>3</B>, <B>5</B> and <B>6</B>), without the angeloyl or tigloyl groups and with modified glycosidic linkages by hydrolysis, have PEDV inhibitory effects with less cytotoxicity. Compounds <B>1</B>–<B>7</B> had no cytotoxicity at 20μM on VERO cells, while compounds <B>8</B>–<B>10</B> showed strong cytotoxicity at similar concentrations on PEDV. Our results suggest that escin derivatives showed strong inhibitory activities on PEDV replication with lowered cytotoxicity. These studies propose a method to utilize Japanese horse chestnut for treating PEDV and to increase the diversity of its bioactive compounds.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
Nguyen, Quy Thi Cam,Lee, Sun-ji,Choi, Seo-wha,Na, Yeon-ju,Song, Mi-ran,Hoang, Quyen Thi Ngoc,Sim, Seo Young,Kim, Min-Sik,Kim, Jeong-Il,Soh, Moon-Soo,Kim, Soo Young Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.9
Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates subclass III SnRK2s (SnRK2.2, SnRK2.3, and SnRK2.6), which are key positive regulators, and our study focused on SnRK2.3 indicates that Raf10 enhances its kinase activity and may facilitate its release from negative regulators. Raf10 also phosphorylates transcription factors (ABI5, ABF2, and ABI3) critical for ABA-regulted gene expression. Furthermore, Raf10 was found to be essential for the in vivo functions of SnRK2s and ABI5. Collectively, our data demonstrate that Raf10 is a novel regulatory component of core ABA signaling.
Effects of piperlongumine on cognitive function and amyloid pathology
Jun Go,Thi-Kim-Quy Ha,Ji Yeon Seo,Tae-Shin Park,Young-Kyoung Ryu,Hye-Yeon Park,Jung-Ran Noh,Yong-Hoon Kim,Jung Hwan Hwang,Dong-Hee Choi,Sang Hee Kim,Chul-Ho Lee,Won Keun Oh,Kyoung-Shim Kim 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.1
Circadian control of <i>ORE1</i> by PRR9 positively regulates leaf senescence in <i>Arabidopsis</i>
Kim, Hyunmin,Kim, Hyo Jung,Vu, Quy Thi,Jung, Sukjoon,McClung, C. Robertson,Hong, Sunghyun,Nam, Hong Gil National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.33
<▼1><P><B>Significance</B></P><P>The circadian clock is involved in aging in animals, where mutations in core clock genes accelerate aging. However, little is known about the relationship between aging and the circadian clock in plants. Using the well-studied process of leaf senescence in <I>Arabidopsis</I>, a higher plant, as a model for aging, we show that the circadian clock has a critical role in regulating the aging process in plants. Specifically, we show that PSEUDO-RESPONSE REGULATOR 9 (PRR9), a core clock component, positively regulates leaf senescence. <I>ORESARA 1</I> (<I>ORE1</I>), an aging regulator, is controlled by PRR9 via direct transcriptional activation and indirectly by suppressing <I>miR164</I>, a posttranscriptional repressor of <I>ORE1</I>, thus forming a coherent feed-forward regulatory loop.</P></▼1><▼2><P>The circadian clock coordinates the daily cyclic rhythm of numerous biological processes by regulating a large portion of the transcriptome. In animals, the circadian clock is involved in aging and senescence, and circadian disruption by mutations in clock genes frequently accelerates aging. Conversely, aging alters circadian rhythmicity, which causes age-associated physiological alterations. However, interactions between the circadian clock and aging have been rarely studied in plants. Here, we investigated potential roles for the circadian clock in the regulation of leaf senescence in plants. Members of the evening complex in <I>Arabidopsis</I> circadian clock, EARLY FLOWERING 3 (ELF3), EARLY FLOWERING 4 (ELF4), and LUX ARRHYTHMO (LUX), as well as the morning component PSEUDO-RESPONSE REGULATOR 9 (PRR9), affect both age-dependent and dark-induced leaf senescence. The circadian clock regulates the expression of several senescence-related transcription factors. In particular, PRR9 binds directly to the promoter of the positive aging regulator <I>ORESARA1</I> (<I>ORE1</I>) gene to promote its expression. PRR9 also represses <I>miR164</I>, a posttranscriptional repressor of <I>ORE1</I>. Consistently, genetic analysis revealed that delayed leaf senescence of a <I>prr9</I> mutant was rescued by <I>ORE1</I> overexpression. Thus, PRR9, a core circadian component, is a key regulator of leaf senescence via positive regulation of <I>ORE1</I> through a feed-forward pathway involving posttranscriptional regulation by <I>miR164</I> and direct transcriptional regulation. Our results indicate that, in plants, the circadian clock and leaf senescence are intimately interwoven as are the clock and aging in animals.</P></▼2>
Development of porous silicon-coated gold nanoparticles as potential theragnostic material
Jiwon Kim,Sumin Hwang,Quy Son Luu,Donghyuk Jo,Uyen Thi Do,Quynh Thi Nguyen,Jae-Sung Kwon,Seunghyun Lee,Youngbok Lee 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.12
Gold nanoparticles (AuNPs) have been used widely as multifunctional materials for several biomedical applications due to their attractive characteristics. However, toxicity and aggregation of AuNPs are critical issues, and methods of effective surface modification are required to overcome these problems. In this study, porous silicon-coated gold nanoparticles (AuNP@pSi) were fabricated as a hybrid nanocomposite capable of surface-enhanced Raman scattering (SERS)-sensing and drug carrier. First, size-controlled AuNPs were coated with a silica nano-shell, and the resulting silica layers were converted to porous silicon through magnesiothermic reduction. Overall results suggest that AuNP@pSi can be exploited as a SERS probe with efficient Raman signal improvement of benzenethiol as well as a drug carrier based on its high surface area (113.7 m2 g?1) and porosity (13.38?nm, 0.3805?cm3 g?1). Since the porous silicon possibly can serve as magnetic resonance imaging probes with DNP technology, this hybrid platform potentially can be utilized as powerful material capable of theragnosis system.