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Respiratory syncytial virus-associated seizures in Korean children, 2011–2016
Tea-hyen Cha,Young Jin Choi,Jae-WonOh,김창렬,Dong-WooPark,In Joon Seol,Jin-Hwa Moon 대한소아청소년과학회 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.4
Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that present with seizures. Methods: We retrospectively reviewed the medical records of patients aged less than 15 years with laboratory-confirmed RSV infections and seizures between January 2011 and December 2016 in a regional hospital in South Korea. Results: During this period, 1,193 patients with laboratory-confirmed RSV infection were identified. Of these, 35 (35 of 1,193, 2.93%; boys, 19; girls, 16; mean age: 20.8±16.6 months) presented with seizure. Febrile seizure was the most common diagnosis (27 of 35, 77.1%); simple febrile seizures in 13 patients (13 of 27, 48.1%) and complex febrile seizures in 14 (14 of 27, 51.9%). Afebrile seizures without meningitis or encephalopathy were observed in 5 patients (5 of 35, 14.3%), seizures with meningitis in 2 (2 of 35, 5.7%), and seizure with encephalopathy in 1 (1 of 35, 2.9%) patient. Lower respiratory symptoms were not observed in 8 patients. In a patient with encephalopathy, brain diffusion-weighted magnetic resonance imaging revealed transient changes in white matter, suggesting cytotoxic edema as the mechanism underlying encephalopathy. Most patients recovered with general management, and progression to epilepsy was noted in only 1 patient. Conclusion: Although febrile seizures are the most common type of seizure associated with RSV infection, the proportion of patients with complex febrile seizures was higher than that of those with general febrile seizures. Transient cytotoxic edema may be a pathogenic mechanism in RSV-related encephalopathy with seizures.
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( Jae-kyoon Hwang ),( Tea-hyen Cha ),( Ja-hyun Jang ),( Hyun-kyung Park ),( Chang-ryul Kim ),( In Joon Seol ),( Hyun Ju Lee ) 대한주산의학회 2016 Perinatology Vol.27 No.4
Multiple congenital anomalies-hypotonia-seizures syndrome-2 is a genetic disorder also known as infantile epileptic encephalopathy. This disorder is associated with a mutation in the PIGA gene, resulting in defective in glycosylphosphatidylinositol biosynthesis. Multiple congenital anomalies-hypotonia-seizures syndrome has variable clinical symptoms; the severity of the congenital anomalies has been reported to be correlated with the loss of PIGA activity. We report a neonatal case of multiple congenital anomalies-hypotonia-seizures syndrome-2 with a PIGA c.1234C>T (p.Arg412*) mutation, which was discovered by exome sequencing and confirmed by Sanger sequencing. The reported patient had omphalocele, facial dysmorphism, neonatal hypotonia, and seizures. To our knowledge, this is the first report in Korea of a neonatal case diagnosed with multiple congenital anomalies-hypotonia-seizures syndrome-2 associated with a germline PIGA c.1234C>T (p.Arg412*) mutation.
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페그인터페론 알파-2a에 무반응인 환자에서 페그인터페론 알파-2b로 치유된 만성 C형 간염 1예
서광원,김태균,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2007 仁濟醫學 Vol.28 No.-
페그인터페론과 리바비린의 병합요법은 현재 만성 C형 간염의 표준치료로서 유전자형과 체중에 따라 치료기간과 용량에 약간의 차이가 있고 치료기간도 24주, 48주로 단순화 되어있다. 현재의 치료가 기존의 인터페론과 리바비린의 병합요법보다 효과가 많이 높아졌으나 임상에서 치료에 무반응인 환자들을 볼 수 있다. 만성 C형간염 치료 시 무반응인 경우도 환자에게 맞는 맞춤형 치료를 시도해 봄으로써 지속적 바이러스 반응을 높일 수 있을 것으로 생각되어 적정치료를 위한 노력들이 계속되고 있다. 저자들은 페그인터페론 알파-2a로 치료하다가 무반응인 환자에서 페그인터페론 알파-2b로 바꾸어 치료후 바이러스 지속반응을 보인 환자 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Combination therapy with peginterferon(PEG-IFN) and ribavirin is standard treatment for patients with chronic hepatitis C. Nonresponse to treatment is defined as the failure to achieve a 2-log(IU/ml) decline in serum HCV RNA during the first 12 weeks of the therapy. Nonresponders rarely have further decline in serum HCV RNA with the continued therapy and are unlikely to respond during retreatment. The length and shape of each polyethylene glycol(PEG) moiety are crucial in determining the effect on pharmacokinetic and phamacodynamic properties. PEG-IFN alfa-2b has the advantage of weight-adjusted dosing and better extravascular tissue infiltration. We report here a case of an obese women who was a nonresponder to previous treatment with PEG-IFN alfa-2a during the first 16 weeks, but achieved a sustained viral response to PEG-IFN alfa-2b during the next 16 weeks for chronic hepatitis C infection.
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김주영,서은영,김미리,전남희,정현미,김명운,안태석,Kim, Ju-Young,Seo, Eun-Young,Kim, Mi-Ree,Jeon, Nam-Hui,Chung, Hyen-Mi,Kim, Myeong-Woon,Ahn, Tea-Seok 한국미생물학회 2008 미생물학회지 Vol.44 No.1
정도관리는 분석 결과의 신뢰성을 높이기 위해 필수적인 과정이며, 이를 위해서는 일정한 농도의 표준시료가 필요하다. 본 연구에서는 정도관리의 정략분석을 위해 실온에서도 일정시간 개체수가 유지되는 미생물 정도관리용 표준시료를 제작하였다. 대장균으로 조제한 미생물 시료에 세포 분열을 억제하기 위해 nalidixic acid ($100\;{\mu}g/ml$)와 cephalexin ($50\;{\mu}g/ml$)을 첨가하였다. 이후 12시간 간격으로 acridine orange로 염색 후 현미경으로 계수하는 방법과 한천 배지에 배양하여 집락을 계수하는 평판집락계수법으로 개체수 변화를 측정하였다. 현미경 계수 결과 초기간이 $3.7{\times}10^5\;cells/ml$이었을 때 대장균의 개체수는 48시간 동안 $3.5{\sim}4.2{\times}10^5\;cells/ml$의 범위를 보였고, 평판집락법 결과 초기값이 $1.2{\times}10^4\;CFU/ml$ 이었을 경우에는 $1.0{\sim}1.2{\times}10^4\;CFU/ml$로 조사되어 냉장 및 냉동의 필요 없이 실온에서도 48시간 동안 개체수가 비교적 안정적으로 유지되는 미생물 표준시료를 제작할 수 있었다. 따라서 본 연구에서 제작된 표준시료는 현재 상업적으로 판매되고 있는 표준균주 제품과 함께 정도관리의 정략분석을 위해 사용될 수 있을 것이다. Standard sample for quality control of total coliform measurement was procured by addition of nalidixic acid and cephalexin as bacteriostatic agents to Escherichia coli cultured broth. After making the standard sample, the number of E. coli was measured by fluorescence microscopic count method and plate count method by 12 hr interval. The numbers of E. coli remained unchanged for at least for 48 hr at room temperature which ranged from 3.5 to $4.2{\times}10^5\;cells/ml$ and from 1.0 to $1.2{\times}10^4\;CFU/ml$ by direct fluorescence microscopic count method and plate count method, respectively. This result suggests that microbial standard sample with bacteriostatic agents of nalidixic acid and cephalexin is usable for quantitative quality control.
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