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Nonlinear vibration of nanosheets subjected to electromagnetic fields and electrical current
Pourreza, Tayyeb,Alijani, Ali,Maleki, Vahid A.,Kazemi, Admin Techno-Press 2021 Advances in nano research Vol.10 No.5
Graphene Nanosheets play an important role in nanosensors due to their proper surface to volume ratio. Therefore, the main purpose of this paper is to consider the nonlinear vibration behavior of graphene nanosheets (GSs) under the influence of electromagnetic fields and electrical current create forces. Considering more realistic assumptions, new equations have been proposed to study the nonlinear vibration behavior of the GSs carrying electrical current and placed in magnetic field. For this purpose, considering the influences of the magnetic tractions created by electrical and eddy currents, new relationships for electromagnetic interaction forces with these nanosheets have been proposed. Nonlinear coupled equations are discretized by Galerkin method, and then solved via Runge-Kutta method. The effect of different parameters such as size effect, electrical current magnitude and magnetic field intensity on the vibration characteristics of GSs is investigated. The results show that the magnetic field increases the linear natural frequency, and decreases the nonlinear natural frequency of the GSs. Excessive increase of the magnetic field causes instability in the GSs.
Abdul Jaleel,Tayyeb Mahmood,Ahsen Tahir,Shehzad Aslam,Ubaid Ullah Fayyaz 한국통신학회 2022 ICT Express Vol.8 No.4
The interoperability concerns horizontal integration among IoT devices which form vendor- or protocol-specific silos. To answer, this brief presents an architectural design of an autonomic interoperability manager (AIM) that is capable of self-configuration, self-healing, self-optimization, and self-protection. With AIM, IoT devices having diverse protocols, syntax, and semantics can collaborate and interact, and its plugin-based autonomic, service-oriented architecture ensures scalability and extendability. We simulated a healthcare use-case with a range of virtual IoT devices to demonstrate that the AIM dramatically reduces the average response time in a highly dynamic environment, by proactively pruning the network traffic and optimizing the compute resources.
Rafiee, Marjan A.,Partoee, Tayyebe Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.1
In this work, the calculated nuclear quadrupole coupling constants of $^{17}O$ in some styrylquinoline conformers were presented. The calculations were carried out to find the relationships between the charge distribution of styrylquinolines and their pharmaceutical behavior and to explore the differences among the electronic structures of some conformers of these potent HIV IN inhibitors. Furthermore, the HIV IN inhibitory of R1 and R2 rotamers was compared. On the basis of our results: - Charge density on oxygen atoms of carboxyl moiety has a dominant role in the drug activity. - The a conformer in which a divalent hydrogen atom is a link, has more capability in antiviral drug treatment. - The R1 conformer, as a $Mg^{+2}$ chelating agent, is better than R2 conformer and thus it is more inhibitor of HIV IN.
Fatemeh Azadegan-Dehkordi,Tayyebe Bahrami,Maryam Shirzad,Gelareh Karbasi,Nasrin Yazdanpanahi,Effat Farrokhi,Mahbobeh Koohiyan,Mohammad Amin Tabatabaiefar,Morteza Hashemzadeh-Chaleshtori 대한청각학회 2019 Journal of Audiology & Otology Vol.23 No.1
Background and Objectives: Autosomal recessive non-syndromic hearing loss (ARNSHL)with genetic origin is common (1/2000 births). ARNSHL can be associated with mutations ingap junction protein beta 2 (GJB2). To this end, this cohort investigation aimed to find thecontribution of GJB2 gene mutations with the genotype-phenotype correlations in 45 ARNSHLcases in the Kurdish population. Subjects and Methods: Genomic DNA was extractedfrom a total of 45 ARNSHL families. The linkage analysis with 3 short tandem repeat markerslinked to GJB2 was performed on 45 ARNSHL families. Only 9 of these families werelinked to the DFNB1 locus. All the 45 families who took part were sequenced for confirmationlinkage analysis (to perform a large project). Results: A total of three different mutationswere determined. Two of which [c.35delG and c.-23+1G>A (IVS1+1G>A)] were previouslyreported but (c.299-300delAT) mutation was novel in the Kurdish population. The homozygouspathogenic mutations of GJB2 gene was observed in nine out of the 45 families(20%), also heterozygous genotype (c.35delG/N)+(c.-23+1G>A/c.-23+1G>A) were observedin 4/45 families (8.8%). The degree of hearing loss (HL) in patients with other mutationswas less severe than patients with c.35delG homozygous mutation (p<0.001). Conclusions:Our data suggest that GJB2 mutations constitute 20% of the etiology of ARNSHL inIran; moreover, the c.35delG mutation is the most common HL cause in the Kurdish population. Therefore, these mutations should be included in the molecular testing of HL in thispopulation.
Marjan A. Rafiee,Tayyebe Partoee 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.1
In this work, the calculated nuclear quadrupole coupling constants of ^17O in some styrylquinoline conformers were presented. The calculations were carried out to find the relationships between the charge distribution of styrylquinolines and their pharmaceutical behavior and to explore the differences among the electronic structures of some conformers of these potent HIV IN inhibitors. Furthermore, the HIV IN inhibitory of R1 and R2 rotamers was compared. On the basis of our results: - Charge density on oxygen atoms of carboxyl moiety has a dominant role in the drug activity. - The a conformer in which a divalent hydrogen atom is a link, has more capability in antiviral drug treatment. - The R1 conformer, as a Mg^+2 chelating agent, is better than R2 conformer and thus it is more inhibitor of HIV IN.
Radioprotective effect of mefenamic acid against radiation-induced genotoxicity in human lymphocytes
Seyed Jalal Hosseinimehr,Reyhaneh Nobakht,Arash Ghasemi,Tayyeb Allahverdi Pourfallah 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.3
Purpose: Mefenamic acid (MEF) as a non-steroidal anti-inflammatory drug is used as a medication for relieving of pain and inflammation. Radiation-induced inflammation process is involved in DNA damage and cell death. In this study, the radioprotective effect of MEF was investigated against genotoxicity induced by ionizing radiation in human blood lymphocytes. Materials and Methods: Peripheral blood samples were collected from human volunteers and incubated with MEF at different concentrations (5, 10, 50, or 100 μM) for two hours. The whole blood was exposed to ionizing radiation at a dose 1.5 Gy. Lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis blocked binucleated lymphocyte. Results: A significant decreasing in the frequency of micronuclei was observed in human lymphocytes irradiated with MEF as compared to irradiated lymphocytes without MEF. The maximum decreasing in frequency of micronuclei was observed at 100 μM of MEF (38% decrease), providing maximal protection against ionizing radiation. Conclusion: The radioprotective effect of MEF is probably related to anti-inflammatory property of MEF on human lymphocytes
Radioprotective effect of mefenamic acid against radiation-induced genotoxicity in human lymphocytes
Hosseinimehr, Seyed Jalal,Nobakht, Reyhaneh,Ghasemi, Arash,Pourfallah, Tayyeb Allahverdi The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.3
Purpose: Mefenamic acid (MEF) as a non-steroidal anti-inflammatory drug is used as a medication for relieving of pain and inflammation. Radiation-induced inflammation process is involved in DNA damage and cell death. In this study, the radioprotective effect of MEF was investigated against genotoxicity induced by ionizing radiation in human blood lymphocytes. Materials and Methods: Peripheral blood samples were collected from human volunteers and incubated with MEF at different concentrations (5, 10, 50, or $100{\mu}M$) for two hours. The whole blood was exposed to ionizing radiation at a dose 1.5 Gy. Lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis blocked binucleated lymphocyte. Results: A significant decreasing in the frequency of micronuclei was observed in human lymphocytes irradiated with MEF as compared to irradiated lymphocytes without MEF. The maximum decreasing in frequency of micronuclei was observed at $100{\mu}M$ of MEF (38% decrease), providing maximal protection against ionizing radiation. Conclusion: The radioprotective effect of MEF is probably related to anti-inflammatory property of MEF on human lymphocytes.
Mokmeli, Sharareh,Tehrani, Golnaz Asaadi,Zamiri, Reza Eghdam,Bahrami, Tayyeb Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Platinum compounds are the main drugs for treatment of advanced gastric cancer. Previous studies have shown that clinical outcome with platinum-based compounds depends on ERCC1 polymorphisms. The aim of this study was to investigate the frequency of a common polymorphism of ERCC1 gene (C8092A) in Iranian patients with advanced gastric cancer receiving platinum chemotherapy. Materials and Methods: Genetic analysis of the ERCC1 C8092A polymorphism was performed by the PCR - RFLP method using 50 paraffin-embedded tissue specimens. Results: Of the 50 cases, 32% of individuals showed CC genotype, 24% of them had CA genotype and 44% of patients had AA genotype. Conclusions: Based on the results, using of platinum-based chemotherapy would be expected to be specifically beneficial in only 32% of patients.
Sabrieh Amini,Fardin Fathi,Jafar Mobalegi,Heshmatollah Sofimajidpour,Tayyeb Ghadimi 대한해부학회 2014 Anatomy & Cell Biology Vol.47 No.1
Uncontrolled self-renewal plays a direct function in the progression of different types of carcinomas. The same molecular pathway that manages self-renewal in normal stem cells also seems to manage cancer stem cells. Here, we examine the expressions of self-renewal regulatory factors Oct4, Nanog, Sox2, nucleostemin, Zfx, Esrrb, Tcl1, Tbx3, and Dppa4 in tissue samples of colon, prostate, and bladder carcinomas as well as cancer cell lines HT-29, Caco-2, HT-1376, LNCaP, and HepG2. We used reverse transcriptase polymerase chain reaction to examine expressions of the above mentioned regulatory factors in cancer cell lines HT-29, Caco-2, HT-1376, LNCaP, and HepG2 and in 20 tumor tissue samples. Total RNA was isolated by the ISOGEN method. RNA integrity was checked by agarose gel electrophoresis and spectrophotometry. Expressions of Oct4 and nucleostemin at the protein level were determined by immunocytochemistry. A significant relationship was found between tumor grade and self-renewal gene expression. Expressions of stem cell specific marker genes were detected in all examined cancer cell lines, in 40% to 100% of bladder cancer samples, and in 60% to 100% of colon and prostate cancer samples. Oct4 expressed in 100% of tumor tissue samples. Our data show that stem cell markers Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Esrrb, Tcl1, Tbx3, and Dppa4 significantly express in cancer cell lines and cancer tissues. Hence, these markers might be useful as potential tumor markers in the diagnosis and/or prognosis of tumors.
Radiosensitization Effects of a Zataria multiflora Extract on Human Glioblastoma Cells
Aghamohammadi, Azar,Hosseinimehr, Seyed Jalal,Ghasemi, Arash,Azadbakht, Mohammad,Pourfallah, Tayyeb Allahverdi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: Although radiotherapy is one of the most effective strategies in the treatment of cancers, it is associated with short and long term side effects on normal tissues. Zataria multiflora Boiss (Laminacea) (ZM) has several biological properties such as antioxidant and anti-inflammation activities.Here we investigated cell killing effects of a hydroalcoholic Zataria multiflora extract on cell death induced by ionizing radiation in a human glioblastoma cell line (A172) and human non-malignant fibroblasts (HFFF2) in vitro. Materials and Methods: A172 and HFFF2 cells were treated with a hydroalcoholic extract of dried aerial parts of Zataria multiflora at different concentrations (25, 50, 100, 150 and $200{\mu}g/ml$) and then exposed to ionizing radiation (IR). Cell proliferation and DNA fragmentation were evaluated. Thymol content in the extract was analyzed and quantified by HPLC methods. Results: A172 cell proliferation was significantly inhibited by ZM. The percentage cell survival was $91.8{\pm}8.57$ for cells treated with $200{\mu}g/ml$ of ZM extract alone while it was $76.0{\pm}4.27$ and $66.2{\pm}8.42$ for cells treated with ZM and exposed to IR at doses of 3Gy and 6Gy, respectively. Radiation-induced apoptosis in A172 cells was significantly increased following treatment with ZM at doses of $200{\mu}g/ml$. ZM extract did not exhibit any enhanced cell killing effects and apoptosis caused by IR on HFFF2 cells. Conclusions: These data show selective radiosensitization effects of ZM in A172 cells apparently due to increased radiation-induced apoptosis.