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Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure
Takehiro Kamo,Hiroshi Akazawa,Jun ichi suzuki,Issei Komuro 대한심장학회 2017 Korean Circulation Journal Vol.47 No.5
Patients with heart failure (HF) have structural and functional changes of the gut as a result of microcirculatory disturbances. A disrupted gut epithelial barrier may lead to translocation of microbial products into systemic circulation, possibly aggravating HF by inducing inflammatory responses. Gut microbiota play an essential role in the maintenance of host homeostasis because large quantities of their gene products complement host physiological processes. Emerging evidence has suggested the potential clinical significance of gut microbiota in the pathophysiology of HF. Imbalances of gut microbe-derived metabolites can contribute to cardiac dysfunction and other morbidities in patients with HF. Therapeutic research for HF through targeting microbiota is under way. Thus, the novel concept of a heart-gut axis may lead to breakthroughs in the development of innovative diagnostics and therapeutic approaches for HF.
Takehiro Tashiro,Kanta Aoki,Yongkwun Lee,Taisuke Sakaki 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
Human Robotics Research Center (HRRC) has established in 2013 as an R&D center. Our objective is implement robots at the site of rehabilitation and nursing care. HRRC is working on the research and development of wearable auxiliary tool for behavior assistance of elderly who requires nursing care in cooperation with Kashiihara Hospital since 2015. Purpose of this research is to develop wearable device that can be reduce body burden of caregivers who carry out standing assistance / transfer assistance frequently at bathing care. We started this activity in 2015, and we have made 2 mockups so far. In 2016, a verification experiment of standing assistance / transfer assistance was conducted using prototype-1 that made based on the advice from Kashiihara hospital. As a result of the verification experiment, we assume 1st prototype will reduce the burden on caregivers. In the future, we will study "Powered Exoskeleton for Bathing Care" which applied ultra-mini hydraulic technology for body assistance and “Wearable Auxiliary Tool” that does not have body assistance".
Proposal of a flexible translational joint mechanism for humanoid robots
Takehiro Yoneyama,Kazuyuki Ito 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
Recently, applications of robots for home assistant, helper and rehabilitation have attracted considerable attention, and various humanoid robots are developed. In such environments, robots have to handle unexpected disturbance very quickly. Especially, external forces owing to collision to obstacles or people are one of significant problems, because they causes risks to injure human bodies or to break own structures. However, almost conventional robots consist of rigid structures, so, many sensors and high-spec controller is required for handling external forces. To address this problem, flexible structures like a muscle have attracted considerable attentions. By employing flexible structures, we can reduce sensors and controllers, because the flexible structures can adapt themselves to the unknown environment by utilizing their physical properties without sensors or controllers. In this paper, we focus on flexible mechanism, and propose a flexible translational joint of which flexibility can be adjusted adaptively. We employ the proposed flexible joints for legs of a humanoid robot, and we conduct experiments of walking on vibrated plane. As the result, we confirm that the developed humanoid robot can walk on the vibrated plane, due to the filtering properties of the flexible joints.