남성 건강검진 수진자에서 간기능 장애 및 비알코올성 지방간과 대사 증후군과의 관련성

최태성,유재영,김진석,장은철,박주언,김병익 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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뇌 심혈관계 관련질환 유소견 근로자들의 의료이용에 관한 연구

최태성,유재영,김진석,장은철,박주언,우극현 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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大學 男女 球技選手들의 最大無機的 Power

김태운,유재충,안덕균,선우섭,이한,손두욱,박충서 慶熙大學校 社會體育硏究所 1994 體育科學論叢 Vol.- No.7

The purpose of the present research is to compare characteristics of maximal anaerobic power observed in different types of sports and player's sex differences. We have reached the following conclusions from the results we obtained by measuring maximal anaerobic power and blood lactate concentration of 60 elite university male and female players during the exercise of bicycle ergometer: 1. As to absolute and relative values of maximal anaerobic power, male players are higher in the order of rugby and handball, whereas female players are higher in the order of hockey and soccer, but no significant differences are observed between types of sports. 2. Male players are noticably higher in absolute values of maximal anaerobic power(p<0.001), but relative value is very simi1ar to that of female players. 3. It is estimated that the fact, that female players show obvious higher mean anaerobic power(p<0.001) during the 3,4KP excercise is due to sex differences in ocdurrence work load of maximal anaerobic power. 4. Comparison of blood lactate concentration at each work load in different types of sports and player's sex differences show an increase in proportion to mean anaerobic power. The results given above clearly show the differences between the type of sports such as rugby and hockey requiring power and speed, and the type of sports such as handball and soccer requiring edurance.

주요 우울증에서 종양괴사인자-베타 유전자의 다형성

전태연,배치운,김영호,장계호,이정태,박원명,김광수 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 주요 우울증은 역학적 유전연구 등을 통하여 유전적 영향이 높은 것으로 알려져 있으며 최근에는 분자 유전학적 연구로 유전자 다형성과 질병의 연관성을 밝히는 것이 정신질환의 유전학적 연구에서 중요한 부분을 차지하고 있다. 이에 본 연구는 중추신경계와 면역계간의 상호작용에 관여하는 싸이토카인 중 TNF-β 유전자의 다형성을 분석하여 주요 우울증과의 유전학적 관련성을 알아보고자 하였다. 방 법 : DSM-IV에 의하여 주요 우울증으로 진단된95명을 환자군으로 선정하였고 가톨릭조혈모세포정보은행에서 보유하고 있는 정상 한국인 202명의 자료를 정상 대조군으로 사용하였다. 전혈에서 DNA를 추출하고 TNF-β 유전자 부위를 증폭한 후 제한효소 Nco Ⅰ으로 절단하여 555bp와 185bp의 절편을 갖는 TNFB*1과 Nco Ⅰ절단부가 없는 740bp의 절편 TNFB*2등 2가지 대립유전자의 제한효소절편길이 다형성을 조사하였다. 모든 자료의 분석은 x²검증을 이용하였다. 결 과 : 1) 주요 우울증과 정상 대조군 간에 TNFB유전자인 TNFB*1/1, TNFB*1/2 및 TNFB*2/2의 발현 빈도에는 유의한 차이가 없었다. 2) 두 군 간에 TNFB*1 과 TNFB*2 두 대립유전자의 빈도에는 유의한 차이가 없었다. 결 론 : 본 연구에서는 주요 울울증군과 정상 대조군 간에 TNFB*1과 TNFB*2의 두 대립유전자 발현 빈도에 유의한 차이를 발견하지 못하였다. 따라서 TNFB 유전자다형성과 주요 우울증과의 유전학적인 연관성이 없었다. 향후 연구에서는 다양한 임상변인을 포함하여 보다 통합적이고 체계적인 연구가 이루어져야 할 것으로 생각되었다. Objective : Major depressive disorder is known to have high genetic predisposition and the main focus of recent genetic studies in major depressive disorder has been concentrated on association studies between genetic polymorphism and disease, since molecular genetic methods have been developed. This study was designed to investigate the relationship between major depressive disorder and immunogenetic influences by analyzing polymorphism of TNFB gene, which is involved in interaction of immune system and CNS. Method : 95 persons who had been diagnosed of major depressive disorder were assigned as patient group and, 202 data obtained from Catholic hemopoietic stem cell bank, College of medicine, the Catholic University of Korea, were used as normal controls in this study. DNA was extracted from whole blood, thereafter amplified by polymerase chain reaction, and digested by Nco Ⅰ.After that procedure, we obtained and assessd restriction fragment length polymorphism of two alleles, TNFV*1 which has 555bp and 185bp fragments and carries the Nco Ⅰ restriction site, and TNFB*2 of 740 bp fragment lacks the Nco Ⅰ restriction site. All data were analyzed by x²test with two-tailed Fisher's exact test. Results : 1) The frequencies of TNFB*1/1, TNFB*1/2, and TNFB*2/2 were not statistically different between major depressive disorder patients and control group. 2) The frequencies of TNFB*2 and TNFB*1 were not statistically different between major depressive disorder patient group and normal control group. Conclusion : We did not verified the differences of frequency in TNFB*1/TNFB*2 gene between the major depressive disorder and normal controls, respectively. Consequently, there is no genetic relationship between major depressive disorder and gene polymorphism of TNFB. We do suggest that further systematic studies including various clinical variables should be conducted.

Monocyte Chemoattractant Protein-1[MCP1] -2518 유전자 다형성과 주요 우울장애

배치운,이지현,신윤경,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Object : This study was designed to examine the association between monocyte chemoattractant protein-l (MCPl) -2518poly morphism and major depressive disorder (MDD). Methods : Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results : Genotype and allele distributions in patients with MDD were significantly different from those of the controls, In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion : The present study suggests that the MCPl -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

정신분열병과 Glutathione S-Transferase M1유전자 다형성

배치운,조자현,김연주,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : This study aimed to test the possible association between Glutathione S-Transferase Ml gene (GSTMl) variants and schizophrenia. Methods : One hundred and eleven inpatients with schizophrenia and 130 healthy controls were recruited. Genotyping was performed by polymerase chain reaction-based method. Results : The GSTMl null genotype was significantly more frequent in patients with schizophrenia than in controls (p=0.014, odd ratio=1.93, 95% confidence interva1=1.115-3.351), while GSTMl genotype vahants were not associated with either tardive dyskinesia (TD) or total Abnormal Involuntary Movement Scale (AIMS) scores. Conclusion : The present study suggests that the GSTMl polymorphism may confer susceptibility to the development of schizophrenia but not to TD, at least in Korean population.

서울시내 특급호텔 한식당의 현황

윤은숙,나영아,송태희 서울保健大學 1998 論文集 Vol.18 No.1

This study was investigated to the Korean restaurant menus from eight of the first class and five of the second class hotels in Seoul, and attempted to evaluate the restaurant evaluation and cooks job satisfaction with questionnaire surveys. The results were as follows : Korean restaurants of the first class hotel was on sale classified with a large table of food (so called kjo-ja-sang), Korean tabled hotel dinner(chong-sik), a Ia carte (il-pum yori), dessert, and wine with various prices and dishes. The first class hotel sold a lot of a large tables, second class hotel merchandised many Korean tabled hate dinner, both of them served from soup and stew of low price to high class dishes, served rice drink(sik-hei) and ginger tea with dried persimmons (su choung-kwa) with dessert, and served so-ju and bop-ju with Wine. Cooks whose sex were composed of 20% of female and 80% of male, ages were 52% of 20th, most of them graduated from high school or more. They had Korean, Western. Japanese or two or more of cooking license, had engaged in cooking for 5-10 years, worked 8 hours a day, made 1,000,000-1,500,000 won in a month. Most of them were satisfied with their job, possibilities, education training, and salary, whereas they dissatisfied with a cuisine environment such as room temperature, noise, illuminations. Therefore Korean restaurants need improve their working environment. Korean restaurants of the first class hotel had job description. standard cooking recipe, and job planing, hence we know that they were managed with scientific systems. We must attempt to survey menu design of food service system, western and Chinese restaurant as well.

정신분열증 환자에서 Risperidone과 Haloperidol이 혈장 Homovanillic Acid와 5-Hydroxy Indolacetic Acid농도에 미치는 영향

여운태,김중영,김영섭,곽용태 용인정신의학연구소 1998 용인정신의학보 Vol.5 No.2

취학전 아동들의 체격 및 기초체력에 관한 비교 연구

김태운,안병철,고기준,한재웅,이재규 釜山大學校 附設 體育科學硏究所 1997 體育科學硏究所 論文集 Vol.13 No.-

The purpose of the present investigation was to compare and analyze the physique and physical fitness for children(boys:876, girls:784, age: 7 yrs), and to correlation between physique and physical fitness 5 items. The measurement items of physique and physical fitness were height, weight and sitting trunk flexion, 50M run, standing long jump, foot balance, flexed arm hang test. The statistical analysis were calculated to mean and standard deviation for all measurement values and correlation coefficients between physique and physical fitness 5 items for children using SPSS/PC+ statistical package(α=.05). The conclusion of the present investigation was as follows; 1. Physique 1) In height, boys(118.31 ±23.92cm) has been significantly higher than girls(116.11 ±4.72cm)(P<0.05). 2) In weight, boys(22.31 ±3.54kg) has been significantly higher than girls(21.17 ±3.31kg)(P<0.01). 2. Physical fitness 1) In sitting trunk flexion, girls(11.67 ±4.37cm) has been significantly higher than boys(9.97 ±4.48cm)(P<0.01). 2) In 50M run, boys(12.58 ±1.30sec) has been significantly faster than girls(13.30 ±1.59sec)(P<0.01). 3) In standing long jump, boys(112.99 ±16.36cm) has been significantly higher than girls(98.94 ±16.24cm)(P<0.01). 4) In foot balance, girls(30.90 ±19.66sec) has been significantly higher than boys(26.65 ±19.25sec)(P<0.01). 5) In flexed arm hang, boys(8.68 ±7.94sec) and girls(8.58 ±8.11sec) had no significant difference. 3. Correlation between physique and physique and physical fitness 1) In correlation between height and physical fitness, boys were no little correlation in 5 items all, and girls and total were significantly low correlation(P<0.01) between height and 50M run, standing long jump. 2) In correlation between weight and physical fitness, boys and girls all were significantly low correlation between weight and standing long jump(P<0.05), flexed arm hang(P<0.01), and total were significantly low correlation between weight and 50M run(P<0.05), standing long jump(P<0.01), flexed arm hang(P<0.01).

지단백 대사 기전에 대한 문헌 고찰

김태운,박태곤 부산대학교 과학교육연구소 2006 교사교육연구 Vol.45 No.-

Atherosclerosis, along with the resultant coronary artery disease (CAD), is a leading cause of mortality in industrialized countries. Lipoproteins (LP) are generally classified according to their density. Triglycerides are mainly transported in chylomicrons and very low density LP (VLDL), cholesterol is mainly transported in low density LP (LDL) and high density LP (HDL). The metabolism of LP is controlled by their apolipoproteins, by specific receptors, enzymes, and transfer proteins. Lipoprotein receptors are membrane proteins which play a central role in lipid metabolism. The low density lipoprotein (LDL) receptor recognises lipoproteins containing apolipoprotein B100 or an activated form of apo E. The LDL receptor therefore mediates the uptake of intermediate density lipoprotein (IDL) and LDL by the liver, and it also facilitates uptake of LDL by other tissues. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase (LCAT). Cholesterol ester accumulating in HDL can then follow a number of different fates: uptake in the liver in HDL containing apolipoprotein (particle uptake) by LDL receptors, selective uptake of HDL cholesterol ester in liver or other tissues involving scavenger receptor B1 (SRBI), or transfer to triglyceride-rich lipoproteins as a result of the activity of cholesterol ester transfer protein (CETP), with subsequent uptake of triglyceride-rich lipoprotein remnants in the liver. CETP promotes the transfer of cholesterol esters (CE) from antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including VLDLs, VLDL remnants, IDLs, and LDLs. A deficiency of CETP is associated with increased HDL levels and decreased LDL levels, a profile that is typically antiatherogenic. Recently, another key molecule involved in this pathway was identified, scavenger receptor BI ; this mediates the selective uptake of HDL cholesterol esters in the liver and thus constitutes a pathway of reverse cholesterol transport parallel to that mediated by CETP. Thus, the remodeling of human HDL by CETP, involving CE;-TG interchange, followed by the action of hepatic lipase (HL), leads to the enhanced uptake of HDL CE by cellular SR-BI. These observations suggest that in animals such as humans in which both the selective uptake and CETP pathways are active, the two pathways could operate in a synergistic fashion to enhance reverse cholesterol transport. In conclusion, a major challenge will be to determine if manipulation of RCT pathway by targeting molecules such CEPT, LCAT, HL, or SRBI can be used for therapeutic benefit.