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      • Proposed Digital Control Scheme for Improved Current Share of Multiphase DC/DC Converters

        Jen-Ta Su,Chih-Wen Liu 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

        In this paper, a novel control scheme is proposed to improve the current share for multiphase DC/DC converters. The proposed control scheme is based upon gain scheduling method to automatically tune the parameters such as on resistance of power MOSFET or board impedance between each phase for optimization in current balance. The purpose of this paper is proposed a digitally control method to implement the voltage mode control with current sense by inductor series resistance and combined with gain scheduling method. The proposed scheme is verified on 12V input with 1 V output, 40 A 2-phases interleaved DC/DC buck converter and the simulation and experimental results are presented to demonstrate the theoretical analysis.

      • KCI등재

        Effect of H2O and CO2 on NOx emission control for lean-burn engines by electrochemical-catalytic cells

        Ta-Jen Huang,Chung-Ying Wu,De-Yi Chiang 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.3

        Lean-burn engines can offer superior fuel efficiency but require advanced technology for NOx emission control. Electrochemical-catalytic cell has been proposed for lean DeNOx. This work demonstrates that the DeNOx rate can be enhanced by the presence of H2O and/or CO2, and can increase with increasing H2O and CO2 concentrations, although the increased extent is quite small. In the low NOx concentration range,relatively constant DeNOx rates were observed and can result in zero NOx emissions, where the presence of H2O and CO2 has important enhancement effect. Higher temperature generally results in larger N2selectivity in the low NOx concentration region.

      • Tumor Suppressor Gene Therapy for Brain Tumor

        Liu,Ta Jen 가톨릭중앙의료원 가톨릭암센터 1999 암심포지움 Vol.- No.2

        Although there is tremendous advance in conventional therapeutic measures, most patients with glioblastoma and brain stem glioma die within 12 months after diagnosis independent of treatment modality. Malignant gliomas do not respond sufficiently to radiotherapy and inert to chemotherapy. Therefore, alternative modality using advance molecular technology for glioma warrants exploration. Loss or inactivation of several key tumor suppressor genes such as p53, p16, Rb and MMAC/PTEN plays an important role in the etiology of human gliomas. The efficacy of replacement gene therapy using replication defective adenoviral vector has been investigated both in vitro and in vivo. Among these tumor suppressor genes, reintroduction of p53 appears to be the most effective in suppressing tumor growth via inducing apoptosis. However, one caveat for such modality is that overexpression of p53 induces apoptosis only in tumor cells containing mutant p53 and causes G1 arrest in tumor cells with wild-type p53 gene. Acute expression of either p16 or Rb resulted only in attenuating cell growth. Forced expression of MMAC/PTEN in glioblastoma cell lines does not induce apoptiosis despite result in growth suppression. Intervention aiming at disrupting tumor angiogenesis in gliomas has also been explored. Using an antisense strategy targeted the VEGF expression in glioblastoma cells leads to suppression of tumor growth in vivo. Recently, we have shown that forced expression of tumor suppressor gene, E2F-1, in various types of cancer including glioma resulted in apoptosis. The induction of apoptosis by E2F-1 appeared to be independent of the p53 status of tumor cells. Intratumoral injection of AdE2F-1 into animals with established s.c. tumor resulted in tumor regression. Moreover, results from our preliminary study revealed that E2F-1 also could suppress the expression of VEGF in glioblastoma cell lines in addition of VEGF in glioblastoma cell lines in addition to its ability to induce apoptosis, suggesting the anti-angiogenic function of E2F-1.

      • KCI등재

        Laser Interference Lithography and Nanoimprint Techniques for Lower Reflection Transparent Conducting Oxide Hybrid Films

        Ta-Hsin Chou,Kuei-Yuan Cheng,Chih-Chieh Su,Tien-Li Chang,Chih-Wei Hsieh,Jen-Hui Tsai 한국정밀공학회 2010 International Journal of Precision Engineering and Vol.11 No.4

        The transparent conducting oxide (TCO) film is a significant component in flat panel display industry, applied for flexible display, e-paper, and touch panel. The TCO materials have high refractive index, so the phenomenon of high reflectance is the major issue and needs solved in present and future market. In this study, the structure and process of new lower reflection TCO hybrid film is introduced. The laser interference lithography and UV nanoimprint are combined for fabrication of sub-wavelength structures on PET film, then the tin-doped indium oxide (ITO) deposited on structures. Finally, the best result of this hybrid film is reflectance reduced to 3.3% at wavelength 550nm, just 13% of the original film, and the resistance of ITO layer is 1.05x10-3 Ω-cm. This result is useful for the TCO film applied in low reflection demand products in the future.

      • KCI등재

        Comparisons of Moisturizing Function Between Rayon Fabric with Collagen Peptides from Fish Scales and Regular Rayon Fabric Under Various Relative Humidity

        Chi‑Shih Huang,Erh‑Jen Hou,Ying‑Chou Lee,Tzong‑Huei Lee,Yi‑Jun Pan,Ta Yu,Wei‑Hsin Lin,Chun‑Han Shih,Wei‑Che Chang 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12

        The study was inspired by the specialized facial masks made of rayon non-woven fabrics which contained collagen peptides for improving moisturizing function. This study explored the moisturizing function of a rayon fabric containing collagen peptides extracted from tilapia fish scales under various conditions of relative humidity. This research had implications for the development of clothing that can prevent dry skin. A two-stage nested design experiment was adopted. The first-stage factor such as the fabric has two levels and the second-stage factor such as the relative humidity with three levels nested under each level of the first-stage factor. Preliminary results indicated that introducing a new variable (i.e., fabric moisturizing value, which combines the moisture regains of adsorption and desorption) would be useful. The moisturizing value of the novel rayon fabric and regular rayon fabric increased with the increase in relative humidity, and moisturizing effect of the novel rayon fabric with collagen peptides was better than that of the regular rayon fabric. Therefore, the novel rayon fabric may be suitable for preventing dry skin in winter.

      • KCI등재

        Establishment of the Model Widely Valid for the Melting and Vaporization Zones in Selective Laser Melting Printings Via Experimental Verifications

        Chang-Shuo Chang,Kuan-Ta Wu,Chang-Fu Han,Tsung-Wen Tsai,Sung-Ho Liu,Jen-Fin Lin 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.1

        The thermally affected material properties operating in the three phases and porosity variations in the SS316L steel powder have been introduced to the numerical analyses for the transient volumetric heat source (Q) models developed for the solid powder, melting, and vaporization regions in the selective laser melting (SLM). The bulk Q is thus a function of these heat sources and their ratio defined for the liquid and vapor phases. The heat conduction developed for the solid powders with porosity strings the heat convection with Q as the moving heat source to solve two-dimensional temperature distributions efficiently without the confinement of operating conditions and phase presumption. The specimens with single- and multiple-track printings are prepared to investigate the effects of incident energy density (E) and power intensity (I o) on the geometries of single-track printings and the areal surface roughness (Sa) values of the multiple-track printings with 0 and 50% overlap ratios. Laser power and scanning velocity are the controlling factors for the melting pool depth D and width W . D and W become the governing factors for the keyhole with evaporations, which affects the height H of single track after solidification. The W and D results predicted by the theoretical models developed in this study have an error range, 5–20%, compared to the experimental ones, which is much lower than those reported in the literatures (Gusarov et al. in J Heat Transf 131(7):072101, 2009. https ://doi.org/10.1115/1.31092 45 ; Hussein et al. in Mater Des 52:638–647, 2013. https ://doi.org/10.1016/j.matde s.2013.05.070 ; Yin et al. Int J Adv Manuf Technol 83(9–12): 1847–1859, 2016. https ://doi.org/10.1007/s0017 0-015-7609-x ; Andreotta et al. in Finite Elem Anal Des 135: 36–43, 2017. https ://doi.org/10.1016/j.finel .2017.07.002 ). The contact angle ( ϕ * ) is defined as a function of single-track width ( W ) and solidification height ( H ). ϕ * and Sa are significantly reduced as an E is applied beyond its critical value (47.62–57.14 J/mm 3 ). Significant change in Sa is ascribed to the big difference in the morphology and its surface pattern when E or I o reaches its critical value.

      • KCI등재

        Type 2 Diabetes Mellitus Increases Peritonsillar Abscess Susceptibility: Real-World Evidence

        Ching-Lung Wu,Ming-Shao Tsai,Ta-Jen Lee,Yun-Ting Wang,Chia-Yen Liu,Yao-Hsu Yang,Yao-Te Tsai,Cheng-Ming Hsu,Ching-Yuan Wu,Pey-Jium Chang,Geng-He Chang 대한이비인후과학회 2021 Clinical and Experimental Otorhinolaryngology Vol.14 No.3

        Objectives. Type 2 diabetes mellitus (T2DM) is a risk factor for deep neck infection (DNI) and leads to complications and poor outcomes. Our study aimed to investigate the risk, prognosis, and complications of peritonsillar abscess (PTA) in patients with T2DM. Methods. We extracted data of patients newly diagnosed as having T2DM between January 2000 and December 2011 from Taiwan’s National Health Insurance Research Database. These patients were matched with patients without T2DM, and PTA incidence was compared between both cohorts. Results. In total, 67,852 patients with and 135,704 patients without T2DM were enrolled. PTA incidence was significantly higher in patients with T2DM (incidence rate ratio, 1.91; P<0.001); moreover, PTA incidence was higher at 1 to 5 years after T2DM diagnosis than at <1 and >5 years after T2DM diagnosis. Cox regression analysis showed that patients with T2DM had an approximately 2-fold higher PTA risk (adjusted hazard ratio [aHR]: 1.89, P<0.001). Patients with a higher adapted Diabetes Complications Severity Index (aDCSI) had higher PTA risk than those with a lower aDCSI (aHRs: 2.17 for aDCSI ≥1, P=0.006 and 1.81 for aDCSI=0, P=0.002). T2DM patients with a high aDCSI (≥1) had a nonsignificantly longer hospitalization duration and a higher rate of DNI complications than did those with a low aDCSI (=0). Conclusion. In patients with T2DM, PTA incidence was relatively high, and it increased with T2DM severity. Moreover, T2DM patients should be particularly careful about PTA within 1 to 5 years after the diagnosis, and physicians should keep in mind that the prognosis of PTA was correlated with T2DM severity.

      • KCI등재

        Application of cepstrum and neural network to bearing fault detection

        Yean-Ren Hwang,Kuo-Kuang Jen,Yu-Ta Shen 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.10

        This paper proposes an integrated system for motor bearing diagnosis that combines the cepstrum coefficient method for feature extraction from motor vibration signals and artificial neural network (ANN) models. We divide the motor vibration signal, obtain the corresponding cepstrum coefficients, and classify the motor systems through ANN models. Utilizing the proposed method, one can identify the characteristics hiding inside a vibration signal and classify the signal, as well as diagnose the abnormalities. To evaluate this method, several tests for the normal and abnormal conditions were performed in the laboratory. The results show the effectiveness of cepstrum and ANN in detecting the bearing condition. The proposed method successfully extracted the corresponding feature vectors, distinguished the difference, and classified bearing faults correctly.

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