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An Sunho,Vo Tam Thuy Lu,Son Taekwon,Choi Hoon,Kim Jinyoung,Lee Juyeon,Kim Byung Hoon,Choe Misun,Ha Eunyoung,Surh Young-Joon,Kim Kyu-Won,Seo Ji Hae 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Human sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) infections and regulate the cell cycle. Although SAMHD1 mutations have been identified in various cancer types, their role in cancer is unclear. Here, we aimed to investigate the oncogenic role of SAMHD1 in human clear cell renal cell carcinoma (ccRCC), particularly as a core molecule promoting cancer cell migration. We found that SAMHD1 participated in endocytosis and lamellipodia formation. Mechanistically, SAMHD1 contributed to the formation of the endosomal complex by binding to cortactin. Thereafter, SAMHD1-stimulated endosomal focal adhesion kinase (FAK) signaling activated Rac1, which promoted lamellipodia formation on the plasma membrane and enhanced the motility of ccRCC cells. Finally, we observed a strong correlation between SAMHD1 expression and the activation of FAK and cortactin in tumor tissues obtained from patients with ccRCC. In brief, these findings reveal that SAMHD1 is an oncogene that plays a pivotal role in ccRCC cell migration through the endosomal FAK-Rac1 signaling pathway.
Sunho Park,Hyun-Ha Park,Woochan Kim,Yonghyun Gwon,Hoon Eui Jeong,Jangho Kim 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Aligned nanotopography including nanopattern, nanoneedle, and nanowire hold strong potential to regulate stem cell behaviors. In this study, we present a highly flexible hydrogel nanospike array as a precisely defined, vertically aligned polymeric platform for enhancing the differentiation of stem cells and efficiently suppressing biofilm. This vertical nanostructure not only imposes a strong physical stimulus to the cells but also leads to a three-dimensional spherical morphology of the cells, which remarkably promotes their osteogenic differentiation and secretion of growth factors. At the same time, it shows efficient biofilm resistance. This multifunctional flexible hydrogel platform with its vertical nanoarchitectures can be used as transplantable stem cell scaffold or biomedical implant with enhanced stem cell and anti-pathogenic functions.
SCP 운영 프로세스와 ISO 8000-61 데이터품질관리 프로세스 통합
Sunho Kim(김선호),Changsoo Lee(이창수),Dongwoo Lee(이동우),Sangyup Lee(이상엽),Seongwoo Hwangbo(황보성우),Jinwoo Lee(이진우),Ricardo Perez-Castillo,Ismael Caballero 대한산업공학회 2019 대한산업공학회 춘계학술대회논문집 Vol.2019 No.4
SCP (Smart, Connected Product) 운영시 개별 센서나 디바이스에서 스트리밍 데이터가 대량으로 시스템으로 입력되며 비즈니스 데이터 및 외부 데이터와 통합되어 사용된다. 이러한 통합된 데이터를 IoT데이터라고 한다. 고객에게 SCP 의 우수한 운영 능력을 제공하기 위해서는 운영 전반에 걸쳐 고품질의 IoT 데이터가 필수적이다. 고품질의 IoT데이터를 유지하기 위해서는, 센서 데이터를 분석하고 센서/시스템 오류의 잘못된 데이터를 제거하는 데이터 중심 접근 방식만으로는 충분하지 않다. 높은 IoT 데이터 품질을 일관되게 유지하기 위해서 프로세스 중심 접근 방식이 필요하다. 따라서 이 논문에서는 IoT데이터 품질 향상을 위해 SCP운영 프로세스에 필요한 데이터품질관리 프로세스를 제시한다. 첫째 SCP가 운영되는 클라우드 환경, SCP운영 프로세스 범위, IoT 유형을 제시한다. 둘째, IoT 환경에서 필요한 SCP 운영 프로세스를 정의한다. 마지막으로 SCP 운영 프로세스와 데이터 품질관리 프로세스간의 통합 방안을 제시한다. 여기서는 ISO 8000-61에서 정의한 데이터 품질관리 프로세스 참조모델을 기반으로 통합하는 대안들을 제시한다.
Full Scale Performance Prediction of an Energy Saving Device by Using Computational Fluid Dynamics
Sunho Park,Gwangho Oh,Shin Hyung Rhee 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.10
Recently interest on energy saving devices (ESD’s) has increased with the enforcement of the energy efficiency design index (EEDI) verification proposed by the international maritime organization (IMO). Extension of propulsive performance results from model to full scale ships plays an important role in verification of ships with ESD’s. The present study proposed a reliable and efficient propulsive performance prediction method for full scale ships with ESD’s. The propulsive performance prediction in full scale KVLCC2 with pre-swirl stator (PSS) was conducted by the proposed method. Its results were then compared with those by the existing extension methods and by full scale CFD computations. From the results, it was confirmed that the proposed method could extend the model scale results to full scale ones with ESD’s performance improvement effects. Unlike the existing methods, it takes into account of ESD’s and consumes much less computational resources and time than full scale CFD computations.
A Study on the Possibility of Using Automated Vehicles in the Variable
Sunho Kim,Jaehyeon Lee,Yeong-beom Kwon,Chungwon Lee 한국도로학회 2018 한국도로학회 학술대회 발표논문 초록집 Vol.2018 No.05
As interest in automated vehicles increases, there is a need for automated vehicles and traffic management for them in transportation field is being raised, and related researches are being actively carried out. Traffic management for automated vehicles can be divided into longitudinal and lateral directions as in existing traffic management, but traffic management detailed strategies can be different for each direction. In this study, automated vehicles are applied to the variable speed limit, which is one of the longitudinal traffic management techniques, and the possibility of using automated vehicles in the variable speed limiting system is examined. Manual vehicles can receive traffic information by VMS, while V2X is used for automated vehicles. Therefore, various traffic information including speed limit information can be received from the road infrastructure ahead of manual vehicles. Simulation of how such a vehicle-infrastructure cooperation system can be utilized in a variable speed limit system is conducted and analyzed by market penetration rate (MPR) of automated vehicles. It is expected that the variable speed limit system of automated vehicles utilization, which is invetigated in this study, will be utilized for transportation management in the automated vehicles future.
( Sunho Park ),( Dohyon Lee ),( Daun Kim ),( Jangho Kim ) 한국농업기계학회 2016 한국농업기계학회 학술발표논문집 Vol.21 No.2
The development of an efficient in vitro device to process various living systems including animals and plants would represent a major milestone in biological science and engineering. Here we propose the design and manipulation of microfluidic devices mimicking the complex environments for living systems such as yeasts, microalgaes, and tissues. A simple microfluidic-based in vitro cell culture device containing a cell culture channel and an air channel was developed to investigate physical pressure stress-induced behavior in yeasts and microalgae. The shapes of Saccharomyces cerevisiae and Chlamydomonas reinhardtii could be controlled under compressive stress. The lipid production by Chlamydomonas reinhardtii was significantly enhanced by compressive stress in the microfluidic device when compared to cells cultured without compressive stress. In addition, we propose microvascular networks in a hydroxyapatite-incorporated extracellular matrix for manipulating a vascularized bone tissue model in a microfluidic device. These microfluidic-based in vitro devices can be used as a tool for quantitative analysis of living systems under complex physical and chemical conditions.