규폐결핵 3례의 임상 및 병리학적 소견의 비교 검토

김상호,이수영,윤임중,이승한,조규상,김영제 카톨릭대학산업의학센타 산업의학연구소 1972 韓國의 産業醫學 Vol.11 No.3

Among the pneumoconiosis, the silicosis is an occupational lung disease, ordinally due to prolonged inhalation of air containing free silicon dioxide. We had chance to perform autopsy of three cases of silicotuberculosis. Both lungs with hard and contracted appearance, were showed massive fibrous adhesion to pleura and also revealed gritty appearance on cut sectioning, and the cut surfaces were shown dark greenish to black pigmentation. Characteristically, many dense black or grey colored silicotic nodules measuring upto 1-4 mm in diameter, with anthracotic pigments distributed throughout both lung parenchyma especially along the peribronchial regions in all three cases, commonly. Microscopically, the nodules were noted as the mass of concentrically laminated dense fibrotic tissue. In addition to those findings, the pulmonary parenchymas were replaced by wide areas of fibrosis and also accompanied with exudative and productive form of tuberculosis (common in all three cases), bronchopneumonia (except case-1) and also compensating emphysema, atelectatic lesions. At the peripheral areas of the silicotic nodules, focal accumulation of the plasma cells, lymphocytes and many foci of endarteritis were shown in three cases, commonly. The silica was confirmed by polarizing microscopy as birefringent, white colored crystals.

스트레스 관리 훈련이 대학생들의 A 유형 행동 및 혈압변화율에 미치는 효과

권현용,장현갑,홍성화 한국동서정신과학회 1998 동서정신과학 Vol.1 No.1

본 연구는 스트레스 관리 훈련이 대학생들의 A유형 행동 및 혈압변화율에 미치는 효과를 알아보기 위한 것이었다. A유형 대학생을 고르기 위해, 약 600여명에게 대학생용 JAS와 Framingham TABP를 실시하였다. 두 검사 모두에서 상위 30%에 해당하는 점수을 받은 학생들을 선발하였다. 본 연구의 피험자는 21명이다. 이들은 무선적으로 스트레스 관리 훈련집단, Roskies의 훈련집단, 통제집단에 각각 할당되었다. 스트레스 관리 훈련집단과 Roskies의 훈련집단은 8주 동안 90분씩 실시하였고, 통제집단은 1회의 스트레스 강의만을 받았다. 본 연구의 결과는 다음과 같다. 첫째, 스트레스 관리 훈련집단과 Roskies의 훈련집단은 통제집단보다 A유형 행동(JAS, Framingham TABP)의 유의미한 감소를 보였다. 둘째, 스트레스 관리 훈련집단과 Roskies의 훈련집단 및 통제집단은 풀기 어려운 과제에 직면했을 때, 혈압율의 감소에 있어서 차이를 보이지 않았다. 결론적으로, 스트레스 관리 훈련은 A유형 행동의 감소에는 효과가 있지만, 생리적 반응인 혈압율의 감소에 있어서는 즉각적인 효과가 없었다. This study was designed to examine the effects of stress managenment on reducing Type A behavior and altertation rate of blood pressure among students of college. About 600 students were give JAS Form-T and Framingham TABP, to select Type A students of college. The responses of Type A the college students got score a high rank 30% in all of tests. Subject for this study were 21 Type A students of college. They were ramdomly assigned to the three grooup; Stress management training group, Roskies' s training group, control group. The Stress management training group and The Roskies' s training group received a 90 minute program for 8 weeks, and The Control group receivd only one stress lecture. The results of this study were as follows; First, Compared to Control group, The stress management training group ans Roskies' s training group showed significant reductions in Type A behavior pattern(JAS Form-T, Framingham TABP). Scond, When given the difficult tast, reduction of blood pressure rate was not significamtly different among three group. In conclusion, stress management training had some effectcts on reducing of Type A behavior pattern, but not biological response as blood pressure rate.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

교양강좌 개선방안

권기성,권영길 광운대학교 인문사회과학연구소 2000 인문사회과학논문집 Vol.29 No.-

흉통의 양상에 따라 분류한 불안정형 협심증 환자의 임상적 소견의 비교

김명수,김성구,정호석,온영근,신원용,김철현,최태명,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Background and aims : The clinical syndrome unstable angina pectoris that encompasses a variety of symptoms and clincal presentations of transient episode of myocardial ischemia, was devided to several subgroups. Also, it has variable pathophysiologic factors to cause myocardial ischemia. According to clincal presentation, coronary angiographic finding and prognostic factor, the result of unstable angina pectoris is variable. In fact, there were a few data reported on the prognosis of wide spectrum of patients with unstable angina. However, the precise risk of subgroups according to classitication has not been established because it was difficult to compare between studies. We classified unstable angina pectoris by clinical nature of chest pain, and performed to establish and compare the clinical presentations, coronary angiographic findings, treatement and prognosis of patients with unstable angina within subgroups of classification. Methods : Retrospenctive data for 164 unstable angina pectoris patients admitted to the Internal Cardiology Division of Soon Chun Hyang University Hospital from May 1996 to July 1999 was analyzed. The patients were classified into one of the following categories: Class I, new onset of severe angina; Class II, acceleration of previous chronic stable angina; Class III, angina at rest. Clinical presentations, echocardiographic findings, coronary angiographic findings, treatment and prognosis were compared. Results : From the total 164 patients, the subjects of classes were as follows : Class I, 46 cases (28.1%); Class II, 74 cases (45.1%); Class III, 44 cases (26.8%). In view of age distribution, the 7th decade had the highest incidence, and then, 6th, 8th decades were followed. There was no baseline differences among the 3 classes with respect to gender, number of risk factors. Significantly, class II showed more severe findings in abnormal Q wave 15 cases (20.8%), total occclusive lesion 10 cases (20.8%) and three vessel coronary disease 11 cases (22.9%) than other classes. The change of ST segment was significantly apparent (p<0.02) among class I 28 cases (60.8%), class III 26 cases (59.0%), comparing with class II 30 cases (40.5%). Class III had the higher incidence of one vessel coronary artery disease than class I and III. The heparin treatment was performed in 99 cases (60.1%). The incidence of nonfatal myocardial infarction was much more in class I and III, each 4 cases (8.7%, 9.8%) than in class II 1 cases (1.4%). In-Hospital death was occurred in class I and II, each 1 case. Conclusion : The patients with the acclerated angina from chronic stable angina had more severe coronary artery disease than other classes, but they had better in-hospital prognosis.

퍼지 플로킹 기반의 보이드 생태계 행동 모델링

권일경,이상용 公州大學校 工學硏究院 生産技術硏究所 2003 論文集 Vol.11 No.-

Computer games are using an intelligent method called flocking for boids' group behavioral modeling. Flocking can naturally model group behavioral patterns of unpredictable forms such as birds and fished using somecomputer resource. In this paper, we implemented an ecosystem which is composed of predator and preyfor group behavioral modeling of real underwater ecosystem. Also fuzzy logic is applied to implement instinct desire of ecosystem elements. As the result, we confirmed that the model can overcome breakdown of ecosystem and model naturally ecosystem behavior.

24주간 추적하는 임상 연구에서 한국인 남자 알코올 의존 환자의 비재발률

강철중,김성곤,남궁기,조동환,이병욱,최인근,최용성,박성봉,제영묘,김현경,김성연 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objetives : In order to provide useful data tbr the further clinical studies with Korean alcohol-dependent patients, enrollment and non-relapse rates were investigated while alcohol-dependent patients wcre followed up for 24 weeks. Methods : The subjects of this study were alcohol-dependent male patients who, for the first time, visited a hospital among 3 groups of hospitals, University Hospital, General Hospital or Mental Hospital, or those who needed to be followed up after discharge from those hospitals. After assigning 12 subjects to each hospital, we investigated enrollment and non-relapse rates while cognitive-behavioral therapy and pharmacotherapy were provided. Results : 1) Forty-eight patients were enrolled and the rate of enrollment was 36.4%. The enrollment rate in the University Hospital group was 52.1%, in the General Hospital group 50.0%. and in the Mental Hospital group 10.4%. 2) In 48 patients, non-relapse rate was 27.1% at 12 week and 18.8% at 24 weeks after starting follow-up. It was 24.4% and 20.0% at 12 and 24 weeks, repectively, in the University Hospital group while the General Hospital group showed 33.3% and 16.7%, respectively, and the Mental Hospital Group showed 20.0% at both 12 and 24 weeks. Conclusion : These results provide important data for further clinical studies of Korean alcohol-dependent patients.

Activation of microglia and increases in inflammatory cytokines in the hippocampus of type 2 diabetic rats

Sung Min Nam(남성민),Dae Youg Yoo,Woosuk Kim,Sun Shin Yi,In Koo Hwang,Je Kyung Seong,Yeo sung Yoon 한국실험동물학회 2011 한국실험동물학회 학술발표대회 논문집 Vol.2011 No.2

Alkylldimethylbenzylammonium chlorides의 Micelle 형성에 대한 열역학적 연구

성용길,이병수 동국대학교 자연과학연구소 1986 자연과학연구 논문집 Vol.6 No.-

Alkylkimethyl benzyl ammonium chlorides의 陽이온 界面活性劑 (?水性炭素鎖 C, C 및 C)를 合成하고 界面活性劑들에 對한 critical micelle concentration (cmc)를 表面張力法과 傳導度法으로 각각 20℃, 35℃ 및 50℃에서 測定하였다. cmc 形成에 있어서 micelle化의 enthalpy 變化 △Hm, entropy 變化 △Sm 및 free energy 變化 △Gm를 測定 data로 부터 計算하였다. △Hm을 △Sm에 對하여 plot한 結果 直線을 나타냈고 이 直線은 界面活性劑의 ?水性炭素鎖가 길어질 수록 石側으로 平行移動하였다. Micelle 形成時에 entropy 變化量은 界面活性劑의 濃度增加에 따라 增加함을 나타냈고 炭素鎖가 긴 界面活性劑일수록 그 entropy 變化量은 더욱 增加하였으나 溫度가 上昇하면 減少함을 보였다. 이 micelle 形成에 對한 entropy 變化量이 주로 界面活性劑의 ?水性炭素鎖 주위의 構造水의 量에 기인한다는 事實도 論議하였다. Alkyldimethyl benzyl ammonium chlorides which have hydrocarbon chains with C, C and C were synthesized and identified. The critical micelle concentrations (cmc) of these cationic surfactants were measured by surface tention and conductivity methods at 20℃, 30℃ and 50℃, respectively. The enthalpy change △Hm, entropy change △Sm, free energy change △Gm for the micellization have been calculated from the measured cmc data. The plot of △Hm vs △Sm shows straight line shich shifts slightly to light hand side with the increase fo hydrocarbon chain length. The entropy of micellization has been increased with the number of hydrocarbon chains and the concentration fo the surfactants but the entropy has been decreased with the increase of temperature. It has been also discussed that the entropy of micellization is mainly due to the quantity of water cluster around the hydrocabon chains of surfactants.

콘크리트 교량의 건전도 및 손상평가에 관한 기초적 연구

成基泰,金容道 충주대학교 산업대학원 1999 大學院論文輯 Vol.1 No.-

Most of existing reinforced concrete bridges was built with cement concrete. Almost every structures have more or less damaged because of various reasons such as material used, construction methods, conditions when constructed, structure and external load condition, water guality, and management methods. The damaged structres have posed huge problem in effectively managing and maintaining the system and damaged to repair and reinforce before use in season. Criterion for repairing and reingforcing material, selection methods,and evaluation methods for repaired and reinforced structures do not exit. In addition,existing and materials for repair and reinforcement are too difficult or expensive to apply to bridges structures. In this paper, Data are collected and analyzed to existing reinforced bridges,sprcific topics that were studied are as follow; 1. Evaluation of damaged bridges. 2. Examination of damaged structures. 3. Suggestions.