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Sang-In Park,Sungjeong Lee,Hwa-Young Lee,Sung-VinYim,Bo-Hyung Kim 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.6
There is a lack of studies on the effects of Korean ginseng (Panax ginseng C.A. Meyer) on face or body temperature. Therefore, in this study, we evaluated the effects of a black ginseng extract, KGR-BG1, on head and face temperatures and compared them with those of red ginseng extract and a placebo. We assessed their safety and tolerability and examined changes in the serum levels of biomarkers associated with immune responses, as well as with glucose and lipid metabolism. A randomized, double-blind, placebo-controlled study was conducted with 180 participants. The participants were randomly assigned to the KGR-BG1, red ginseng extract, or placebo group. Each group received a 1500 mg oral dose of their respective substances containing 1000 mg of the active component or placebo twice daily for 6 weeks. After treatment, changes in the head, face, and body temperature were measured, and serum biomarkers were evaluated. A total of 172 participants completed the evaluation after 6 weeks of treatment. No significant differences were observed in the head, face, and body temperatures among the treatment groups. After 6 weeks of treatment, the serum levels of biomarkers associated with inflammation, glucose metabolism, and lipid metabolism were similar to the baseline levels in all treatment groups. KGR-BG1 was well-tolerated compared with red ginseng extract and placebo. KGR-BG1 did not significantly alter head, face, or body temperature, or serum biomarker levels, and it was well tolerated in healthy volunteers over 6 weeks of treatment. Study Registration: Registered at Clinical Research Information Service (CRIS; https://cris.nih.go.kr) as KCT0003126.
Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients
Jung-ChulSeo,Sang-WonHan,Chang-SikYin,Hyung-KyunKoh,Chang-HwanKim,Ee-HwaKim,Kang-HyunLeem,Hyang-SookLee,Hi-JoonPark,Soon-AeKim,Bong-KeunChoe,Hee-JaeLee,Sung-VinYim,Chang-JuKim,Joo-HoChung 생화학분자생물학회 2002 Experimental and molecular medicine Vol.34 No.4
Apoptosis has been implicated in the pathogenesis ofneurodegenerative diseases such as stroke and Alzhe-imer's disease. Apo-1/Fas gene is one of the mediatorsof apoptosis in stroke. MvaI polymorphism is the firstpolymorphic marker identified in the Apo-1/Fas genepromoter, which was typed by PCR and folowed byMvaI digestion and gel electrophoresis. DNA isolatedfrom peripheral blood collected from 91 strokepatients and 103 healthy blood donors was used forgenotypes of GG, GA and AA by sequence specificprimer PCR. MvaI polymorphism was examined basedon Fas gene promotor region by restriction fragmentlength polymorphism (RFLP). The Fas-G genotypewas the least frequent in patients with stroke andhealthy controls (P= 0.57). In normal Korean controlsthe MvaI polymorphism GA, AA and GG were 48.6%,34.9% and 16.5%. In stroke patients were 56.2%, 29.6%and 14.2% respectively. And the allelic frequencies ofMvaI*2 (G) alle were les frequent than MvaI*1 (A)alle in patients with stroke and healthy controls(P= 0.76). In normal Korean controls MvaI*1 (A) andMvaI*2 (G) alles were 59.2% and 40.8%. In strokepatients were 57.6% and 42.4%, respectively. Ourresults, pending confirmation in a larger study, indi-cate that the Fas genotype may not apear to be a riskfactor for stroke in Korean stroke patients.
Angiotensin converting enzyme gene polymorphism in Korean patients with primary knee osteoarthritis
Seung-JaeHong,Hyung-InYang,MyungChulYoo,Chang-SikIn,Sung-VinYim,Sheng-YuJin,Bong-KeunChoe,Joo-HoChung 생화학분자생물학회 2003 Experimental and molecular medicine Vol.35 No.3
portant role in the physiology of vasculature, blod presure and inflamation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has ben widely investigated in its relation with cardiovas-cular and neurodegenerative diseases and longe-vity. ACE gene polymorphism in an inflamation asociated osteoarthritis (OA) patients is not known. Here we have investigated ACE gene polymor-phism in 142 Korean primary kne OA patients and 135 healthy volunters to establish any cli-nical corelates between ACE polymorphism and disease onset age, Kelgren-Lawrence grade and Lequesne's functional index provided additional analysis of the relationship of ACE polymorphism and clinical features of OA. Early onset OA showed significantly higher allele frequency and cariage rate of I than late onset OA. Radio-graphically severe and functionaly por OA showed higher cariage rate of I allele than radiogra-phically mild and functionally god OA, respec-tively. This study first reports ACE gene poly-morphism to be a risk factor for early onset, se-vere form primary knee OA.angiotensin converting enzyme; osteoar-thritis; polymorphism; risk factor