http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Kyu Sik Jung ),( Jun Yong Park ),( Mi Na Kim ),( Hana Park ),( Yun Bin Lee ),( Joo Ho Lee ),( Yeonjung Ha ),( Beom Kyung Kim ),( Seung Up Kim ),( Sang Hoon Ahn ),( Do Young Kim ),( Hana Park ),( Kyu 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: The change of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients under regular follow up has not been widely investigated. We investigated the serial changes of hepatic steatosis assessed by controlled attenuation parameter (CAP) and the predictors for improvement of hepatic steatosis in NAFLD patients. Methods: Among 513 NAFLD patients diagnosed upon ultrasound and CAP > 250 dB/m at baseline, 304 patients underwent repeated CAP measurement at baseline and at follow up. The improvement of hepatic steatosis was defined as a >10% decline of CAP value from the baseline. Results: Mean age of 304 patients was 58.8 ± 11.4 years and 80.1% were male. The mean CAP value significantly decreased from baseline to follow up (292.3 dB/m to 277.1 dB/m, P<0.001). During the median follow up of 15.3 (9.5-20.3) months, 34.5% patients showed improvement of hepatic steatosis. In a univariate analysis, low body mass index (BMI), low weight, low liver stiffness value, low triglyceride level, and low ALT at follow up were predictors for improvement of hepatic steatosis. In multivariate analyses, low weight (P=0.004; hazard ratio [HR],0.965; confidence interval [CI], 0.941-0.988) and low ALT (P=0.004; HR,0.971;CI, 0.951-0.990) at follow up, or low BMI (P=0.006; HR,0.881; CI, 0.805-0.964) and low ALT (P=0.004; HR,0.971; CI, 0.951-0.990) at follow up were the independent predictors. In patients with weight reduction more than 10% (n=22), CAP value significantly decreased (from 288.0 dB/m to 228.9dB/m, P<0.001). Conclusions: Weight reduction, and ALT decrease were independent predictors for improvement of hepatic steatosis. Long term effect of weight reduction on improvement of hepatic steatosis and fibrosis should be investigated further.
이성룡(Seong-Ryong Lee),이수원(Su-Won Lee),고성훈(Sung-Hun Ko),강대업(Dae-Up Kang) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7
본 논문에서는 계통연계형 인버터에서 요구되는 전력품질 개선 기능, 부하수요관리 기능, 무정전전원공급 기능 등을 전류제어형 전압원 인버터 시스템에서 통합적으로 수행할 수 있는 UPS를 고려한 계통연계형 전류제어 인버터를 제안한다. 제안된 시스템은 평상시에는 무효전력 보상, 고조파 저감, 부하수요관리 등의 PCS(Power Conditioning System) 기능을 을 수행하고 계통 고장시에는 배터리에 저장된 에너지를 이용하여 부하에 즉시 정전압을 공급하는 UPS 기능을 수행한다. 본 연구에서는 제안된 시스템의 동작원리 및 제어 알고리즘을 이론적으로 해석하고 시뮬레이션을 통하여 유용성을 확인한다.
Dkk-1 Promotes Angiogenesis through Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
( Sang Hyun Seo ),( Hye Jung Park ),( Kyungjoo Cho ),( Hye Won Lee ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Seung Up Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Dickkopf-1(DKK1), a negative regulator of the Wnt/ ß-catenin pathway, has been recently found to be up-regulated in hepatocellular carcinoma (HCC). However, the biological function of DKK1 in HCC has not yet been well documented. Our previous in vitro data suggest that DKK1 can enhance angiogenesis by endothelial cell, independent of the Wnt signaling pathway. This study aimed to investigate the tumorigenic potential and angiogenic role of DKK1 in mouse model. Methods: We assessed tumorigenic functions of DKK1 in Hep3B cells expressing endogenous DKK-1 and in DKK1-deficient Hep3B cells created using CRISPR/Cas9 technology. These edited cells were injected subcutaneously in immunosuppressed mice and tumor growth was followed for 6 weeks. With the evidence of tumorigenic potential in DKK1, transgenic mouse models expressing DKK-1 or luciferase were developed using hydrodynamic transfection. Transposons encoding an activated form of human H-RAS were mixed with transposons encoding either DKK1 or luciferase. All mice were monitored at least twice per week and sacrificed when moribund. Subcutaneous tumors and tumor-bearing livers were formalin fixed for hematoxylin- eosin and immunofluoroscence staining. Results: DKK1-deficient Hep3B xenografts exhibited significantly less growth compared to control Hep3B cells expressing DKK1. In addition, the forced expression of DKK1 with H-RAS through the hydrodynamic transfection formed many tumors in the liver, compared to luciferase liver. We investigated the expression of angiogenesis markers, including CD31, VEGFR2 and mesenchymal markers, including vimentin, fibronectin in the subcutaneous tumors and tumor-bearing livers. Quantity of angiogenic and mesenchymal cells were found to be reduced in the established DKK1 homozygous knockout mice (all P<0.05). Taken together, it was confirmed that the expression of CD31 (P<0.0001), VEGFR2 (P<0.0001), vimentin, and fibronectin (P<0.0001) were up-regulated with DKK1 in the mouse liver. Conclusions: Our findings indicate that DKK1 appears to facilitate angiogenesis, and the progression of HCC through inducing the EMT.
日本 '武士道'에 대한 考察 : 죽음의 超克을 中心으로 Especially on Theire Attitude Toward Physical Death
이상업,梁元錫 慶尙大學校 1980 論文集 Vol.19 No.2
Bushido, Japanese Kinghtship, is a kind of regulation for behavior imposed on the Japanese Samurai classes, so that the history of this regulation began with the appearance of the Samurai classes. As soon as the Imperial rule of Heian dynasty was practically collapsed by local Samurai, a primitive feudalism appeared with a Samurai boss, Kamakura Dono, as its leader. We can say Bushido is a product of the feudalism and compare it with the knightship in mediaeval Europe. But Japanese Bushido must be ditinguished from European knightship, because it had absorbed many kinds of native faiths, sects of Budhism, especially Zennism. No one can deny that Zennism affected exclusively the growth of Japanese Bushido. Zennism came from Chinese Song dynasty during the age of Kamakura Shogunate about the middle of 12th century. As it treated life and death on the same level, the Samurai of Kamakura who had to abide by death-in-action found in it a queer fascination. Zennism a faith of willingness, resultingly appealed to Samurai more morally than philosophycally. The always death-in-action-destined Samurai accepted willingly all of the had training that Zennism required; simplicity, straightness, self-defiance, et cetera. These requisitions coincided also with the combater's spirits. The fact that a great combater was without fail a stuborn ascetic and stoic intimates the relations between Zen and Samurai. No other one has expressed the spirit of Bushido more exactly and pithily than the author of "Hagakure"-an essay written for true Samurai about 1710 AD. -who said "Bushido is found in death" This strange exhortation covers the basic meaning of Japanese Bushido. The most gruesome way of suicide, Harakiri(cutting up belly with a sharp dagger) is a direct product of Samurai affected by Zennism. In other words, the Harakiri is the most sprended fruit of Bushido. We can not find such a ghastly death except the religious martyrdom that is to be compared with Harakiri. The age of Tokugawa Shogunate breeded many Confucianists, and they tried to strike out various kinds of chatty rhetorics for adorning Bushido, consequently Bushido was full dreassed outside. But Bushido's inner vitality was beginning to dwindle through long & steady times of peace during Tokukawa Shogunate. Nevertheless for Samurai who were accustomed to think that the true Samurai must be either killed in battle or kill themselves through Harakiri, to find some proper chance to die Samurai-like death was their final hope. The Girl, duty or obligation in Japanese, for their master was only a rational pretence to accomplish their purpose. For example, Akao affair(In this affair 46 Samurais who had belonged to Akao clan were sentenced to death through Harakiri because of their vendetta against Kira Yoshinaka who caused their master's death) was also a case of seeking the place to die. Recentry novelist Mishima Yukio took the same method as Akao Samurais, he also was seeking a proper place for completing his aesthetic death. No one would believe that he had faith that his petit militant squad would defend Japan from foreign aggression. All the things he invented were merely a contrivance for his great death stage.
이상업 慶尙大學校 1982 論文集 Vol.21 No.2
In this study, I could extract the 5 kinds of patterns on the sensibility of the beautiful in the "Turedure-gusa" which is supposed to be written by Yoshida-Genko (1283-1350) The 5 patterns are as follow. 1. The beauty of the imperfectness. 2. The beauty of the intimation. 3. The beauty of the vagueness. 4. The beauty of the simplicity. 5. The beauty of the archaic. I put focus on the patterns of above 1&2. and I could conclude the following facts. i) The sensibility to the beautiful of a nation has a traditionlity and has the same root as the national culture. ii) The sensibility to the beautiful in Manyoshu & Kokinshu has influence on the building up of the aesthetic sense of Japanese medieval times. iii) The building up of the sensibility to the beautiful of the nature -including all kinds of seasonable goods- is to be illustrated by diagram as follow. a. An outlook on nature founded on nature itself. ↓ -in Manyoshu Age- b. An outlook on nature founded on idealized nature ↓ - in Kokinshu Age- c. An outlook on nature founded on the transiency of Buddhism. ↓ -in Medieval Age-
日本文學과 自然觀照 : in the Manyoshu 特히 萬葉植物을 中心으로 하여
이상업 慶尙大學校 1976 論文集 Vol.15 No.-
It is a common phenomenon that nature takes part in the field of literature, and Japanese literature has pioneerd an unique genre in that field. This report treats the manner of contemplation concerning nature(especially plants) in Japanese literature. Generally speaking it is the medium for the expression of feeligns. Subjects of nature is used to explain two different ideas. one is the intuititve concept or pure feeling concept. and the other is the moral concept or artificially valued concept. In Japanese literature-especially in Manyoshu-, the plants take part in it as an intuitive creation, in other words thepoetsof Manyoshu had found the beauty of plants not throught their moral significance but through their original beauty without adding any moral explanation. In this report I have compared and analyzed the Shijo plants and Manyoshuplants(I have named the plants which take park in Shijo & Manyoshu. see table #1) I am afraid of being criticized because both poems were written at different periods of time. but I beg you ot passover this for the moment. The result of comparign literary plants has made it us possible to classify into the following three groups. The first group; pine and palm blossoms are treasured by bothpoets of Shijo & Manyoshu poetry. The Second grup; which is treasured eccentrically by Manyoshu poets, but is treated coldly by Shijo poets. For example, bush clover, pink, ominaeshi (a grass which blows at autumn and belongs to genus patrinia), common reed grass, pampas grass, lawn grass. Above all, the busy clover is cited in Manyoshu poetry more than 140 times and acquired the first rank in frequency. but in Shino poetry bush clover is nearly forgotten and is cited only twice. (as fire wood and as symbol of a grave-yard tree) The third group; whcih is treasured by Shijo-poets. They accepted these without any antagonistic argument. The idea of these plants was transmitted through the eyes of chinese poets-so that the plants were cited in idiomatic form, for example, green-willow, heaven-peach, pear-brossom, red-lotus, cold-chrisanthmum. It is very notable point that poets of Manyoshu have discriminated against 157 kinds of plants about 1,300years ago. These fact teach us not only their penetrating influence concerning nature in poetry, but also their adhesion with nature it-self. "The seven grasses of autumn" which were selected by Yamanoueno-okura(a representative poet of Manyoshu) displays the essence of Manyoshu poetry using delicacy & lonleness. In hisworks the essence may be linking with the penetrating sensibility of Japanese culture. In the famous "Genjimonogatari", a long love story by Murasaki-shikibu in Heian dynasty, we can find the following sentence. "In china, the spring landscape decorated by beautiful flowers is treasured, but In Japan, the sadness of autumn is valued." And "the seven grasses of autumn" is the concrete expression of sorrow which is created by Manyoshu-poetry, Hagi, the name of bush clover, comes from two different chnise characters. the upper part "? " means grass, and the lower part "秋"autumn. These two part are combined by the Japanese originally, so that we cannot find this character in the chinese dictionary. This fact teaches us that poets of Manoshu poetry thought that "Hagi" si a represented "grass" of autumn. and we also can imagine their thoughts. In summary, I would say that the essence of Manyoshu is a concept of "flowers and leaves of bush clover". Going a step further, I would define this as "dew-pearled flowers and leaves of bush clover.".
이상업,梁元碩 慶尙大學校 1981 論文集 Vol.20 No.2
In this report I have compared the Shijo plants…the plants which appear in Shijo Anthology…with Manyoshu plants. It is a very notable point that poets of Manyoshu have discriminated between 175 kinds of plants about 1200 years ago. This fact teaches us not only their penetrating influence concerning nature in poetry, but also their adhesion to nature itself. In Japanese literature…especially in Manylshu and the other Wakas plants take part in it as an intuitive creation, in other words the poets of Manyoshu and the other Waska had found the beauty of plants not through their oral significance but through their original beauty without adding any moral explanation.
이상우,정대업,이수열,차상곤,심명석 대한건축학회 2003 대한건축학회논문집 Vol.19 No.4
This study aims at providing useful data for the design of underground stations through an extensive survey of acoustic properties in underground stations in Seoul. In order to improve the sound efficiency at the underground station, sound characteristics in the space of the underground station were studied. Architectural features of underground stations located in Seoul were examined by visiting every site and analyzing drawings. The distinction in architectural features of this study resulted in the line-side section, the shape of under-platform section and ceiling material. Number of underground stations was selected and categorized based on architectural features, such as line-side section, the shape of platform section and ceiling material. Each selected station was revisited and the noise levels were measured and compared with the architectural features. The study found that the Sum-Sik type is more efficient than the one of the Sang-Dae-Sik type, which can be used for subway stations. The semi-circular section for the railway-side seems to contribute on the attenuation of noise transmitting from trains to the platform. In addition, the aluminum absorbing panel, net luber and zinc plate (panel 40% and net 60%) as ceiling meterial are more efficient than the horizontal aluminum spendral panel, vertical aluminum spendral panel with line and zinc plate (panel 40% and net 60%), respectively.