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Quantitative Assay for the Binding of Jun-Fos Dimer and Activator Protein-1 Site
Lee, Sang-Kyou,Park, Se-Yeon,Jun, Gyo,Hahm, Eun-Ryeong,Lee, Dug-Keun,Yang, Chul-Hak Korean Society for Biochemistry and Molecular Biol 1999 Journal of biochemistry and molecular biology Vol.32 No.6
The Jun and Fos families of eukaryotic transcription factors form heterodimers capable of binding to their cognate DNA enhancer elements. We are interested in searching for inhibitors or antagonists of the binding of the Jun-Fos heterodimer to the activator protein-1 (AP-1) site. The basic-region leucine zipper (bZIP) domain of c-Fos was expressed as a fusion protein with glutathione S-transferase, and allowed to form a heterodimer with the bZIP domain of c-Jun. The heterodimer was bound to glutathione-agarose, to which were added radiolabeled AP-1 nucleotides. After thorough washing, the gel-bound radioactivity was counted. The assay is faster than the coventional electrophoretic mobility shift assay because the gel electrophoresis step and the autoradiography step are eliminated. Moreover, the assay is very sensitive, allowing the detection of picomolar quantities of nucleotides, and is not affected by up to 50% dimethylsulfoxide, a solvent for hydrophobic inhibitors. Curcumin and dihydroguaiaretic acid, recently known inhibitors of Jun-Fos-DNA complex formation, were applied to this Jun-GST-fused Fos system and revealed to decrease the dimer-DNA binding.
실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교
황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2
Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.
위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예
김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.
SGML을 이용한 제안서, 보고서 관리시스템 기술 개발
전병현,한치근,이상훈 경희대학교 산학협력기술연구원 1997 산학협력기술연구논문집 Vol.3 No.-
We designed an SGML-Based Proposal and Report Management System in this paper. In this system, SGML files are stored in a database and can be searched using keywords. Hence, the documents can be handled efficiently. The relational database structure is recommended for the system and also a hybrid approach is discussed for multimedia information in the text. Functions for each module of the system are defined and conceptual and practical design issues are provided.
제조업의 생산성 관리를 위한 다요소생산성 지표체계에 관한 연구 : 우리나라 철강산업을 중심으로
전상봉 대구산업정보대학 1994 논문집 Vol.8 No.-
Importance of productivity improvement has been recognized in Korea manufacturing in recent years as a means of international competitiveness enhancement. Well-established productivity management is what is needed in manufacturing in order to improve productivity. Thus far, Korea manufacturing's emphasis for productivity management has been focused mainly on the measurement of labor productivity. Effective productivity management, however generally requires the following stages : establishment of productivity strategies, productivity measurement, productivity evaluation, productivity planning, and implementation of productivity improvement programs. In this study, company-based and plant-based "productivity management index systems(PIMS)"are developed for application to measurement and evaluation stages of Korea manufacturing's productivity management.
성정훈,강대원,이윤수,임준우,홍영호,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
High selective and sensitive thick film type methane gas sensors were fabricated and their sensing characteristics for various hydrocarbon gases were investigated. Raw material, SnO_(2)/Au, prepared by coprecipitation was even grain size. SEM, TEM, BET and XRD analyses were carried out for investigation of surface morphology and crystalline structure. The thick film devices using the above materials exhibited high sensitivity to methane gas at the operating temperature of 400°C. The sensitivity of SnO_(2)/Au+Pd thick film devices to methane gas was higher than that to the other hydrocarbon gases such as iso-butane and propane. The optimal adding amounts of Au and Pd were 1wt.% and 3wt.%, respectively. The sensitivity, S, is defined as {(R_(A)-R_(G))/R_(A)}><100, which R_(A) and R_(G) are resistance in air and that in the gas ambient, respectively.
기능현 전치부 반대교합자의 ACTIVATOR 치료 효과에 관한 임상적 고찰
성재현,전준영,서혜경 慶北大學校 齒科大學 1987 慶北齒大論文集 Vol.4 No.1
The authors treated eight mixed dentiton patients with functional anterior cross-bite by using activator. The lateral roentgenographic cephalograms were analyzed before and after treatment, and skeletal and dental changes following the activator therapy were evaluated. The results were as follows: 1. The mandible was rotated backward and downward. 2. There were labioversion of upper incisors and slight linguoversion of lower incisors. 3. There was little effect of treatment upon maxillary skeletal structures. 4. LFH was increased slightly and soft tissue profile was improved.
체내 Glycogen 함량과 운동과의 관계에 관한 이론적 연구
金鍾貴,金承烈 忠南大學校體育科學硏究所 1985 體育科學硏究誌 Vol.3 No.1
This review was based on the premise that it is “what comes out”rather than “what goes in,” which provides the clues to carbohydrate, specifically muscle glycogen for athletic performance. Through the search on the related literatures, the authors reached the following conclusions. 1. Glycogen is a kind of polysaccharide formed, stored, and breaked down in the animal liver and muscles. 2. Muscle glycogen, specifically is an obligatory fuel for the aerobic and anaerobic metabolism. 3. Muscle glycogen content is a limiting factor to athletic performance required endurance. 4. When muscle glycogen level is elevated by exercise and dietary regimens, athletic performance will be improved.