두개강내 정맥기형들과 동반된 안와내 해면상 혈관종 1례

조도상,송준혁,김명현,박향권,김성학,신규만,박동빈 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.6

혈압 및 혈관손상에 대한 Candesartan과 Cilnidipine의 병용투여 효능 평가

정상혁,한주희,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

This study was designed to evaluate the effect of candesartan combined with cilnidipine on high blood pressure in spontaneous hypertensive rats (SHRs) and vascular injury induced by cuff-placed neointimal hyperplasia model. To measure blood pressure, low and high doses of candesartan (0.765 and 1.53 mg/kg/day) and cilnidipine (0.96 and 1.92 mg/kg/day) alone or in combination were orally administered in telemetered-SHRs for 2 weeks. To examine the protective action of vascular injury, high doses of candesartan (1.53 mg/kg/day) and cilnidipine (1.92 mg/kg/day) alone or in combination was orally administered for 2 weeks in cuff-induced neointimal hyperplasia model of C56BL/6 mice. As a result, high doses of candesartan and cilnidipine in combination decreased in systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of high dose of each drug, but not statistically significant. In vascular injury model, candesartan and cilnidipine in combination decreased BrdU-positive cells in neointima and vascular smooth muscle cell proliferation as compared with monotheray of each drug. Thus, these results indicate that the combination of candesartan with cilnidipine is effective for the protection of vascular injury, suggesting this combination to be a valuable tool for the management of vascular remodelling such as restenosis.

고양이 위 평활근 수축에 대한 Vanadate와 Pervanadate의 효과

심상수,최효봉,심혜선,이덕주,윤신희,한상준,김명석,조양혁 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1

고양이 위 평활근에서 KCI에 의한 근수축에 대한 Protein Kinase의 조절

심상수,김승록,심혜선,이덕주,한상준,윤신희,조양혁,김명석 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

돼지 미성숙 난포란의 회수 및 체외수정에 관한 연구

박성원,김정혁,홍승표,이지삼,정장용,박희성 진주산업대학교 농업기술연구소 1999 農業技術硏究所報 Vol.12 No.-

본 연구는 돼지의 체외수정에 있어서 난포란의 회수방법과 체외수정란 및 체외발달율을 조사하여 체외수정의 기본 원리를 밝히고자 본 연구를 수행하였다. 도축장으로부터 채집한 난소의 난포에서 흡입법, 세절법 및 흡입후세절법 등으로 난포란을 채취하여 등급별로 분류하여 회수율을 조사하였으며, 채취한 난포란은 액상정액과 정소상체미부 정액을 사용하여 체외수정을 시킨후 TCM-199 와 NCSU-23 배양액으로 체외배양을 실시하였다. 본 연구에서 얻은 결과를 요약하면 다음과 같다. 회수방법당 각각 37개의 난소에서 회수한 난포란의 수는 흡입법이 1,365개, 세절법이 1,884개 및 흡입후 세절법이 3.830개로써 난소당 난포란의 수는 각각 36.9, 50.9 및 103.5개로써 회수방법간에 유의적(P<0.05)인 차이가 있었다. 액상정액과 정소상체미부 정액을 사용하였을 때 수정율은 각각 83.0 및 83.% 로써 정액간에 유의적(P<0.05) 인 차이는 없었다. 체외수정이 이루어진 난자들의 분할율도 액상정액(60.8%) 과 정소상체미부 정액(69.0%) 간에 유의적(P<0.05) 인 차이는 없었다. 2-4세포기로의 발달율은 24.6 및 28.4%로써 배양액간에 위의적(P<0.05)인 차이는 없었으며, 상실배로의 발달율도 TCM-199 와 NCSU-23 배양액이 각각 14.8 및 24.5% 로써 이들간에 유의적(P<0.05)인 차이는 없었다. To improve the efficiency of in vitro production of embryos with follicular oocytes in pig, the recovery rates, in vitro fertilization and development, and the time required for collectng and processing oocytes by aspiration with or without slicing were evaluated comparatively. The oocytes were collected by aspiration of follicles(2-6mm) with or without slicing ovaries after aspiration, and classified into grade I-IV oocytes by the morpholoy of cumulus cells attached and the homogeneity of cytoplasmic granules. The grade Ⅰ-Ⅱ oocytes were matured invitro for 46 hours in TCM-199 and NCSU-23 supplemented with 1㎍/㎖ FSH, 2IU/㎖ hCG, 1㎍/㎖ estradiol-17 at 39℃ under 5% CO_2 in air. They were fertilized in vitro by epididymis sperm and ejaculated sperm treated with hypotaurin for 24 hours. and then the zygotes were co-cultured in vitro with pFF(porcine follicular fluid) for 7-9 days. The results obtained were as follows: The number of ocytes recovered per ovary was averaged 30.7 by aspiration, 50.8 by slicing and 103.5 by aspiration post slicing. The number of grade Ⅰ oocytes recovered was total 0.2% by aspiration, 0.1% by slicing and 0.1% by aspiration post slicing. The oocytes recovered per ovary was significantly(P<0.05) higher as recovery methods. The cleavage rates of the embryos obtained from 83.0(ejaculate sperm) and 83.1(epididymis sperm) respectively(P<0.05). In vitro developmental rates(9.9 and 18.6%) of embryos cultured in TCM-199 and NCSU-23 up to morula stage were non significantly(P<0.05) different between the culture media.

전립선암과 전립선비대증 환자에서 혈청 유리 및 총전립선특이항원 측정의 의의

서혁준,박형민,권태균,정성광,김법완,이재태 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Purpose: This study was peformed to investigate whether the free to total PSA ratio(F/T PSA ratio) offers a better discriminant for the detection of patient with prostatic cancer(CaP) and those with benign prostatic hyperplasia(BPH) than serum total PSA alone. Materials and Methods: From September 1996 to February 1999, free and total PSA levels were measured on frozen sera samples of 154 men with BPH and 46 with CaP using immunoradiometric assay. Results: In all subjects, the mean total PSA was significantly higher in CaP group(72.57±66.58ng/ml) than BPH group(3.12±4.10ng/ml). The mean PSAD was significantly higher in CaP group(1.64± 1.86) than BPH group(0.08±0.01). The mean F/T PSA ratio was significantly lower in CaP group(0.19± 0.07) than BPH group(0.30±0.13). Among 41 subjects whose total PSA were between 4-20ng/ml, the mean PSAD was significantly higher in CaP group(0.37±7.16) than BPH group(0.17± 0.07), but the mean F/T PSA ratio was not significantly different between CaP(0.19± 0.10) and BPH group(0.25±7.13). By comparing the sensitivity and specificity of total PSA alone, PSAD and F/T PSA ratio on receiver operating characterislic (ROC) Cutie in all subiects and subiects with total PSA between 4-20ng/ml, F/T PSA ratio had no superiority than total PSA alone and PSAD for discrimination between CaP and BPH. Conclusions: We suggest that the F/T PSA ratio is not superior to total PSA alone and FSAD in the detection of prostatic cancer, and further evaluation of the usefulness of F/T PSA ratio should be required.

다문화교육 관련 법령의 문제점과 개선방향

박성혁,곽한영 이화여자대학교 교과교육연구소 2008 교과교육학연구 Vol.12 No.3

세계화 추세와 함께 국내 이주노동자 및 결혼 이민자의 수가 급증하면서 본격적인 다문화사회로의 진입이 현실화되고 있다. 이러한 사회 환경의 변화는 사회과교육에도 다문화교육을 통한 시민의 양성이라는 새로운 과제를 던져주고 있다. 본 연구는 다문화교육의 제도적 기반이라 할 수 있는 관련 법령들을 이해하고 그 문제점과 개선방향을 제시함으로써 보다 적실성 있는 다문화교육의 틀을 구성하는데 기여하고자 하였다. 우리나라의 다문화교육은 헌법과 국제법, 국적법, 출입국관리법, 노동법과 사회보장법 및 교육관련법의 영향을 받고 있다. 다문화교육에 대해 체계적으로 정리된 법은 없으며 다양한 법령들에 관련 내용들이 분산되어 있어 일관성이 부족하거나 법적 권리보장이 미비한 부분들이 적지 않다. 특히 ‘다문화 가정’이라는 용어 속에서 다문화가정의 다양성이 제대로 반영되지 못하여 대상에 적합한 법령이나 정책이 구현되지 못하고 있다는 점, 다문화 구성원에 대한 보편적 인권보장과 실정법이 충돌할 경우 어떤 기준으로 이 문제를 해결할 것인가 하는 점, 국적 개념의 다양화를 통해‘국민’에서 ‘시민’으로 확장하는 작업을 어떻게 진행할 것인가에 대한 문제 등은 현행 다문화 관련법령에서 제대로 다루어지지 못한 채 공백상태로 남아있다. 이러한 문제들이 해결되기 위해서는 다문화가정의 다양성과 인권보장의 정책적 한계, 국적 개념의 재설정 등에 대해 보다 풍부한 논의를 통해 합의에 이르는 과정이 필요할 것으로 보인다. 사회과교육에서 다문화교육은 다문화가정 구성원들에 대한 교육을 의미하기도 하지만 다른 한편으로 내국인들에게 이러한 법제도적 논의를 통해 시민성의 영역을 확장하는 계기를 마련한다는 점에서도 큰 의의를 지닌다고 할 수 있다. Korea rapidly turns out to be the multi-cultural society along with the increasing numbers of foreign workers and marriage immigrants and with the wave of globalization. The change of social environment renders new problems of developing multi-cultural citizenship to social studies. In this study, we wish to give understandings about the laws which related to the multi-cultural education and analyse them to find the points to improve for making a better educational circumstance. Multi-cultural education in this country affected by Constitutional law, International law, theKorean Nationality Act, Emigration and immigration control Act, Labor law, Welfare Law andeducation related acts. But the legal articles are scattered and there is no integral law formulti-cultural education. To solve this problem, there should be profound conversations toreach the rational agreements about how to deal with the variety of multi-cultural families, howfar their rights could be secured, how we could make new sense about nationality. In socialstudies, multi-cultural education could be the education for the multi-cultural minorities but onthe other hand it also means the education about the social majorities to expand the horizonsof citizenship. This study could be the starting point to tell the social system aboutmulti-cultural education in our country.

지리산편마암복합체의 지온 및 지압계에 관한 연구

이상원,이혁우 부산대학교 사범대학 1990 교사교육연구 Vol.21 No.-

The Chirisan gneiss complex is composed of various paragneisses and small amounts of orthogneisses metamorphosed in Precambrian, which are intruded by gabbroic rock, porphyritic granite and Namwon granite. The gneiss complex was undergone multimetamorhism that early high-grade progressive metamorphism reached to upper amphibolite facies, later amphibolite and epidote-amphinbolite facies(partially to greenschist facies) were overlapped by retrogressive metamorphism. Major mineral assemblage of those gneisses are biotite-garnet,biotitie-garnet-sillimanite,biotite-garnet-cordierite,biotite-garnet-cordierite-sillimanite. Coexisting minerals of 14 samples were analysed by EPMA. Metamorphic conditions were estimated using various experimental, theoretical geothermometers and geobarometers. They show wide ranges of temperature and pressure as 600∼750℃, 720∼820℃, 420∼550℃ of biotite-garnet, cordierite-garnet, alkali feldspar-plagioclase geothermometer and 4.6~6.2Kb, 4.5~7Kb of cordierite-garnet, plagioclase-garnet geobarometer, respectively. But peak metamorphic condition is about 700℃ with 4.67Kb(X=0.40) inferred by plotting of cordierite composition to the P-T diagram under consideration of H₂0 content. The metamorphic path, according to the inferred P-T conditions with the reaction of coexisting minerals and analyses of various geothermo-barometers, is considered that progressive peak metamorphism reached to upper amphibolite facies with partial melting under 700∼750℃, 4.67Kb of temperature and pressure, and later epidote-amphibolite facies was overlapped by the retrogressive metamorphism.

자궁내막암 환자에서 복강경하 자궁적출술과 복식 자궁적출술의 비교 연구

김종혁,이상수,김천복,김대연,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

목적 : 자궁내막암 환자에서 시행된 복강경 수술의 임상적 결과를 평가하고 수술적 지표 및 재발률에 대하여 기존의 개복 수술과 비교하고자 하였다. 연구 방법 : 1997년 8월부터 2003년 11월까지 저자들은 임상적 병기 I기인 79명의 자궁내막암 환자에서 복강경하 자궁적출술과 골반 및 부대동맥 림프절 절제술을 시행하였다. 총 79명의 환자 중, 수술적 병기 I기와 II기로 판명된 74명의 환자를 연구 대상으로 하였다. 대조군으로는 같은 기간 동안에 개복수술을 시행한 환자중 복강경 수술군과 병기가 같은 168예를 선정하였다. 결과 : 평균 수술 기간, 수혈량은 양군에서 비슷하였으며, 평균 재원 기간은 복강경 수술군에서 유의하게 짧았다. 수술전후 및 만성 합병증의 발생은 개복 수술군에서 유의하게 증가되었으며, 획득한 림프절의 수는 복강경 수술군에서 유의하게 더 많았다. 복강경 수술군에서 1예, 개복 수술군에서는 2예에서 재발하였고, 2년 무병 생존률은 복강경 수술군과 개복 수술군에서 각각 97.5%와 98.6%으로 유의한 차이는 관찰되지 않았다. 결론 : 자궁내막암 치료로서 복강경 수술은 기존의 개복술을 대신할 수 있는 안전하고 효과적인 시술 방법이다. 개복 수술과 비교해 볼 때, 재발 및 생존율 면에서 차이가 없었지만, 향후 전향적이고 더 오랜 추적기간을 갖는 연구가 필요하다고 사료된다. Objective : To evaluate the outcomes of laparoscopic surgery and to compare surgical parameters and recurrence rate of these with those of conventional abdominal surgery in patients with endometrial cancer. Methods : From August 1997 to November 2003, we have performed 79 cases of LAVH (laparoscopically assisted vaginal hysterectomy) with or without lymph node dissection. Laparoscopic approach was adapted in patients with FIGO clinical stage I by imaging study. Of the 79 patients, 74 patients who were proved to be surgical stage I and II were enrolled in this comparative study. As a control group, We selected 168 cases for the laparotomy group of the same stages. Results : The mean duration of surgery, the amount of blood transfusion and hemoglobin chamges were similar in both the laparoscory and the convertional alparotomy group. The mean duration of hospital stay was significantly shorter in patients treated by laparoscopic surgery (10.2 vs. 15.5 days). The number of lymph node obtained was significantly higher in the laparoscopy group. Two year recurrence-free survival rates were 97.5% in laparoscopy group and 98.6% in laparotomy group (p=0.763). Conclusion : Laparoscopic surgery for the treatment of early stage endometrial cancer is safe and effective altematives in terms of perioperative complications. Overall and recurrence-free survival did not differ significantly in both groups however long term risk for recurrence and survival has yet to be defined.

임진왜란 관련 한일 역사서사문학의 성격 : <임진록> 과 <태합기(太閤記)>· <조선정벌기> 의 비교를 중심으로 Focusing on the comparative study between " Imjinrok " and " Taikouki " , " Chosenseipatski "

설성경,최문정,권혁래 국제비교한국학회 2002 비교한국학 Comparative Korean Studies Vol.10 No.1

On the subject of Japanese invasion of Korea in 1592(briefly called Imjin Invasion), it was studied for the character of Korea-Japan historic literature; Imjinrok, Taikouki, Chosenseipatski. The approach was made focusing on the environment, narrative method, plot and the characters, consciousess of writers etc. This discussion can be briefed out as follows. First of all, Imjinrok of Chosun Dynasty has been written with a great influence from both practical literature and historic description after Imjin Invasion. The Chronicle recording can counted as one of the major method of narration. The Japanese works such as Taikouki and Chosenseipatski were made on the tradition of military literature of previous generation. One of distinctive feature is the beautification and the heroism that is introduced as the repose for the defeated. It comes from the intended efforts to shape the works as the historical records outwardly, continuously following the trend of military records of previous generations. When the plot is compared, it is as follows, It can be categorized on the narrative novels; before the war, in the beginning of the war, in the midst of war, in the end of war, Three different copies of Imjinrok are almost identical with the stage as the midst of war as the historical records. However, it shows big difference in the peace treaty is made after the death of Toyotomi Hediyoshi, but the Hangul version presents that the Samyunhdangs heroic story over the Japanese after the General Lee Sunsin furthering the final ending with colonialism over Japan. It is one of the important pattern that the important pattern that the writers consciousness is found from post-war novels, even in the historical narration. The plot of Taikouki is composed as two parts: the combat story telling the invasion to the Chosun and the non-combat story showing the personal glorification of Toyotomi. The combat story showing the personal glorification of Toyotomi, The combat story is generally written with victorious events of Japanese military and the sudden final end without a clear description over peace treaty with Ming Dynasty and the defeat of Japan. In the middle of the combat story, it is full with non-combat statement and anecdote designed to chant the glorious Toyotomi and his ruling. On the contrary, two works of chosenseipataki is filled with the combat story on the whole. The first half of the Hori-copy makes the description comparatively as it is, but the second half relatively centered on the battle against Ming. On the non-combat narration, it shows the strong will of the writer who is going to emphasize the ideology of Japanese king. The Oseiki-copy is similar with the Hory-copy, but it is added up with new anecdotes with extended explanation for some simple contents, particularly on the heroism for Toyotomi and the martial story of Gato and Konisi. The comparison between the chosun and the Japanese is tried from different perspectives of counter partner each other: Imjinrok with the brutal and avaricious hegemony of the Japanese, Tailouki and Chosenseipatski with the lustful and extravagant, incompetent martiality of the Chosun. Compared with characters and consciousness of writer, Imjinrok represents the type of royal personality and the inevitable Gods providence in detail. For the Chosun Dynasty, it is counted as the winning forces: civil volunteer soldiers, the royal military warlords, foreign troops from Ming Dynasty, the Royal ministers asking the augmentation troops of Ming. Among the three copies, it brings about the active roles of commanders of civil volunteer forces and generals, remarkably displaying royalty and patriotism. Meanwhile, Lee Sunsin is shaped as the most important character form lots of commanders. Out of the defeated generals, it is presented with the outstanding character with fidelity, surpassing over victorious generals. On the other works, the dispatched troops of Ming seems to play a decisive role in the descriptive narration. It can mean the meritorious achievement in the history, but it seems for the writer to consider Ming as the God-sent troops. What draws the attention is the active involvement of characters who is praised with superpower of with deity. On the Chinese copy of Kukdo, this phenomenon is found with partial involvements, but on the Hangul copies with decisive and overall roles. From the Hangul copies, it is understandable with detailed pattern as a the providence of a God, theorized with untouchable presence of the Chosun Dynasty whom is protected by an Heavenly God and the Budda from any Japanese intrusive invasion. In connection with the reality in fact, the recognition of the God providence is quite superficial, resulting in the evidence of conservative ideology of actual politics. The writers of Tiakouki and Chosunseipatski tried to depict the ideal supreme commander and warriorship with the introduction of characters: Toyotomi Hideyoshi, Gato Kiyomasa, Konisi Yukinaga etc. It seems to foster the warrior spirit by the guideline of warrior way for the next generation. It is also originated from the intention to serve repose of the Toyotomi family, which is defeated by the Tokugawa Shogun.